JP2008525526A5 - - Google Patents

Info

Publication number

JP2008525526A5

JP2008525526A5 JP2007549530A JP2007549530A JP2008525526A5 JP 2008525526 A5 JP2008525526 A5 JP 2008525526A5 JP 2007549530 A JP2007549530 A JP 2007549530A JP 2007549530 A JP2007549530 A JP 2007549530A JP 2008525526 A5 JP2008525526 A5 JP 2008525526A5

Authority

JP

Japan

Prior art keywords

aryl

alkyl

halo

compound according

alkoxy

Prior art date

2005-12-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 62
• 125000003118 aryl group Chemical group 0.000 claims 35
• 125000005843 halogen group Chemical group 0.000 claims 35
• 125000001424 substituent group Chemical group 0.000 claims 27
• 125000000217 alkyl group Chemical group 0.000 claims 24
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 24
• 229910052799 carbon Inorganic materials 0.000 claims 11
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 229910052739 hydrogen Inorganic materials 0.000 claims 8
• 125000004122 cyclic group Chemical group 0.000 claims 7
• 125000004093 cyano group Chemical group *C#N 0.000 claims 6
• 230000000694 effects Effects 0.000 claims 6
• 125000001072 heteroaryl group Chemical group 0.000 claims 6
• 125000000623 heterocyclic group Chemical group 0.000 claims 6
• 229920006395 saturated elastomer Polymers 0.000 claims 6
• -1 wherein Chemical compound 0.000 claims 6
• 125000002619 bicyclic group Chemical group 0.000 claims 5
• 229910052757 nitrogen Inorganic materials 0.000 claims 5
• 229910052760 oxygen Inorganic materials 0.000 claims 5
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
• 239000003937 drug carrier Substances 0.000 claims 4
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
• 125000003545 alkoxy group Chemical group 0.000 claims 3
• 125000000753 cycloalkyl group Chemical group 0.000 claims 3
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
• 108091000080 Phosphotransferase Proteins 0.000 claims 2
• 125000004429 atom Chemical group 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 102000020233 phosphotransferase Human genes 0.000 claims 2
• 125000006413 ring segment Chemical group 0.000 claims 2
• 230000003381 solubilizing effect Effects 0.000 claims 2
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
• QRKLUICYAXZGJB-UHFFFAOYSA-N 4-[4-(2-fluorophenyl)piperazin-1-yl]-1h-pyrazolo[3,4-d]pyrimidine Chemical compound FC1=CC=CC=C1N1CCN(C=2C=3C=NNC=3N=CN=2)CC1 QRKLUICYAXZGJB-UHFFFAOYSA-N 0.000 claims 1
• LCGMENDABLGZBC-UHFFFAOYSA-N 4-[4-(3-chlorophenyl)piperazin-1-yl]-1h-pyrazolo[3,4-d]pyrimidine Chemical compound ClC1=CC=CC(N2CCN(CC2)C=2C=3C=NNC=3N=CN=2)=C1 LCGMENDABLGZBC-UHFFFAOYSA-N 0.000 claims 1
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
• 101100322915 Caenorhabditis elegans akt-1 gene Proteins 0.000 claims 1
• 101100162366 Caenorhabditis elegans akt-2 gene Proteins 0.000 claims 1
• 102000001253 Protein Kinase Human genes 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 230000005856 abnormality Effects 0.000 claims 1
• 125000003342 alkenyl group Chemical group 0.000 claims 1
• 125000000304 alkynyl group Chemical group 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 125000001246 bromo group Chemical group Br* 0.000 claims 1
• 230000001413 cellular effect Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 150000004677 hydrates Chemical class 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 230000002503 metabolic effect Effects 0.000 claims 1
• 239000002207 metabolite Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• IVXQBCUBSIPQGU-UHFFFAOYSA-N piperazine-1-carboxamide Chemical compound NC(=O)N1CCNCC1 IVXQBCUBSIPQGU-UHFFFAOYSA-N 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 108060006633 protein kinase Proteins 0.000 claims 1
• 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1