JP2008525342A5 - - Google Patents
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- Publication number
- JP2008525342A5 JP2008525342A5 JP2007547323A JP2007547323A JP2008525342A5 JP 2008525342 A5 JP2008525342 A5 JP 2008525342A5 JP 2007547323 A JP2007547323 A JP 2007547323A JP 2007547323 A JP2007547323 A JP 2007547323A JP 2008525342 A5 JP2008525342 A5 JP 2008525342A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- antibody
- factor xii
- protease
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04030593.0 | 2004-12-23 | ||
| EP04030593 | 2004-12-23 | ||
| PCT/EP2005/013714 WO2006066878A1 (en) | 2004-12-23 | 2005-12-20 | Prevention of thrombus formation and/or stabilization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525342A JP2008525342A (ja) | 2008-07-17 |
| JP2008525342A5 true JP2008525342A5 (cg-RX-API-DMAC7.html) | 2009-02-19 |
| JP5118492B2 JP5118492B2 (ja) | 2013-01-16 |
Family
ID=34927953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547323A Expired - Lifetime JP5118492B2 (ja) | 2004-12-23 | 2005-12-20 | 血栓の形成の防止および/または安定化の防止 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8119137B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2272565A3 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5118492B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101277097B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101102819A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005318464B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0519349A8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2591786C (cg-RX-API-DMAC7.html) |
| DK (1) | DK1830924T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2407965T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007006997A (cg-RX-API-DMAC7.html) |
| PL (1) | PL1830924T3 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2514878C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006066878A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| PT2298278E (pt) | 2002-06-07 | 2016-02-25 | Dyax Corp | Prevenção e redução da perda de sangue e resposta inflamatória |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| WO2004019968A1 (en) | 2002-08-28 | 2004-03-11 | Dyax Corp. | Methods for preserving organs and tissues |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| GB0607515D0 (en) * | 2006-04-13 | 2006-05-24 | Axis Shield Diagnostics Ltd | Anti-factor xlla therapy |
| EP2051707B1 (en) | 2006-07-31 | 2013-07-17 | Activesite Pharmaceuticals, Inc. | Inhibitors of plasma kallikrein |
| DK2109457T3 (en) | 2007-02-12 | 2016-04-11 | Csl Behring Gmbh | THERAPEUTIC USE OF KAZAL TYPE SERINE PROTEASE INHIBITORS |
| WO2009026539A1 (en) * | 2007-08-23 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| EP2215256A1 (en) * | 2007-10-22 | 2010-08-11 | Georg Dewald | Disorders of vasoregulation and methods of diagnosing them |
| EP2103311A1 (en) | 2008-03-20 | 2009-09-23 | CSL Behring GmbH | The calcium sensor STIM1 is essential for pathological thrombus formation |
| EP2145900A1 (en) | 2008-07-15 | 2010-01-20 | CSL Behring GmbH | Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation |
| JP2013516389A (ja) | 2009-01-06 | 2013-05-13 | ダイアックス コーポレーション | カリクレイン阻害剤による粘膜炎治療 |
| EP2269597A1 (en) | 2009-06-22 | 2011-01-05 | CSL Behring GmbH | CLEC-2 is an essential platelet activating receptor in hemostasis and thrombosis |
| EP2272874A1 (en) | 2009-07-10 | 2011-01-12 | CSL Behring GmbH | Role of PLD1 in thrombus formation and integrin alpha IIb beta 3 activation |
| ES2905545T3 (es) | 2010-01-06 | 2022-04-11 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática |
| EP2371857A1 (en) * | 2010-04-01 | 2011-10-05 | CSL Behring GmbH | Factor XII inhibitors for treating interstitial lung disease |
| WO2012064758A2 (en) * | 2010-11-08 | 2012-05-18 | Isis Pharmaceuticals, Inc. | Methods for modulating factor 12 expression |
| KR102011156B1 (ko) | 2011-01-06 | 2019-08-16 | 다이액스 코포레이션 | 혈장 칼리크레인 결합 단백질 |
| CN103415301A (zh) * | 2011-03-09 | 2013-11-27 | 德国杰特贝林生物制品有限公司 | 用于与包括与人造表面接触的医疗操作一起施用的fxii抑制剂 |
| EP2497489A1 (en) * | 2011-03-09 | 2012-09-12 | CSL Behring GmbH | Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs |
| US9187749B2 (en) | 2011-06-10 | 2015-11-17 | Isis Pharmaceuticals, Inc. | Methods for modulating factor 12 expression |
| HRP20250164T1 (hr) | 2011-07-22 | 2025-04-11 | Csl Behring Gmbh | Inhibitorna monoklonska antitijela protiv faktora xii/xiia i njihove uporabe |
| EP2548892A1 (en) | 2011-07-22 | 2013-01-23 | CSL Behring GmbH | Inhibitory anti-Factor XII/XIIa monoclonal Antibodies and their uses |
| US20140296146A1 (en) * | 2011-08-23 | 2014-10-02 | Synapse B.V. | Thermostable Inhibitors of Activation of the Blood Clotting System Through Contact with Foreign Surfaces |
| EP2623110A1 (en) * | 2012-01-31 | 2013-08-07 | CSL Behring GmbH | Factor XII inhibitors for the treatment of neurological inflammatory disorders |
| WO2014089493A1 (en) * | 2012-12-07 | 2014-06-12 | Vanderbilt University | Antibodies against factor xii and uses thereof |
| WO2014135694A1 (en) | 2013-03-08 | 2014-09-12 | Csl Behring Ag | Treatment and prevention of remote ischemia-reperfusion injury |
| CA2916399C (en) * | 2013-06-28 | 2022-08-02 | Marc Nolte | Combination therapy using a factor xii inhibitor and a c1-inhibitor |
| DK3157548T3 (da) * | 2014-06-18 | 2021-09-06 | Csl Behring Gmbh | Terapi anvendelse af en faktor xii-inhibitor i en neurotraumatisk sygdom |
| CA2972800A1 (en) | 2015-01-02 | 2016-07-07 | Dyax Corp. | Bispecific antibodies against plasma kallikrein and factor xii |
| JP2018521960A (ja) * | 2015-04-28 | 2018-08-09 | エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ(ウペエフエル)Ecole Polytechnique Federale de Lausanne (EPFL) | 酵素で活性化された第XII因子(FXIIa)の新規阻害剤 |
| EP3325516B1 (en) | 2015-07-21 | 2021-12-15 | Takeda Pharmaceutical Company Limited | A monoclonal antibody inhibitor of factor xiia |
| US11286307B2 (en) | 2015-12-11 | 2022-03-29 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| EP3440107A4 (en) * | 2016-04-06 | 2020-02-19 | CSL Limited | METHOD FOR TREATING ATHEROSCLEROSIS |
| WO2019113642A1 (en) | 2017-12-15 | 2019-06-20 | Csl Limited | Use of a fxiia-inhibitor in the treatment of renal fibrosis and/or chronic kidney disease |
| EA202190056A1 (ru) * | 2018-06-19 | 2021-05-28 | Ридженерон Фармасьютикалз, Инк. | АНТИТЕЛА ПРОТИВ ФАКТОРА XII/XIIa И ИХ ПРИМЕНЕНИЕ |
| US12134657B2 (en) | 2018-11-28 | 2024-11-05 | Oregon Health & Science University | Therapeutic factor XII antibody |
| WO2021007190A1 (en) | 2019-07-08 | 2021-01-14 | Rezolute, Inc. | Processes for preparing plasma kallikrein inhibitors |
| AU2021209045A1 (en) | 2020-01-13 | 2022-07-28 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
| US20240352150A2 (en) * | 2020-06-16 | 2024-10-24 | Ningbo Comgen Biotech Co., Ltd. | Anti-factor xii (fxii) nanobody or antigen-binding fragment thereof, and use thereof |
| AR124408A1 (es) | 2020-12-18 | 2023-03-22 | Ionis Pharmaceuticals Inc | Compuestos y métodos para modular el factor xii |
| KR20260042526A (ko) | 2023-07-19 | 2026-03-31 | 리제너론 파아마슈티컬스, 인크. | 항-인자 XII/XIIa 항체 및 이의 용도 |
| TWI918151B (zh) | 2024-09-25 | 2026-03-11 | 吳文良 | 毛豆胜肽在抗血栓形成上的用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK225488D0 (da) * | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
| US4963657A (en) * | 1988-06-09 | 1990-10-16 | Temple University Of The Commonwealth System Of Higher Education | Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same |
| WO1994020535A1 (en) * | 1992-12-11 | 1994-09-15 | Corvas International, Inc. | ECOTIN AS A FACTOR Xa, XIa, AND XIIa INHIBITOR |
| CA2170030A1 (en) | 1993-09-14 | 1995-03-23 | Robert A. Lazarus | Pharmaceutical compositions containing ecotin and homologs thereof |
| ZA963619B (en) | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
| US20030109680A1 (en) * | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| DE19725014A1 (de) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
| GB9800817D0 (en) | 1998-01-16 | 1998-03-11 | Bio Discovery Ltd | Serine protease inhibitors |
| JP2002517739A (ja) * | 1998-06-08 | 2002-06-18 | ユニバーシティ オブ バーモント アンド ステイト アグリカルチャー カレッジ | 血液および血液製剤における凝固の抑制 |
| CA2345641A1 (en) * | 1998-09-28 | 2000-04-06 | Merck & Co., Inc. | A method for treating inflammatory diseases by administering a thrombin inhibitor |
| DK1222929T3 (da) * | 2001-01-11 | 2010-09-06 | Life Sciences Res Partners Vzw | Fremgangsmåde og farmaceutisk sammensætning til forebyggelse og/eller behandling af systematisk betændelsesreaktionssyndrom |
| PT2298278E (pt) * | 2002-06-07 | 2016-02-25 | Dyax Corp | Prevenção e redução da perda de sangue e resposta inflamatória |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| WO2004004640A2 (en) | 2002-07-05 | 2004-01-15 | Tetragrammaton Inc. | Methods, compositions and kits for treating damage to excitable tissue |
| WO2004019968A1 (en) * | 2002-08-28 | 2004-03-11 | Dyax Corp. | Methods for preserving organs and tissues |
| US20040229778A1 (en) * | 2003-05-13 | 2004-11-18 | Elmaleh David R. | Pharmaceutical compositions of antithrombin III for the treatment of retroviral diseases |
| WO2004110356A2 (en) | 2003-05-15 | 2004-12-23 | Cbr Institute For Biomedical Research, Inc. | Methods for modulating cell-to-cell adhesion using an agonist of c1inh-type protein activity |
| US7544853B2 (en) | 2003-05-16 | 2009-06-09 | Pharming Intellectual Property B.V. | C1 inhibitor with short half-life transient treatment |
| EP1673134A4 (en) * | 2003-09-12 | 2007-03-21 | Marinepolymer Tech Inc | RECEIVING VASCULAR ACCESS IN HEMODIALYSIS PATIENTS |
| GB0411145D0 (en) | 2004-05-19 | 2004-06-23 | Imp College Innovations Ltd | Protease inhibitors and their therapeutic applications |
| US8569277B2 (en) * | 2004-08-11 | 2013-10-29 | Palo Alto Investors | Methods of treating a subject for a condition |
| GB0418877D0 (en) | 2004-08-24 | 2004-09-29 | Univ Edinburgh | Heart |
| US20060104944A1 (en) * | 2004-11-18 | 2006-05-18 | Mousa Shaker A | Activators and inhibitors of protease activated receptor2 (PAR2) and methods of use |
| SI1669074T1 (sl) | 2004-12-01 | 2010-10-29 | Par Pharmaceuticals Inc | Uporaba megestrol acetata za izboljšanje delovanja srca in zdravljenje srčnega popuščanja |
-
2005
- 2005-12-20 CN CNA2005800465756A patent/CN101102819A/zh active Pending
- 2005-12-20 EP EP10183075A patent/EP2272565A3/en not_active Withdrawn
- 2005-12-20 US US11/793,820 patent/US8119137B2/en active Active
- 2005-12-20 RU RU2007123797/14A patent/RU2514878C2/ru not_active Application Discontinuation
- 2005-12-20 PL PL05820601T patent/PL1830924T3/pl unknown
- 2005-12-20 MX MX2007006997A patent/MX2007006997A/es active IP Right Grant
- 2005-12-20 CA CA2591786A patent/CA2591786C/en not_active Expired - Lifetime
- 2005-12-20 ES ES05820601T patent/ES2407965T3/es not_active Expired - Lifetime
- 2005-12-20 DK DK05820601.2T patent/DK1830924T3/da active
- 2005-12-20 EP EP05820601A patent/EP1830924B1/en not_active Expired - Lifetime
- 2005-12-20 KR KR1020077016992A patent/KR101277097B1/ko not_active Expired - Lifetime
- 2005-12-20 WO PCT/EP2005/013714 patent/WO2006066878A1/en not_active Ceased
- 2005-12-20 BR BRPI0519349A patent/BRPI0519349A8/pt not_active Application Discontinuation
- 2005-12-20 AU AU2005318464A patent/AU2005318464B2/en not_active Expired
- 2005-12-20 JP JP2007547323A patent/JP5118492B2/ja not_active Expired - Lifetime
-
2011
- 2011-12-29 US US13/339,793 patent/US20120148688A1/en not_active Abandoned
-
2012
- 2012-12-21 US US13/723,847 patent/US8715672B2/en not_active Expired - Fee Related
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