JP2008525005A5 - - Google Patents
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- Publication number
- JP2008525005A5 JP2008525005A5 JP2007547622A JP2007547622A JP2008525005A5 JP 2008525005 A5 JP2008525005 A5 JP 2008525005A5 JP 2007547622 A JP2007547622 A JP 2007547622A JP 2007547622 A JP2007547622 A JP 2007547622A JP 2008525005 A5 JP2008525005 A5 JP 2008525005A5
- Authority
- JP
- Japan
- Prior art keywords
- substance
- hcap18
- cancer cells
- substance according
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000126 substance Substances 0.000 claims 61
- 210000004027 cell Anatomy 0.000 claims 38
- 206010028980 Neoplasm Diseases 0.000 claims 18
- 201000011510 cancer Diseases 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 206010006187 Breast cancer Diseases 0.000 claims 8
- 208000026310 Breast neoplasm Diseases 0.000 claims 8
- 238000009007 Diagnostic Kit Methods 0.000 claims 7
- 108091034117 Oligonucleotide Proteins 0.000 claims 7
- 108020004459 Small interfering RNA Proteins 0.000 claims 6
- 230000004071 biological effect Effects 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000004055 small Interfering RNA Substances 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 239000000074 antisense oligonucleotide Substances 0.000 claims 4
- 238000012230 antisense oligonucleotides Methods 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 210000000481 breast Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101000818546 Homo sapiens N-formyl peptide receptor 2 Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102100021126 N-formyl peptide receptor 2 Human genes 0.000 claims 1
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 1
- 238000002105 Southern blotting Methods 0.000 claims 1
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 1
- 125000004057 biotinyl group Chemical group [H]N1C(=O)N([H])[C@]2([H])[C@@]([H])(SC([H])([H])[C@]12[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 230000002250 progressing effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63775904P | 2004-12-22 | 2004-12-22 | |
| PCT/GB2005/004900 WO2006067402A2 (en) | 2004-12-22 | 2005-12-16 | Agents inibiting the cathelin-like protein cap18/ll-37 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525005A JP2008525005A (ja) | 2008-07-17 |
| JP2008525005A5 true JP2008525005A5 (https=) | 2009-02-12 |
Family
ID=36283015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547622A Abandoned JP2008525005A (ja) | 2004-12-22 | 2005-12-16 | 新規の物質、および、それらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7741275B2 (https=) |
| EP (1) | EP1846444A2 (https=) |
| JP (1) | JP2008525005A (https=) |
| CN (1) | CN101142233A (https=) |
| CA (1) | CA2593956A1 (https=) |
| WO (1) | WO2006067402A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0608797D0 (en) * | 2006-05-04 | 2006-06-14 | Lipopeptide Ab | Novel agents and the use thereof |
| AU2007262776A1 (en) * | 2006-06-20 | 2007-12-27 | Lipopeptide Ab | Use cathelicidin antimicrobial protein (hCAP18 ) as anticancer agent |
| US20120315290A1 (en) * | 2006-12-15 | 2012-12-13 | Board Of Regents, The University Of Texas System | Inhibitors of ll-37 mediated immune reactivity to self nucleic acids |
| CN101571549B (zh) * | 2008-04-30 | 2013-08-14 | 上海泽润生物科技有限公司 | Vero细胞HCP检测试剂盒及其应用 |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| CN111973805B (zh) * | 2019-08-16 | 2022-03-01 | 苏州吉美瑞生医学科技有限公司 | 抗菌肽hCAP18/LL-37在抗感染生物工程肺中的应用 |
| MX2023002285A (es) * | 2020-08-26 | 2023-05-16 | Cila Therapeutic Inc | Agentes terapeuticos inhalables. |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5116742A (en) * | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) * | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5168053A (en) * | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
| US5149796A (en) * | 1989-08-31 | 1992-09-22 | City Of Hope | Chimeric DNA-RNA catalytic sequences |
| US5180818A (en) * | 1990-03-21 | 1993-01-19 | The University Of Colorado Foundation, Inc. | Site specific cleavage of single-stranded dna |
| GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| SE9400088D0 (sv) * | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| ES2183865T3 (es) | 1994-02-04 | 2003-04-01 | Lipocore Holding Ab | Preparaciones de doble capa de galactolipido que contienen digalactosildiacilglicerol. |
| BR9506681A (pt) | 1994-02-04 | 1997-11-18 | Scotia Lipidteknik Ab | Emulsão oleo em água e composição farmacêutica |
| FI963066A7 (fi) | 1994-02-04 | 1996-09-30 | Lipocore Holding Ab | Lipofiiliset kantoainevalmisteet |
| EP1358888A1 (en) | 2002-02-28 | 2003-11-05 | Robert Bals | The human peptide antibiotic LL-37/hCAP-18 is an inducer of angiogenesis |
| SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| WO2004009640A1 (ja) * | 2002-07-22 | 2004-01-29 | Seikagaku Corporation | 抗菌性ペプチドに対する抗体及びその利用 |
| AU2003288507A1 (en) | 2002-12-19 | 2004-07-14 | Yitzchak Hillman | Disease treatment via antimicrobial peptide inhibitors |
| SE0300207D0 (sv) | 2003-01-29 | 2003-01-29 | Karolinska Innovations Ab | New use and composition |
| WO2004098536A2 (en) * | 2003-03-06 | 2004-11-18 | The Regents Of The University Of California | Anti-viral activity of cathelicidin peptides |
-
2005
- 2005-12-16 WO PCT/GB2005/004900 patent/WO2006067402A2/en not_active Ceased
- 2005-12-16 CA CA002593956A patent/CA2593956A1/en not_active Abandoned
- 2005-12-16 CN CNA2005800482770A patent/CN101142233A/zh active Pending
- 2005-12-16 JP JP2007547622A patent/JP2008525005A/ja not_active Abandoned
- 2005-12-16 EP EP05847503A patent/EP1846444A2/en not_active Withdrawn
- 2005-12-16 US US11/793,708 patent/US7741275B2/en not_active Expired - Fee Related
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