JP2008521920A5 - - Google Patents
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- JP2008521920A5 JP2008521920A5 JP2007544495A JP2007544495A JP2008521920A5 JP 2008521920 A5 JP2008521920 A5 JP 2008521920A5 JP 2007544495 A JP2007544495 A JP 2007544495A JP 2007544495 A JP2007544495 A JP 2007544495A JP 2008521920 A5 JP2008521920 A5 JP 2008521920A5
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- JP
- Japan
- Prior art keywords
- compound
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- genbank accession
- antibody
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C)C(C(N[C@@](CCCNC(N)=O)C(*(C)(C)*)=O)=O)N*(C(C)*)=C Chemical compound CC(C)C(C(N[C@@](CCCNC(N)=O)C(*(C)(C)*)=O)=O)N*(C(C)*)=C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63261304P | 2004-12-01 | 2004-12-01 | |
| US60/632,613 | 2004-12-01 | ||
| PCT/US2005/043409 WO2006060533A2 (en) | 2004-12-01 | 2005-11-29 | Conjugates of 1, 8-bis-naphthalimides with an antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521920A JP2008521920A (ja) | 2008-06-26 |
| JP2008521920A5 true JP2008521920A5 (https=) | 2008-12-25 |
| JP4993645B2 JP4993645B2 (ja) | 2012-08-08 |
Family
ID=36263731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544495A Expired - Fee Related JP4993645B2 (ja) | 2004-12-01 | 2005-11-29 | 抗体薬剤結合体および方法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1817059A2 (https=) |
| JP (1) | JP4993645B2 (https=) |
| WO (1) | WO2006060533A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070134243A1 (en) * | 2004-12-01 | 2007-06-14 | Gazzard Lewis J | Antibody drug conjugates and methods |
| US7947839B2 (en) | 2004-12-01 | 2011-05-24 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
| FR2898902B1 (fr) * | 2006-03-24 | 2010-09-10 | Oreal | Colorants particuliers de type naphtalimide, composition tinctoriale comprenant au moins un tel colorant, procede de mise en oeuvre et utilisations |
| ATE518916T1 (de) | 2006-03-24 | 2011-08-15 | Oreal | Färbezusammensetzung mit einem thiol/disulfid- leuchtfarbstoff mit einem heterozyklus und einer internen kationischen ladung sowie verfahren zur aufhellung von keratinmaterial mit diesem farbstoff |
| FR2898903B1 (fr) | 2006-03-24 | 2012-08-31 | Oreal | Composition de teinture comprenant un colorant disulfure fluorescent, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| EP2024444B1 (fr) | 2006-03-24 | 2011-07-06 | L'Oréal | Composition de teinture comprenant un colorant fluorescent naphtylimide thiol/disulfure, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| EP2069308B1 (en) * | 2006-09-12 | 2017-03-29 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Azonafide derived tumor and cancer targeting compounds |
| NZ583318A (en) | 2007-07-16 | 2012-07-27 | Genentech Inc | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| DK2474557T3 (da) | 2007-07-16 | 2014-11-10 | Genentech Inc | Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse |
| FR2921381B1 (fr) | 2007-09-21 | 2009-10-30 | Oreal | Colorant hemicyanine styryle thiol/disulfure, composition tinctoriale comprenant ce colorant, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| FR2921373B1 (fr) | 2007-09-21 | 2009-10-30 | Oreal | Colorant derive d'indole styryle a linker alkylene, composition tinctoriale comprenant ce colorant, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| FR2921377B1 (fr) | 2007-09-21 | 2009-10-30 | Oreal | Compose styryl a motif hydroxy(cyclo)alkylamino thiol/disulfure, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| FR2921376B1 (fr) | 2007-09-21 | 2009-10-30 | Oreal | Compose styryl tetrahydroquinolinium thiol/disulfure, procede d'eclaircissement des matieres keratiniques a partir de ce colorant |
| US8119656B2 (en) | 2007-12-07 | 2012-02-21 | The Board Of Regents Of The University Of Texas System | Inhibitors of the influenza virus non-structural 1 protein |
| WO2009089537A2 (en) * | 2008-01-11 | 2009-07-16 | Northwestern University | Anti-cancer compounds |
| SG187517A1 (en) | 2008-01-31 | 2013-02-28 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
| WO2009144205A1 (en) | 2008-05-30 | 2009-12-03 | Basf Se | Rylene-based semiconductor materials and methods of preparation and use thereof |
| US20100189651A1 (en) | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| TWI429453B (zh) | 2010-02-23 | 2014-03-11 | 建南德克公司 | 抗tat419抗體及其用途 |
| PE20141114A1 (es) | 2010-12-20 | 2014-09-15 | Genentech Inc | Anticuerpos anti-mesotelina e inmunoconjugados |
| AR090549A1 (es) | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| AU2013256596A1 (en) | 2012-05-01 | 2014-10-09 | Genentech, Inc. | Anti-PMEL17 antibodies and immunoconjugates |
| IN2014DN08841A (https=) * | 2012-05-02 | 2015-05-22 | Lubrizol Advanced Mat Inc | |
| US9981046B2 (en) | 2012-05-15 | 2018-05-29 | Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. | Drug-conjugates, conjugation methods, and uses thereof |
| BR112014028366A2 (pt) | 2012-05-21 | 2017-06-27 | Genentech Inc | anticorpos anti-ly6e e imunoconjugados e métodos de uso |
| CA2879665A1 (en) | 2012-08-02 | 2014-02-06 | Genentech, Inc. | Anti-etbr antibodies and immunoconjugates |
| MX2015001407A (es) | 2012-08-02 | 2015-05-08 | Genentech Inc | Inmunoconjugados y anticuerpos anti-etbr. |
| CN103013497A (zh) * | 2012-12-21 | 2013-04-03 | 武汉大学 | 一种巯基荧光探针及其制备方法 |
| GB201309807D0 (en) | 2013-05-31 | 2013-07-17 | Pharma Mar Sau | Antibody drug conjugates |
| WO2015042108A1 (en) | 2013-09-17 | 2015-03-26 | Genentech, Inc. | Methods of using anti-lgr5 antibodies |
| CN105658237B (zh) | 2013-10-21 | 2021-03-09 | 基因泰克公司 | 抗Ly6E抗体及使用方法 |
| PT3262071T (pt) | 2014-09-23 | 2020-06-16 | H Hoffnabb La Roche Ag | Métodos de utilização de imunoconjugados anti-cd79b |
| JP6486316B2 (ja) | 2015-11-03 | 2019-03-20 | 財團法人工業技術研究院Ｉｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 抗体−薬物複合体（ａｄｃ）およびそれを形成するための方法 |
| TR201618160A2 (tr) * | 2016-12-09 | 2018-06-21 | T C Istanbul Medipol Ueniversitesi | Parazi̇ti̇k ve neoplasti̇k hastaliklarin tedavi̇si̇nde kullanima uygun özgün i̇laç molekülleri̇ ve bunlarin hazirlanmasinda kullanilacak usuller |
| HRP20231233T1 (hr) | 2017-04-27 | 2024-01-19 | Pharma Mar, S.A. | Antitumorski spojevi |
| CN107625771B (zh) * | 2017-09-27 | 2018-12-14 | 徐州玖胜医疗器械有限公司 | 一种miR-17基因抑制剂及用于治疗胃癌的用途 |
| JOP20200268A1 (ar) | 2018-06-01 | 2020-10-26 | Eisai R&D Man Co Ltd | تضفير مترافقات عقار جسم مضاد معدل وطرق استخدامها |
| TWI824043B (zh) | 2018-10-25 | 2023-12-01 | 西班牙商瑪製藥股份有限公司 | 藥物抗體共軛物 |
| CN114615999B (zh) | 2019-09-05 | 2024-03-08 | 法马马有限公司 | 药物抗体偶联物 |
| KR20230004714A (ko) | 2020-04-21 | 2023-01-06 | 파르마 마르, 에스.에이. | 약물 항체 접합체 |
| CN116063284A (zh) * | 2023-02-10 | 2023-05-05 | 河南大学 | 一类含有与黏蛋白共价结合片段的肠限制性tgr5激动剂及其在治疗糖尿病药物中的应用 |
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| US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| US5079233A (en) | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
| DE3707651A1 (de) | 1987-03-10 | 1988-09-22 | Knoll Ag | Bis-naphthalimide, ihre herstellung und verwendung |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| US5416089A (en) | 1993-06-24 | 1995-05-16 | The Du Pont Merck Pharmaceutical Company | Polycyclic and heterocyclic chromophores for bis-imide tumoricidals |
| IL110460A (en) | 1993-08-18 | 2001-01-11 | Basf Ag | Bis-naphthalimides, their preparation and pharmaceutical compositions containing them |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5561042A (en) * | 1994-07-22 | 1996-10-01 | Cancer Therapy And Research Center | Diamine platinum naphthalimide complexes as antitumor agents |
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| JP3646191B2 (ja) | 1996-03-19 | 2005-05-11 | 大塚製薬株式会社 | ヒト遺伝子 |
| AU778199B2 (en) | 1999-10-29 | 2004-11-25 | Genentech Inc. | Anti-prostate stem cell antigen (PSCA) antibody compositions and methods of use |
| EP1235847B1 (en) | 1999-11-29 | 2016-01-20 | The Trustees of Columbia University in the City of New York | ISOLATION OF FIVE NOVEL GENES CODING FOR NEW Fc RECEPTORS-TYPE MELANOMA INVOLVED IN THE PATHOGENESIS OF LYMPHOMA/MELANOMA |
| EP2180054A1 (en) | 1999-12-24 | 2010-04-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
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| AU2002243495A1 (en) | 2001-01-12 | 2002-07-24 | University Of Medicine And Dentistry Of New Jersey | Bone morphogenetic protein-2 in the treatment and diagnosis of cancer |
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-
2005
- 2005-11-29 EP EP05852595A patent/EP1817059A2/en not_active Withdrawn
- 2005-11-29 WO PCT/US2005/043409 patent/WO2006060533A2/en not_active Ceased
- 2005-11-29 JP JP2007544495A patent/JP4993645B2/ja not_active Expired - Fee Related
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