JP2008520695A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008520695A5 JP2008520695A5 JP2007543250A JP2007543250A JP2008520695A5 JP 2008520695 A5 JP2008520695 A5 JP 2008520695A5 JP 2007543250 A JP2007543250 A JP 2007543250A JP 2007543250 A JP2007543250 A JP 2007543250A JP 2008520695 A5 JP2008520695 A5 JP 2008520695A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methyl
- pyrazol
- ethoxy
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RLNQKFLDMDEXFL-UHFFFAOYSA-N CC(N1CCN(CCOc(ccc(NC(c2cccc(F)c2)=O)c2)c2-c2ccn[n]2C)CC1)=O Chemical compound CC(N1CCN(CCOc(ccc(NC(c2cccc(F)c2)=O)c2)c2-c2ccn[n]2C)CC1)=O RLNQKFLDMDEXFL-UHFFFAOYSA-N 0.000 description 2
- 0 C[n]1ncc(Br)c1-c1cc(N)ccc1OC*N(CC1)CCC1OC Chemical compound C[n]1ncc(Br)c1-c1cc(N)ccc1OC*N(CC1)CCC1OC 0.000 description 2
- NLTCSYNRJNXHJM-UHFFFAOYSA-N CC(C)[N](C)(C)C Chemical compound CC(C)[N](C)(C)C NLTCSYNRJNXHJM-UHFFFAOYSA-N 0.000 description 1
- ZUTCVANZJSSJQV-UHFFFAOYSA-N CC(CCC(C1)C(NC(CC2C(N(C)NC3)=C3Cl)=CC=C2OCCN2CCOCC2)=O)=C1F Chemical compound CC(CCC(C1)C(NC(CC2C(N(C)NC3)=C3Cl)=CC=C2OCCN2CCOCC2)=O)=C1F ZUTCVANZJSSJQV-UHFFFAOYSA-N 0.000 description 1
- JUIQSTODGNFHBE-UHFFFAOYSA-N C[U]C(C(C=N)Cl)c1cc(N)ccc1OCCN1CCOCC1 Chemical compound C[U]C(C(C=N)Cl)c1cc(N)ccc1OCCN1CCOCC1 JUIQSTODGNFHBE-UHFFFAOYSA-N 0.000 description 1
- SYJVABDKKVMFJH-UHFFFAOYSA-N C[n]1ncc(Br)c1-c1cc(NC(c2cccc(F)c2)=O)ccc1OCCN(CC1)CCC1OC Chemical compound C[n]1ncc(Br)c1-c1cc(NC(c2cccc(F)c2)=O)ccc1OCCN(CC1)CCC1OC SYJVABDKKVMFJH-UHFFFAOYSA-N 0.000 description 1
- HIEXOUCDZZPETA-UHFFFAOYSA-N C[n]1nccc1-c(cc(cc1)NC(NCc2ccccc2)=O)c1OCCN1CCCCC1 Chemical compound C[n]1nccc1-c(cc(cc1)NC(NCc2ccccc2)=O)c1OCCN1CCCCC1 HIEXOUCDZZPETA-UHFFFAOYSA-N 0.000 description 1
- BVMGOLVERDLUFN-UHFFFAOYSA-N C[n]1nccc1-c1cc(N)ccc1OCCN1CCCCC1 Chemical compound C[n]1nccc1-c1cc(N)ccc1OCCN1CCCCC1 BVMGOLVERDLUFN-UHFFFAOYSA-N 0.000 description 1
- XHXMQSPBUDVSJW-UHFFFAOYSA-N C[n]1nccc1-c1cc(NC(Cc2cc(C(F)(F)F)ccc2)=O)ccc1OCCN1CCOCC1 Chemical compound C[n]1nccc1-c1cc(NC(Cc2cc(C(F)(F)F)ccc2)=O)ccc1OCCN1CCOCC1 XHXMQSPBUDVSJW-UHFFFAOYSA-N 0.000 description 1
- NLONUUNPZPRXON-UHFFFAOYSA-N C[n]1nccc1-c1cc(NC(Nc(cc2)ccc2Cl)=O)ccc1O Chemical compound C[n]1nccc1-c1cc(NC(Nc(cc2)ccc2Cl)=O)ccc1O NLONUUNPZPRXON-UHFFFAOYSA-N 0.000 description 1
- VCHNOCSZCQRIQZ-UHFFFAOYSA-N C[n]1nccc1-c1cc(NC(Nc(cc2)ccc2Cl)=O)ccc1OC Chemical compound C[n]1nccc1-c1cc(NC(Nc(cc2)ccc2Cl)=O)ccc1OC VCHNOCSZCQRIQZ-UHFFFAOYSA-N 0.000 description 1
- BNIYFNNAALYAED-UHFFFAOYSA-N C[n]1nccc1-c1cc(NC(c2cccc(F)c2)=O)ccc1OCCBr Chemical compound C[n]1nccc1-c1cc(NC(c2cccc(F)c2)=O)ccc1OCCBr BNIYFNNAALYAED-UHFFFAOYSA-N 0.000 description 1
- NXPMSMYAMLYDNT-UHFFFAOYSA-O C[n]1nccc1-c1cc([N+](OC)=O)ccc1O Chemical compound C[n]1nccc1-c1cc([N+](OC)=O)ccc1O NXPMSMYAMLYDNT-UHFFFAOYSA-O 0.000 description 1
- XRNDVRILXGIXIN-UHFFFAOYSA-N C[n]1nccc1-c1cc([NH+]([O-])OC)ccc1OCCN1CCOCC1 Chemical compound C[n]1nccc1-c1cc([NH+]([O-])OC)ccc1OCCN1CCOCC1 XRNDVRILXGIXIN-UHFFFAOYSA-N 0.000 description 1
- LPXGDRDHJJJXRL-UHFFFAOYSA-N C[n]1nccc1C(C(CC1)OCCBr)=CC1[N+]([O-])=O Chemical compound C[n]1nccc1C(C(CC1)OCCBr)=CC1[N+]([O-])=O LPXGDRDHJJJXRL-UHFFFAOYSA-N 0.000 description 1
- OOJYNFXEHNWCDQ-UHFFFAOYSA-O C[n]1nccc1C(C(OCCN(CCC1)C1C(OC)=O)=CC1)=CC1C([NH2+]OC)O Chemical compound C[n]1nccc1C(C(OCCN(CCC1)C1C(OC)=O)=CC1)=CC1C([NH2+]OC)O OOJYNFXEHNWCDQ-UHFFFAOYSA-O 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62977404P | 2004-11-19 | 2004-11-19 | |
| US60/629,774 | 2004-11-19 | ||
| US64763905P | 2005-01-26 | 2005-01-26 | |
| US60/647,639 | 2005-01-26 | ||
| US65838405P | 2005-03-02 | 2005-03-02 | |
| US60/658,384 | 2005-03-02 | ||
| US71338405P | 2005-09-01 | 2005-09-01 | |
| US60/713,384 | 2005-09-01 | ||
| US73316505P | 2005-11-04 | 2005-11-04 | |
| US60/733,165 | 2005-11-04 | ||
| PCT/US2005/041726 WO2006055734A2 (en) | 2004-11-19 | 2005-11-17 | 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008520695A JP2008520695A (ja) | 2008-06-19 |
| JP2008520695A5 true JP2008520695A5 (https=) | 2009-01-08 |
| JP5016494B2 JP5016494B2 (ja) | 2012-09-05 |
Family
ID=36218810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543250A Expired - Lifetime JP5016494B2 (ja) | 2004-11-19 | 2005-11-17 | ５−ｈｔ２ａセロトニン受容体媒介障害の処置に有用な５−ｈｔ２ａセロトニン受容体のモジュレーターとしての３−フェニル−ピラゾール誘導体の使用 |
Country Status (36)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| ATE548353T1 (de) * | 2004-03-23 | 2012-03-15 | Arena Pharm Inc | Verfahren zur herstellung von substituierte n- aryl-n'-ä3-(1h-pyrazol-5-yl)phenylü-harnstoffe and intermediate davon. |
| SA05260357B1 (ar) | 2004-11-19 | 2008-09-08 | ارينا فارماسيتو تيكالز ، أنك | مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به |
| CA2646076C (en) * | 2006-05-18 | 2015-06-30 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| SG171681A1 (en) * | 2006-05-18 | 2011-06-29 | Arena Pharm Inc | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-ht2a serotonin receptor |
| JP5406018B2 (ja) | 2006-05-18 | 2014-02-05 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ａセロトニンレセプターに関連する障害の処置に有用な５−ｈｔ２ａセロトニンレセプターのモジュレーターとしての１級アミン、およびその誘導体 |
| WO2008027483A1 (en) * | 2006-08-31 | 2008-03-06 | Arena Pharmaceuticals, Inc. | Benzofuran derivatives as modulators of the 5-ht2a receptor |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| WO2008054748A2 (en) * | 2006-10-31 | 2008-05-08 | Arena Pharmaceuticals, Inc. | Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| ITMI20062230A1 (it) * | 2006-11-22 | 2008-05-23 | Acraf | Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende |
| JP5393677B2 (ja) | 2007-08-15 | 2014-01-22 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ＨＴ２Ａセロトニン受容体に関連した障害の治療のための５−ＨＴ２Ａセロトニン受容体のモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン誘導体 |
| EP2222301B1 (en) * | 2007-12-13 | 2014-10-08 | Vanda Pharmaceuticals Inc. | Method and composition for treating an alpha adrenoceptor-mediated condition |
| WO2009076664A1 (en) | 2007-12-13 | 2009-06-18 | Vanda Pharmaceuticals Inc. | Method and composition for treating a serotonin receptor-mediated condition |
| US20110021538A1 (en) * | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| CA2741731A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Compositions of a 5-ht2a serotonin receptor modulator useful for the treatment of disorders related thereto |
| WO2011075596A1 (en) * | 2009-12-18 | 2011-06-23 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| US10022263B2 (en) | 2011-07-14 | 2018-07-17 | Cook Medical Technologies Llc | Sling-based treatment of obstructive sleep apnea |
| CA2888030A1 (en) | 2012-10-16 | 2014-11-27 | Cook Medical Technologies Llc | Method and apparatus for treating obstructive sleep apnea (osa) |
| US9867733B2 (en) | 2013-08-01 | 2018-01-16 | Cook Medical Technologies Llc | Tissue adjustment implant |
| AU2014306232B2 (en) | 2013-08-05 | 2018-12-06 | C2Dx, Inc. | Medical devices having a releasable tubular member and methods of using the same |
| US9956384B2 (en) | 2014-01-24 | 2018-05-01 | Cook Medical Technologies Llc | Articulating balloon catheter and method for using the same |
| US9974563B2 (en) | 2014-05-28 | 2018-05-22 | Cook Medical Technologies Llc | Medical devices having a releasable member and methods of using the same |
| US9913661B2 (en) | 2014-08-04 | 2018-03-13 | Cook Medical Technologies Llc | Medical devices having a releasable tubular member and methods of using the same |
| US10022355B2 (en) | 2015-06-12 | 2018-07-17 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder |
| BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
| WO2019006218A1 (en) | 2017-06-29 | 2019-01-03 | Oconnor Peter | MEDICAL DEVICES IMPLANTABLE TO REPOSITION A FABRIC |
| WO2019060298A1 (en) | 2017-09-19 | 2019-03-28 | Neuroenhancement Lab, LLC | METHOD AND APPARATUS FOR NEURO-ACTIVATION |
| WO2019099307A1 (en) * | 2017-11-17 | 2019-05-23 | Hepagene Therapeutics, Inc. | Urea derivatives as inhibitors of ask1 |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US11478603B2 (en) | 2017-12-31 | 2022-10-25 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| US11452839B2 (en) | 2018-09-14 | 2022-09-27 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| EP4236942A4 (en) * | 2020-10-27 | 2024-10-09 | Arena Pharmaceuticals, Inc. | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE SEROTONIN 5-HT2A RECEPTOR USEFUL IN THE TREATMENT OF DISORDERS ASSOCIATED THERETO |
| CA3206840A1 (en) * | 2020-12-31 | 2022-07-07 | Arena Pharmaceuticals, Inc. | Methods of treatment |
| KR20240058859A (ko) | 2021-08-12 | 2024-05-03 | 쿨레온 엘엘씨 | 환각성 및 비환각성 세로토닌 수용체 작용제 및 이의 제조 및 사용 방법 |
| EP4452986A4 (en) * | 2021-12-22 | 2025-11-12 | Kuleon Llc | Serotonin receptor agonists and their manufacturing and use processes |
| WO2024122617A1 (ja) | 2022-12-08 | 2024-06-13 | 塩野義製薬株式会社 | セロトニン受容体結合活性を有する含窒素複素環および炭素環誘導体 |
Family Cites Families (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4099012A (en) * | 1975-08-28 | 1978-07-04 | Ciba-Geigy Corporation | 2-pyrazolyl-benzophenones |
| DE2926517A1 (de) * | 1979-06-30 | 1981-01-15 | Beiersdorf Ag | Substituierte 3-aryl-pyrazole und 5-aryl-isoxazole und verfahren zu ihrer herstellung |
| DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
| US4985352A (en) * | 1988-02-29 | 1991-01-15 | The Trustees Of Columbia University In The City Of New York | DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof |
| US5661024A (en) * | 1989-10-31 | 1997-08-26 | Synaptic Pharmaceutical Corporation | DNA encoding a human serotonic (5-HT2) receptor and uses thereof |
| US5077409A (en) * | 1990-05-04 | 1991-12-31 | American Cyanamid Company | Method of preparing bis-aryl amide and urea antagonists of platelet activating factor |
| US5128351A (en) * | 1990-05-04 | 1992-07-07 | American Cyanamid Company | Bis-aryl amide and urea antagonists of platelet activating factor |
| FR2682379B1 (fr) * | 1991-10-09 | 1994-02-11 | Rhone Poulenc Agrochimie | Nouveaux phenylpyrazoles fongicides. |
| FR2690440B1 (fr) * | 1992-04-27 | 1995-05-19 | Rhone Poulenc Agrochimie | Arylpyrazoles fongicides. |
| US5905080A (en) * | 1993-08-20 | 1999-05-18 | Smithkline Beecham, P.L.C. | Amide and urea derivatives as 5HT1D receptor antagonists |
| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| FR2722369B1 (fr) | 1994-07-13 | 1998-07-10 | Rhone Poulenc Agrochimie | Compositions fongicides a base de derives 3-phenyl-pyrazoles pour le traitement du materiel vegetal de multiplication, nouveaux derives 3-phenyl-pyrazoles et leurs applications fongicides |
| KR970706242A (ko) | 1994-10-04 | 1997-11-03 | 후지야마 아키라 | 우레아 유도체 및 ACAT-억제제로서 그의 용도(Urea derivatives and their use as ACAT-inhibitors) |
| DK0808312T3 (da) * | 1995-02-02 | 2001-02-12 | Smithkline Beecham Plc | Indolderivater som 5-HT-receptorantagonist |
| JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| AU6526896A (en) | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
| US6054472A (en) * | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
| US6005008A (en) * | 1996-02-16 | 1999-12-21 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| GB9607219D0 (en) * | 1996-04-04 | 1996-06-12 | Smithkline Beecham Plc | Novel compounds |
| EP0910358A1 (en) | 1996-05-24 | 1999-04-28 | Neurosearch A/S | Phenyl derivatives useful as blockers of chloride channels |
| CA2255858C (en) * | 1996-05-24 | 2007-09-11 | Neurosearch A/S | Phenyl derivatives containing an acidic group, their preparation and their use as chloride channel blockers |
| US6271261B1 (en) * | 1996-06-27 | 2001-08-07 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| JP2001508767A (ja) | 1996-12-02 | 2001-07-03 | 藤沢薬品工業株式会社 | ５―ｈｔ拮抗作用を有するインドール―ウレア誘導体 |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| US6541209B1 (en) | 1997-04-14 | 2003-04-01 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof |
| US6696475B2 (en) * | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| US6297261B1 (en) * | 1997-04-22 | 2001-10-02 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| AU8673198A (en) | 1997-07-29 | 1999-02-22 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| PT1027328E (pt) * | 1997-10-31 | 2006-11-30 | Aventis Pharma Ltd | Anilidas substituídas |
| CN1213022C (zh) | 1997-12-22 | 2005-08-03 | 拜尔有限公司 | 用对称和不对称的取代二苯脲抑制raf激酶 |
| US7517880B2 (en) * | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| WO1999032463A1 (en) | 1997-12-22 | 1999-07-01 | Bayer Corporation | INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS |
| US6107324A (en) | 1998-04-14 | 2000-08-22 | Arena Pharmaceuticals Inc. | 5-HT2A receptor inverse agonists |
| US6140509A (en) * | 1998-06-26 | 2000-10-31 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof |
| GB9816263D0 (en) * | 1998-07-24 | 1998-09-23 | Merck Sharp & Dohme | Therapeutic agents |
| PL198852B1 (pl) * | 1998-10-22 | 2008-07-31 | Neurosearch As | Podstawione pochodne fenylu, kompozycja farmaceutyczna je zawierająca oraz ich zastosowanie |
| US6150393A (en) | 1998-12-18 | 2000-11-21 | Arena Pharmaceuticals, Inc. | Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors |
| TW502019B (en) | 1999-03-26 | 2002-09-11 | Cocensys Inc | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| GB9909409D0 (en) | 1999-04-24 | 1999-06-23 | Zeneca Ltd | Chemical compounds |
| WO2001021160A2 (en) | 1999-09-23 | 2001-03-29 | Axxima Pharmaceuticals Aktiengesellschaft | Carboxymide and aniline derivatives as selective inhibitors of pathogens |
| US6531291B1 (en) * | 1999-11-10 | 2003-03-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof |
| EP1108720A1 (en) | 1999-12-08 | 2001-06-20 | Basf Aktiengesellschaft | Herbicidal 2-Pyrazolyl-6-Aryloxy-Pyri(mi)dines |
| FR2810979B1 (fr) * | 2000-06-29 | 2002-08-23 | Adir | Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2002039987A2 (en) | 2000-11-14 | 2002-05-23 | Neurosearch A/S | Use of malaria parasite anion channel blockers for treating malaria |
| AR035521A1 (es) | 2000-12-22 | 2004-06-02 | Lundbeck & Co As H | Derivados de 3-indolina y composicion farmaceutica que los comprende |
| US20020156068A1 (en) | 2001-03-22 | 2002-10-24 | Behan Dominic P. | Anti-psychosis combination |
| CN104744461A (zh) * | 2001-09-21 | 2015-07-01 | 百时美施贵宝公司 | 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂 |
| EP1509505A2 (en) * | 2002-01-23 | 2005-03-02 | Arena Pharmaceuticals, Inc. | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO |
| AU2003275093A1 (en) | 2002-09-24 | 2004-04-19 | Arena Pharmaceuticals, Inc. | Process of making phenylpyrazoles useful as selective 5ht2a modulators and intermediates thereof |
| TWI258934B (en) | 2002-11-08 | 2006-07-21 | Interdigital Tech Corp | Composite channel quality estimation techniques and systems for wireless receivers |
| WO2004058722A1 (en) * | 2002-12-24 | 2004-07-15 | Arena Pharmaceuticals, Inc. | Diarylamine and arylheteroarylamine pyrazole derivatives as modulators of 5ht2a |
| EP1594512A4 (en) | 2003-02-11 | 2007-07-11 | Kemia Inc | COMPOUNDS FOR THE TREATMENT OF VIRUS INFECTIONS |
| WO2004085433A2 (en) | 2003-03-28 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Positive allosteric modulators of the nicotinic acetylcholine receptor |
| GB0309781D0 (en) | 2003-04-29 | 2003-06-04 | Glaxo Group Ltd | Compounds |
| DE602004000260T2 (de) * | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| US20050054691A1 (en) * | 2003-08-29 | 2005-03-10 | St. Jude Children's Research Hospital | Carboxylesterase inhibitors |
| WO2005077345A1 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
| ATE548353T1 (de) * | 2004-03-23 | 2012-03-15 | Arena Pharm Inc | Verfahren zur herstellung von substituierte n- aryl-n'-ä3-(1h-pyrazol-5-yl)phenylü-harnstoffe and intermediate davon. |
| US20060014705A1 (en) * | 2004-06-30 | 2006-01-19 | Howitz Konrad T | Compositions and methods for selectively activating human sirtuins |
| EP1786422A2 (en) | 2004-08-16 | 2007-05-23 | Prosidion Limited | Aryl urea derivatives for treating obesity |
| US20060063754A1 (en) * | 2004-09-21 | 2006-03-23 | Edgar Dale M | Methods of treating a sleep disorder |
| WO2006045010A2 (en) * | 2004-10-20 | 2006-04-27 | Resverlogix Corp. | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
| WO2006049941A2 (en) | 2004-10-27 | 2006-05-11 | Neurogen Corporation | Diaryl ureas as cb1 antagonists |
| US7563785B2 (en) | 2004-10-29 | 2009-07-21 | Hypnion, Inc. | Quetiapine analogs and methods of use thereof |
| SA05260357B1 (ar) * | 2004-11-19 | 2008-09-08 | ارينا فارماسيتو تيكالز ، أنك | مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به |
| GB0426313D0 (en) | 2004-12-01 | 2005-01-05 | Merck Sharp & Dohme | Therapeutic agents |
| WO2006060654A2 (en) | 2004-12-01 | 2006-06-08 | Divergence, Inc. | Pesticidal compositions and methods |
| US20080015223A1 (en) * | 2004-12-03 | 2008-01-17 | Arena Pharmaceuticals, Inc. | Pyrazole Derivatives as Modulators of the 5-Ht2a Serotonin Receptor Useful for the Treatment of Disorders Related Thereto |
| WO2006070394A1 (en) | 2004-12-28 | 2006-07-06 | Council Of Scientific And Industrial Research | Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors |
| EP1858877B1 (en) | 2005-01-14 | 2014-03-12 | Gilead Connecticut, Inc. | 1,3 substituted diaryl ureas as modulators of kinase activity |
| US20080200530A1 (en) * | 2005-01-19 | 2008-08-21 | Unett David J | Diaryl and Arylheteroaryl Urea Derivatives as Modulators of 5-Ht2a Serotonin Receptor Useful for the Prophylaxis or Treatment of Progressive Multifocal Leukoencephalopathy |
| AR052886A1 (es) | 2005-01-26 | 2007-04-11 | Arena Pharm Inc | Procedimientos para preparar fenilpirazol ureas sustituidas y para la obtencion de sus intermediarios de sintesis |
| CA2595170C (en) | 2005-01-27 | 2014-08-05 | Janssen Pharmaceutica N.V. | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5ht2 inhibitors in the treatment of cns disorders |
| GT200600042A (es) | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
| WO2006089871A2 (en) | 2005-02-23 | 2006-08-31 | Neurosearch A/S | Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias |
| GB0504828D0 (en) | 2005-03-09 | 2005-04-13 | Merck Sharp & Dohme | Therapeutic agents |
| GB0505437D0 (en) | 2005-03-17 | 2005-04-20 | Merck Sharp & Dohme | Therapeutic agents |
| GB0505725D0 (en) | 2005-03-19 | 2005-04-27 | Merck Sharp & Dohme | Therapeutic agents |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| AU2006239302B2 (en) | 2005-04-26 | 2011-07-07 | Hypnion, Inc. | Benzisoxazole piperazine compounds and methods of use thereof |
| EP1734039A1 (en) | 2005-06-13 | 2006-12-20 | Esbatech AG | Aryl urea compounds as BETA-secretase inhibitors |
| BRPI0612287A8 (pt) | 2005-06-27 | 2019-01-22 | Exelixis Inc | composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear |
| US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| AR055203A1 (es) | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
| WO2007120600A2 (en) | 2006-04-10 | 2007-10-25 | Arena Pharmaceuticals, Inc. | 3-pyridinyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| GB0608655D0 (en) | 2006-05-03 | 2006-06-14 | Merck Sharp & Dohme | Therapeutic Treatment |
| JP5406018B2 (ja) | 2006-05-18 | 2014-02-05 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ａセロトニンレセプターに関連する障害の処置に有用な５−ｈｔ２ａセロトニンレセプターのモジュレーターとしての１級アミン、およびその誘導体 |
| CA2646076C (en) * | 2006-05-18 | 2015-06-30 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| WO2007136875A2 (en) | 2006-05-18 | 2007-11-29 | Arena Pharmaceuticals, Inc. | Acetamide derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| SG171681A1 (en) | 2006-05-18 | 2011-06-29 | Arena Pharm Inc | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-ht2a serotonin receptor |
| WO2008027483A1 (en) | 2006-08-31 | 2008-03-06 | Arena Pharmaceuticals, Inc. | Benzofuran derivatives as modulators of the 5-ht2a receptor |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| WO2008054748A2 (en) | 2006-10-31 | 2008-05-08 | Arena Pharmaceuticals, Inc. | Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| JP5393677B2 (ja) | 2007-08-15 | 2014-01-22 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ＨＴ２Ａセロトニン受容体に関連した障害の治療のための５−ＨＴ２Ａセロトニン受容体のモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン誘導体 |
| JP2009196349A (ja) * | 2008-01-25 | 2009-09-03 | Canon Finetech Inc | バーコード印刷装置およびバーコード印刷方法 |
| WO2011075596A1 (en) | 2009-12-18 | 2011-06-23 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
-
2005
- 2005-11-16 SA SA05260357A patent/SA05260357B1/ar unknown
- 2005-11-16 PE PE2005001343A patent/PE20061130A1/es active IP Right Grant
- 2005-11-17 PL PL05849546T patent/PL1833799T3/pl unknown
- 2005-11-17 RS RSP-2008/0443A patent/RS50698B/sr unknown
- 2005-11-17 KR KR1020137001609A patent/KR20130027039A/ko not_active Ceased
- 2005-11-17 MY MYPI20055376A patent/MY147684A/en unknown
- 2005-11-17 GT GT200500336A patent/GT200500336A/es unknown
- 2005-11-17 WO PCT/US2005/041726 patent/WO2006055734A2/en not_active Ceased
- 2005-11-17 CN CN2005800392789A patent/CN101084195B/zh not_active Expired - Fee Related
- 2005-11-17 SI SI200530504T patent/SI1833799T1/sl unknown
- 2005-11-17 HR HR20080592T patent/HRP20080592T3/xx unknown
- 2005-11-17 KR KR1020077013740A patent/KR101275380B1/ko not_active Expired - Fee Related
- 2005-11-17 CA CA2588513A patent/CA2588513C/en not_active Expired - Fee Related
- 2005-11-17 CN CN2012105332199A patent/CN103012378A/zh active Pending
- 2005-11-17 EA EA200701101A patent/EA011935B1/ru not_active IP Right Cessation
- 2005-11-17 MX MX2007005959A patent/MX2007005959A/es active IP Right Grant
- 2005-11-17 DK DK05849546T patent/DK1833799T3/da active
- 2005-11-17 DE DE602005009748T patent/DE602005009748D1/de not_active Expired - Lifetime
- 2005-11-17 CN CN201210532179.6A patent/CN102977029B/zh not_active Expired - Fee Related
- 2005-11-17 EP EP05849546A patent/EP1833799B1/en not_active Expired - Lifetime
- 2005-11-17 NZ NZ554817A patent/NZ554817A/en not_active IP Right Cessation
- 2005-11-17 JP JP2007543250A patent/JP5016494B2/ja not_active Expired - Lifetime
- 2005-11-17 EP EP08010784A patent/EP1978019A1/en not_active Withdrawn
- 2005-11-17 ES ES05849546T patent/ES2314750T3/es not_active Expired - Lifetime
- 2005-11-17 AU AU2005307744A patent/AU2005307744C1/en not_active Ceased
- 2005-11-17 US US11/597,306 patent/US20070244086A1/en not_active Abandoned
- 2005-11-17 PT PT05849546T patent/PT1833799E/pt unknown
- 2005-11-17 BR BRPI0518446-0A patent/BRPI0518446A2/pt not_active Application Discontinuation
- 2005-11-17 AR ARP050104844A patent/AR051675A1/es active IP Right Grant
- 2005-11-17 AT AT05849546T patent/ATE407927T1/de active
- 2005-11-18 TW TW094140731A patent/TWI377059B/zh not_active IP Right Cessation
- 2005-11-18 HN HN2005032627A patent/HN2005032627A/es unknown
- 2005-11-18 TW TW101110198A patent/TWI409062B/zh not_active IP Right Cessation
- 2005-11-18 SV SV2005002307A patent/SV2008002307A/es unknown
-
2006
- 2006-11-20 US US11/602,164 patent/US7884101B2/en not_active Expired - Lifetime
-
2007
- 2007-05-02 IL IL182945A patent/IL182945A/en active IP Right Grant
- 2007-05-04 CR CR9098A patent/CR9098A/es unknown
- 2007-05-16 TN TNP2007000188A patent/TNSN07188A1/fr unknown
- 2007-05-17 NI NI200700127A patent/NI200700127A/es unknown
- 2007-05-30 MA MA29958A patent/MA29081B1/fr unknown
- 2007-06-11 NO NO20072986A patent/NO340656B1/no not_active IP Right Cessation
-
2008
- 2008-11-13 CY CY20081101299T patent/CY1108508T1/el unknown
-
2010
- 2010-12-22 US US12/976,887 patent/US20110105456A1/en not_active Abandoned
-
2012
- 2012-09-14 US US13/616,842 patent/US8785441B2/en not_active Expired - Lifetime
-
2016
- 2016-04-25 US US15/137,228 patent/US20160304463A1/en not_active Abandoned
-
2018
- 2018-11-01 US US16/177,672 patent/US10781180B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5016494B2 (ja) | ５−ｈｔ２ａセロトニン受容体媒介障害の処置に有用な５−ｈｔ２ａセロトニン受容体のモジュレーターとしての３−フェニル−ピラゾール誘導体の使用 | |
| JP2008520695A5 (https=) | ||
| JP5389642B2 (ja) | ５−ｈｔ２ａセロトニンレセプターに関連する障害の処置に有用な５−ｈｔ２ａセロトニンレセプターのモジュレーターとしての３−ピラゾリル−ベンズアミド−４−エーテル、二級アミンおよびその誘導体 | |
| JP5406018B2 (ja) | ５−ｈｔ２ａセロトニンレセプターに関連する障害の処置に有用な５−ｈｔ２ａセロトニンレセプターのモジュレーターとしての１級アミン、およびその誘導体 | |
| TWI415845B (zh) | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 | |
| JP2009533442A (ja) | ５−ｈｔ２ａセロトニン受容体関連障害の治療のために有用な５−ｈｔ２ａセロトニン受容体のモジュレータとしての３−ピリジニル−ピラゾール誘導体 | |
| JP2009537556A (ja) | ５−ｈｔ２ａセロトニンレセプターに関連する障害の処置に有用な５−ｈｔ２ａセロトニンレセプターのモジュレーターとしてのアセトアミド誘導体 | |
| HK1102818B (en) | 3-phenyl-pyrazole derivatives as modulators of the 5-ht-2a serotonin receptor useful for the treatment of disorders related thereto | |
| HK1118552A (en) | 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |