JP2008519838A - 遺伝子調節のための酸化防止剤の使用 - Google Patents
遺伝子調節のための酸化防止剤の使用 Download PDFInfo
- Publication number
- JP2008519838A JP2008519838A JP2007541282A JP2007541282A JP2008519838A JP 2008519838 A JP2008519838 A JP 2008519838A JP 2007541282 A JP2007541282 A JP 2007541282A JP 2007541282 A JP2007541282 A JP 2007541282A JP 2008519838 A JP2008519838 A JP 2008519838A
- Authority
- JP
- Japan
- Prior art keywords
- genes
- gene
- gene encoding
- products
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 61
- 108090000623 proteins and genes Proteins 0.000 title claims description 330
- 230000033228 biological regulation Effects 0.000 title description 4
- 230000014509 gene expression Effects 0.000 claims abstract description 114
- 239000000203 mixture Substances 0.000 claims abstract description 64
- 238000000034 method Methods 0.000 claims abstract description 61
- 241000124008 Mammalia Species 0.000 claims abstract description 58
- 230000001105 regulatory effect Effects 0.000 claims abstract description 19
- 235000006708 antioxidants Nutrition 0.000 claims description 57
- 102000004169 proteins and genes Human genes 0.000 claims description 47
- 235000018102 proteins Nutrition 0.000 claims description 46
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 45
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 44
- 230000000694 effects Effects 0.000 claims description 40
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 37
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 29
- 210000004185 liver Anatomy 0.000 claims description 29
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 27
- 229930003427 Vitamin E Natural products 0.000 claims description 22
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 22
- 230000037361 pathway Effects 0.000 claims description 22
- 235000019165 vitamin E Nutrition 0.000 claims description 22
- 239000011709 vitamin E Substances 0.000 claims description 22
- 229940046009 vitamin E Drugs 0.000 claims description 22
- 210000004100 adrenal gland Anatomy 0.000 claims description 21
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 19
- 229930003268 Vitamin C Natural products 0.000 claims description 19
- 235000019154 vitamin C Nutrition 0.000 claims description 19
- 239000011718 vitamin C Substances 0.000 claims description 19
- 102000004190 Enzymes Human genes 0.000 claims description 18
- 108090000790 Enzymes Proteins 0.000 claims description 18
- 229960003180 glutathione Drugs 0.000 claims description 18
- 210000003710 cerebral cortex Anatomy 0.000 claims description 16
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims description 15
- 230000036737 immune function Effects 0.000 claims description 15
- 108010071619 Apolipoproteins Proteins 0.000 claims description 14
- 102000007592 Apolipoproteins Human genes 0.000 claims description 14
- 235000019136 lipoic acid Nutrition 0.000 claims description 14
- 229960002663 thioctic acid Drugs 0.000 claims description 14
- 231100000277 DNA damage Toxicity 0.000 claims description 13
- 230000005778 DNA damage Effects 0.000 claims description 12
- 240000008042 Zea mays Species 0.000 claims description 12
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 12
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 12
- 235000005822 corn Nutrition 0.000 claims description 12
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 12
- 230000000004 hemodynamic effect Effects 0.000 claims description 12
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 11
- 230000002414 glycolytic effect Effects 0.000 claims description 11
- 230000002438 mitochondrial effect Effects 0.000 claims description 11
- 230000001590 oxidative effect Effects 0.000 claims description 11
- 230000000770 proinflammatory effect Effects 0.000 claims description 11
- 230000009962 secretion pathway Effects 0.000 claims description 11
- 238000013518 transcription Methods 0.000 claims description 11
- 230000035897 transcription Effects 0.000 claims description 11
- 244000000626 Daucus carota Species 0.000 claims description 10
- 235000002767 Daucus carota Nutrition 0.000 claims description 10
- 102000002278 Ribosomal Proteins Human genes 0.000 claims description 10
- 108010000605 Ribosomal Proteins Proteins 0.000 claims description 10
- 230000022131 cell cycle Effects 0.000 claims description 10
- 235000012054 meals Nutrition 0.000 claims description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 10
- 108010068370 Glutens Proteins 0.000 claims description 9
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 9
- 235000021312 gluten Nutrition 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 9
- 239000011669 selenium Substances 0.000 claims description 9
- 229910052711 selenium Inorganic materials 0.000 claims description 9
- 235000011649 selenium Nutrition 0.000 claims description 9
- 235000009337 Spinacia oleracea Nutrition 0.000 claims description 8
- 244000269722 Thea sinensis Species 0.000 claims description 8
- 235000009569 green tea Nutrition 0.000 claims description 8
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims description 7
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims description 7
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims description 7
- 241000207199 Citrus Species 0.000 claims description 7
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 7
- 240000007594 Oryza sativa Species 0.000 claims description 7
- 235000007164 Oryza sativa Nutrition 0.000 claims description 7
- 240000003768 Solanum lycopersicum Species 0.000 claims description 7
- 235000020971 citrus fruits Nutrition 0.000 claims description 7
- 235000009566 rice Nutrition 0.000 claims description 7
- 241000195493 Cryptophyta Species 0.000 claims description 6
- 108010024636 Glutathione Proteins 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 6
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 6
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 6
- 240000006365 Vitis vinifera Species 0.000 claims description 6
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 6
- 239000011648 beta-carotene Substances 0.000 claims description 6
- 229960002747 betacarotene Drugs 0.000 claims description 6
- 239000004148 curcumin Substances 0.000 claims description 6
- 235000012754 curcumin Nutrition 0.000 claims description 6
- 229940109262 curcumin Drugs 0.000 claims description 6
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 6
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 5
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 5
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 claims description 5
- 229960004308 acetylcysteine Drugs 0.000 claims description 5
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 5
- 235000013734 beta-carotene Nutrition 0.000 claims description 5
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 5
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 5
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 5
- 235000003969 glutathione Nutrition 0.000 claims description 5
- 235000012680 lutein Nutrition 0.000 claims description 5
- 239000001656 lutein Substances 0.000 claims description 5
- 229960005375 lutein Drugs 0.000 claims description 5
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 5
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims description 5
- 229960003080 taurine Drugs 0.000 claims description 5
- 239000011731 tocotrienol Substances 0.000 claims description 5
- 229930003802 tocotrienol Natural products 0.000 claims description 5
- 235000019148 tocotrienols Nutrition 0.000 claims description 5
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 5
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 5
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 5
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 claims description 4
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 4
- 244000068988 Glycine max Species 0.000 claims description 4
- 235000010469 Glycine max Nutrition 0.000 claims description 4
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 4
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 4
- 229960001570 ademetionine Drugs 0.000 claims description 4
- 235000013793 astaxanthin Nutrition 0.000 claims description 4
- 229940022405 astaxanthin Drugs 0.000 claims description 4
- 239000001168 astaxanthin Substances 0.000 claims description 4
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 4
- 229940110767 coenzyme Q10 Drugs 0.000 claims description 4
- 235000012661 lycopene Nutrition 0.000 claims description 4
- 239000001751 lycopene Substances 0.000 claims description 4
- 229960004999 lycopene Drugs 0.000 claims description 4
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 4
- 235000013824 polyphenols Nutrition 0.000 claims description 4
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 4
- 229930003935 flavonoid Natural products 0.000 claims description 3
- 235000017173 flavonoids Nutrition 0.000 claims description 3
- 150000002215 flavonoids Chemical class 0.000 claims description 3
- 235000021466 carotenoid Nutrition 0.000 claims description 2
- 150000001747 carotenoids Chemical class 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims description 2
- 235000008696 isoflavones Nutrition 0.000 claims description 2
- 229940091258 selenium supplement Drugs 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 2
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims 2
- 244000300264 Spinacia oleracea Species 0.000 claims 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 abstract description 29
- 230000036542 oxidative stress Effects 0.000 abstract description 14
- 235000013305 food Nutrition 0.000 description 124
- 239000000047 product Substances 0.000 description 57
- 241000699670 Mus sp. Species 0.000 description 42
- 230000007423 decrease Effects 0.000 description 34
- 230000008859 change Effects 0.000 description 30
- 210000001519 tissue Anatomy 0.000 description 20
- 108010053070 Glutathione Disulfide Proteins 0.000 description 17
- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 17
- 229940088598 enzyme Drugs 0.000 description 16
- 108090000765 processed proteins & peptides Proteins 0.000 description 16
- 230000009758 senescence Effects 0.000 description 16
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 15
- 229920001184 polypeptide Polymers 0.000 description 15
- 102000004196 processed proteins & peptides Human genes 0.000 description 15
- 230000006866 deterioration Effects 0.000 description 14
- 102000003849 Cytochrome P450 Human genes 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 13
- 108020004999 messenger RNA Proteins 0.000 description 11
- 241000282472 Canis lupus familiaris Species 0.000 description 10
- 230000001629 suppression Effects 0.000 description 10
- 238000003556 assay Methods 0.000 description 9
- 238000012252 genetic analysis Methods 0.000 description 9
- 150000003254 radicals Chemical class 0.000 description 9
- 102000003945 NF-kappa B Human genes 0.000 description 8
- 108010057466 NF-kappa B Proteins 0.000 description 8
- 238000009826 distribution Methods 0.000 description 8
- 206010061218 Inflammation Diseases 0.000 description 7
- 241000219315 Spinacia Species 0.000 description 7
- 230000001919 adrenal effect Effects 0.000 description 7
- 230000032683 aging Effects 0.000 description 7
- 230000004054 inflammatory process Effects 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 230000004060 metabolic process Effects 0.000 description 7
- 238000002493 microarray Methods 0.000 description 7
- 241000282326 Felis catus Species 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000006735 deficit Effects 0.000 description 6
- 239000003925 fat Substances 0.000 description 6
- 235000019197 fats Nutrition 0.000 description 6
- 230000001976 improved effect Effects 0.000 description 6
- 230000003647 oxidation Effects 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- 235000020934 caloric restriction Nutrition 0.000 description 5
- 239000003623 enhancer Substances 0.000 description 5
- 230000037406 food intake Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000006698 induction Effects 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 102000001253 Protein Kinase Human genes 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 230000002490 cerebral effect Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 235000012631 food intake Nutrition 0.000 description 4
- YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 4
- 108060006633 protein kinase Proteins 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 108091006112 ATPases Proteins 0.000 description 3
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 3
- 108010008184 Aryldialkylphosphatase Proteins 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 3
- 101150107931 CORO1A gene Proteins 0.000 description 3
- 102000019034 Chemokines Human genes 0.000 description 3
- 108010012236 Chemokines Proteins 0.000 description 3
- 108010076525 DNA Repair Enzymes Proteins 0.000 description 3
- 108010029485 Protein Isoforms Proteins 0.000 description 3
- 102000001708 Protein Isoforms Human genes 0.000 description 3
- 102000040945 Transcription factor Human genes 0.000 description 3
- 108091023040 Transcription factor Proteins 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 230000036523 atherogenesis Effects 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000003920 cognitive function Effects 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 230000001054 cortical effect Effects 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000000955 neuroendocrine Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000003863 physical function Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000003248 secreting effect Effects 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 210000002027 skeletal muscle Anatomy 0.000 description 3
- 235000003687 soy isoflavones Nutrition 0.000 description 3
- 230000000365 steroidogenetic effect Effects 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 210000003568 synaptosome Anatomy 0.000 description 3
- 108700026220 vif Genes Proteins 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 238000011740 C57BL/6 mouse Methods 0.000 description 2
- 102000013135 CD52 Antigen Human genes 0.000 description 2
- 108010065524 CD52 Antigen Proteins 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 102100026548 Caspase-8 Human genes 0.000 description 2
- 108010053835 Catalase Proteins 0.000 description 2
- 102000013717 Cyclin-Dependent Kinase 5 Human genes 0.000 description 2
- 108010025454 Cyclin-Dependent Kinase 5 Proteins 0.000 description 2
- 102000011724 DNA Repair Enzymes Human genes 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 2
- 102100029095 Exportin-1 Human genes 0.000 description 2
- 235000011201 Ginkgo Nutrition 0.000 description 2
- 244000194101 Ginkgo biloba Species 0.000 description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 description 2
- 239000009429 Ginkgo biloba extract Substances 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 101150075063 HOMER1 gene Proteins 0.000 description 2
- 101150007616 HSP90AB1 gene Proteins 0.000 description 2
- 101150051208 HSPH1 gene Proteins 0.000 description 2
- 102000010029 Homer Scaffolding Proteins Human genes 0.000 description 2
- 101000658114 Homo sapiens Synaptotagmin-like protein 4 Proteins 0.000 description 2
- 101150054249 Hspa4 gene Proteins 0.000 description 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 2
- 102000004083 Lymphotoxin-alpha Human genes 0.000 description 2
- 108090000542 Lymphotoxin-alpha Proteins 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 2
- 108010014251 Muramidase Proteins 0.000 description 2
- 101100059597 Mus musculus Cebpz gene Proteins 0.000 description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 2
- 102100023233 Neurensin-1 Human genes 0.000 description 2
- 102000001105 Phosphofructokinases Human genes 0.000 description 2
- 108010069341 Phosphofructokinases Proteins 0.000 description 2
- 102000006010 Protein Disulfide-Isomerase Human genes 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
- 108010010469 Qa-SNARE Proteins Proteins 0.000 description 2
- 239000013614 RNA sample Substances 0.000 description 2
- 241000283984 Rodentia Species 0.000 description 2
- 101150092128 SYTL4 gene Proteins 0.000 description 2
- 102100037044 Serine/arginine-rich splicing factor 1 Human genes 0.000 description 2
- 102100035476 Serum paraoxonase/arylesterase 1 Human genes 0.000 description 2
- 102100035002 Synaptotagmin-like protein 4 Human genes 0.000 description 2
- 101710116664 Thermosome subunit Proteins 0.000 description 2
- 101150094313 XPO1 gene Proteins 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000027455 binding Effects 0.000 description 2
- 238000009739 binding Methods 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 230000004637 cellular stress Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 101150077768 ddb1 gene Proteins 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000001819 effect on gene Effects 0.000 description 2
- 108700002148 exportin 1 Proteins 0.000 description 2
- 235000019261 food antioxidant Nutrition 0.000 description 2
- 235000012041 food component Nutrition 0.000 description 2
- 239000005428 food component Substances 0.000 description 2
- -1 fumarate ester Chemical class 0.000 description 2
- 235000020686 ginkgo biloba extract Nutrition 0.000 description 2
- 229940068052 ginkgo biloba extract Drugs 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000007417 hierarchical cluster analysis Methods 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 235000010335 lysozyme Nutrition 0.000 description 2
- 229960000274 lysozyme Drugs 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000000116 mitigating effect Effects 0.000 description 2
- 239000003226 mitogen Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000009894 physiological stress Effects 0.000 description 2
- 108020003519 protein disulfide isomerase Proteins 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000004739 secretory vesicle Anatomy 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 230000003827 upregulation Effects 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 description 1
- 102100027831 14-3-3 protein theta Human genes 0.000 description 1
- YHPKGSLWSUCJQK-UHFFFAOYSA-N 2-[[2-[[2-[[2-[[2-[[2-[[5-amino-2-[[2-[(2,4-diamino-4-oxobutanoyl)amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino) Chemical compound NC(N)=NCCCC(C(=O)NC(C(C)C)C(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(N)CC(N)=O YHPKGSLWSUCJQK-UHFFFAOYSA-N 0.000 description 1
- 102100030872 28S ribosomal protein S15, mitochondrial Human genes 0.000 description 1
- 102100034147 39S ribosomal protein L44, mitochondrial Human genes 0.000 description 1
- 102100021759 39S ribosomal protein L54, mitochondrial Human genes 0.000 description 1
- 102100023912 40S ribosomal protein S12 Human genes 0.000 description 1
- 102100033051 40S ribosomal protein S19 Human genes 0.000 description 1
- 102100037513 40S ribosomal protein S23 Human genes 0.000 description 1
- 102100027337 40S ribosomal protein S26 Human genes 0.000 description 1
- 102100033409 40S ribosomal protein S3 Human genes 0.000 description 1
- 102100037663 40S ribosomal protein S8 Human genes 0.000 description 1
- 102000001762 6-phosphogluconolactonase Human genes 0.000 description 1
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
- 102100022289 60S ribosomal protein L13a Human genes 0.000 description 1
- 102100021206 60S ribosomal protein L19 Human genes 0.000 description 1
- 101710187808 60S ribosomal protein L19 Proteins 0.000 description 1
- 102100021927 60S ribosomal protein L27a Human genes 0.000 description 1
- 102100022048 60S ribosomal protein L36 Human genes 0.000 description 1
- 101710187872 60S ribosomal protein L36 Proteins 0.000 description 1
- 102100040131 60S ribosomal protein L37 Human genes 0.000 description 1
- 102100035931 60S ribosomal protein L8 Human genes 0.000 description 1
- 101150051089 A3 gene Proteins 0.000 description 1
- 101150014309 ALCAM gene Proteins 0.000 description 1
- 101150008694 ANXA1 gene Proteins 0.000 description 1
- 101150070863 ANXA2 gene Proteins 0.000 description 1
- 101150071783 APOA1 gene Proteins 0.000 description 1
- 101150009437 APOA2 gene Proteins 0.000 description 1
- 101150077253 APOA5 gene Proteins 0.000 description 1
- 101150063992 APOC2 gene Proteins 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 101150099236 Acly gene Proteins 0.000 description 1
- 101150020691 Aifm1 gene Proteins 0.000 description 1
- 101000852665 Alopecosa marikovskyi Omega-lycotoxin-Gsp2671a Proteins 0.000 description 1
- 102100022460 Alpha-1-acid glycoprotein 2 Human genes 0.000 description 1
- 101710186699 Alpha-1-acid glycoprotein 2 Proteins 0.000 description 1
- 102100038910 Alpha-enolase Human genes 0.000 description 1
- 101710165425 Alpha-enolase Proteins 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 102000052583 Anaphase-Promoting Complex-Cyclosome Apc8 Subunit Human genes 0.000 description 1
- 102100022987 Angiogenin Human genes 0.000 description 1
- 102000004881 Angiotensinogen Human genes 0.000 description 1
- 108090001067 Angiotensinogen Proteins 0.000 description 1
- 102000004145 Annexin A1 Human genes 0.000 description 1
- 108090000663 Annexin A1 Proteins 0.000 description 1
- 102100034613 Annexin A2 Human genes 0.000 description 1
- 108090000668 Annexin A2 Proteins 0.000 description 1
- 101600129809 Aplysia californica Synaptotagmin-1 (isoform 2) Proteins 0.000 description 1
- 101150104773 Apoh gene Proteins 0.000 description 1
- 102000005666 Apolipoprotein A-I Human genes 0.000 description 1
- 108010059886 Apolipoprotein A-I Proteins 0.000 description 1
- 102000009081 Apolipoprotein A-II Human genes 0.000 description 1
- 108010087614 Apolipoprotein A-II Proteins 0.000 description 1
- 108010024284 Apolipoprotein C-II Proteins 0.000 description 1
- 102100039998 Apolipoprotein C-II Human genes 0.000 description 1
- 101100004408 Arabidopsis thaliana BIG gene Proteins 0.000 description 1
- 102000000090 Bcl2-like Human genes 0.000 description 1
- 108050008428 Bcl2-like Proteins 0.000 description 1
- 102100036200 Bisphosphoglycerate mutase Human genes 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101150006869 CACYBP gene Proteins 0.000 description 1
- 101150111331 CCL5 gene Proteins 0.000 description 1
- 101150016724 CCND3 gene Proteins 0.000 description 1
- 101150065209 CCNG1 gene Proteins 0.000 description 1
- 102100031025 CCR4-NOT transcription complex subunit 2 Human genes 0.000 description 1
- 101150083731 CCT5 gene Proteins 0.000 description 1
- 101150082143 CD24 gene Proteins 0.000 description 1
- 102000000796 CD79 Antigens Human genes 0.000 description 1
- 108010001445 CD79 Antigens Proteins 0.000 description 1
- 101150029001 CDH2 gene Proteins 0.000 description 1
- 101150075558 CHGA gene Proteins 0.000 description 1
- 101150035856 CTSB gene Proteins 0.000 description 1
- 101150066398 CXCR4 gene Proteins 0.000 description 1
- 102000000905 Cadherin Human genes 0.000 description 1
- 108050007957 Cadherin Proteins 0.000 description 1
- 101100495256 Caenorhabditis elegans mat-3 gene Proteins 0.000 description 1
- 101100346438 Caenorhabditis elegans mrg-1 gene Proteins 0.000 description 1
- 101100360571 Caenorhabditis elegans mrpl-44 gene Proteins 0.000 description 1
- 101100422638 Caenorhabditis elegans syx-4 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 108030005456 Calcium/calmodulin-dependent protein kinases Proteins 0.000 description 1
- 102100039901 Calcyclin-binding protein Human genes 0.000 description 1
- 101710194360 Calcyclin-binding protein Proteins 0.000 description 1
- 102100021868 Calnexin Human genes 0.000 description 1
- 108010056891 Calnexin Proteins 0.000 description 1
- 101150051353 Canx gene Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 101150015105 Casp12 gene Proteins 0.000 description 1
- 101150056960 Casp8 gene Proteins 0.000 description 1
- 108090000570 Caspase-12 Proteins 0.000 description 1
- 102000004066 Caspase-12 Human genes 0.000 description 1
- 102100025597 Caspase-4 Human genes 0.000 description 1
- 108090000538 Caspase-8 Proteins 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 108090000613 Cathepsin S Proteins 0.000 description 1
- 102100035654 Cathepsin S Human genes 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 101150079049 Ccnd2 gene Proteins 0.000 description 1
- 101150043916 Cd52 gene Proteins 0.000 description 1
- 102100024495 Cdc42 effector protein 4 Human genes 0.000 description 1
- 101150090188 Cdk8 gene Proteins 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 102000005483 Cell Cycle Proteins Human genes 0.000 description 1
- 108010031896 Cell Cycle Proteins Proteins 0.000 description 1
- 102100024046 Cell adhesion molecule 3 Human genes 0.000 description 1
- 101710197433 Cell adhesion molecule 3 Proteins 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 108050001186 Chaperonin Cpn60 Proteins 0.000 description 1
- 102000052603 Chaperonins Human genes 0.000 description 1
- 108010038447 Chromogranin A Proteins 0.000 description 1
- 102000010792 Chromogranin A Human genes 0.000 description 1
- 101710117584 Chymase Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 102100037529 Coagulation factor V Human genes 0.000 description 1
- 102100029117 Coagulation factor X Human genes 0.000 description 1
- 241000761389 Copa Species 0.000 description 1
- 101150089641 Copb2 gene Proteins 0.000 description 1
- 108050007222 Coronin Proteins 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 108010058544 Cyclin D2 Proteins 0.000 description 1
- 108010058545 Cyclin D3 Proteins 0.000 description 1
- 108090000404 Cyclin G1 Proteins 0.000 description 1
- 102000004012 Cyclin G1 Human genes 0.000 description 1
- 102000013742 Cyclin-Dependent Kinase 8 Human genes 0.000 description 1
- 108010025415 Cyclin-Dependent Kinase 8 Proteins 0.000 description 1
- 101150094420 Cyp2c70 gene Proteins 0.000 description 1
- 101150107021 Cyp4a10 gene Proteins 0.000 description 1
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 1
- 108090000365 Cytochrome-c oxidases Proteins 0.000 description 1
- 102100036674 DNA damage-binding protein 1 Human genes 0.000 description 1
- 102100033195 DNA ligase 4 Human genes 0.000 description 1
- 102100034157 DNA mismatch repair protein Msh2 Human genes 0.000 description 1
- 230000033616 DNA repair Effects 0.000 description 1
- 230000008265 DNA repair mechanism Effects 0.000 description 1
- 101150099255 DNAJA1 gene Proteins 0.000 description 1
- 101150095228 DNAJC2 gene Proteins 0.000 description 1
- 101100382103 Danio rerio alcama gene Proteins 0.000 description 1
- 102100020977 DnaJ homolog subfamily A member 1 Human genes 0.000 description 1
- 102100031695 DnaJ homolog subfamily C member 2 Human genes 0.000 description 1
- 102100022840 DnaJ homolog subfamily C member 7 Human genes 0.000 description 1
- 101150006098 Dnm1l gene Proteins 0.000 description 1
- 102100029952 Double-strand-break repair protein rad21 homolog Human genes 0.000 description 1
- 101100485279 Drosophila melanogaster emb gene Proteins 0.000 description 1
- 102000043859 Dynamin Human genes 0.000 description 1
- 108700021058 Dynamin Proteins 0.000 description 1
- 102100024827 Dynamin-1-like protein Human genes 0.000 description 1
- 101150015836 ENO1 gene Proteins 0.000 description 1
- 102000008013 Electron Transport Complex I Human genes 0.000 description 1
- 108010089760 Electron Transport Complex I Proteins 0.000 description 1
- 101710184673 Enolase 1 Proteins 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108010014172 Factor V Proteins 0.000 description 1
- 108010014173 Factor X Proteins 0.000 description 1
- 108010080865 Factor XII Proteins 0.000 description 1
- 102000000429 Factor XII Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 102100028313 Fibrinogen beta chain Human genes 0.000 description 1
- 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 description 1
- 102100037859 G1/S-specific cyclin-D3 Human genes 0.000 description 1
- 101150111296 GRIA2 gene Proteins 0.000 description 1
- 101150074655 GTF2I gene Proteins 0.000 description 1
- 101150112014 Gapdh gene Proteins 0.000 description 1
- 102100038073 General transcription factor II-I Human genes 0.000 description 1
- 101710144827 General transcription factor II-I Proteins 0.000 description 1
- 208000031448 Genomic Instability Diseases 0.000 description 1
- 102000005731 Glucose-6-phosphate isomerase Human genes 0.000 description 1
- 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 1
- 102000018899 Glutamate Receptors Human genes 0.000 description 1
- 108010027915 Glutamate Receptors Proteins 0.000 description 1
- 102100030651 Glutamate receptor 2 Human genes 0.000 description 1
- 101150009243 HAP1 gene Proteins 0.000 description 1
- 101150112743 HSPA5 gene Proteins 0.000 description 1
- 101150043239 HSPA8 gene Proteins 0.000 description 1
- 102100028829 Heat shock 70 kDa protein 4L Human genes 0.000 description 1
- 102100030338 Hexokinase-1 Human genes 0.000 description 1
- 101710198391 Hexokinase-1 Proteins 0.000 description 1
- 102000030789 Histidine Ammonia-Lyase Human genes 0.000 description 1
- 108700006308 Histidine ammonia-lyases Proteins 0.000 description 1
- 108010014095 Histidine decarboxylase Proteins 0.000 description 1
- 102100037095 Histidine decarboxylase Human genes 0.000 description 1
- 101000635682 Homo sapiens 28S ribosomal protein S15, mitochondrial Proteins 0.000 description 1
- 101000711597 Homo sapiens 39S ribosomal protein L44, mitochondrial Proteins 0.000 description 1
- 101001107003 Homo sapiens 39S ribosomal protein L54, mitochondrial Proteins 0.000 description 1
- 101001097953 Homo sapiens 40S ribosomal protein S23 Proteins 0.000 description 1
- 101000862491 Homo sapiens 40S ribosomal protein S26 Proteins 0.000 description 1
- 101000681240 Homo sapiens 60S ribosomal protein L13a Proteins 0.000 description 1
- 101000753696 Homo sapiens 60S ribosomal protein L27a Proteins 0.000 description 1
- 101000671735 Homo sapiens 60S ribosomal protein L37 Proteins 0.000 description 1
- 101000594702 Homo sapiens Bisphosphoglycerate mutase Proteins 0.000 description 1
- 101000919667 Homo sapiens CCR4-NOT transcription complex subunit 2 Proteins 0.000 description 1
- 101000933112 Homo sapiens Caspase-4 Proteins 0.000 description 1
- 101000762421 Homo sapiens Cdc42 effector protein 4 Proteins 0.000 description 1
- 101000912124 Homo sapiens Cell division cycle protein 23 homolog Proteins 0.000 description 1
- 101000931227 Homo sapiens DnaJ homolog subfamily A member 1 Proteins 0.000 description 1
- 101000845887 Homo sapiens DnaJ homolog subfamily C member 2 Proteins 0.000 description 1
- 101000903053 Homo sapiens DnaJ homolog subfamily C member 7 Proteins 0.000 description 1
- 101000584942 Homo sapiens Double-strand-break repair protein rad21 homolog Proteins 0.000 description 1
- 101000909218 Homo sapiens Dynamin-1-like protein Proteins 0.000 description 1
- 101000917163 Homo sapiens Fibrinogen beta chain Proteins 0.000 description 1
- 101001010449 Homo sapiens Glutamate receptor 2 Proteins 0.000 description 1
- 101001078634 Homo sapiens Heat shock 70 kDa protein 4L Proteins 0.000 description 1
- 101001112219 Homo sapiens Neutrophil cytosol factor 4 Proteins 0.000 description 1
- 101000611939 Homo sapiens Programmed cell death protein 2 Proteins 0.000 description 1
- 101000742859 Homo sapiens Retinoblastoma-associated protein Proteins 0.000 description 1
- 101000987310 Homo sapiens Serine/threonine-protein kinase PAK 2 Proteins 0.000 description 1
- 101000577652 Homo sapiens Serine/threonine-protein kinase PRP4 homolog Proteins 0.000 description 1
- 101000637821 Homo sapiens Serum amyloid A-2 protein Proteins 0.000 description 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 description 1
- 101000707569 Homo sapiens Splicing factor 3A subunit 3 Proteins 0.000 description 1
- 101001131930 Homo sapiens Transcriptional activator protein Pur-beta Proteins 0.000 description 1
- 101000734338 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial Proteins 0.000 description 1
- 101150101510 Hsp90aa1 gene Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 101150011508 Ighg1 gene Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102100029572 Immunoglobulin kappa constant Human genes 0.000 description 1
- 108010090227 Immunoglobulin kappa-Chains Proteins 0.000 description 1
- 102100029620 Immunoglobulin lambda constant 2 Human genes 0.000 description 1
- 108010004020 Immunoglobulin lambda-Chains Proteins 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 102100030126 Interferon regulatory factor 4 Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108010077861 Kininogens Proteins 0.000 description 1
- 102000010631 Kininogens Human genes 0.000 description 1
- 101150034901 LRP2 gene Proteins 0.000 description 1
- 101150108332 LYL1 gene Proteins 0.000 description 1
- 101710172064 Low-density lipoprotein receptor-related protein Proteins 0.000 description 1
- 101150070547 MAPT gene Proteins 0.000 description 1
- 101150005609 MED20 gene Proteins 0.000 description 1
- 101150072208 MPEG1 gene Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 208000027382 Mental deterioration Diseases 0.000 description 1
- 206010027374 Mental impairment Diseases 0.000 description 1
- 108010040897 Microfilament Proteins Proteins 0.000 description 1
- 102000002151 Microfilament Proteins Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 102000005431 Molecular Chaperones Human genes 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 101150091488 Mrps15 gene Proteins 0.000 description 1
- 101150033433 Msh2 gene Proteins 0.000 description 1
- 101100215821 Mus musculus Aldoa gene Proteins 0.000 description 1
- 101100166214 Mus musculus Capza1 gene Proteins 0.000 description 1
- 101100218984 Mus musculus Cdc42ep4 gene Proteins 0.000 description 1
- 101100005882 Mus musculus Cel gene Proteins 0.000 description 1
- 101100496420 Mus musculus Cma1 gene Proteins 0.000 description 1
- 101100440866 Mus musculus Cyp2a12 gene Proteins 0.000 description 1
- 101100061204 Mus musculus Cyp2a4 gene Proteins 0.000 description 1
- 101100440875 Mus musculus Cyp2b10 gene Proteins 0.000 description 1
- 101100385048 Mus musculus Cyp2c37 gene Proteins 0.000 description 1
- 101100385051 Mus musculus Cyp2c40 gene Proteins 0.000 description 1
- 101100114688 Mus musculus Cyp3a11 gene Proteins 0.000 description 1
- 101100385057 Mus musculus Cyp3a25 gene Proteins 0.000 description 1
- 101100334029 Mus musculus F13b gene Proteins 0.000 description 1
- 101000755880 Mus musculus Fructose-bisphosphate aldolase A Proteins 0.000 description 1
- 101100013840 Mus musculus Gpi gene Proteins 0.000 description 1
- 101100116982 Mus musculus H2-DMb1 gene Proteins 0.000 description 1
- 101100125779 Mus musculus Ighm gene Proteins 0.000 description 1
- 101100289046 Mus musculus Lias gene Proteins 0.000 description 1
- 101100344220 Mus musculus Lyz1 gene Proteins 0.000 description 1
- 101100344221 Mus musculus Lyz2 gene Proteins 0.000 description 1
- 101100000208 Mus musculus Orm2 gene Proteins 0.000 description 1
- 101100095661 Mus musculus Sf3a3 gene Proteins 0.000 description 1
- 101100095663 Mus musculus Sf3b1 gene Proteins 0.000 description 1
- 108700031745 MutS Homolog 2 Proteins 0.000 description 1
- 101150106646 NCF1 gene Proteins 0.000 description 1
- 102000011178 NFI Transcription Factors Human genes 0.000 description 1
- 108010023243 NFI Transcription Factors Proteins 0.000 description 1
- 101150073096 NRAS gene Proteins 0.000 description 1
- 108050002720 Neurensin-1 Proteins 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 102100036248 Neuroendocrine protein 7B2 Human genes 0.000 description 1
- 102000002111 Neuropilin Human genes 0.000 description 1
- 108050009450 Neuropilin Proteins 0.000 description 1
- 102100023620 Neutrophil cytosol factor 1 Human genes 0.000 description 1
- 102100023617 Neutrophil cytosol factor 4 Human genes 0.000 description 1
- 101150022485 Nfkb1 gene Proteins 0.000 description 1
- 101150091206 Nfkbia gene Proteins 0.000 description 1
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 description 1
- 102100023782 Nucleoporin SEH1 Human genes 0.000 description 1
- 108050000942 Nucleoporin Seh1 Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 101150108716 PAK2 gene Proteins 0.000 description 1
- 101150009383 PFKL gene Proteins 0.000 description 1
- 101150004726 PFKP gene Proteins 0.000 description 1
- 101150005879 PKM gene Proteins 0.000 description 1
- 101150054116 PRPF4B gene Proteins 0.000 description 1
- 101150087533 PTGR1 gene Proteins 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 101150053284 Pcdha4 gene Proteins 0.000 description 1
- 101150010728 Pdcd6ip gene Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 102100038124 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 101150100678 Pon1 gene Proteins 0.000 description 1
- 101150043906 Pon2 gene Proteins 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 102100033344 Programmed cell death 6-interacting protein Human genes 0.000 description 1
- 101710198445 Programmed cell death 6-interacting protein Proteins 0.000 description 1
- 102100040676 Programmed cell death protein 2 Human genes 0.000 description 1
- 101710098761 Protein alpha-1 Proteins 0.000 description 1
- 101710106234 Protein disulfide-isomerase A5 Proteins 0.000 description 1
- 102100037061 Protein disulfide-isomerase A6 Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 102100024261 Protocadherin alpha-4 Human genes 0.000 description 1
- 101710167874 Protocadherin alpha-4 Proteins 0.000 description 1
- 102100034911 Pyruvate kinase PKM Human genes 0.000 description 1
- 101710152724 Pyruvate kinase PKM Proteins 0.000 description 1
- 101150050921 RBBP7 gene Proteins 0.000 description 1
- 101150080869 RBM10 gene Proteins 0.000 description 1
- 102000015097 RNA Splicing Factors Human genes 0.000 description 1
- 108010039259 RNA Splicing Factors Proteins 0.000 description 1
- 101710133282 RNA-binding protein 1 Proteins 0.000 description 1
- 102100027514 RNA-binding protein 10 Human genes 0.000 description 1
- 101710203305 RNA-binding protein 10 Proteins 0.000 description 1
- 101150079964 RPL13 gene Proteins 0.000 description 1
- 101150078607 RPL36 gene Proteins 0.000 description 1
- 101150021839 RPL37 gene Proteins 0.000 description 1
- 101150055163 RPS26 gene Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 101100168384 Rattus norvegicus Cyp2c12 gene Proteins 0.000 description 1
- 101100114680 Rattus norvegicus Cyp3a2 gene Proteins 0.000 description 1
- 101100520188 Rattus norvegicus Pkn2 gene Proteins 0.000 description 1
- 101100424635 Rattus norvegicus Tuba3b gene Proteins 0.000 description 1
- 101150042152 Rbbp9 gene Proteins 0.000 description 1
- 102000018779 Replication Protein C Human genes 0.000 description 1
- 108010027647 Replication Protein C Proteins 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 108010071034 Retinoblastoma-Binding Protein 4 Proteins 0.000 description 1
- 102000007508 Retinoblastoma-Binding Protein 4 Human genes 0.000 description 1
- 102100038042 Retinoblastoma-associated protein Human genes 0.000 description 1
- 102000004285 Ribosomal Protein L3 Human genes 0.000 description 1
- 108090000894 Ribosomal Protein L3 Proteins 0.000 description 1
- 102000013817 Ribosomal protein L13 Human genes 0.000 description 1
- 108050003655 Ribosomal protein L13 Proteins 0.000 description 1
- 102000003926 Ribosomal protein L18 Human genes 0.000 description 1
- 108090000343 Ribosomal protein L18 Proteins 0.000 description 1
- 101150014879 RpL13A gene Proteins 0.000 description 1
- 101150034081 Rpl18 gene Proteins 0.000 description 1
- 101150106534 Rps23 gene Proteins 0.000 description 1
- 101150004811 Rps4x gene Proteins 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 101150077008 SCG3 gene Proteins 0.000 description 1
- 101150026037 SEC22 gene Proteins 0.000 description 1
- 101150046023 SEC22B gene Proteins 0.000 description 1
- 101150026061 STX4 gene Proteins 0.000 description 1
- 101100485284 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CRM1 gene Proteins 0.000 description 1
- 101150094811 Scamp1 gene Proteins 0.000 description 1
- 101150078339 Scg5 gene Proteins 0.000 description 1
- 102100035897 Secretogranin-3 Human genes 0.000 description 1
- 102100037230 Secretory carrier-associated membrane protein 1 Human genes 0.000 description 1
- 101710153936 Secretory carrier-associated membrane protein 1 Proteins 0.000 description 1
- 102100023569 Serine hydrolase RBBP9 Human genes 0.000 description 1
- 101710097062 Serine hydrolase RBBP9 Proteins 0.000 description 1
- 101710123510 Serine/arginine-rich splicing factor 1 Proteins 0.000 description 1
- 102100026180 Serine/threonine-protein kinase N2 Human genes 0.000 description 1
- 102100027939 Serine/threonine-protein kinase PAK 2 Human genes 0.000 description 1
- 102100028868 Serine/threonine-protein kinase PRP4 homolog Human genes 0.000 description 1
- 102100032007 Serum amyloid A-2 protein Human genes 0.000 description 1
- 102100022824 Serum paraoxonase/arylesterase 2 Human genes 0.000 description 1
- 102100038081 Signal transducer CD24 Human genes 0.000 description 1
- 101150024495 Snap91 gene Proteins 0.000 description 1
- 101150002205 Snapin gene Proteins 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 description 1
- 102100031710 Splicing factor 3A subunit 3 Human genes 0.000 description 1
- 102000000019 Sterol Esterase Human genes 0.000 description 1
- 108010055297 Sterol Esterase Proteins 0.000 description 1
- 208000032978 Structural Congenital Myopathies Diseases 0.000 description 1
- 101150020365 Stx6 gene Proteins 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 102000050389 Syntaxin Human genes 0.000 description 1
- 102100027866 Syntaxin-6 Human genes 0.000 description 1
- 102100021679 Syntaxin-binding protein 3 Human genes 0.000 description 1
- 101710096024 Syntaxin-binding protein 3 Proteins 0.000 description 1
- 102000017354 TATA-Box binding protein-like Human genes 0.000 description 1
- 108050005399 TATA-Box binding protein-like Proteins 0.000 description 1
- 101150013037 TCF12 gene Proteins 0.000 description 1
- 101150017815 TCF4 gene Proteins 0.000 description 1
- 101001110004 Tetrahymena thermophila 60S acidic ribosomal protein P1 Proteins 0.000 description 1
- 101150009046 Tnfrsf1a gene Proteins 0.000 description 1
- 102100028601 Transaldolase Human genes 0.000 description 1
- 101710094436 Transaldolase 1 Proteins 0.000 description 1
- 108010048992 Transcription Factor 4 Proteins 0.000 description 1
- 102100021123 Transcription factor 12 Human genes 0.000 description 1
- 101710119706 Transcription factor 12 Proteins 0.000 description 1
- 102100023489 Transcription factor 4 Human genes 0.000 description 1
- 102100034549 Transcriptional activator protein Pur-beta Human genes 0.000 description 1
- 102100031142 Transcriptional repressor protein YY1 Human genes 0.000 description 1
- 102000014701 Transketolase Human genes 0.000 description 1
- 108010043652 Transketolase Proteins 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 1
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 description 1
- 102000027316 Vesicle-associated membrane protein 4 Human genes 0.000 description 1
- 108091013883 Vesicle-associated membrane protein 4 Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 208000025033 X-linked centronuclear myopathy Diseases 0.000 description 1
- 108010042669 YY1 Transcription Factor Proteins 0.000 description 1
- 102100034824 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial Human genes 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 108091006088 activator proteins Proteins 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001780 adrenocortical effect Effects 0.000 description 1
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 108010072788 angiogenin Proteins 0.000 description 1
- 230000000489 anti-atherogenic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000003782 apoptosis assay Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 230000037007 arousal Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000037180 bone health Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 101150015293 cct8 gene Proteins 0.000 description 1
- 108700021031 cdc Genes Proteins 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 208000013896 centronuclear myopathy X-linked Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229940105756 coagulation factor x Drugs 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 102000018123 coronin Human genes 0.000 description 1
- KRQUGYHEWIVMJV-UHFFFAOYSA-N coronin Natural products CCCCCCCCCCCCC=C/CCC1OC1CCC2OC2CCCCCCCCCCC3=CC(C)OC3=O KRQUGYHEWIVMJV-UHFFFAOYSA-N 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000002222 downregulating effect Effects 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 102000013035 dynein heavy chain Human genes 0.000 description 1
- 108060002430 dynein heavy chain Proteins 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 101150001367 eif3d gene Proteins 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006846 excision repair Effects 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 230000009246 food effect Effects 0.000 description 1
- 230000002431 foraging effect Effects 0.000 description 1
- 235000014106 fortified food Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 108010017007 glucose-regulated proteins Proteins 0.000 description 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 108010051920 interferon regulatory factor-4 Proteins 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 230000037231 joint health Effects 0.000 description 1
- HSMPDPBYAYSOBC-UHFFFAOYSA-N khellin Chemical compound O1C(C)=CC(=O)C2=C1C(OC)=C1OC=CC1=C2OC HSMPDPBYAYSOBC-UHFFFAOYSA-N 0.000 description 1
- 201000003723 learning disability Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 101150091094 lipA gene Proteins 0.000 description 1
- YAFQFNOUYXZVPZ-UHFFFAOYSA-N liproxstatin-1 Chemical compound ClC1=CC=CC(CNC=2C3(CCNCC3)NC3=CC=CC=C3N=2)=C1 YAFQFNOUYXZVPZ-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 208000003747 lymphoid leukemia Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000020779 micronutrient status Nutrition 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 230000004220 muscle function Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 108010021016 neutrophil cytosolic factor 1 Proteins 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000021048 nutrient requirements Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000002966 oligonucleotide array Methods 0.000 description 1
- 230000008723 osmotic stress Effects 0.000 description 1
- 230000008789 oxidative DNA damage Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 150000002942 palmitic acid derivatives Chemical class 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 101150000743 pdcd-2 gene Proteins 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 108010055837 phosphocarrier protein HPr Proteins 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 101150005648 polB gene Proteins 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000005522 programmed cell death Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000025220 protein targeting to vacuole Effects 0.000 description 1
- 238000000575 proteomic method Methods 0.000 description 1
- 108700042226 ras Genes Proteins 0.000 description 1
- 108010013519 rat ribosomal protein L8 Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000022983 regulation of cell cycle Effects 0.000 description 1
- 230000014493 regulation of gene expression Effects 0.000 description 1
- 230000028617 response to DNA damage stimulus Effects 0.000 description 1
- 230000031070 response to heat Effects 0.000 description 1
- 102000004413 ribosomal protein S11 Human genes 0.000 description 1
- 108090000930 ribosomal protein S11 Proteins 0.000 description 1
- 108010092841 ribosomal protein S12 Proteins 0.000 description 1
- 108010093046 ribosomal protein S19 Proteins 0.000 description 1
- 108010033804 ribosomal protein S3 Proteins 0.000 description 1
- 108010033786 ribosomal protein S4 Proteins 0.000 description 1
- 102000004337 ribosomal protein S5 Human genes 0.000 description 1
- 108090000902 ribosomal protein S5 Proteins 0.000 description 1
- 108010033800 ribosomal protein S8 Proteins 0.000 description 1
- 101150096543 rpl19 gene Proteins 0.000 description 1
- 101150073388 rpl3 gene Proteins 0.000 description 1
- 101150042484 rps11 gene Proteins 0.000 description 1
- 101150015537 rps12 gene Proteins 0.000 description 1
- 101150064292 rps19 gene Proteins 0.000 description 1
- 101150013092 rps3 gene Proteins 0.000 description 1
- 101150007711 rps5 gene Proteins 0.000 description 1
- 101150077391 rps8 gene Proteins 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 108010007653 secretogranin III Proteins 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 230000013707 sensory perception of sound Effects 0.000 description 1
- 101150080510 snap25 gene Proteins 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000037359 steroid metabolism Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 101150059799 stip-1 gene Proteins 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000003977 synaptic function Effects 0.000 description 1
- 210000002182 synaptic membrane Anatomy 0.000 description 1
- 102000003137 synaptotagmin Human genes 0.000 description 1
- 108060008004 synaptotagmin Proteins 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000008354 tissue degradation Effects 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 229940068778 tocotrienols Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 108010045994 tricholysine Proteins 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 230000028973 vesicle-mediated transport Effects 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 230000037221 weight management Effects 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62616204P | 2004-11-09 | 2004-11-09 | |
| PCT/US2005/040515 WO2006053010A2 (en) | 2004-11-09 | 2005-11-09 | Use of antioxidants for gene modulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008519838A true JP2008519838A (ja) | 2008-06-12 |
| JP2008519838A5 JP2008519838A5 (https=) | 2009-01-15 |
Family
ID=39012035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541282A Pending JP2008519838A (ja) | 2004-11-09 | 2005-11-09 | 遺伝子調節のための酸化防止剤の使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11077165B2 (https=) |
| EP (1) | EP1814394A4 (https=) |
| JP (1) | JP2008519838A (https=) |
| CN (2) | CN101098623B (https=) |
| AU (1) | AU2005304546B2 (https=) |
| BR (1) | BRPI0517563A (https=) |
| CA (1) | CA2586936C (https=) |
| RU (1) | RU2433819C2 (https=) |
| WO (1) | WO2006053010A2 (https=) |
| ZA (1) | ZA200704210B (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011528556A (ja) * | 2008-07-18 | 2011-11-24 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高齢の動物の生活の質を向上させるための方法 |
| JP2011528555A (ja) * | 2008-07-18 | 2011-11-24 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高齢の動物の生活の質を向上させるための方法 |
| JP2012513766A (ja) * | 2008-12-30 | 2012-06-21 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | コンパニオンアニマルにおける変性関節病、骨関節炎、軟骨損傷、および関連する障害を処置する、または予防する方法 |
| JP2012513767A (ja) * | 2008-12-30 | 2012-06-21 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | リポ酸を含むコンパニオンアニマル用組成物およびその使用の方法 |
| JP2013532128A (ja) * | 2010-05-12 | 2013-08-15 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 愛玩動物の炎症を抑制および予防し、炎症状態を緩和する方法 |
| JP2013172732A (ja) * | 2006-09-01 | 2013-09-05 | Hill's Pet Nutrition Inc | 動物用食物組成物を設計するための方法およびシステム |
| JP2014018172A (ja) * | 2012-07-20 | 2014-02-03 | Kohjin Life Sciences Co Ltd | 過酸化脂質生成を抑制するペットフード |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2433819C2 (ru) | 2004-11-09 | 2011-11-20 | Хилл'С Пет Ньютришн, Инк. | Применение антиоксидантов для модуляции генов |
| AU2005322887B2 (en) * | 2004-12-30 | 2010-03-11 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| CN101287460B (zh) | 2005-08-17 | 2012-04-25 | 希尔氏宠物营养品公司 | 预防和治疗肾病的组合物 |
| CN100462074C (zh) * | 2007-02-14 | 2009-02-18 | 北京东方兴企食品工业技术有限公司 | 一种具有缓解视疲劳作用的口嚼片 |
| EP2323638B1 (en) * | 2008-07-18 | 2014-05-07 | Hill's Pet Nutrition, Inc. | Compositions and methods for treating osteoarthritis |
| WO2010078319A1 (en) * | 2008-12-30 | 2010-07-08 | Hill's Pet Nutrition, Inc. | Lipoic acid containing compositions for use in the treatment and prevention of ki dney- related disorders in companion animals |
| WO2011084886A1 (en) * | 2010-01-06 | 2011-07-14 | Nestec S. A. | Dietary regimens useful for mimicking caloric restriction |
| CA2795726A1 (en) * | 2010-04-06 | 2011-10-13 | Edison Pharmaceuticals, Inc. | Treatment of ataxia telangiectasia |
| CN102884434B (zh) | 2010-05-12 | 2015-08-19 | 希尔氏宠物营养品公司 | 用于诊断、控制和预防犬科动物炎症及减轻犬科动物炎性病况的方法 |
| US20120282373A1 (en) * | 2011-05-02 | 2012-11-08 | Ashok Premchand Luhadiya | Compositions Comprising a Glucose Anti-Metabolite and Selenium |
| EP2580967A1 (en) * | 2011-10-11 | 2013-04-17 | Nestec S.A. | Accelerating muscle recovery after immobilization-induced muscle atrophy |
| CN103305579B (zh) * | 2013-06-29 | 2014-08-27 | 吉林大学 | 一种玉米源辅助增强记忆肽及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090414A (en) * | 1970-05-20 | 2000-07-18 | Life Science Labs, Inc. | Method and composition to reduce cancer incidence |
| GB2367489A (en) * | 2000-07-31 | 2002-04-10 | Mars Inc | Anti-oxidant compositions for companion animals |
| WO2003013268A1 (en) * | 2001-08-03 | 2003-02-20 | Mars Uk Limited | Foodstuff |
| JP2004512053A (ja) * | 2000-10-31 | 2004-04-22 | コルゲート・パーモリブ・カンパニー | ペットフード組成物および方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58129954A (ja) * | 1982-01-29 | 1983-08-03 | Riboseren:Kk | 新しき健康食品の製造法 |
| US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| US20050027004A1 (en) * | 1993-06-09 | 2005-02-03 | Martek Biosciences Corporation | Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions |
| DE4427079C2 (de) | 1994-07-30 | 2002-12-19 | Viatris Gmbh | Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure |
| US6184227B1 (en) * | 1995-07-21 | 2001-02-06 | Savvipharm Inc. | Salts of aminoimidazole carboxamide useful in the prevention and treatment of liver diseases |
| US6465466B1 (en) * | 1995-12-22 | 2002-10-15 | Leif J. I. Lundblad | Uses of indolo-2 [2,3b] -quinoxalines |
| IT1290907B1 (it) * | 1997-01-31 | 1998-12-14 | Idi Farmaceutici Spa | Composizione per prodotto dietetico efficace nel combattere lo stress ossidativo e il decadimento cellulare. |
| GB9722361D0 (en) * | 1997-10-24 | 1997-12-17 | Pharma Nord Uk Ltd | Pharmaceutical formulation for treating liver disorders |
| US6858399B2 (en) * | 1998-06-29 | 2005-02-22 | Robert Lamb | Test for oxidative stress using cell suspensions |
| US20030198661A1 (en) * | 2000-01-31 | 2003-10-23 | Mars Incorporated | Antioxidant compositions and methods for companion animals |
| NZ527924A (en) | 1999-01-29 | 2005-01-28 | Mars Uk Ltd | Antioxidant compositions and methods for companion animals |
| WO2000057876A1 (en) * | 1999-03-26 | 2000-10-05 | Lipogenics, Inc. | Novel antioxidant formulations and methods for using them |
| US6352712B1 (en) * | 1999-04-30 | 2002-03-05 | Daniel O. Lukaczer | Dietary supplements for treating fatigue-related syndromes |
| MXPA02002195A (es) | 1999-09-09 | 2002-09-18 | Nestle Sa | Mejoramiento del estado de mascotas viejas. |
| US20020077349A1 (en) * | 1999-11-03 | 2002-06-20 | Hamilton Nathan D. | Method of treating age-related vision impairment |
| US6207702B1 (en) * | 1999-11-17 | 2001-03-27 | Mars, Incorporated | Method for reducing postprandial oxidative stress using cocoa procyanidins |
| AUPQ429399A0 (en) * | 1999-11-26 | 1999-12-23 | Heart Research Institute, The | Oxidized apolipoproteins and methods of use |
| WO2001045661A2 (de) * | 1999-12-20 | 2001-06-28 | Cognis France, S.A. | Kosmetische und/oder pharmazeutische zubereitungen |
| US20010043983A1 (en) * | 2000-01-25 | 2001-11-22 | Hamilton Nathan D. | Nutritional supplements for aged pets |
| CN1423528A (zh) * | 2000-04-18 | 2003-06-11 | 雀巢制品公司 | 营养单元 |
| PT1317272E (pt) * | 2000-05-25 | 2006-06-30 | Boehringer Ingelheim Int | Composicao para melhoramento da proteccao celular compreendendo um antioxidante lipofilo e um antioxidante hidrofilo |
| US20030036203A1 (en) * | 2000-09-26 | 2003-02-20 | Geoff Duke | Method and graphic representation for profiling oxidative stress and cardiovascular risk |
| US20020115710A1 (en) | 2000-10-31 | 2002-08-22 | Zicker Steven Curtis | Composition and method |
| DE10057290B4 (de) * | 2000-11-17 | 2004-01-08 | Fresenius Kabi Deutschland Gmbh | Enteral zu verabreichendes Supplement zur parenteralen Ernährung oder partiellen enteralen/oralen Ernährung bei kritisch Kranken, chronisch Kranken und Mangelernährten |
| EA006429B1 (ru) | 2001-03-09 | 2005-12-29 | Сосьете Де Продюи Нестле С.А. | Композиция для предупреждения или восстановления возрастных функциональных дефицитов у млекопитающих и способ ее применения |
| US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
| ES2269671T3 (es) * | 2001-04-25 | 2007-04-01 | Cobalz Limited | Composiciones medicas para su uso en el tratamiento o la prevencion de una insuficiencia de vitamina b12 funcional. |
| US6596762B2 (en) * | 2001-05-17 | 2003-07-22 | The Regents Of The University Of Colorado | Antioxidant compositions and use for treatment of hepatic steatosis and steatohepatitis |
| US20050244422A1 (en) * | 2004-04-16 | 2005-11-03 | Desmond Mascarenhas | Methods for delivering MBD peptide-linked agent into cells under conditions of cellular stress |
| US7247714B2 (en) * | 2001-10-16 | 2007-07-24 | Atherogenics, Inc. | Protection against oxidative stress and inflammation by a cytoprotective response element |
| NO323683B1 (no) * | 2002-03-14 | 2007-06-25 | Pronova Biocare As | Anvendelse av marine og/eller vegetabilske oljer som er behandlet med urea og/eller andre aminer eller amider i fôr til marine arter |
| JP4771697B2 (ja) * | 2002-09-24 | 2011-09-14 | サントリーホールディングス株式会社 | 認知能力の正常応答の低下予防、改善又は向上作用を有する組成物 |
| US6974841B1 (en) * | 2002-09-27 | 2005-12-13 | Rapisarda Family Irrevocable Trust | Pet anti-aging wellness supplement |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| CA2525560A1 (en) * | 2003-05-13 | 2004-11-25 | The Regents Of The University Of Colorado | Diagnostic and therapeutic treatments related to mitochondrial disorders |
| DK1641351T3 (da) | 2003-07-03 | 2014-08-25 | Hills Pet Nutrition Inc | Sammensætninger og fremgangsmåder til at formindske aldersrelateret forringelse af mental aktivitet hos familiedyr |
| MXPA06000580A (es) * | 2003-07-21 | 2006-03-30 | Unilever Nv | Auxiliar de la funcion cognitiva. |
| US7078202B2 (en) * | 2003-11-18 | 2006-07-18 | Ultra Biotech Limited | Methods and compositions for treating vascular dementia |
| EP2266586A1 (en) * | 2004-03-23 | 2010-12-29 | Lifeline Nutraceuticals Corporation | Compositions and method for alleviating inflammation and oxidative stress in a mammal |
| AU2005232392B2 (en) * | 2004-04-16 | 2011-01-06 | Société des Produits Nestlé S.A. | Method and compositions for reducing oxidative stress in an animal |
| US20050266051A1 (en) * | 2004-05-27 | 2005-12-01 | The Procter & Gamble Company | Pet food compositions and methods |
| US20060094734A1 (en) * | 2004-11-04 | 2006-05-04 | Newman Arnold L | Composition and method for inducing alertness |
| RU2433819C2 (ru) | 2004-11-09 | 2011-11-20 | Хилл'С Пет Ньютришн, Инк. | Применение антиоксидантов для модуляции генов |
-
2005
- 2005-11-09 RU RU2007121735/15A patent/RU2433819C2/ru not_active IP Right Cessation
- 2005-11-09 EP EP05851449A patent/EP1814394A4/en not_active Ceased
- 2005-11-09 CN CN2005800462156A patent/CN101098623B/zh not_active Expired - Fee Related
- 2005-11-09 JP JP2007541282A patent/JP2008519838A/ja active Pending
- 2005-11-09 WO PCT/US2005/040515 patent/WO2006053010A2/en not_active Ceased
- 2005-11-09 AU AU2005304546A patent/AU2005304546B2/en not_active Ceased
- 2005-11-09 BR BRPI0517563-1A patent/BRPI0517563A/pt not_active Application Discontinuation
- 2005-11-09 CN CN201210299256.8A patent/CN102784396B/zh not_active Expired - Fee Related
- 2005-11-09 US US11/718,963 patent/US11077165B2/en active Active
- 2005-11-09 CA CA2586936A patent/CA2586936C/en not_active Expired - Fee Related
-
2007
- 2007-05-23 ZA ZA200704210A patent/ZA200704210B/xx unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090414A (en) * | 1970-05-20 | 2000-07-18 | Life Science Labs, Inc. | Method and composition to reduce cancer incidence |
| GB2367489A (en) * | 2000-07-31 | 2002-04-10 | Mars Inc | Anti-oxidant compositions for companion animals |
| JP2004512053A (ja) * | 2000-10-31 | 2004-04-22 | コルゲート・パーモリブ・カンパニー | ペットフード組成物および方法 |
| WO2003013268A1 (en) * | 2001-08-03 | 2003-02-20 | Mars Uk Limited | Foodstuff |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013172732A (ja) * | 2006-09-01 | 2013-09-05 | Hill's Pet Nutrition Inc | 動物用食物組成物を設計するための方法およびシステム |
| JP2011528556A (ja) * | 2008-07-18 | 2011-11-24 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高齢の動物の生活の質を向上させるための方法 |
| JP2011528555A (ja) * | 2008-07-18 | 2011-11-24 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高齢の動物の生活の質を向上させるための方法 |
| JP2015077139A (ja) * | 2008-07-18 | 2015-04-23 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高齢の動物の生活の質を向上させるための方法 |
| JP2015091246A (ja) * | 2008-07-18 | 2015-05-14 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高齢の動物の生活の質を向上させるための方法 |
| JP2012513766A (ja) * | 2008-12-30 | 2012-06-21 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | コンパニオンアニマルにおける変性関節病、骨関節炎、軟骨損傷、および関連する障害を処置する、または予防する方法 |
| JP2012513767A (ja) * | 2008-12-30 | 2012-06-21 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | リポ酸を含むコンパニオンアニマル用組成物およびその使用の方法 |
| JP2015109850A (ja) * | 2008-12-30 | 2015-06-18 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | コンパニオンアニマルにおける変性関節病、骨関節炎、軟骨損傷、および関連する障害を処置する、または予防する方法 |
| JP2015119710A (ja) * | 2008-12-30 | 2015-07-02 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | リポ酸を含むコンパニオンアニマル用組成物およびその使用の方法 |
| JP2013532128A (ja) * | 2010-05-12 | 2013-08-15 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 愛玩動物の炎症を抑制および予防し、炎症状態を緩和する方法 |
| JP2015071633A (ja) * | 2010-05-12 | 2015-04-16 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 愛玩動物の炎症を抑制および予防し、炎症状態を緩和する方法 |
| JP2014018172A (ja) * | 2012-07-20 | 2014-02-03 | Kohjin Life Sciences Co Ltd | 過酸化脂質生成を抑制するペットフード |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005304546A1 (en) | 2006-05-18 |
| CN101098623A (zh) | 2008-01-02 |
| CA2586936A1 (en) | 2006-05-18 |
| US11077165B2 (en) | 2021-08-03 |
| EP1814394A4 (en) | 2009-08-19 |
| EP1814394A2 (en) | 2007-08-08 |
| CN102784396A (zh) | 2012-11-21 |
| WO2006053010A2 (en) | 2006-05-18 |
| US20080069834A1 (en) | 2008-03-20 |
| AU2005304546B2 (en) | 2011-07-21 |
| RU2433819C2 (ru) | 2011-11-20 |
| RU2007121735A (ru) | 2008-12-20 |
| CN102784396B (zh) | 2015-07-29 |
| BRPI0517563A (pt) | 2008-10-14 |
| CN101098623B (zh) | 2012-10-10 |
| ZA200704210B (en) | 2008-09-25 |
| CA2586936C (en) | 2019-08-20 |
| WO2006053010A3 (en) | 2006-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008519838A (ja) | 遺伝子調節のための酸化防止剤の使用 | |
| US8759283B2 (en) | Methods for detecting mRNA and/or protein levels of gene in a biological sample | |
| CN1578627A (zh) | 组合物和方法 | |
| Feng et al. | Changes in barrier health status of the gill for grass carp (Ctenopharyngodon idella) during valine deficiency: regulation of tight junction protein transcript, antioxidant status and apoptosis-related gene expression | |
| AU2009270712B2 (en) | Method for enhancing the quality of life of a senior animal | |
| CN103349184A (zh) | 用于增加动物的抗氧化状态的组合物和方法 | |
| AU2009335096A1 (en) | Companion animal compositions including lipoic acid and methods of use thereof | |
| EP1906912A4 (en) | PROCESS FOR EXTENDING ANIMAL LIFE | |
| Weber et al. | Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints | |
| Ranard et al. | Synthetic α-tocopherol, compared with natural α-tocopherol, downregulates myelin genes in cerebella of adolescent Ttpa-null mice | |
| JP5731395B2 (ja) | 愛玩動物において抗ウイルス性免疫を増強する際に使用するための、抗酸化剤を含有する食物組成物 | |
| AU2013200758B2 (en) | Methods for enhancing the quality of life of a senior animal | |
| AU2016200420B2 (en) | Companion animal compositions including lipoic acid and methods of use thereof | |
| CA2862200A1 (en) | Methods for enhancing the quality of life of a senior animal | |
| AU2013209364A1 (en) | Companion animal compositions including lipoic acid and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081110 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20081110 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110620 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20110912 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110920 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110928 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20111020 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111027 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111121 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120419 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20121009 |