JP2008519768A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008519768A5 JP2008519768A5 JP2007540196A JP2007540196A JP2008519768A5 JP 2008519768 A5 JP2008519768 A5 JP 2008519768A5 JP 2007540196 A JP2007540196 A JP 2007540196A JP 2007540196 A JP2007540196 A JP 2007540196A JP 2008519768 A5 JP2008519768 A5 JP 2008519768A5
- Authority
- JP
- Japan
- Prior art keywords
- metanicotine
- salt
- hydroxybenzoate
- excipients
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- RPCVIAXDAUMJJP-PZBABLGHSA-N ispronicline Chemical compound CN[C@@H](C)C\C=C\C1=CN=CC(OC(C)C)=C1 RPCVIAXDAUMJJP-PZBABLGHSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 description 8
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000012535 impurity Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000001530 fumaric acid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 238000006845 Michael addition reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- BPIDLOWRIYHHBQ-UHFFFAOYSA-N pent-4-en-2-amine Chemical compound CC(N)CC=C BPIDLOWRIYHHBQ-UHFFFAOYSA-N 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical class OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62675104P | 2004-11-10 | 2004-11-10 | |
| PCT/US2005/040650 WO2006053082A2 (en) | 2004-11-10 | 2005-11-09 | Hydroxybenzoate salts of metanicotine compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008291862A Division JP4764911B2 (ja) | 2004-11-10 | 2008-11-14 | メタニコチン化合物のヒドロキシ安息香酸塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008519768A JP2008519768A (ja) | 2008-06-12 |
| JP2008519768A5 true JP2008519768A5 (enExample) | 2009-08-20 |
| JP4447038B2 JP4447038B2 (ja) | 2010-04-07 |
Family
ID=36168607
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540196A Expired - Fee Related JP4447038B2 (ja) | 2004-11-10 | 2005-11-09 | メタニコチン化合物のヒドロキシ安息香酸塩 |
| JP2007540192A Withdrawn JP2008519766A (ja) | 2004-11-10 | 2005-11-09 | メタニコチン化合物のヒドロキシ安息香酸塩 |
| JP2008291862A Expired - Fee Related JP4764911B2 (ja) | 2004-11-10 | 2008-11-14 | メタニコチン化合物のヒドロキシ安息香酸塩 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540192A Withdrawn JP2008519766A (ja) | 2004-11-10 | 2005-11-09 | メタニコチン化合物のヒドロキシ安息香酸塩 |
| JP2008291862A Expired - Fee Related JP4764911B2 (ja) | 2004-11-10 | 2008-11-14 | メタニコチン化合物のヒドロキシ安息香酸塩 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20060122238A1 (enExample) |
| EP (3) | EP2371818B1 (enExample) |
| JP (3) | JP4447038B2 (enExample) |
| KR (1) | KR101268890B1 (enExample) |
| CN (3) | CN101068785A (enExample) |
| AU (2) | AU2005304575A1 (enExample) |
| BR (1) | BRPI0517621A (enExample) |
| CA (3) | CA2584586A1 (enExample) |
| CY (1) | CY1113542T1 (enExample) |
| DK (1) | DK2371818T3 (enExample) |
| ES (1) | ES2404506T3 (enExample) |
| HR (1) | HRP20130215T1 (enExample) |
| IL (2) | IL182573A (enExample) |
| ME (1) | ME01503B (enExample) |
| MX (1) | MX2007005710A (enExample) |
| NO (1) | NO20072160L (enExample) |
| NZ (1) | NZ554689A (enExample) |
| PL (1) | PL2371818T3 (enExample) |
| PT (1) | PT2371818E (enExample) |
| RS (1) | RS52681B (enExample) |
| RU (1) | RU2409566C2 (enExample) |
| SG (1) | SG157379A1 (enExample) |
| SI (1) | SI2371818T1 (enExample) |
| UA (1) | UA88792C2 (enExample) |
| WO (2) | WO2006053082A2 (enExample) |
| ZA (2) | ZA200703759B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
| US7459469B2 (en) * | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| WO2007055928A1 (en) * | 2005-11-03 | 2007-05-18 | Targacept, Inc. | 5-membered ring metanicotine analogs |
| CN101528698A (zh) * | 2006-05-09 | 2009-09-09 | 阿斯利康公司 | (2s)-(4e)-n-甲基-5-[3-(5-异丙氧基吡啶)基]-4-戊烯-2-胺的盐形式 |
| TWI389889B (zh) * | 2006-05-09 | 2013-03-21 | Targacept Inc | （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型 |
| CL2007002684A1 (es) * | 2006-09-15 | 2008-06-27 | Astrazeneca Ab Targacept Inc | Combinacion que comprende un antipsicotico y (2s)-(4e)-n-metil-5-[3-(5-isopropoxipiridin)il]-4-penten-2-amina; composicion farmaceutica que la comprende; kit farmaceutico; y uso para tratar perjuicio cognitivo y/o trastorno psicoticos. |
| EP2112923A1 (en) * | 2007-01-22 | 2009-11-04 | Targacept Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| KR20100052490A (ko) * | 2007-07-31 | 2010-05-19 | 타가셉트 인코포레이티드 | (2ｓ)-(4ｅ)-ｎ-메틸-5-(3-(5-이소프로폭시피리딘)일)-4-펜텐-2-아민의 경피투여 |
| WO2009018367A2 (en) * | 2007-07-31 | 2009-02-05 | Targacept, Inc. | Novel salt forms of (2s)-(4e)-n-methyl-5-[3-(5-methoxypyridin)yl]-4-penten-2-amine |
| CN101774922B (zh) * | 2010-01-29 | 2012-12-26 | 浙江大学 | 2,3-二羟基苯甲酸酯类化合物及制备和应用 |
| JP2013528601A (ja) * | 2010-05-20 | 2013-07-11 | アストラゼネカ・アクチエボラーグ | アリール置換オレフィン系アミンの新規な製造方法 |
| ES2999088T3 (en) * | 2013-05-06 | 2025-02-24 | Juul Labs Inc | Nicotine salt formulations for aerosol devices and methods thereof |
| EP3838316B1 (en) * | 2013-07-11 | 2024-04-03 | Alexza Pharmaceuticals, Inc. | Drug delivery and drug cessation system |
| IL295735B2 (en) | 2013-12-05 | 2024-04-01 | Juul Labs Inc | Nicotine liquid formulations for aerosol devices and methods thereof |
| US9896429B2 (en) | 2014-05-27 | 2018-02-20 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| US10508096B2 (en) | 2014-05-27 | 2019-12-17 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| EP3148982A1 (en) | 2014-05-27 | 2017-04-05 | R. J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| EP3746138B1 (en) | 2018-02-02 | 2025-12-10 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
| CN113200967B (zh) * | 2021-05-07 | 2022-05-24 | 中国人民解放军陆军军医大学 | 吲哚苯醌类化合物、其制备方法及其应用 |
| CN113475740B (zh) * | 2021-07-10 | 2022-10-21 | 深圳市真味生物科技有限公司 | 一种手性合成尼古丁的制备方法 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4192946A (en) | 1978-06-29 | 1980-03-11 | Ciba-Geigy Corporation | Process for producing 3-hydroxy-5-halopyridines |
| DE3148651A1 (de) | 1981-12-09 | 1983-07-21 | Henkel Kgaa | "haarfaerbemittel, enthaltend 5-halo-2,3-pyridindiole als kupplerkomponente" |
| US4582823A (en) * | 1984-08-15 | 1986-04-15 | Warner-Lambert Company | Method for treating schizophrenia and medicaments therefor |
| WO1989000158A1 (en) | 1987-07-02 | 1989-01-12 | Pfizer Inc. | Bridged-diazabicycloalkyl quinolone carboxylic acids and esters |
| IT1226727B (it) * | 1988-07-29 | 1991-02-05 | Simes | Farmaci precursori della dopamina. |
| US4922901A (en) | 1988-09-08 | 1990-05-08 | R. J. Reynolds Tobacco Company | Drug delivery articles utilizing electrical energy |
| ES2070994T3 (es) * | 1989-04-20 | 1995-06-16 | Zambon Spa | Profarmaco de dopamina. |
| US5187166A (en) | 1990-07-31 | 1993-02-16 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives and their use as antiemetics |
| AU9171791A (en) | 1990-12-27 | 1992-08-17 | Abbott Laboratories | N-protected aminoalkylaldehydes |
| DE69213559T2 (de) | 1991-05-30 | 1997-02-27 | Mitsui Toatsu Chemicals | Tetravinylpyrazine-Verbindung, Verfahren zur Herstellung derselben und elektrolumineszentes Element und damit hergesteller nichtlinearer optischer Stoff |
| US5212188A (en) * | 1992-03-02 | 1993-05-18 | R. J. Reynolds Tabacco Company | Method for treatment of neurodegenerative diseases |
| IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
| US5852041A (en) | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
| IT1274018B (it) * | 1994-02-23 | 1997-07-14 | Riace Ets | Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica |
| GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| US5604231A (en) | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
| US5616707A (en) * | 1995-01-06 | 1997-04-01 | Crooks; Peter A. | Compounds which are useful for prevention and treatment of central nervous system disorders |
| US5597919A (en) | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5585388A (en) | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| IL118279A (en) | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
| US5616716A (en) | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| US20020052497A1 (en) * | 2000-03-09 | 2002-05-02 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| US5663356A (en) * | 1996-04-23 | 1997-09-02 | Ruecroft; Graham | Method for preparation of aryl substituted alefinic secondary amino compounds |
| WO1997040011A1 (en) * | 1996-04-23 | 1997-10-30 | R. J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5811442A (en) * | 1997-02-21 | 1998-09-22 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow |
| US5861423A (en) * | 1997-02-21 | 1999-01-19 | Caldwell; William Scott | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
| WO1998050367A1 (en) * | 1997-05-08 | 1998-11-12 | Pfizer Products Inc. | Processes and intermediates for preparing substituted indazole derivatives |
| BR9813279B1 (pt) | 1997-10-27 | 2010-11-16 | derivado de homopiperazina, composição farmacêutica, e, uso do derivado de homopiperazina. | |
| US6632823B1 (en) * | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| ATE273956T1 (de) | 1998-06-16 | 2004-09-15 | Targacept Inc | Arylsubstituierte olefinische amine und ihre verwendung als cholinergische rezeptoragonisten |
| US6232316B1 (en) * | 1998-06-16 | 2001-05-15 | Targacept, Inc. | Methods for treatment of CNS disorders |
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| US6337351B1 (en) | 1998-10-22 | 2002-01-08 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| GB9922271D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Formulation |
| US6506769B2 (en) * | 1999-10-06 | 2003-01-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
| US20030026766A1 (en) * | 2000-04-13 | 2003-02-06 | Mark Sanders | Medicaments for treating respiratory disorders comprising formoterol and fluticasone |
| US6432954B1 (en) * | 2000-07-14 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6743812B1 (en) * | 2000-07-14 | 2004-06-01 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| GB2381750A (en) * | 2001-10-10 | 2003-05-14 | Inspire Pharmaceuticals Inc | Treatment for enhancing joint lubrication |
| US20040044023A1 (en) * | 2002-08-30 | 2004-03-04 | Marc Cantillon | Compositions and methods for treating or preventing memory impairment |
| US20050203130A1 (en) * | 2003-12-02 | 2005-09-15 | Erik Buntinx | Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
| US7459469B2 (en) * | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| TWI389889B (zh) * | 2006-05-09 | 2013-03-21 | Targacept Inc | （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型 |
| CL2007002684A1 (es) * | 2006-09-15 | 2008-06-27 | Astrazeneca Ab Targacept Inc | Combinacion que comprende un antipsicotico y (2s)-(4e)-n-metil-5-[3-(5-isopropoxipiridin)il]-4-penten-2-amina; composicion farmaceutica que la comprende; kit farmaceutico; y uso para tratar perjuicio cognitivo y/o trastorno psicoticos. |
-
2005
- 2005-09-11 UA UAA200706359A patent/UA88792C2/ru unknown
- 2005-11-09 CA CA002584586A patent/CA2584586A1/en not_active Abandoned
- 2005-11-09 BR BRPI0517621-2A patent/BRPI0517621A/pt not_active Application Discontinuation
- 2005-11-09 JP JP2007540196A patent/JP4447038B2/ja not_active Expired - Fee Related
- 2005-11-09 RU RU2007121697/04A patent/RU2409566C2/ru not_active IP Right Cessation
- 2005-11-09 ME MEP-2013-25A patent/ME01503B/me unknown
- 2005-11-09 CN CNA2005800416143A patent/CN101068785A/zh active Pending
- 2005-11-09 EP EP11002581A patent/EP2371818B1/en not_active Expired - Lifetime
- 2005-11-09 RS RS20130081A patent/RS52681B/sr unknown
- 2005-11-09 SG SG200907438-6A patent/SG157379A1/en unknown
- 2005-11-09 EP EP05851465A patent/EP1814853A2/en not_active Withdrawn
- 2005-11-09 CA CA2793138A patent/CA2793138C/en not_active Expired - Fee Related
- 2005-11-09 CN CNA2005800416139A patent/CN101068784A/zh active Pending
- 2005-11-09 KR KR1020077010149A patent/KR101268890B1/ko not_active Expired - Fee Related
- 2005-11-09 PL PL11002581T patent/PL2371818T3/pl unknown
- 2005-11-09 WO PCT/US2005/040650 patent/WO2006053082A2/en not_active Ceased
- 2005-11-09 ES ES11002581T patent/ES2404506T3/es not_active Expired - Lifetime
- 2005-11-09 CN CN2012100831307A patent/CN102643228A/zh active Pending
- 2005-11-09 DK DK11002581.4T patent/DK2371818T3/da active
- 2005-11-09 MX MX2007005710A patent/MX2007005710A/es active IP Right Grant
- 2005-11-09 PT PT110025814T patent/PT2371818E/pt unknown
- 2005-11-09 US US11/270,753 patent/US20060122238A1/en not_active Abandoned
- 2005-11-09 AU AU2005304575A patent/AU2005304575A1/en not_active Abandoned
- 2005-11-09 CA CA2584448A patent/CA2584448C/en not_active Expired - Fee Related
- 2005-11-09 NZ NZ554689A patent/NZ554689A/en not_active IP Right Cessation
- 2005-11-09 SI SI200531683T patent/SI2371818T1/sl unknown
- 2005-11-09 JP JP2007540192A patent/JP2008519766A/ja not_active Withdrawn
- 2005-11-09 WO PCT/US2005/040588 patent/WO2006053039A2/en not_active Ceased
- 2005-11-09 EP EP05819967.0A patent/EP1814852B1/en not_active Expired - Lifetime
- 2005-11-09 AU AU2005304526A patent/AU2005304526B2/en not_active Ceased
-
2007
- 2007-04-16 IL IL182573A patent/IL182573A/en not_active IP Right Cessation
- 2007-04-26 NO NO20072160A patent/NO20072160L/no not_active Application Discontinuation
- 2007-05-09 ZA ZA200703759A patent/ZA200703759B/xx unknown
-
2008
- 2008-06-19 US US12/142,471 patent/US20080249142A1/en not_active Abandoned
- 2008-11-14 JP JP2008291862A patent/JP4764911B2/ja not_active Expired - Fee Related
-
2009
- 2009-04-16 ZA ZA2009/02634A patent/ZA200902634B/en unknown
-
2012
- 2012-12-17 IL IL223681A patent/IL223681A0/en unknown
-
2013
- 2013-01-14 CY CY20131100038T patent/CY1113542T1/el unknown
- 2013-03-12 HR HRP20130215TT patent/HRP20130215T1/hr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008519768A5 (enExample) | ||
| AU2022215155B2 (en) | Ribociclib tablet | |
| JP2014515013A5 (enExample) | ||
| JP2007016035A5 (enExample) | ||
| WO2009104739A1 (ja) | 経口投与用固形製剤 | |
| JP2012031131A5 (enExample) | ||
| JP2015145410A5 (enExample) | ||
| JP2008516004A5 (enExample) | ||
| Badawy et al. | 3 Salt Selection for Pharmaceutical Compounds | |
| JP5101007B2 (ja) | 安定化された医薬製剤 | |
| JP6179515B2 (ja) | 安定化された内服用固形製剤 | |
| CN1636553A (zh) | 防挥发型固体制剂及其制造方法 | |
| JP2013536823A5 (enExample) | ||
| JP5113476B2 (ja) | 保存安定性に優れた塩酸テモカプリルの錠剤 | |
| JP2010528088A5 (enExample) | ||
| KR20120116422A (ko) | 경구 투여용 의약 조성물 | |
| JP2018062510A (ja) | ロキソプロフェン含有製剤 | |
| KR101841355B1 (ko) | D-싸이클로세린의 약제학적 제형 및 이의 제조방법 | |
| JP6206069B2 (ja) | 固形製剤 | |
| JP2016003224A (ja) | ホリナートカルシウム含有錠 | |
| JP6149625B2 (ja) | 医薬組成物 | |
| WO2005084679A1 (ja) | ベンズアミジン誘導体含有組成物及びベンズアミジン誘導体の安定化方法 | |
| JP2022007461A (ja) | トルバプタン含有口腔内崩壊錠 | |
| EA045037B1 (ru) | Фармацевтические составы ингибиторов индоламин-2,3-диоксигеназы | |
| US20240122857A1 (en) | Pharmaceutical formulations of indoleamine 2, 3-dioxygenase inhibitors |