JP2008515405A5 - - Google Patents
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- JP2008515405A5 JP2008515405A5 JP2007534921A JP2007534921A JP2008515405A5 JP 2008515405 A5 JP2008515405 A5 JP 2008515405A5 JP 2007534921 A JP2007534921 A JP 2007534921A JP 2007534921 A JP2007534921 A JP 2007534921A JP 2008515405 A5 JP2008515405 A5 JP 2008515405A5
- Authority
- JP
- Japan
- Prior art keywords
- ligand
- agent
- nucleic acid
- target gene
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003446 ligand Substances 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 5
- 230000001717 pathogenic effect Effects 0.000 claims 5
- 108091023037 Aptamer Proteins 0.000 claims 4
- 230000024245 cell differentiation Effects 0.000 claims 4
- 230000010261 cell growth Effects 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 230000003833 cell viability Effects 0.000 claims 3
- 230000008859 change Effects 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000030833 cell death Effects 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 230000033458 reproduction Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 230000004565 tumor cell growth Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61597704P | 2004-10-05 | 2004-10-05 | |
| US60/615,977 | 2004-10-05 | ||
| US64165805P | 2005-01-06 | 2005-01-06 | |
| US60/641,658 | 2005-01-06 | ||
| PCT/US2005/036161 WO2006042112A2 (en) | 2004-10-05 | 2005-10-05 | Aptamer regulated nucleic acids and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012178625A Division JP5795563B2 (ja) | 2004-10-05 | 2012-08-10 | アプタマー調節される核酸及びその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515405A JP2008515405A (ja) | 2008-05-15 |
| JP2008515405A5 true JP2008515405A5 (enExample) | 2008-11-27 |
| JP5101288B2 JP5101288B2 (ja) | 2012-12-19 |
Family
ID=36075582
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534921A Expired - Fee Related JP5101288B2 (ja) | 2004-10-05 | 2005-10-05 | アプタマー調節される核酸及びその利用 |
| JP2012178625A Expired - Fee Related JP5795563B2 (ja) | 2004-10-05 | 2012-08-10 | アプタマー調節される核酸及びその利用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012178625A Expired - Fee Related JP5795563B2 (ja) | 2004-10-05 | 2012-08-10 | アプタマー調節される核酸及びその利用 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9315862B2 (enExample) |
| EP (1) | EP1799825B1 (enExample) |
| JP (2) | JP5101288B2 (enExample) |
| AT (1) | ATE514776T1 (enExample) |
| WO (1) | WO2006042112A2 (enExample) |
Families Citing this family (98)
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| WO2009137136A2 (en) | 2008-02-15 | 2009-11-12 | Trustees Of Boston University | In vivo gene sensors |
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| US8241854B2 (en) * | 2008-05-22 | 2012-08-14 | California Institute Of Technology | Triggered RNAi |
| JP5594838B2 (ja) * | 2008-07-09 | 2014-09-24 | 公立大学法人大阪市立大学 | オリゴヌクレオチド構造体および遺伝子発現制御方法 |
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| US8329882B2 (en) | 2009-02-18 | 2012-12-11 | California Institute Of Technology | Genetic control of mammalian cells with synthetic RNA regulatory systems |
| US9145555B2 (en) * | 2009-04-02 | 2015-09-29 | California Institute Of Technology | Integrated—ligand-responsive microRNAs |
| US9284559B2 (en) * | 2009-04-14 | 2016-03-15 | Wake Forest University Health Sciences | Multivalent aptamer complexes |
| WO2011050000A2 (en) * | 2009-10-20 | 2011-04-28 | The Regents Of The University Of California | Single molecule nucleic acid nanoparticles |
| US8658780B2 (en) | 2010-05-18 | 2014-02-25 | California Institute Of Technology | Triggered covalent probes for imaging and silencing genetic expression |
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| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
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| WO2013142735A1 (en) | 2012-03-21 | 2013-09-26 | California Institute Of Technology | Targeting domain and related signal activated molecular delivery |
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| JP6930834B2 (ja) | 2014-06-16 | 2021-09-01 | ザ・ジョンズ・ホプキンス・ユニバーシティー | H1プロモーターを用いるcrisprガイドrnaの発現のための組成物および方法 |
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- 2005-10-05 WO PCT/US2005/036161 patent/WO2006042112A2/en not_active Ceased
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- 2006-02-09 US US11/884,110 patent/US8772464B2/en active Active
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