JP2008514722A5 - - Google Patents
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- Publication number
- JP2008514722A5 JP2008514722A5 JP2007534782A JP2007534782A JP2008514722A5 JP 2008514722 A5 JP2008514722 A5 JP 2008514722A5 JP 2007534782 A JP2007534782 A JP 2007534782A JP 2007534782 A JP2007534782 A JP 2007534782A JP 2008514722 A5 JP2008514722 A5 JP 2008514722A5
- Authority
- JP
- Japan
- Prior art keywords
- atorvastatin calcium
- amorphous atorvastatin
- amorphous
- drying
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 claims 27
- 229960001770 atorvastatin calcium Drugs 0.000 claims 27
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims 4
- 239000006096 absorbing agent Substances 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 239000002274 desiccant Substances 0.000 claims 3
- 239000011261 inert gas Substances 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 2
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 2
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000473 propyl gallate Substances 0.000 claims 2
- 235000010388 propyl gallate Nutrition 0.000 claims 2
- 229940075579 propyl gallate Drugs 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 239000010409 thin film Substances 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 238000002390 rotary evaporation Methods 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61457804P | 2004-09-30 | 2004-09-30 | |
| IN715CH2005 | 2005-06-10 | ||
| PCT/US2005/035094 WO2006039441A2 (en) | 2004-09-30 | 2005-09-29 | Amorphous atorvastatin calcium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514722A JP2008514722A (ja) | 2008-05-08 |
| JP2008514722A5 true JP2008514722A5 (enExample) | 2009-03-12 |
Family
ID=36143063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534782A Pending JP2008514722A (ja) | 2004-09-30 | 2005-09-29 | 非結晶性アトルバスタチンカルシウム |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080009540A1 (enExample) |
| EP (1) | EP1793815A4 (enExample) |
| JP (1) | JP2008514722A (enExample) |
| KR (1) | KR20070106680A (enExample) |
| CA (1) | CA2582449A1 (enExample) |
| TW (1) | TW200618795A (enExample) |
| WO (1) | WO2006039441A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009013633A2 (en) * | 2007-07-20 | 2009-01-29 | Actavis Group Ptc Ehf | Amorphous coprecipitates of atorvastatin pharmaceutically acceptable salts |
| EP2075246A1 (en) * | 2007-12-27 | 2009-07-01 | M. J. Institute of Research | A process for preparation of amorphous form of atorvastatin hemi-calcium salt |
| WO2009090544A2 (en) * | 2008-01-16 | 2009-07-23 | Matrix Laboratories Limited | Process for producing amorphous atorvastatin calcium |
| WO2010066687A2 (en) * | 2008-12-11 | 2010-06-17 | Dsm Ip Assets B.V. | Stabalized statin-comprising compositions |
| HUP1000299A2 (hu) | 2010-06-08 | 2012-02-28 | Nanoform Cardiovascular Therapeutics Ltd | Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra |
| WO2013072770A2 (en) | 2011-11-15 | 2013-05-23 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical formulations comprising atorvastatin and glimepiride |
| WO2014041059A1 (en) * | 2012-09-17 | 2014-03-20 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process to produce atorvastatin intermediates |
| JPWO2017042995A1 (ja) * | 2015-09-07 | 2018-06-28 | パナソニックＩｐマネジメント株式会社 | 車載用ステレオカメラ装置、およびその補正方法 |
| CN109280024A (zh) * | 2018-10-09 | 2019-01-29 | 河南师范大学 | 一种高纯度阿托伐他汀叔丁酯的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210840A (en) * | 1984-01-18 | 1987-05-29 | Johnson & Johnson Baby Prod | Composition comprising synergistic combination of miconazole nitrate and zinc oxide |
| HRP960312B1 (en) * | 1995-07-17 | 2001-10-31 | Warner Lambert Co | NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1) |
| US6673374B2 (en) * | 1998-07-31 | 2004-01-06 | Howard Murad | Pharmaceutical compositions and methods for managing skin conditions |
| JP2002035579A (ja) * | 2000-07-24 | 2002-02-05 | Mitsubishi Gas Chem Co Inc | 水蒸気を吸収する脱酸素剤組成物 |
| US7501450B2 (en) * | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
| IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| IN190564B (enExample) | 2001-04-11 | 2003-08-09 | Cadila Heathcare Ltd | |
| AU2003245736A1 (en) * | 2002-02-14 | 2003-09-04 | Ranbaxy Laboratories Limited | Formulations of atorvastatin stabilized with alkali metal additions |
| IL163594A0 (en) * | 2002-02-19 | 2005-12-18 | Teva Pharma | Processes for desolvating solvates of atorvastatinhemi-calcium and atorvastatin hemi-calcium essentially free of organic solvent |
| SI21302A (sl) * | 2002-10-11 | 2004-04-30 | LEK farmacevtska dru�ba d.d. | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
| US7655692B2 (en) * | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
| TW200513199A (en) * | 2003-08-12 | 2005-04-16 | Mitsubishi Gas Chemical Co | Oxygen absorber composition, oxygen absorber packaging and oxygen absorption method |
| EP1723157B2 (en) * | 2004-02-26 | 2017-02-08 | Zentiva, k.s. | Amorphous forms of risedronate monosodium |
| WO2005090301A1 (en) * | 2004-03-17 | 2005-09-29 | Ranbaxy Laboratories Limited | Crystalline form of atorvastatin hemi calcium |
| DE602004032578D1 (de) * | 2004-03-19 | 2011-06-16 | Vb Medicare Pvt Ltd | Verbessertes verfahren zur herstellung von chlorierter saccharose |
-
2005
- 2005-09-29 JP JP2007534782A patent/JP2008514722A/ja active Pending
- 2005-09-29 WO PCT/US2005/035094 patent/WO2006039441A2/en not_active Ceased
- 2005-09-29 US US11/576,396 patent/US20080009540A1/en not_active Abandoned
- 2005-09-29 EP EP05803604A patent/EP1793815A4/en not_active Withdrawn
- 2005-09-29 CA CA002582449A patent/CA2582449A1/en not_active Abandoned
- 2005-09-29 KR KR1020077007918A patent/KR20070106680A/ko not_active Ceased
- 2005-09-30 TW TW094134218A patent/TW200618795A/zh unknown
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