JP2008514703A5 - - Google Patents
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- JP2008514703A5 JP2008514703A5 JP2007534673A JP2007534673A JP2008514703A5 JP 2008514703 A5 JP2008514703 A5 JP 2008514703A5 JP 2007534673 A JP2007534673 A JP 2007534673A JP 2007534673 A JP2007534673 A JP 2007534673A JP 2008514703 A5 JP2008514703 A5 JP 2008514703A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- cycloalkyl
- alkoxy
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 125000000217 alkyl group Chemical group 0.000 claims 67
- 150000001875 compounds Chemical class 0.000 claims 25
- 239000000203 mixture Substances 0.000 claims 25
- 229910052736 halogen Inorganic materials 0.000 claims 24
- 150000002367 halogens Chemical class 0.000 claims 24
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 14
- 125000003282 alkyl amino group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 10
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 9
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 8
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 6
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- -1 cyano, hydroxy Chemical group 0.000 claims 6
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000002393 azetidinyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 5
- 125000003386 piperidinyl group Chemical group 0.000 claims 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 4
- 239000003146 anticoagulant agent Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical group C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 230000000702 anti-platelet effect Effects 0.000 claims 2
- 229940127219 anticoagulant drug Drugs 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 206010002388 Angina unstable Diseases 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 208000033463 Ischaemic neuropathy Diseases 0.000 claims 1
- 206010038563 Reocclusion Diseases 0.000 claims 1
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 229940122388 Thrombin inhibitor Drugs 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 206010043647 Thrombotic Stroke Diseases 0.000 claims 1
- 229940123987 Thromboxane A2 receptor antagonist Drugs 0.000 claims 1
- 208000032109 Transient ischaemic attack Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003529 anticholesteremic agent Substances 0.000 claims 1
- 229940127226 anticholesterol agent Drugs 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 229940030600 antihypertensive agent Drugs 0.000 claims 1
- 239000003420 antiserotonin agent Substances 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000007887 coronary angioplasty Methods 0.000 claims 1
- 229940072645 coumadin Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003480 fibrinolytic effect Effects 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 229940118179 lovenox Drugs 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 239000002570 phosphodiesterase III inhibitor Substances 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 239000003868 thrombin inhibitor Substances 0.000 claims 1
- 239000003769 thromboxane A2 receptor blocking agent Substances 0.000 claims 1
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 claims 1
- 0 CC=*(c1ccc(OC)[s]1)NC(Nc(cc1)ccc1N(COc(c1c2)cc(NC)c2F)C1=O)=O Chemical compound CC=*(c1ccc(OC)[s]1)NC(Nc(cc1)ccc1N(COc(c1c2)cc(NC)c2F)C1=O)=O 0.000 description 4
- BVLVBLYZSSBNKL-UHFFFAOYSA-N C/C=S(/c([s]1)ccc1Cl)\NC(Nc(c(F)cc(N(COc(c1c2)cc(NC)c2F)C1=O)c1)c1F)=O Chemical compound C/C=S(/c([s]1)ccc1Cl)\NC(Nc(c(F)cc(N(COc(c1c2)cc(NC)c2F)C1=O)c1)c1F)=O BVLVBLYZSSBNKL-UHFFFAOYSA-N 0.000 description 1
- GTJUJMDVJWGZSV-UHFFFAOYSA-N C/C=S(/c1ccc(C)[s]1)\NC(Nc(cc1)ncc1N(COc(c1c2)cc(NC)c2F)C1=O)=O Chemical compound C/C=S(/c1ccc(C)[s]1)\NC(Nc(cc1)ncc1N(COc(c1c2)cc(NC)c2F)C1=O)=O GTJUJMDVJWGZSV-UHFFFAOYSA-N 0.000 description 1
- OCNDYBAHYJKQCK-UHFFFAOYSA-N CNc(cc(c1c2)OCN(c(cc3)ccc3C(NS(C)(c([s]3)ccc3Cl)=O)=O)C1=O)c2F Chemical compound CNc(cc(c1c2)OCN(c(cc3)ccc3C(NS(C)(c([s]3)ccc3Cl)=O)=O)C1=O)c2F OCNDYBAHYJKQCK-UHFFFAOYSA-N 0.000 description 1
- KGWVNJJUMGZQND-UHFFFAOYSA-N CNc(cc(c1c2)OCN(c(ccc(NC(NS(c([s]3)ccc3Cl)OC)=O)c3)c3OC)C1=O)c2F Chemical compound CNc(cc(c1c2)OCN(c(ccc(NC(NS(c([s]3)ccc3Cl)OC)=O)c3)c3OC)C1=O)c2F KGWVNJJUMGZQND-UHFFFAOYSA-N 0.000 description 1
- LWRDKCOFIXEBNQ-UHFFFAOYSA-N CNc(cc(c1c2)OCN(c3cccc(CNC(NS(c([s]4)ccc4Cl)(=O)=O)=O)c3)C1=O)c2F Chemical compound CNc(cc(c1c2)OCN(c3cccc(CNC(NS(c([s]4)ccc4Cl)(=O)=O)=O)c3)C1=O)c2F LWRDKCOFIXEBNQ-UHFFFAOYSA-N 0.000 description 1
- OVBNRMWLXYEIQR-UHFFFAOYSA-N Cc([s]1)ccc1/S(/NC(Nc(c(C)cc(N(COc(c1c2)cc(NC)c2F)C1=O)c1)c1OC)=O)=[O]/C Chemical compound Cc([s]1)ccc1/S(/NC(Nc(c(C)cc(N(COc(c1c2)cc(NC)c2F)C1=O)c1)c1OC)=O)=[O]/C OVBNRMWLXYEIQR-UHFFFAOYSA-N 0.000 description 1
- ASCRMSOACALAGG-UHFFFAOYSA-N Cc(cc(c(OCN1c2ccc(C(NS(c([s]3)ccc3Cl)(=O)=O)=O)c(F)c2)c2)C1=O)c2NC Chemical compound Cc(cc(c(OCN1c2ccc(C(NS(c([s]3)ccc3Cl)(=O)=O)=O)c(F)c2)c2)C1=O)c2NC ASCRMSOACALAGG-UHFFFAOYSA-N 0.000 description 1
- BRQCPFPVSBLYJG-UHFFFAOYSA-N Cc1cc(N(COc(c2c3)cc(NC)c3F)C2=O)cc(Cl)c1NC(NSc([s]1)ccc1Cl)=O Chemical compound Cc1cc(N(COc(c2c3)cc(NC)c3F)C2=O)cc(Cl)c1NC(NSc([s]1)ccc1Cl)=O BRQCPFPVSBLYJG-UHFFFAOYSA-N 0.000 description 1
- VDUPLNMVHVDKNL-UHFFFAOYSA-N Cc1ccc(SNC(Nc(cc2)ccc2N(COc(c2c3)cc(NC)c3F)C2=O)=O)[s]1 Chemical compound Cc1ccc(SNC(Nc(cc2)ccc2N(COc(c2c3)cc(NC)c3F)C2=O)=O)[s]1 VDUPLNMVHVDKNL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61456404P | 2004-09-29 | 2004-09-29 | |
| PCT/US2005/034246 WO2006039212A2 (en) | 2004-09-29 | 2005-09-26 | Substituted 2h-1,3-benzoxazin-4(3h)-ones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514703A JP2008514703A (ja) | 2008-05-08 |
| JP2008514703A5 true JP2008514703A5 (enExample) | 2008-09-18 |
Family
ID=36142983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534673A Ceased JP2008514703A (ja) | 2004-09-29 | 2005-09-26 | 置換２ｈ−１，３−ベンゾオキサジン−４（３ｈ）−オン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7205296B2 (enExample) |
| EP (1) | EP1812429A4 (enExample) |
| JP (1) | JP2008514703A (enExample) |
| KR (1) | KR20070064356A (enExample) |
| CN (1) | CN101031565B (enExample) |
| AU (1) | AU2005292314B2 (enExample) |
| BR (1) | BRPI0516181A (enExample) |
| CA (1) | CA2581638A1 (enExample) |
| IL (1) | IL182180A0 (enExample) |
| MX (1) | MX2007003836A (enExample) |
| NZ (1) | NZ554211A (enExample) |
| WO (1) | WO2006039212A2 (enExample) |
| ZA (1) | ZA200702688B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8933236B2 (en) * | 2012-05-22 | 2015-01-13 | Xenon Pharmaceuticals Inc. | N-substituted benzamides and methods of use thereof |
| US7834023B2 (en) * | 2006-09-20 | 2010-11-16 | Portola Pharmaceuticals, Inc. | Substituted dihydroquinazolines as platelet ADP receptor inhibitors |
| US7740693B2 (en) * | 2007-10-01 | 2010-06-22 | Honeywell International Inc. | Organic fluorescent sulfonyl ureido benzoxazinone pigments |
| JP6014154B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用 |
| WO2013064984A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
| BR112015000187A2 (pt) | 2012-07-06 | 2017-06-27 | Genentech Inc | benzamidas substituídas com n e métodos de uso das mesmas |
| EP2900243A4 (en) | 2012-09-27 | 2016-04-13 | Portola Pharm Inc | BICYCLIC OXA LACTAM KINASE HEMMER |
| KR20150131233A (ko) | 2013-03-14 | 2015-11-24 | 제넨테크, 인크. | 치환된 트리아졸로피리딘 및 이의 사용 방법 |
| US9493429B2 (en) | 2013-03-15 | 2016-11-15 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
| CR20160296A (es) | 2013-11-27 | 2016-09-20 | Genentech Inc | Benzamidas sustituidas y métodos para usarlas |
| WO2016007534A1 (en) | 2014-07-07 | 2016-01-14 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| WO2016020288A1 (en) | 2014-08-04 | 2016-02-11 | Nuevolution A/S | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| AU2015328174B2 (en) | 2014-10-06 | 2020-05-21 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| IL253661B2 (en) | 2015-02-16 | 2024-01-01 | Univ Queensland | Sulfonylureas bearing a five-membered ring, and pharmaceutical compositions and uses thereof |
| EP3297989A1 (en) | 2015-05-22 | 2018-03-28 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| CN108137477A (zh) | 2015-08-27 | 2018-06-08 | 基因泰克公司 | 治疗化合物及其使用方法 |
| CN108290881B (zh) | 2015-09-28 | 2021-12-07 | 健泰科生物技术公司 | 治疗性化合物和其使用方法 |
| EP3380466A1 (en) | 2015-11-25 | 2018-10-03 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| US10766858B2 (en) | 2016-03-30 | 2020-09-08 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| AU2017240685B2 (en) | 2016-03-31 | 2021-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| JOP20190042B1 (ar) | 2016-09-30 | 2021-08-17 | Vertex Pharma | مُعدِّل لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل |
| MX388175B (es) | 2016-10-17 | 2025-03-19 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
| JOP20190125B1 (ar) | 2016-12-09 | 2022-03-14 | Vertex Pharma | مُعدِّل لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل |
| EP3601273B1 (en) | 2017-03-24 | 2021-12-01 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| EP3634402A1 (en) | 2017-06-08 | 2020-04-15 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| DK3661925T3 (da) | 2017-07-07 | 2022-02-28 | Inflazome Ltd | Hidtil ukendte sulfonamidcarboxamidforbindelser |
| AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| US11434201B2 (en) | 2017-08-02 | 2022-09-06 | Vertex Pharmaceuticals Incorporated | Processes for preparing pyrrolidine compounds |
| WO2019034693A1 (en) | 2017-08-15 | 2019-02-21 | Inflazome Limited | SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3 |
| TW201910317A (zh) | 2017-08-15 | 2019-03-16 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
| MA49903A (fr) | 2017-08-15 | 2020-06-24 | Inflazome Ltd | Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3 |
| EP3694861A4 (en) | 2017-10-09 | 2021-05-19 | Nuvation Bio Inc. | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| CA3078945A1 (en) | 2017-10-09 | 2019-04-18 | Nuvation Bo Inc. | Heterocyclic compounds and uses thereof |
| US10654829B2 (en) | 2017-10-19 | 2020-05-19 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
| US12221434B2 (en) | 2017-11-09 | 2025-02-11 | Inflazome Limited | Sulfonamide carboxamide compounds |
| MA50567A (fr) | 2017-11-09 | 2020-09-16 | Inflazome Ltd | Nouveaux composés de sulfonamide carboxamide |
| CA3085006A1 (en) | 2017-12-08 | 2019-06-13 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| CN112041313A (zh) | 2018-02-26 | 2020-12-04 | 基因泰克公司 | 吡啶-磺酰胺化合物及其针对疼痛和相关疾患的用途 |
| EP3759077A1 (en) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Novel compounds |
| JP2021519788A (ja) | 2018-03-30 | 2021-08-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ナトリウムチャネル阻害剤としての縮合環ヒドロピリド化合物 |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| WO2020210377A1 (en) * | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| WO2020210383A1 (en) * | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| AU2020271837A1 (en) | 2019-04-09 | 2021-11-18 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| CN112939961B (zh) * | 2019-12-10 | 2023-04-14 | 上海挚盟医药科技有限公司 | 一类具有神经保护作用的化合物及其制备方法和用途 |
| EP4076657A1 (en) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
| JOP20220160A1 (ar) | 2019-12-20 | 2023-01-30 | Nuevolution As | مركبات فعّالة نحو مستقبلات نووية |
| MX2022012259A (es) | 2020-03-31 | 2022-12-08 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| MX2022012260A (es) | 2020-03-31 | 2022-11-30 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI101150B (fi) | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
| FR2702477B1 (fr) * | 1993-03-08 | 1995-04-28 | Synthelabo | Dérivés de benzoxazine, leur préparation et leur application en thérapeutique. |
| JP3814742B2 (ja) * | 1996-10-18 | 2006-08-30 | イハラケミカル工業株式会社 | ４−フルオロサリチル酸類 |
| SE9702774D0 (sv) | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| WO1999036425A1 (en) | 1998-01-15 | 1999-07-22 | Cor Therapeutics, Inc. | Platelet adp receptor inhibitors |
| US6248729B1 (en) | 1998-06-17 | 2001-06-19 | Bristol-Myers Squibb Co. | Combination of an ADP-receptor blocking antiplatelet drug and antihypertensive drug and a method for preventing a cerebral infarction employing such combination |
| US6509348B1 (en) | 1998-11-03 | 2003-01-21 | Bristol-Myers Squibb Company | Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination |
| US6906063B2 (en) * | 2000-02-04 | 2005-06-14 | Portola Pharmaceuticals, Inc. | Platelet ADP receptor inhibitors |
| DK1257550T3 (da) | 2000-02-04 | 2006-03-27 | Portola Pharm Inc | Blodplade-ADP-receptor-inhibitor |
| ES2282304T3 (es) | 2000-11-01 | 2007-10-16 | Astellas Pharma Inc. | Procedimiento para seleccionar antiplaquetas. |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| WO2004052871A1 (ja) * | 2002-12-06 | 2004-06-24 | Toray Industries, Inc. | ベンゾモルホリン誘導体 |
| US7294635B2 (en) * | 2003-10-03 | 2007-11-13 | Portola Pharmaceuticals, Inc. | Substituted isoquinolinones |
| WO2005032488A2 (en) * | 2003-10-03 | 2005-04-14 | Portola Pharmaceuticals, Inc. | 2,4-dioxo-3-quinazolinylaryl sulfonylureas |
-
2005
- 2005-09-26 WO PCT/US2005/034246 patent/WO2006039212A2/en not_active Ceased
- 2005-09-26 BR BRPI0516181-9A patent/BRPI0516181A/pt not_active IP Right Cessation
- 2005-09-26 KR KR1020077009902A patent/KR20070064356A/ko not_active Ceased
- 2005-09-26 MX MX2007003836A patent/MX2007003836A/es active IP Right Grant
- 2005-09-26 AU AU2005292314A patent/AU2005292314B2/en not_active Ceased
- 2005-09-26 ZA ZA200702688A patent/ZA200702688B/en unknown
- 2005-09-26 US US11/236,051 patent/US7205296B2/en not_active Expired - Lifetime
- 2005-09-26 NZ NZ554211A patent/NZ554211A/en not_active IP Right Cessation
- 2005-09-26 CA CA002581638A patent/CA2581638A1/en not_active Abandoned
- 2005-09-26 CN CN2005800328848A patent/CN101031565B/zh not_active Expired - Fee Related
- 2005-09-26 EP EP05798632A patent/EP1812429A4/en not_active Withdrawn
- 2005-09-26 JP JP2007534673A patent/JP2008514703A/ja not_active Ceased
-
2007
- 2007-03-26 IL IL182180A patent/IL182180A0/en unknown
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