JP2008519087A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008519087A5 JP2008519087A5 JP2007540710A JP2007540710A JP2008519087A5 JP 2008519087 A5 JP2008519087 A5 JP 2008519087A5 JP 2007540710 A JP2007540710 A JP 2007540710A JP 2007540710 A JP2007540710 A JP 2007540710A JP 2008519087 A5 JP2008519087 A5 JP 2008519087A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- formula
- hydrogen
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 37
- 125000004429 atom Chemical group 0.000 claims 23
- 229910052760 oxygen Inorganic materials 0.000 claims 21
- 229910052757 nitrogen Inorganic materials 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 239000001257 hydrogen Substances 0.000 claims 19
- 125000005842 heteroatom Chemical group 0.000 claims 14
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 12
- 125000005647 linker group Chemical group 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- -1 cyano, nitro, carboxy, amino Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 238000006243 chemical reaction Methods 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 7
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 6
- 150000001204 N-oxides Chemical class 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 239000011737 fluorine Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 5
- 229910052794 bromium Inorganic materials 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000004043 oxo group Chemical group O=* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- 239000003054 catalyst Substances 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 2
- 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 claims 2
- 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 108091008611 Protein Kinase B Proteins 0.000 claims 2
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 2
- 125000000586 2-(4-morpholinyl)ethoxy group Chemical group [H]C([H])(O*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims 1
- JPAOSCNZYJIWGU-UHFFFAOYSA-N 4-(4-chlorophenyl)-n-(4-oxo-1h-quinazolin-7-yl)piperidine-4-carboxamide Chemical compound C1=CC(Cl)=CC=C1C1(C(=O)NC=2C=C3C(C(NC=N3)=O)=CC=2)CCNCC1 JPAOSCNZYJIWGU-UHFFFAOYSA-N 0.000 claims 1
- LKLACGZUXOSYME-UHFFFAOYSA-N 4-amino-2-(3,4-dichlorophenyl)-n-(4-oxo-1h-quinazolin-7-yl)butanamide Chemical compound C=1C=C(C(NC=N2)=O)C2=CC=1NC(=O)C(CCN)C1=CC=C(Cl)C(Cl)=C1 LKLACGZUXOSYME-UHFFFAOYSA-N 0.000 claims 1
- 125000006164 6-membered heteroaryl group Chemical group 0.000 claims 1
- AKWWVGIPWJYWOJ-UHFFFAOYSA-N 7-[2-[4-(4-chlorophenyl)piperidin-4-yl]ethenyl]-1h-quinazolin-4-one Chemical compound C1=CC(Cl)=CC=C1C1(C=CC=2C=C3C(C(NC=N3)=O)=CC=2)CCNCC1 AKWWVGIPWJYWOJ-UHFFFAOYSA-N 0.000 claims 1
- CQCZVSPWCJSNOE-UHFFFAOYSA-N 7-[4-(aminomethyl)-4-(4-chlorophenyl)piperidin-1-yl]-1h-quinazolin-4-one Chemical compound C1CN(C=2C=C3C(C(NC=N3)=O)=CC=2)CCC1(CN)C1=CC=C(Cl)C=C1 CQCZVSPWCJSNOE-UHFFFAOYSA-N 0.000 claims 1
- CNOUMTJGSIBEDM-UHFFFAOYSA-N 7-[4-(aminomethyl)-4-(4-chlorophenyl)piperidin-1-yl]-2-methyl-1h-quinazolin-4-one Chemical compound C=1C=C2C(=O)NC(C)=NC2=CC=1N(CC1)CCC1(CN)C1=CC=C(Cl)C=C1 CNOUMTJGSIBEDM-UHFFFAOYSA-N 0.000 claims 1
- PIXXOEINPBZHFJ-UHFFFAOYSA-N 7-[4-(aminomethyl)-4-[(4-chlorophenyl)methyl]piperidin-1-yl]-1-methylquinazoline-2,4-dione Chemical compound C=1C=C2C(=O)NC(=O)N(C)C2=CC=1N(CC1)CCC1(CN)CC1=CC=C(Cl)C=C1 PIXXOEINPBZHFJ-UHFFFAOYSA-N 0.000 claims 1
- PCQFKJJJPQIJHA-UHFFFAOYSA-N 7-[4-(aminomethyl)-4-[(4-chlorophenyl)methyl]piperidin-1-yl]-1h-quinazolin-4-one Chemical compound C1CN(C=2C=C3C(C(NC=N3)=O)=CC=2)CCC1(CN)CC1=CC=C(Cl)C=C1 PCQFKJJJPQIJHA-UHFFFAOYSA-N 0.000 claims 1
- AHCDLSCQWMMXGO-UHFFFAOYSA-N 7-[4-[amino-(4-chlorophenyl)methyl]piperidin-1-yl]-1h-quinazolin-4-one Chemical compound C1CN(C=2C=C3C(C(NC=N3)=O)=CC=2)CCC1C(N)C1=CC=C(Cl)C=C1 AHCDLSCQWMMXGO-UHFFFAOYSA-N 0.000 claims 1
- BYPCNAQSAXHLDB-UHFFFAOYSA-N 7-[4-amino-4-(4-chlorophenyl)piperidin-1-yl]-1h-quinazolin-4-one Chemical compound C1CN(C=2C=C3C(C(NC=N3)=O)=CC=2)CCC1(N)C1=CC=C(Cl)C=C1 BYPCNAQSAXHLDB-UHFFFAOYSA-N 0.000 claims 1
- IDKVLXLJSXYUOF-UHFFFAOYSA-N 7-[4-amino-4-[(4-chlorophenyl)methyl]piperidin-1-yl]-1h-quinazolin-4-one Chemical compound C1CN(C=2C=C3C(C(NC=N3)=O)=CC=2)CCC1(N)CC1=CC=C(Cl)C=C1 IDKVLXLJSXYUOF-UHFFFAOYSA-N 0.000 claims 1
- NQKSXMPLSLVNNT-UHFFFAOYSA-N 7-[[4-(4-chlorophenyl)piperidin-4-yl]methoxy]-1-methylquinazoline-2,4-dione Chemical compound C=1C=C2C(=O)NC(=O)N(C)C2=CC=1OCC1(C=2C=CC(Cl)=CC=2)CCNCC1 NQKSXMPLSLVNNT-UHFFFAOYSA-N 0.000 claims 1
- 238000001321 HNCO Methods 0.000 claims 1
- OWIKHYCFFJSOEH-UHFFFAOYSA-N Isocyanic acid Chemical group N=C=O OWIKHYCFFJSOEH-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 claims 1
- WUUXBBLJAGVZKB-UHFFFAOYSA-N n-(4-oxo-1h-quinazolin-7-yl)-4-phenylpiperidine-4-carboxamide Chemical compound C=1C=C(C(NC=N2)=O)C2=CC=1NC(=O)C1(C=2C=CC=CC=2)CCNCC1 WUUXBBLJAGVZKB-UHFFFAOYSA-N 0.000 claims 1
- QAMJPJFFOJCDKP-UHFFFAOYSA-N n-[3-amino-1-(4-chlorophenyl)propyl]-4-oxo-1h-quinazoline-7-carboxamide Chemical compound C=1C=C(C(NC=N2)=O)C2=CC=1C(=O)NC(CCN)C1=CC=C(Cl)C=C1 QAMJPJFFOJCDKP-UHFFFAOYSA-N 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62640304P | 2004-11-09 | 2004-11-09 | |
| GB0424742A GB0424742D0 (en) | 2004-11-09 | 2004-11-09 | Pharmaceutical compounds |
| PCT/GB2005/004323 WO2006051290A2 (en) | 2004-11-09 | 2005-11-09 | Compounds for treating protein-kinase mediated disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008519087A JP2008519087A (ja) | 2008-06-05 |
| JP2008519087A5 true JP2008519087A5 (enExample) | 2008-12-25 |
Family
ID=35695751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540710A Withdrawn JP2008519087A (ja) | 2004-11-09 | 2005-11-09 | 医薬品 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080275029A1 (enExample) |
| EP (1) | EP1814552A2 (enExample) |
| JP (1) | JP2008519087A (enExample) |
| AR (1) | AR053778A1 (enExample) |
| UY (1) | UY29198A1 (enExample) |
| WO (1) | WO2006051290A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007008926A1 (en) * | 2005-07-11 | 2007-01-18 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| US7618985B2 (en) | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
| US7893088B2 (en) * | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| ES2553827T3 (es) * | 2009-05-01 | 2015-12-14 | Aerie Pharmaceuticals, Inc. | Inhibidores de mecanismo doble para el tratamiento de enfermedad |
| RU2451010C1 (ru) * | 2011-01-11 | 2012-05-20 | Закрытое Акционерное Общество "Ива Фарм" | Палладиево-медные катализаторы гомогенного селективного окисления тиольных групп, комбинация и композиция на их основе и способ терапевтического воздействия |
| HUE061618T2 (hu) | 2013-03-15 | 2023-07-28 | Aerie Pharmaceuticals Inc | Vegyület szemrendellenességek kezelésére |
| CN103524431B (zh) * | 2013-09-24 | 2016-01-13 | 西安交通大学 | 3-苄基-4-喹唑啉酮类化合物及其合成方法和应用 |
| KR102633122B1 (ko) | 2014-08-01 | 2024-02-05 | 누에볼루션 에이/에스 | 브로모도메인에 대하여 활성을 갖는 화합물 |
| US10239845B2 (en) | 2015-02-02 | 2019-03-26 | Forma Therapeutics, Inc. | 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| KR102579582B1 (ko) | 2015-11-17 | 2023-09-15 | 에어리 파마슈티컬즈, 인코포레이티드 | 키나아제 억제제 및 이의 중간체의 제조 방법 |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| WO2018045091A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| JP2020515583A (ja) | 2017-03-31 | 2020-05-28 | アエリエ ファーマシューティカルズ インコーポレイテッド | アリールシクロプロピル−アミノ−イソキノリニルアミド化合物 |
| US20220089609A1 (en) | 2018-07-26 | 2022-03-24 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN116057052B (zh) | 2020-08-12 | 2024-09-03 | 基因泰克公司 | 喹唑啉化合物之合成 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4281127A (en) * | 1979-07-09 | 1981-07-28 | Hoffmann-La Roche Inc. | Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives |
| UA73993C2 (uk) * | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| TW200301123A (en) * | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
-
2005
- 2005-11-08 UY UY29198A patent/UY29198A1/es not_active Application Discontinuation
- 2005-11-09 AR ARP050104700A patent/AR053778A1/es not_active Application Discontinuation
- 2005-11-09 WO PCT/GB2005/004323 patent/WO2006051290A2/en not_active Ceased
- 2005-11-09 US US11/718,943 patent/US20080275029A1/en not_active Abandoned
- 2005-11-09 EP EP05801609A patent/EP1814552A2/en not_active Withdrawn
- 2005-11-09 JP JP2007540710A patent/JP2008519087A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008519087A5 (enExample) | ||
| CN103974950B (zh) | 作为ccr(4)拮抗剂的取代的苯并咪唑类和苯并吡唑类 | |
| JP3073238B2 (ja) | １−（１，２−ジ置換ピペリジニル）−４−置換ピペラジン誘導体 | |
| JP4259877B2 (ja) | Ｃｘｃｒ３アンタゴニスト | |
| JP5411300B2 (ja) | 可溶性グアニレートシクラーゼ活性化剤 | |
| JP4039691B2 (ja) | タキキニンレセプターアンタゴニストとしての１−（１，２−ジ置換ピペリジニル）−４−置換ピペリジン誘導体 | |
| SK16152002A3 (sk) | Farmacueticky účinné piperidínové deriváty, najmä ako modulátory aktivity chemokínového receptora | |
| SK90297A3 (en) | 1,4,5-tri-substituted imidazole compounds, producing method thereof, pharmaceutical composition containing them and their use | |
| BG64848B1 (bg) | Циклични аминопроизводни и използването им като лекарства | |
| JP2005517723A (ja) | 炎症性疾患の治療用ケモカイン受容体阻害剤としてのピペリジン−４−イル尿素誘導体及び関連化合物 | |
| JP2012529535A (ja) | キナーゼモジュレーターとして有用なニコチンアミド化合物 | |
| KR102000770B1 (ko) | Ｃｃｒ(4) 길항제로서의 치환된 아닐린 | |
| CA2498051A1 (en) | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes | |
| SK4796A3 (en) | Tri-substituted imidazoles, manufacturing process thereof, pharmaceutical agent containing them and their use | |
| AU2015335694A1 (en) | Indole carboxamide compounds useful as kinase inhibitors | |
| JP2005536533A (ja) | 置換ベンゾイミダゾール化合物 | |
| CN101460482A (zh) | 具有cxcr3拮抗剂活性的杂环取代的吡啶化合物 | |
| JP2010526793A (ja) | Ｐ２ｘ７調節因子としてのピラゾール誘導体 | |
| JP6567505B2 (ja) | キナゾリン誘導体およびｄｎａメチルトランスフェラーゼ阻害剤としてのその使用 | |
| JP2008504301A (ja) | 炎症性及び免疫調節性の障害及び疾患の予防及び治療に有用である、ｃｘｃｒ３受容体モジュレーターとしての縮合ピリミジン誘導体及びその組成物 | |
| WO2017049462A1 (zh) | 一类新型的flt3激酶抑制剂及其用途 | |
| KR20140083058A (ko) | G 단백질-커플링된 Mas 수용체의 조절제 및 그와 관련된 장애의 치료 | |
| CN1416421A (zh) | 新的ccr5调节剂:苯并咪唑或苯并三唑 | |
| AU2013331493A1 (en) | Heteroaryl linked quinolinyl modulators of RORyt | |
| JP2012507525A5 (enExample) |