JP2008514646A5 - - Google Patents
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- JP2008514646A5 JP2008514646A5 JP2007533786A JP2007533786A JP2008514646A5 JP 2008514646 A5 JP2008514646 A5 JP 2008514646A5 JP 2007533786 A JP2007533786 A JP 2007533786A JP 2007533786 A JP2007533786 A JP 2007533786A JP 2008514646 A5 JP2008514646 A5 JP 2008514646A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 20
- 230000003474 anti-emetic effect Effects 0.000 claims 11
- 239000002111 antiemetic agent Substances 0.000 claims 11
- 206010047700 Vomiting Diseases 0.000 claims 10
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims 9
- 229920001710 Polyorthoester Polymers 0.000 claims 8
- 239000002745 poly(ortho ester) Substances 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 6
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 6
- -1 polyethylene Polymers 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 230000003444 anaesthetic effect Effects 0.000 claims 5
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims 5
- 229960003727 granisetron Drugs 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000000018 receptor agonist Substances 0.000 claims 5
- 229940044601 receptor agonist Drugs 0.000 claims 5
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 229960005343 ondansetron Drugs 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- ZNRGQMMCGHDTEI-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CNC2=C1 ZNRGQMMCGHDTEI-ITGUQSILSA-N 0.000 claims 4
- 229960003688 tropisetron Drugs 0.000 claims 4
- 239000003185 4 aminobutyric acid B receptor stimulating agent Substances 0.000 claims 3
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 3
- 239000000812 cholinergic antagonist Substances 0.000 claims 3
- 239000003210 dopamine receptor blocking agent Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 230000005855 radiation Effects 0.000 claims 3
- 229940044551 receptor antagonist Drugs 0.000 claims 3
- 239000002464 receptor antagonist Substances 0.000 claims 3
- 239000003981 vehicle Substances 0.000 claims 3
- 230000008673 vomiting Effects 0.000 claims 3
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical compound C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims 2
- 229940121947 Alpha 2 adrenoreceptor agonist Drugs 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 230000002980 postoperative effect Effects 0.000 claims 2
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 claims 2
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 claims 2
- 229960001600 xylazine Drugs 0.000 claims 2
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- SGUAFYQXFOLMHL-UHFFFAOYSA-N 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide Chemical compound C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 SGUAFYQXFOLMHL-UHFFFAOYSA-N 0.000 claims 1
- DHSSDEDRBUKTQY-UHFFFAOYSA-N 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine Chemical compound C1CN(CC=C)CCC2=C1N=C(N)S2 DHSSDEDRBUKTQY-UHFFFAOYSA-N 0.000 claims 1
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 1
- WDZVGELJXXEGPV-YIXHJXPBSA-N Guanabenz Chemical compound NC(N)=N\N=C\C1=C(Cl)C=CC=C1Cl WDZVGELJXXEGPV-YIXHJXPBSA-N 0.000 claims 1
- INJOMKTZOLKMBF-UHFFFAOYSA-N Guanfacine Chemical compound NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl INJOMKTZOLKMBF-UHFFFAOYSA-N 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- CQXADFVORZEARL-UHFFFAOYSA-N Rilmenidine Chemical compound C1CC1C(C1CC1)NC1=NCCO1 CQXADFVORZEARL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 229960002610 apraclonidine Drugs 0.000 claims 1
- IEJXVRYNEISIKR-UHFFFAOYSA-N apraclonidine Chemical compound ClC1=CC(N)=CC(Cl)=C1NC1=NCCN1 IEJXVRYNEISIKR-UHFFFAOYSA-N 0.000 claims 1
- 239000012298 atmosphere Substances 0.000 claims 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 1
- 229960003679 brimonidine Drugs 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 229960002896 clonidine Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229960001894 detomidine Drugs 0.000 claims 1
- JXMXDKHEZLKQPB-UHFFFAOYSA-N detomidine Chemical compound CC1=CC=CC(CC=2[N]C=NC=2)=C1C JXMXDKHEZLKQPB-UHFFFAOYSA-N 0.000 claims 1
- 229960004253 dexmedetomidine Drugs 0.000 claims 1
- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 claims 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical class OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229960004553 guanabenz Drugs 0.000 claims 1
- 229960002048 guanfacine Drugs 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 125000005462 imide group Chemical group 0.000 claims 1
- 229960001632 labetalol Drugs 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229960002140 medetomidine Drugs 0.000 claims 1
- HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 claims 1
- RXQCGGRTAILOIN-UHFFFAOYSA-N mephentermine Chemical compound CNC(C)(C)CC1=CC=CC=C1 RXQCGGRTAILOIN-UHFFFAOYSA-N 0.000 claims 1
- 229960002342 mephentermine Drugs 0.000 claims 1
- 229960002409 mepivacaine Drugs 0.000 claims 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims 1
- 229960005192 methoxamine Drugs 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 229960005016 naphazoline Drugs 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 229960001528 oxymetazoline Drugs 0.000 claims 1
- 229960001802 phenylephrine Drugs 0.000 claims 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229960001807 prilocaine Drugs 0.000 claims 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 229960000764 rilmenidine Drugs 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229960000337 tetryzoline Drugs 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229960001262 tramazoline Drugs 0.000 claims 1
- QQJLHRRUATVHED-UHFFFAOYSA-N tramazoline Chemical compound N1CCN=C1NC1=CC=CC2=C1CCCC2 QQJLHRRUATVHED-UHFFFAOYSA-N 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 238000009827 uniform distribution Methods 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/953,841 US20050042194A1 (en) | 2000-05-11 | 2004-09-28 | Semi-solid delivery vehicle and pharmaceutical compositions |
| PCT/US2005/035117 WO2006037116A2 (en) | 2004-09-28 | 2005-09-27 | Semi-solid delivery vehicle and pharmaceutical compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012045876A Division JP2012107064A (ja) | 2004-09-28 | 2012-03-01 | 半固体送達賦形剤および薬学的組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514646A JP2008514646A (ja) | 2008-05-08 |
| JP2008514646A5 true JP2008514646A5 (https=) | 2008-10-16 |
Family
ID=36119607
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533786A Withdrawn JP2008514646A (ja) | 2004-09-28 | 2005-09-27 | 半固体送達賦形剤および薬学的組成物 |
| JP2012045876A Withdrawn JP2012107064A (ja) | 2004-09-28 | 2012-03-01 | 半固体送達賦形剤および薬学的組成物 |
| JP2014232639A Expired - Lifetime JP6057972B2 (ja) | 2004-09-28 | 2014-11-17 | 半固体送達賦形剤および薬学的組成物 |
| JP2016203588A Pending JP2017008113A (ja) | 2004-09-28 | 2016-10-17 | 半固体送達賦形剤および薬学的組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012045876A Withdrawn JP2012107064A (ja) | 2004-09-28 | 2012-03-01 | 半固体送達賦形剤および薬学的組成物 |
| JP2014232639A Expired - Lifetime JP6057972B2 (ja) | 2004-09-28 | 2014-11-17 | 半固体送達賦形剤および薬学的組成物 |
| JP2016203588A Pending JP2017008113A (ja) | 2004-09-28 | 2016-10-17 | 半固体送達賦形剤および薬学的組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (10) | US20050042194A1 (https=) |
| EP (4) | EP3834817A1 (https=) |
| JP (4) | JP2008514646A (https=) |
| KR (1) | KR20070083851A (https=) |
| CN (1) | CN101052376A (https=) |
| AU (1) | AU2005289425A1 (https=) |
| CA (1) | CA2579297A1 (https=) |
| ES (1) | ES2529574T3 (https=) |
| TW (1) | TWI407966B (https=) |
| WO (1) | WO2006037116A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| ATE482695T1 (de) | 2002-12-13 | 2010-10-15 | Durect Corp | Orale darreichungsform mit flüssigen hochviskosen trägersystemen |
| SI2415484T1 (sl) * | 2004-09-17 | 2014-10-30 | Durect Corporation | Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| US20070264339A1 (en) * | 2006-05-12 | 2007-11-15 | Ap Pharma, Inc. | Base-stabilized polyorthoester formulations |
| US20070265329A1 (en) * | 2006-05-12 | 2007-11-15 | Devang Shah T | Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) |
| US20070264338A1 (en) * | 2006-05-12 | 2007-11-15 | Shah Devang T | Base-stabilized polyorthoester formulations |
| FR2901702A1 (fr) * | 2006-05-31 | 2007-12-07 | Galderma Res & Dev S N C Snc | Utilisation de granisetron pour le traitement de sous-types de la rosacee, et compositions pharmaceutiques |
| US7875697B2 (en) * | 2006-06-29 | 2011-01-25 | Medtronic, Inc. | Poly(orthoester) polymers, and methods of making and using same |
| EP1917971A1 (en) * | 2006-10-27 | 2008-05-07 | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) | Substained release formulations comprising very low molecular weight polymers |
| AU2007325918B2 (en) | 2006-11-03 | 2013-10-17 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
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| AU2009241847B2 (en) * | 2008-04-28 | 2014-07-10 | Zogenix, Inc. | Novel formulations for treatment of migraine |
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| AU2009270695A1 (en) * | 2008-07-17 | 2010-01-21 | Ap Pharma | Methods for enhancing the stability of polyorthoesters and their formulations |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| TWI372057B (en) * | 2008-12-11 | 2012-09-11 | Dev Center Biotechnology | Sustained release implant for granisetron |
| WO2010068827A1 (en) * | 2008-12-11 | 2010-06-17 | A.P. Pharma, Inc. | Methods for enhancing stability of polyorthoesters and their formulations |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| US9849180B2 (en) * | 2014-09-15 | 2017-12-26 | Hui Rong Shen | Long-acting semi-solid lipid formulations |
| AU2014233453A1 (en) | 2013-03-15 | 2015-10-01 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| CN105358129A (zh) | 2013-03-15 | 2016-02-24 | 赫伦治疗有限公司 | 聚原酸酯和质子惰性溶剂的组合物 |
| US20140323517A1 (en) * | 2013-04-30 | 2014-10-30 | Heron Therapeutics, Inc. | Compositions and methods for injection of a biodegradable polymer-based delivery system |
| BR112016006848A2 (pt) | 2013-10-07 | 2017-08-01 | Teikoku Pharma Usa Inc | métodos e composições para distribuição transdérmica de uma quantidade não sedativa de dexmedetomidina |
| CA2924233C (en) | 2013-10-07 | 2018-10-23 | Teikoku Pharma Usa, Inc. | Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions |
| KR101827980B1 (ko) | 2013-10-07 | 2018-02-13 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법 |
| CA2946281C (en) | 2014-04-21 | 2022-12-13 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
| ES2837149T3 (es) | 2014-04-21 | 2021-06-29 | Heron Therapeutics Inc | Composiciones de un poliortoéster y un excipiente de ácido orgánico |
| US9801945B2 (en) | 2014-04-21 | 2017-10-31 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
| WO2018048460A1 (en) | 2014-04-21 | 2018-03-15 | Heron Therapeutics, Inc. | A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam |
| US12274794B2 (en) | 2016-07-06 | 2025-04-15 | Orient Pharma Co., Ltd. | Oral dosage form with drug composition, barrier layer and drug layer |
| TWI764951B (zh) | 2016-10-31 | 2022-05-21 | 美商帝國製藥美國股份有限公司 | 用於處理疼痛之右美托咪啶經皮遞送裝置 |
| CN107789628B (zh) * | 2016-12-29 | 2021-07-23 | 天津键凯科技有限公司 | 一种聚乙二醇和局部麻醉药的结合物在非麻醉镇痛中的应用 |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| US11162850B2 (en) | 2019-04-25 | 2021-11-02 | Measurement Specialties, Inc. | Sensor assemblies with integrated electrical connections and diaphragm overload protection |
| JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
| CN113980254A (zh) * | 2020-07-10 | 2022-01-28 | 南京泛太化工医药研究所 | 一种具有酸敏感降解、温敏性质的系列聚合物及其载药组合物 |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
| CA3231500A1 (en) * | 2021-09-09 | 2023-03-16 | Xeris Pharmaceuticals, Inc. | Injectable high concentration pharmaceutical formulations and methods of manufacturing and use thereof |
| CN114366711A (zh) * | 2021-12-09 | 2022-04-19 | 安徽大学 | 原酸酯混溶物药用辅料、制备方法、包含该辅料的局部缓释给药制剂 |
| EP4538310A1 (en) * | 2022-01-20 | 2025-04-16 | Nanjing Fantai Chemical Pharmaceutical Research Institute | Series of polymers having properties of acid-sensitive degradation and temperature sensitivity and drug loading composition thereof |
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-
2004
- 2004-09-28 US US10/953,841 patent/US20050042194A1/en not_active Abandoned
-
2005
- 2005-09-27 EP EP20176172.3A patent/EP3834817A1/en not_active Withdrawn
- 2005-09-27 CA CA002579297A patent/CA2579297A1/en not_active Abandoned
- 2005-09-27 KR KR1020077009728A patent/KR20070083851A/ko not_active Withdrawn
- 2005-09-27 EP EP05802951.3A patent/EP1796629B1/en not_active Expired - Lifetime
- 2005-09-27 ES ES05802951.3T patent/ES2529574T3/es active Active
- 2005-09-27 EP EP14192547.9A patent/EP2902012B1/en not_active Expired - Lifetime
- 2005-09-27 JP JP2007533786A patent/JP2008514646A/ja not_active Withdrawn
- 2005-09-27 EP EP18187338.1A patent/EP3424492B1/en not_active Expired - Lifetime
- 2005-09-27 AU AU2005289425A patent/AU2005289425A1/en not_active Abandoned
- 2005-09-27 WO PCT/US2005/035117 patent/WO2006037116A2/en not_active Ceased
- 2005-09-27 CN CNA2005800326804A patent/CN101052376A/zh active Pending
- 2005-09-28 TW TW094133844A patent/TWI407966B/zh not_active IP Right Cessation
-
2009
- 2009-09-22 US US12/564,881 patent/US8252304B2/en not_active Expired - Lifetime
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2011
- 2011-10-24 US US13/279,949 patent/US8252306B2/en not_active Expired - Lifetime
- 2011-10-24 US US13/279,938 patent/US8252305B2/en not_active Expired - Lifetime
-
2012
- 2012-03-01 JP JP2012045876A patent/JP2012107064A/ja not_active Withdrawn
- 2012-07-18 US US13/552,083 patent/US8715710B2/en not_active Expired - Lifetime
-
2014
- 2014-04-15 US US14/253,615 patent/US20140371187A1/en not_active Abandoned
- 2014-11-17 JP JP2014232639A patent/JP6057972B2/ja not_active Expired - Lifetime
-
2016
- 2016-09-19 US US15/269,856 patent/US9913910B2/en not_active Expired - Lifetime
- 2016-10-17 JP JP2016203588A patent/JP2017008113A/ja active Pending
-
2018
- 2018-02-14 US US15/897,093 patent/US10357570B2/en not_active Expired - Lifetime
-
2020
- 2020-09-14 US US17/020,464 patent/US20200405866A1/en not_active Abandoned
-
2021
- 2021-04-26 US US17/240,982 patent/US20210252156A1/en not_active Abandoned
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