JP2008513523A5 - - Google Patents

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Publication number
JP2008513523A5
JP2008513523A5 JP2007532748A JP2007532748A JP2008513523A5 JP 2008513523 A5 JP2008513523 A5 JP 2008513523A5 JP 2007532748 A JP2007532748 A JP 2007532748A JP 2007532748 A JP2007532748 A JP 2007532748A JP 2008513523 A5 JP2008513523 A5 JP 2008513523A5
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JP
Japan
Prior art keywords
tmz
carboxylate
calculated
measured
following formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2007532748A
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English (en)
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JP2008513523A (ja
JP5620046B2 (ja
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Priority claimed from CNA2004100720564A external-priority patent/CN1752088A/zh
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Publication of JP2008513523A publication Critical patent/JP2008513523A/ja
Publication of JP2008513523A5 publication Critical patent/JP2008513523A5/ja
Application granted granted Critical
Publication of JP5620046B2 publication Critical patent/JP5620046B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Description

腫瘍容積(TV)を、次のような式で算出した。
長さ×巾÷2
相対的な腫瘍容積比率を、次のような式で算出した。
/V
ここにおいて、Vは、該動物を別々のゲージに分けて飼育した時に測定したTVであり、 は、その後各々の回に測定されたTVである。
製造方法は、有効成分としてTMZ−8−カルボン酸n−ヘキシルをTMZ−8−カルボン酸オクチルに置き換えて、実施例15に従う。望ましいカプセルが得られた。
JP2007532748A 2004-09-22 2005-09-15 テモゾロマイドエステルよりなる医薬組成物 Expired - Fee Related JP5620046B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNA2004100720564A CN1752088A (zh) 2004-09-22 2004-09-22 含有替莫唑胺酯的药用组合物
CN200410072056.4 2004-09-22
PCT/CN2005/001477 WO2006032190A1 (fr) 2004-09-22 2005-09-15 Composition pharmaceutique comprenant un ester de temozolomide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012209183A Division JP2013028630A (ja) 2004-09-22 2012-09-24 テモゾロマイドエステルよりなる医薬組成物

Publications (3)

Publication Number Publication Date
JP2008513523A JP2008513523A (ja) 2008-05-01
JP2008513523A5 true JP2008513523A5 (ja) 2008-10-09
JP5620046B2 JP5620046B2 (ja) 2014-11-05

Family

ID=36089840

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007532748A Expired - Fee Related JP5620046B2 (ja) 2004-09-22 2005-09-15 テモゾロマイドエステルよりなる医薬組成物
JP2012209183A Pending JP2013028630A (ja) 2004-09-22 2012-09-24 テモゾロマイドエステルよりなる医薬組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012209183A Pending JP2013028630A (ja) 2004-09-22 2012-09-24 テモゾロマイドエステルよりなる医薬組成物

Country Status (21)

Country Link
US (1) US7579336B2 (ja)
EP (1) EP1798234B1 (ja)
JP (2) JP5620046B2 (ja)
KR (1) KR101065984B1 (ja)
CN (1) CN1752088A (ja)
AR (1) AR050947A1 (ja)
AU (1) AU2005287799B2 (ja)
BR (1) BRPI0515555A (ja)
CA (1) CA2580910C (ja)
DK (1) DK1798234T3 (ja)
ES (1) ES2389376T3 (ja)
HK (1) HK1100440A1 (ja)
IL (1) IL182027A (ja)
MX (1) MX2007003366A (ja)
MY (1) MY153713A (ja)
NZ (1) NZ554609A (ja)
PL (1) PL1798234T3 (ja)
RU (1) RU2393160C2 (ja)
UA (1) UA89795C2 (ja)
WO (1) WO2006032190A1 (ja)
ZA (1) ZA200702801B (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1727340B (zh) * 2004-07-29 2011-05-18 天津帝士力投资控股集团有限公司 一种替莫唑胺-8-羧酸酯及其组合物
EP1808173A1 (en) * 2006-01-12 2007-07-18 Matthias Dormeyer Use of CNS penetrating anticancer compounds for the treatment of protozan diseases
US8558511B2 (en) * 2009-04-07 2013-10-15 Battelle Memorial Institute Method and apparatus for smart battery charging including a plurality of controllers each monitoring input variables
KR20140087846A (ko) * 2012-12-31 2014-07-09 주식회사 삼양바이오팜 테모졸로미드를 포함하는 안정성이 개선된 약제학적 조성물 및 이의 제조방법
RU2527258C1 (ru) * 2013-02-19 2014-08-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" 6-ЗАМЕЩЕННЫЕ 3-АЗОЛИЛИМИДАЗО[1,2-b][1,2,4,5]ТЕТРАЗИНЫ, ПРОЯВЛЯЮЩИЕ ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ
US10709715B2 (en) * 2017-12-03 2020-07-14 Cipla Limited Method of treating hypertension
CA3109191A1 (en) * 2018-08-09 2020-02-13 The Board Of Trustees Of The University Of Illinois Imidazotetrazine compounds
CN114014862A (zh) * 2021-06-28 2022-02-08 烟台大学 一种治疗脑胶质瘤的新化合物及其制备和应用
CN115260107B (zh) * 2022-06-23 2023-11-24 烟台邦杰生物科技有限公司 一种抗肿瘤药物前药、药物组合物及在肿瘤靶向治疗领域的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
CN1244583C (zh) 2002-09-29 2006-03-08 天津天士力集团有限公司 替莫唑胺-8-羧酸脂和-8-酰胺衍生物,它们的合成方法以及它们在制备抗癌制剂中的应用
CN1742723A (zh) * 2004-09-02 2006-03-08 天津倍方科技发展有限公司 含有替莫唑胺-8-羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途

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