JP2008512380A5 - - Google Patents
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- JP2008512380A5 JP2008512380A5 JP2007530399A JP2007530399A JP2008512380A5 JP 2008512380 A5 JP2008512380 A5 JP 2008512380A5 JP 2007530399 A JP2007530399 A JP 2007530399A JP 2007530399 A JP2007530399 A JP 2007530399A JP 2008512380 A5 JP2008512380 A5 JP 2008512380A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- alkynyl
- group
- alkenyl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003342 alkenyl group Chemical group 0.000 claims 57
- 125000000304 alkynyl group Chemical group 0.000 claims 57
- 229910052799 carbon Inorganic materials 0.000 claims 48
- 125000001072 heteroaryl group Chemical group 0.000 claims 48
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 45
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 42
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 33
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 33
- 125000003107 substituted aryl group Chemical group 0.000 claims 32
- 125000003710 aryl alkyl group Chemical group 0.000 claims 30
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 30
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 29
- 229910052760 oxygen Inorganic materials 0.000 claims 28
- 150000001336 alkenes Chemical class 0.000 claims 21
- 150000001345 alkine derivatives Chemical class 0.000 claims 21
- 229910052757 nitrogen Inorganic materials 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 13
- 239000001301 oxygen Substances 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 12
- 229910052717 sulfur Inorganic materials 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010052613 Allergic bronchitis Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 201000006474 Brain Ischemia Diseases 0.000 claims 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 206010014561 Emphysema Diseases 0.000 claims 2
- 101000988424 Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4B Proteins 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000010191 Osteitis Deformans Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 208000027868 Paget disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 102100029168 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Human genes 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
- 208000027202 mammary Paget disease Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 208000002865 osteopetrosis Diseases 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 208000035945 Labour pain Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 208000037805 labour Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60740704P | 2004-09-03 | 2004-09-03 | |
| PCT/US2005/031322 WO2006026754A2 (en) | 2004-09-03 | 2005-09-02 | Bicyclic heteroaryl pde4b inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512380A JP2008512380A (ja) | 2008-04-24 |
| JP2008512380A5 true JP2008512380A5 (https=) | 2008-10-23 |
Family
ID=36000749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530399A Pending JP2008512380A (ja) | 2004-09-03 | 2005-09-02 | Ｐｄｅ４ｂ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7605168B2 (https=) |
| EP (1) | EP1786813A2 (https=) |
| JP (1) | JP2008512380A (https=) |
| CN (1) | CN101048407A (https=) |
| AU (1) | AU2005279795A1 (https=) |
| CA (1) | CA2583428A1 (https=) |
| WO (1) | WO2006026754A2 (https=) |
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| DE102006012617A1 (de) * | 2006-03-20 | 2007-09-27 | Merck Patent Gmbh | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
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| JP6530826B2 (ja) | 2015-05-06 | 2019-06-12 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼを修飾する１ｈ−ピロロ［２，３−ｂ］ピリジン誘導体の合成 |
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-
2005
- 2005-09-02 WO PCT/US2005/031322 patent/WO2006026754A2/en not_active Ceased
- 2005-09-02 CN CNA200580036980XA patent/CN101048407A/zh active Pending
- 2005-09-02 JP JP2007530399A patent/JP2008512380A/ja active Pending
- 2005-09-02 AU AU2005279795A patent/AU2005279795A1/en not_active Abandoned
- 2005-09-02 CA CA002583428A patent/CA2583428A1/en not_active Abandoned
- 2005-09-02 EP EP05816059A patent/EP1786813A2/en not_active Withdrawn
- 2005-09-02 US US11/219,635 patent/US7605168B2/en active Active
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