JP2008512366A5 - - Google Patents
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- Publication number
- JP2008512366A5 JP2008512366A5 JP2007529363A JP2007529363A JP2008512366A5 JP 2008512366 A5 JP2008512366 A5 JP 2008512366A5 JP 2007529363 A JP2007529363 A JP 2007529363A JP 2007529363 A JP2007529363 A JP 2007529363A JP 2008512366 A5 JP2008512366 A5 JP 2008512366A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkoxy
- solvate
- salt
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012453 solvate Substances 0.000 claims 39
- 150000003839 salts Chemical class 0.000 claims 37
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 13
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 12
- 229910052731 fluorine Inorganic materials 0.000 claims 12
- 239000011737 fluorine Substances 0.000 claims 12
- -1 1-piperidyl group Chemical group 0.000 claims 11
- 150000004677 hydrates Chemical class 0.000 claims 11
- 150000001204 N-oxides Chemical class 0.000 claims 10
- 125000001153 fluoro group Chemical group F* 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 4
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 2
- 150000002081 enamines Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 150000002466 imines Chemical class 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- RQEUFEKYXDPUSK-UHFFFAOYSA-N 1-phenylethylamine Chemical compound CC(N)C1=CC=CC=C1 RQEUFEKYXDPUSK-UHFFFAOYSA-N 0.000 claims 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
- 238000007355 Double Michael addition reaction Methods 0.000 claims 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical class CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical group [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 150000003528 tetrahydropyranones Chemical class 0.000 claims 1
- 0 *c1c(*)cc(C(COCC2)C2N)cc1 Chemical compound *c1c(*)cc(C(COCC2)C2N)cc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104321.7 | 2004-09-08 | ||
| EP04104321 | 2004-09-08 | ||
| PCT/EP2005/054364 WO2006027344A2 (en) | 2004-09-08 | 2005-09-05 | 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008512366A JP2008512366A (ja) | 2008-04-24 |
| JP2008512366A5 true JP2008512366A5 (enExample) | 2008-10-23 |
| JP5009799B2 JP5009799B2 (ja) | 2012-08-22 |
Family
ID=34929551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007529363A Expired - Fee Related JP5009799B2 (ja) | 2004-09-08 | 2005-09-05 | 新規の３−オキサ−１０−アザ−フェナントレン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7838521B2 (enExample) |
| EP (1) | EP1797098B1 (enExample) |
| JP (1) | JP5009799B2 (enExample) |
| AT (1) | ATE508130T1 (enExample) |
| DE (1) | DE602005027866D1 (enExample) |
| ES (1) | ES2365926T3 (enExample) |
| WO (1) | WO2006027344A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19834353C2 (de) | 1998-07-30 | 2000-08-17 | Hillebrand Walter Gmbh & Co Kg | Alkalisches Zink-Nickelbad |
| EP1791847A2 (en) | 2004-09-08 | 2007-06-06 | Altana Pharma AG | Novel 3-thia-10-aza-phenanthrene derivatives |
| US7707538B2 (en) * | 2007-06-15 | 2010-04-27 | Brion Technologies, Inc. | Multivariable solver for optical proximity correction |
| AR079451A1 (es) | 2009-12-18 | 2012-01-25 | Nycomed Gmbh | Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina |
| GB201502260D0 (en) * | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE233735T1 (de) * | 1996-01-31 | 2003-03-15 | Altana Pharma Ag | Neue phenanthridine |
| NZ334976A (en) * | 1996-11-11 | 2000-10-27 | Byk Gulden Lomberg Chem Fab | Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses |
| SI0968211T1 (en) * | 1997-03-07 | 2004-02-29 | Altana Pharma Ag | Tetrazole derivatives |
| ES2195571T3 (es) | 1998-05-05 | 2003-12-01 | Altana Pharma Ag | Nuevos benzonaftiridin-n-oxidos. |
| AU5970199A (en) * | 1998-08-31 | 2000-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
| IT1303272B1 (it) * | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
| CA2360386A1 (en) * | 1999-01-15 | 2000-07-20 | Beate Gutterer | Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity |
| WO2002005616A1 (en) | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
| AU2003255493B8 (en) | 2002-08-29 | 2009-03-26 | Takeda Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| AU2005221832A1 (en) | 2004-03-10 | 2005-09-22 | Nycomed Gmbh | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
| EP1791847A2 (en) | 2004-09-08 | 2007-06-06 | Altana Pharma AG | Novel 3-thia-10-aza-phenanthrene derivatives |
-
2005
- 2005-09-05 ES ES05786867T patent/ES2365926T3/es not_active Expired - Lifetime
- 2005-09-05 WO PCT/EP2005/054364 patent/WO2006027344A2/en not_active Ceased
- 2005-09-05 DE DE602005027866T patent/DE602005027866D1/de not_active Expired - Lifetime
- 2005-09-05 JP JP2007529363A patent/JP5009799B2/ja not_active Expired - Fee Related
- 2005-09-05 US US11/661,369 patent/US7838521B2/en not_active Expired - Fee Related
- 2005-09-05 AT AT05786867T patent/ATE508130T1/de active
- 2005-09-05 EP EP05786867A patent/EP1797098B1/en not_active Expired - Lifetime