JP2008512129A5 - - Google Patents
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- JP2008512129A5 JP2008512129A5 JP2007531428A JP2007531428A JP2008512129A5 JP 2008512129 A5 JP2008512129 A5 JP 2008512129A5 JP 2007531428 A JP2007531428 A JP 2007531428A JP 2007531428 A JP2007531428 A JP 2007531428A JP 2008512129 A5 JP2008512129 A5 JP 2008512129A5
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- Prior art keywords
- nucleic acid
- target nucleic
- less
- mass
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000007523 nucleic acids Chemical class 0.000 claims 38
- 238000000034 method Methods 0.000 claims 35
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 239000002773 nucleotide Substances 0.000 claims 21
- 125000003729 nucleotide group Chemical group 0.000 claims 21
- 108091034117 Oligonucleotide Proteins 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 16
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 8
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 6
- 239000002751 oligonucleotide probe Substances 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 238000013467 fragmentation Methods 0.000 claims 4
- 238000006062 fragmentation reaction Methods 0.000 claims 4
- 238000001819 mass spectrum Methods 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 238000004949 mass spectrometry Methods 0.000 claims 3
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 238000010276 construction Methods 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 108010042407 Endonucleases Proteins 0.000 claims 1
- 102000004533 Endonucleases Human genes 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 102000006382 Ribonucleases Human genes 0.000 claims 1
- 108010083644 Ribonucleases Proteins 0.000 claims 1
- 238000004590 computer program Methods 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60871204P | 2004-09-10 | 2004-09-10 | |
| PCT/US2005/032441 WO2006031745A2 (en) | 2004-09-10 | 2005-09-08 | Methods for long-range sequence analysis of nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512129A JP2008512129A (ja) | 2008-04-24 |
| JP2008512129A5 true JP2008512129A5 (https=) | 2008-10-09 |
Family
ID=36060614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531428A Pending JP2008512129A (ja) | 2004-09-10 | 2005-09-08 | 核酸の広範囲配列分析法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060073501A1 (https=) |
| EP (1) | EP1802772A4 (https=) |
| JP (1) | JP2008512129A (https=) |
| CN (1) | CN101072882A (https=) |
| AU (1) | AU2005284980A1 (https=) |
| CA (1) | CA2580070A1 (https=) |
| WO (1) | WO2006031745A2 (https=) |
Families Citing this family (73)
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-
2005
- 2005-09-08 AU AU2005284980A patent/AU2005284980A1/en not_active Abandoned
- 2005-09-08 WO PCT/US2005/032441 patent/WO2006031745A2/en not_active Ceased
- 2005-09-08 US US11/222,991 patent/US20060073501A1/en not_active Abandoned
- 2005-09-08 CN CNA2005800360190A patent/CN101072882A/zh active Pending
- 2005-09-08 CA CA002580070A patent/CA2580070A1/en not_active Abandoned
- 2005-09-08 EP EP05804387A patent/EP1802772A4/en not_active Withdrawn
- 2005-09-08 JP JP2007531428A patent/JP2008512129A/ja active Pending
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