JP2008511608A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008511608A5 JP2008511608A5 JP2007529033A JP2007529033A JP2008511608A5 JP 2008511608 A5 JP2008511608 A5 JP 2008511608A5 JP 2007529033 A JP2007529033 A JP 2007529033A JP 2007529033 A JP2007529033 A JP 2007529033A JP 2008511608 A5 JP2008511608 A5 JP 2008511608A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- omv
- concentration
- serum
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 45
- 210000002966 serum Anatomy 0.000 claims 27
- 241000588650 Neisseria meningitidis Species 0.000 claims 9
- 239000012528 membrane Substances 0.000 claims 9
- 231100000331 toxic Toxicity 0.000 claims 5
- 230000002588 toxic effect Effects 0.000 claims 5
- 241000040340 Oat mosaic virus Species 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000003053 immunization Effects 0.000 claims 3
- 206010027249 Meningitis meningococcal Diseases 0.000 claims 2
- 201000010924 Meningococcal meningitis Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101100446533 Neisseria meningitidis serogroup B (strain MC58) fhbP gene Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 1
- 229960003964 deoxycholic acid Drugs 0.000 claims 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0419627.5A GB0419627D0 (en) | 2004-09-03 | 2004-09-03 | Immunogenic bacterial vesicles with outer membrane proteins |
| PCT/IB2005/002801 WO2006024946A2 (en) | 2004-09-03 | 2005-09-05 | Improvements relating to meningococcal outer membrane vesicles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011185225A Division JP2011236254A (ja) | 2004-09-03 | 2011-08-26 | 髄膜炎菌外膜ベシクルに関する改良 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008511608A JP2008511608A (ja) | 2008-04-17 |
| JP2008511608A5 true JP2008511608A5 (https=) | 2011-10-13 |
Family
ID=33156002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007529033A Pending JP2008511608A (ja) | 2004-09-03 | 2005-09-05 | 髄膜炎菌外膜ベシクルに関する改良 |
| JP2011185225A Pending JP2011236254A (ja) | 2004-09-03 | 2011-08-26 | 髄膜炎菌外膜ベシクルに関する改良 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011185225A Pending JP2011236254A (ja) | 2004-09-03 | 2011-08-26 | 髄膜炎菌外膜ベシクルに関する改良 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8808711B2 (https=) |
| EP (1) | EP1784213B1 (https=) |
| JP (2) | JP2008511608A (https=) |
| CN (2) | CN101862451A (https=) |
| AU (1) | AU2005278896B2 (https=) |
| BR (1) | BRPI0514883A (https=) |
| CA (1) | CA2578588A1 (https=) |
| ES (1) | ES2527859T3 (https=) |
| GB (1) | GB0419627D0 (https=) |
| MX (1) | MX2007002633A (https=) |
| NZ (1) | NZ553521A (https=) |
| RU (1) | RU2420312C2 (https=) |
| WO (1) | WO2006024946A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9513371D0 (en) * | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
| EP2270173B1 (en) | 1999-05-19 | 2016-01-06 | GlaxoSmithKline Biologicals SA | Combination neisserial compositions |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| US10828361B2 (en) * | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| PL2004225T3 (pl) | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| WO2009050586A1 (en) | 2007-10-19 | 2009-04-23 | Novartis Ag | Meningococcal vaccine formulations |
| PT2268618E (pt) | 2008-03-03 | 2015-10-12 | Novartis Ag | Compostos e composições moduladores da actividade tlr |
| JP5723768B2 (ja) | 2008-05-30 | 2015-05-27 | ザ ユナイテッド ステイツ オブ アメリカ， アズ レプレゼンテッド バイ ザ セクレタリー オブ ジ アーミー， オン ビハーフ オブ ウォルター リード アーミー インスティチュート オブ リサーチ | 髄膜炎菌性多価未変性外膜小胞ワクチン、その作製方法およびその使用 |
| GB0822634D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| JP2012512240A (ja) | 2008-12-17 | 2012-05-31 | ノバルティス アーゲー | ヘモグロビン受容体を含む髄膜炎菌ワクチン |
| CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| CN102740882A (zh) | 2009-08-27 | 2012-10-17 | 诺华有限公司 | 含有铝、寡核苷酸和聚阳离子的佐剂 |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| SG10201501980SA (en) | 2009-12-15 | 2015-05-28 | Novartis Ag | Homogeneous suspension of immunopotentiating compounds and uses thereof |
| CN102802662A (zh) | 2010-03-18 | 2012-11-28 | 诺华有限公司 | 用于脑膜炎球菌血清组b的含佐剂疫苗 |
| AU2011232421B2 (en) | 2010-03-23 | 2015-08-13 | Novartis Ag | Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| BR112013005626B1 (pt) | 2010-09-10 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição |
| EP2707009A1 (en) | 2011-05-12 | 2014-03-19 | Novartis AG | Antipyretics to enhance tolerability of vesicle-based vaccines |
| JP5957541B2 (ja) | 2012-02-02 | 2016-07-27 | ノバルティス アーゲー | 髄膜炎菌における増加したタンパク質発現のためのプロモータ |
| JP2015517089A (ja) | 2012-03-08 | 2015-06-18 | ノバルティス アーゲー | タンパク質ベースの髄膜炎菌ワクチンのためのインビトロ有効性アッセイ |
| WO2013151706A2 (en) | 2012-04-06 | 2013-10-10 | Cornell University | Subunit vaccine delivery platform for robust humoral and cellular immune responses |
| MX357538B (es) | 2012-06-14 | 2018-07-13 | Novartis Ag | Vacunas para meningococo de serogrupo x. |
| US9526776B2 (en) | 2012-09-06 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Combination vaccines with serogroup B meningococcus and D/T/P |
| US9764027B2 (en) | 2012-09-18 | 2017-09-19 | Glaxosmithkline Biologicals Sa | Outer membrane vesicles |
| JP2016507543A (ja) | 2013-02-07 | 2016-03-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 小胞を含む医薬組成物 |
| JP6786394B2 (ja) | 2014-02-28 | 2020-11-18 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 改変髄膜炎菌ｆＨｂｐポリペプチド |
| AU2015289192A1 (en) | 2014-07-17 | 2017-02-02 | Glaxosmithkline Biologicals S.A. | Modified meningococcal fHbp polypeptides |
| KR102626831B1 (ko) * | 2014-07-17 | 2024-01-22 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 수막구균 백신 |
| KR101742236B1 (ko) * | 2014-10-29 | 2017-05-31 | 인하대학교 산학협력단 | 쯔쯔가무시병에 대한 면역 조성물 및 이의 제조방법 |
| CN105669964B (zh) * | 2016-03-04 | 2017-11-21 | 博瑞生物医药（苏州）股份有限公司 | 卵巢癌特异靶向的生物可降解双亲性聚合物、由其制备的聚合物囊泡及应用 |
| US12161707B2 (en) | 2016-09-02 | 2024-12-10 | Glaxosmithkline Biologicals Sa | Vaccines for Neisseria gonorrhoeae |
| US11524037B2 (en) | 2017-09-08 | 2022-12-13 | Evelo Biosciences, Inc. | Bacterial extracellular vesicles |
| GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
| DK0624376T3 (da) | 1993-05-13 | 2000-07-24 | American Cyanamid Co | Fremstilling og anvendelse af LOS-udtømte ydre membranproteiner af gram-negative cocci |
| AU2356095A (en) | 1994-04-20 | 1995-11-29 | U.S. Department Of The Army | Vaccine against gram-negative bacterial infections |
| US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| PL338146A1 (en) | 1997-07-17 | 2000-09-25 | North American Vaccine | Immunogenic complex combinations consisting of meningococcal porine of b group and h. influenzae polysaccharide |
| BR9910749A (pt) | 1998-05-29 | 2001-02-13 | Chiron Corp | Composições e vacinas imunogênicas combinadas para meningites b e c e método de induzir uma resposta imune por administração da mesma |
| EP1741443B1 (en) | 1998-05-29 | 2014-05-21 | Novartis Vaccines and Diagnostics, Inc. | Combination meningitidis B/C vaccines |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| WO2001034642A2 (en) | 1999-11-12 | 2001-05-17 | University Of Iowa Research Foundation | Control of neisserial membrane synthesis |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| US6936261B2 (en) | 2000-07-27 | 2005-08-30 | Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| CA2452720C (en) * | 2001-07-26 | 2012-04-17 | Chiron S.R.L. | Vaccines comprising aluminium adjuvants and histidine |
| GB0130123D0 (en) | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| GB0213622D0 (en) * | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| EP1524991A1 (en) * | 2002-08-02 | 2005-04-27 | GlaxoSmithKline Biologicals S.A. | Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| AU2003288558A1 (en) | 2002-12-16 | 2004-07-09 | Nasjonalt Folkehelseinstitutt | Meningococcal vaccine based on outer membrane proteins porb2 and pora |
| US7031284B2 (en) * | 2003-03-03 | 2006-04-18 | Interdigital Technology Corporation | Wireless communication method and apparatus for optimizing multi-user detection |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| EP1706481A2 (en) | 2003-12-23 | 2006-10-04 | GlaxoSmithKline Biologicals S.A. | Vaccine |
| DE602007003596D1 (de) * | 2006-06-12 | 2010-01-14 | Glaxosmithkline Biolog Sa | Impfstoff |
-
2004
- 2004-09-03 GB GBGB0419627.5A patent/GB0419627D0/en not_active Ceased
-
2005
- 2005-09-05 NZ NZ553521A patent/NZ553521A/en not_active IP Right Cessation
- 2005-09-05 WO PCT/IB2005/002801 patent/WO2006024946A2/en not_active Ceased
- 2005-09-05 ES ES05782411.2T patent/ES2527859T3/es not_active Expired - Lifetime
- 2005-09-05 US US11/661,996 patent/US8808711B2/en not_active Expired - Fee Related
- 2005-09-05 EP EP05782411.2A patent/EP1784213B1/en not_active Expired - Lifetime
- 2005-09-05 CN CN201010169356A patent/CN101862451A/zh active Pending
- 2005-09-05 BR BRPI0514883-9A patent/BRPI0514883A/pt not_active IP Right Cessation
- 2005-09-05 CA CA002578588A patent/CA2578588A1/en not_active Abandoned
- 2005-09-05 AU AU2005278896A patent/AU2005278896B2/en not_active Ceased
- 2005-09-05 MX MX2007002633A patent/MX2007002633A/es active IP Right Grant
- 2005-09-05 RU RU2007111838/15A patent/RU2420312C2/ru not_active IP Right Cessation
- 2005-09-05 JP JP2007529033A patent/JP2008511608A/ja active Pending
- 2005-09-05 CN CNA2005800294697A patent/CN101115501A/zh active Pending
-
2011
- 2011-08-26 JP JP2011185225A patent/JP2011236254A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008511608A5 (https=) | ||
| RU2007111838A (ru) | Усовершенствования, касающиеся везикул внешней мембраны менингококков | |
| RU2378009C2 (ru) | Иммунизация против менингококков серогруппы y с помощью белков | |
| Keiser et al. | A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression | |
| ES2251124T3 (es) | Vacuna que comprende un antigeno de streptococcus pneumoniae adyuvado por un oligonucleotido cpg. | |
| RU2349342C2 (ru) | Менингококковые вакцины для введения через слизистую оболочку | |
| WO2005105141A3 (en) | Combined meningococcal conjugates with common carrier protein | |
| HU228384B1 (en) | Vaccine compositions | |
| JP2008526939A5 (https=) | ||
| JP2009525260A5 (https=) | ||
| JP5806204B2 (ja) | 肺炎球菌血清型１４の糖を含む組み合わせ | |
| HU229968B1 (hu) | Sztreptokokkusz oltóanyag | |
| JP2007516219A5 (https=) | ||
| JP2007535527A5 (https=) | ||
| JP2021001182A5 (https=) | ||
| RU2006142158A (ru) | Вакцинация менингококковыми конъюгатами | |
| Baudner et al. | Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system | |
| Gulati et al. | Preclinical efficacy of a lipooligosaccharide peptide mimic candidate gonococcal vaccine. mBio 10: e02552-19 | |
| JP2020525495A (ja) | 新規の多価多糖類・タンパク質のコンジュゲートワクチン組成物及びその製剤 | |
| CA2528312A1 (en) | Methods of managing the symptoms of premenstrual syndrome | |
| JP2021066727A5 (https=) | ||
| Rosen et al. | Chronic meningococcal meningitis: an association with C5 deficiency | |
| Chawla et al. | What's new in clinical pharmacology and therapeutics | |
| JP2007197423A (ja) | フドステインと抗コリン薬を含有する医薬組成物 | |
| US20050234024A1 (en) | Materials and methods for the treatment of ulcerative colitis |