JP2008511608A5 - - Google Patents
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- JP2008511608A5 JP2008511608A5 JP2007529033A JP2007529033A JP2008511608A5 JP 2008511608 A5 JP2008511608 A5 JP 2008511608A5 JP 2007529033 A JP2007529033 A JP 2007529033A JP 2007529033 A JP2007529033 A JP 2007529033A JP 2008511608 A5 JP2008511608 A5 JP 2008511608A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- omv
- concentration
- serum
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 45
- 210000002966 serum Anatomy 0.000 claims 27
- 241000588650 Neisseria meningitidis Species 0.000 claims 9
- 239000012528 membrane Substances 0.000 claims 9
- 231100000331 toxic Toxicity 0.000 claims 5
- 230000002588 toxic effect Effects 0.000 claims 5
- 241000040340 Oat mosaic virus Species 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000003053 immunization Effects 0.000 claims 3
- 206010027249 Meningitis meningococcal Diseases 0.000 claims 2
- 201000010924 Meningococcal meningitis Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101100446533 Neisseria meningitidis serogroup B (strain MC58) fhbP gene Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 1
- 229960003964 deoxycholic acid Drugs 0.000 claims 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0419627.5A GB0419627D0 (en) | 2004-09-03 | 2004-09-03 | Immunogenic bacterial vesicles with outer membrane proteins |
| PCT/IB2005/002801 WO2006024946A2 (en) | 2004-09-03 | 2005-09-05 | Improvements relating to meningococcal outer membrane vesicles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011185225A Division JP2011236254A (ja) | 2004-09-03 | 2011-08-26 | 髄膜炎菌外膜ベシクルに関する改良 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008511608A JP2008511608A (ja) | 2008-04-17 |
| JP2008511608A5 true JP2008511608A5 (https=) | 2011-10-13 |
Family
ID=33156002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007529033A Pending JP2008511608A (ja) | 2004-09-03 | 2005-09-05 | 髄膜炎菌外膜ベシクルに関する改良 |
| JP2011185225A Pending JP2011236254A (ja) | 2004-09-03 | 2011-08-26 | 髄膜炎菌外膜ベシクルに関する改良 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011185225A Pending JP2011236254A (ja) | 2004-09-03 | 2011-08-26 | 髄膜炎菌外膜ベシクルに関する改良 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8808711B2 (https=) |
| EP (1) | EP1784213B1 (https=) |
| JP (2) | JP2008511608A (https=) |
| CN (2) | CN101862451A (https=) |
| AU (1) | AU2005278896B2 (https=) |
| BR (1) | BRPI0514883A (https=) |
| CA (1) | CA2578588A1 (https=) |
| ES (1) | ES2527859T3 (https=) |
| GB (1) | GB0419627D0 (https=) |
| MX (1) | MX2007002633A (https=) |
| NZ (1) | NZ553521A (https=) |
| RU (1) | RU2420312C2 (https=) |
| WO (1) | WO2006024946A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9513371D0 (en) * | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
| NZ515935A (en) | 1999-05-19 | 2004-01-30 | Chiron S | Combination Neisserial compositions and vaccines for the prevention of infections due to Neisseria bacteria such as meningococcal meningitis |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| US10828361B2 (en) * | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| PL2004225T3 (pl) * | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| BR122016015627A2 (pt) | 2007-10-19 | 2018-10-30 | Novartis Ag | kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica |
| CN102015651B (zh) | 2008-03-03 | 2014-12-31 | Irm责任有限公司 | 作为tlr活性调节剂的化合物和组合物 |
| UA99659C2 (uk) * | 2008-05-30 | 2012-09-10 | Дзе Ю.Ес.Ей., Ес Репрезентед Бай Дзе Секретарі Оф Дзе Армі, Он Бехаф Оф Уолтер Рід Армі | Мультивалентна вакцина з нативних везикул зовнішньої мембрани менінгококів, способи її застосування |
| GB0822634D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| WO2010070453A2 (en) | 2008-12-17 | 2010-06-24 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| JP5867952B2 (ja) | 2009-06-10 | 2016-02-24 | ノバルティス アーゲー | ベンゾナフチリジン含有ワクチン |
| EP2470205A1 (en) | 2009-08-27 | 2012-07-04 | Novartis AG | Adjuvant comprising aluminium, oligonucleotide and polycation |
| WO2011027222A2 (en) | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| BR112012014624A8 (pt) | 2009-12-15 | 2017-12-26 | Novartis Ag | suspensão homogênea de compostos de imunopotenciação e usos dos destes |
| AU2011288203A1 (en) | 2010-03-18 | 2012-08-23 | Novartis Ag | Adjuvanted vaccines for serogroup B meningococcus |
| EA031379B1 (ru) | 2010-03-23 | 2018-12-28 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
| US9259462B2 (en) | 2010-09-10 | 2016-02-16 | Glaxosmithkline Biologicals Sa | Developments in meningococcal outer membrane vesicles |
| US20150147356A1 (en) | 2011-05-12 | 2015-05-28 | Alan Kimura | Antipyretics to enhance tolerability of vesicle-based vaccines |
| EP3299467B1 (en) | 2012-02-02 | 2021-08-11 | GlaxoSmithKline Biologicals SA | Promoters for increased protein expression in meningococcus |
| US10598666B2 (en) | 2012-03-08 | 2020-03-24 | Glaxosmithkline Biologicals Sa | In vitro potency assay for protein-based meningococcal vaccines |
| EP3693010A1 (en) | 2012-04-06 | 2020-08-12 | Cornell University | Subunit vaccine delivery platform for robust humoral and cellular immune responses |
| AU2013276083B2 (en) | 2012-06-14 | 2018-04-05 | Institut Pasteur | Vaccines for serogroup X meningococcus |
| JP6324961B2 (ja) | 2012-09-06 | 2018-05-16 | ノバルティス アーゲー | 血清群ｂ髄膜炎菌とｄ／ｔ／ｐとの組み合わせワクチン |
| JP6283674B2 (ja) | 2012-09-18 | 2018-02-21 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 外膜小胞 |
| JP2016507543A (ja) | 2013-02-07 | 2016-03-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 小胞を含む医薬組成物 |
| KR20160127104A (ko) | 2014-02-28 | 2016-11-02 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 변형된 수막구균 fhbp 폴리펩티드 |
| EP3169357B1 (en) | 2014-07-17 | 2018-11-07 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
| JP6687597B2 (ja) * | 2014-07-17 | 2020-04-22 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 髄膜炎菌ワクチン |
| KR101742236B1 (ko) * | 2014-10-29 | 2017-05-31 | 인하대학교 산학협력단 | 쯔쯔가무시병에 대한 면역 조성물 및 이의 제조방법 |
| CN105669964B (zh) * | 2016-03-04 | 2017-11-21 | 博瑞生物医药（苏州）股份有限公司 | 卵巢癌特异靶向的生物可降解双亲性聚合物、由其制备的聚合物囊泡及应用 |
| US12109259B2 (en) * | 2016-09-02 | 2024-10-08 | Glaxosmithkline Biologicals Sa | Vaccines for Neisseria gonorrhoeae |
| EP3678693A1 (en) | 2017-09-08 | 2020-07-15 | Evelo Biosciences, Inc. | Bacterial extracellular vesicles |
| GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
| EP0624376B1 (en) | 1993-05-13 | 2000-03-15 | American Cyanamid Company | Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci |
| ATE173634T1 (de) | 1994-04-20 | 1998-12-15 | Us Army | Impfstoff gegen gram-negative bakterielle infektionen |
| US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| CA2297072A1 (en) | 1997-07-17 | 1999-01-28 | Baxter Healthcare S.A. | Immunogenic conjugates comprising a group b meningococcal porin and an h. influenzae polysaccharide |
| EP1741443B1 (en) | 1998-05-29 | 2014-05-21 | Novartis Vaccines and Diagnostics, Inc. | Combination meningitidis B/C vaccines |
| WO1999061053A1 (en) | 1998-05-29 | 1999-12-02 | Chiron Corporation | Combination meningitidis b/c vaccines |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| AU1917501A (en) | 1999-11-12 | 2001-06-06 | University Of Iowa Research Foundation, The | Control of neisserial membrane synthesis |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| ES2519440T3 (es) | 2000-07-27 | 2014-11-07 | Children's Hospital & Research Center At Oakland | Vacunas para la protección de amplio espectro contra enfermedades causadas por Neisseria meningitidis |
| RU2323002C2 (ru) * | 2001-07-26 | 2008-04-27 | Чирон Срл. | Вакцины, содержащие алюминиевые адъюванты и гистидин |
| GB0130123D0 (en) | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| GB0213622D0 (en) * | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| US20060057160A1 (en) * | 2002-08-02 | 2006-03-16 | Ralph Biemans | Vaccine composition |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| AU2003288558A1 (en) * | 2002-12-16 | 2004-07-09 | Nasjonalt Folkehelseinstitutt | Meningococcal vaccine based on outer membrane proteins porb2 and pora |
| US7031284B2 (en) * | 2003-03-03 | 2006-04-18 | Interdigital Technology Corporation | Wireless communication method and apparatus for optimizing multi-user detection |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| JP5173194B2 (ja) | 2003-12-23 | 2013-03-27 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| CA2654706A1 (en) * | 2006-06-12 | 2007-12-21 | Nathalie Devos | Neisseria meningitidis lipooligosaccharide vaccine |
-
2004
- 2004-09-03 GB GBGB0419627.5A patent/GB0419627D0/en not_active Ceased
-
2005
- 2005-09-05 US US11/661,996 patent/US8808711B2/en not_active Expired - Fee Related
- 2005-09-05 RU RU2007111838/15A patent/RU2420312C2/ru not_active IP Right Cessation
- 2005-09-05 WO PCT/IB2005/002801 patent/WO2006024946A2/en not_active Ceased
- 2005-09-05 EP EP05782411.2A patent/EP1784213B1/en not_active Expired - Lifetime
- 2005-09-05 NZ NZ553521A patent/NZ553521A/en not_active IP Right Cessation
- 2005-09-05 AU AU2005278896A patent/AU2005278896B2/en not_active Ceased
- 2005-09-05 CN CN201010169356A patent/CN101862451A/zh active Pending
- 2005-09-05 CN CNA2005800294697A patent/CN101115501A/zh active Pending
- 2005-09-05 CA CA002578588A patent/CA2578588A1/en not_active Abandoned
- 2005-09-05 ES ES05782411.2T patent/ES2527859T3/es not_active Expired - Lifetime
- 2005-09-05 JP JP2007529033A patent/JP2008511608A/ja active Pending
- 2005-09-05 MX MX2007002633A patent/MX2007002633A/es active IP Right Grant
- 2005-09-05 BR BRPI0514883-9A patent/BRPI0514883A/pt not_active IP Right Cessation
-
2011
- 2011-08-26 JP JP2011185225A patent/JP2011236254A/ja active Pending
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