JP2008511572A5 - - Google Patents
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- Publication number
- JP2008511572A5 JP2008511572A5 JP2007528765A JP2007528765A JP2008511572A5 JP 2008511572 A5 JP2008511572 A5 JP 2008511572A5 JP 2007528765 A JP2007528765 A JP 2007528765A JP 2007528765 A JP2007528765 A JP 2007528765A JP 2008511572 A5 JP2008511572 A5 JP 2008511572A5
- Authority
- JP
- Japan
- Prior art keywords
- pcr
- exons
- dhplc
- kit
- rychter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003752 polymerase chain reaction Methods 0.000 description 4
- 229920000665 Exon Polymers 0.000 description 2
- 102100004940 PDGFRA Human genes 0.000 description 1
- 101710018349 PDGFRA Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
Description
配列分析：ゲノムＤＮＡを、Ｈｉｇｈ Ｐｕｒｅ ＰＣＲテンプレート調製キット（Roche, Mannheim, Germany）を用いて急速冷凍（snap−frozen）組織から抽出する。ＫＩＴのエクソン９、１１、１３、１４、１５および１７、ならびにＰＤＧＦＲＡのエクソン１２および１８を、既報のポリメラーゼ連鎖反応（ＰＣＲ）により増幅する（例えば、Debiec−Rychter M et al., J Pathol 2004；202：430−438を参照のこと。）。そのＰＣＲ産物を、精製し（Microcon PCR, Millipore, MA, USA）、そしてＴｒａｎｓｇｅｎｏｍｉｃ ＷＡＶＥ ＤＨＰＬＣシステムの高速液体クロマトグラフィー（ＤＨＰＬＣ；Transgenomic, Inc., UK）により変異をスクリーニングした。異常な溶出プロフィールを示すサンプルを、再増幅し、配列決定した。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60577104P | 2004-08-31 | 2004-08-31 | |
| US60/605,771 | 2004-08-31 | ||
| PCT/EP2005/009337 WO2006024494A1 (en) | 2004-08-31 | 2005-08-30 | Use of midostaurin for treating gastrointestinal stromal tumors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511572A JP2008511572A (ja) | 2008-04-17 |
| JP2008511572A5 true JP2008511572A5 (ja) | 2008-10-16 |
| JP4970262B2 JP4970262B2 (ja) | 2012-07-04 |
Family
ID=35134408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528765A Expired - Fee Related JP4970262B2 (ja) | 2004-08-31 | 2005-08-30 | 消化管間質腫瘍を処置するためのミドスタウリンの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090075972A1 (ja) |
| EP (1) | EP1799226A1 (ja) |
| JP (1) | JP4970262B2 (ja) |
| KR (1) | KR20070046906A (ja) |
| CN (1) | CN101010082A (ja) |
| AU (1) | AU2005279344B2 (ja) |
| BR (1) | BRPI0514765A (ja) |
| CA (1) | CA2576926C (ja) |
| MX (1) | MX2007002415A (ja) |
| RU (1) | RU2410098C2 (ja) |
| WO (1) | WO2006024494A1 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899616A (zh) * | 2006-07-20 | 2007-01-24 | 中国人民解放军军事医学科学院生物工程研究所 | 非受体酪氨酸激酶c－Abl特异性抑制剂的新用途 |
| BRPI0714963A2 (pt) * | 2006-08-16 | 2013-07-30 | Novartis Ag | processo de fabricaÇço de dispersÕes sàlidas de compostos terapÊuticos altamente cristalinos |
| CN111393454A (zh) * | 2020-05-07 | 2020-07-10 | 奥锐特药业(天津)有限公司 | 米哚妥林的新晶型及其制备方法 |
| CN112812129A (zh) * | 2020-12-31 | 2021-05-18 | 浙江海正药业股份有限公司 | 米哚妥林的新晶型及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86632A0 (en) * | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| WO2005027971A1 (en) * | 2003-09-19 | 2005-03-31 | Novartis Ag | Treatment of gastrointestinal stromal tumors with imatinib and midostaurin |
| MXPA06005598A (es) * | 2003-11-18 | 2006-08-11 | Novartis Ag | Inhibidores de la forma mutante de kit. |
-
2005
- 2005-08-30 MX MX2007002415A patent/MX2007002415A/es active IP Right Grant
- 2005-08-30 EP EP05776300A patent/EP1799226A1/en not_active Withdrawn
- 2005-08-30 CN CNA2005800287142A patent/CN101010082A/zh active Pending
- 2005-08-30 JP JP2007528765A patent/JP4970262B2/ja not_active Expired - Fee Related
- 2005-08-30 CA CA2576926A patent/CA2576926C/en not_active Expired - Fee Related
- 2005-08-30 AU AU2005279344A patent/AU2005279344B2/en not_active Ceased
- 2005-08-30 WO PCT/EP2005/009337 patent/WO2006024494A1/en active Application Filing
- 2005-08-30 KR KR1020077004952A patent/KR20070046906A/ko not_active Application Discontinuation
- 2005-08-30 BR BRPI0514765-4A patent/BRPI0514765A/pt not_active IP Right Cessation
- 2005-08-30 US US11/574,342 patent/US20090075972A1/en not_active Abandoned
- 2005-08-30 RU RU2007111754/15A patent/RU2410098C2/ru not_active IP Right Cessation
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