JP2008510841A5 - - Google Patents
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- Publication number
- JP2008510841A5 JP2008510841A5 JP2007537876A JP2007537876A JP2008510841A5 JP 2008510841 A5 JP2008510841 A5 JP 2008510841A5 JP 2007537876 A JP2007537876 A JP 2007537876A JP 2007537876 A JP2007537876 A JP 2007537876A JP 2008510841 A5 JP2008510841 A5 JP 2008510841A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- benzyloxy
- isothiazole
- ureido
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *OC(c1c(S)[s]nc1O*)=O Chemical compound *OC(c1c(S)[s]nc1O*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60454204P | 2004-08-26 | 2004-08-26 | |
| US60/604,542 | 2004-08-26 | ||
| PCT/US2005/027398 WO2006026034A2 (en) | 2004-08-26 | 2005-08-02 | Processes for the preparation of isothiazole derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012079463A Division JP5498524B2 (ja) | 2004-08-26 | 2012-03-30 | イソチアゾール誘導体の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008510841A JP2008510841A (ja) | 2008-04-10 |
| JP2008510841A5 true JP2008510841A5 (cg-RX-API-DMAC10.html) | 2008-09-18 |
| JP5100390B2 JP5100390B2 (ja) | 2012-12-19 |
Family
ID=36000502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007537876A Expired - Fee Related JP5100390B2 (ja) | 2004-08-26 | 2005-08-02 | イソチアゾール誘導体の製造方法 |
| JP2012079463A Expired - Fee Related JP5498524B2 (ja) | 2004-08-26 | 2012-03-30 | イソチアゾール誘導体の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012079463A Expired - Fee Related JP5498524B2 (ja) | 2004-08-26 | 2012-03-30 | イソチアゾール誘導体の製造方法 |
Country Status (21)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101043888B (zh) | 2004-08-26 | 2010-08-11 | 辉瑞有限公司 | 制备异噻唑衍生物的方法 |
| US8969583B2 (en) | 2011-12-28 | 2015-03-03 | Allergan, Inc. | 3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivatives as kinase inhibitors |
| CN103833665B (zh) * | 2014-02-24 | 2015-09-23 | 杰达维（上海）医药科技发展有限公司 | 一种新的合成异噻唑的方法 |
| US9353093B2 (en) | 2014-10-07 | 2016-05-31 | Allergan, Inc. | Indole-1-carboxamides as kinase inhibitors |
| US9403803B2 (en) | 2014-10-08 | 2016-08-02 | Allergan, Inc. | Indole-3-carboxamides as kinase inhibitors |
| US9359336B2 (en) | 2014-10-09 | 2016-06-07 | Allergan, Inc. | Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors |
| US9371314B2 (en) | 2014-10-09 | 2016-06-21 | Allergan, Inc. | Pyridyl benzothiophenes as kinase inhibitors |
| KR20250121146A (ko) * | 2022-12-28 | 2025-08-11 | 비양 테라퓨틱스 컴퍼니 리미티드 | 단백질 티로신 키나제 억제제 및 이의 의약적 용도 |
| WO2026002126A1 (zh) * | 2024-06-27 | 2026-01-02 | 苏州必扬医药科技有限公司 | 一种蛋白酪氨酸激酶抑制剂及其眼用制剂 |
| WO2026002137A1 (zh) * | 2024-06-27 | 2026-01-02 | 苏州必扬医药科技有限公司 | 一种蛋白酪氨酸激酶抑制剂游离碱的晶型 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2408234A1 (de) * | 1974-02-21 | 1975-09-04 | Celamerck Gmbh & Co Kg | Isothiazolylharnstoffe |
| US4059433A (en) * | 1976-06-18 | 1977-11-22 | Fmc Corporation | 3-Alkoxyisothiazole derivatives as herbicides |
| IL72093A0 (en) * | 1983-06-20 | 1984-10-31 | Lilly Co Eli | N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives |
| UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| HN2000000051A (es) * | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
| GB0010188D0 (en) * | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
| CA2493701A1 (en) * | 2002-07-25 | 2004-02-05 | Pfizer Products Inc. | Isothiazole derivatives useful as anticancer agents |
| US20060035954A1 (en) * | 2004-08-11 | 2006-02-16 | Sharma Padam N | Ammonolysis process for the preparation of intermediates for DPP IV inhibitors |
| CN101043888B (zh) | 2004-08-26 | 2010-08-11 | 辉瑞有限公司 | 制备异噻唑衍生物的方法 |
-
2005
- 2005-08-02 CN CN2005800284337A patent/CN101043888B/zh not_active Expired - Fee Related
- 2005-08-02 CA CA2578023A patent/CA2578023C/en not_active Expired - Fee Related
- 2005-08-02 AU AU2005280451A patent/AU2005280451B2/en not_active Ceased
- 2005-08-02 DK DK05778840.8T patent/DK1784183T3/da active
- 2005-08-02 ES ES05778840T patent/ES2378994T3/es not_active Expired - Lifetime
- 2005-08-02 PT PT05778840T patent/PT1784183E/pt unknown
- 2005-08-02 PL PL05778840T patent/PL1784183T3/pl unknown
- 2005-08-02 AT AT05778840T patent/ATE542533T1/de active
- 2005-08-02 BR BRPI0514667-4A patent/BRPI0514667A/pt active Search and Examination
- 2005-08-02 EP EP05778840A patent/EP1784183B1/en not_active Expired - Lifetime
- 2005-08-02 KR KR1020077004371A patent/KR100893977B1/ko not_active Expired - Fee Related
- 2005-08-02 RU RU2007106847/04A patent/RU2349588C2/ru not_active IP Right Cessation
- 2005-08-02 MX MX2007002246A patent/MX2007002246A/es active IP Right Grant
- 2005-08-02 US US11/574,046 patent/US8884025B2/en not_active Expired - Fee Related
- 2005-08-02 JP JP2007537876A patent/JP5100390B2/ja not_active Expired - Fee Related
- 2005-08-02 WO PCT/US2005/027398 patent/WO2006026034A2/en not_active Ceased
- 2005-08-22 TW TW094128618A patent/TWI361688B/zh not_active IP Right Cessation
- 2005-08-23 AR ARP050103539A patent/AR050613A1/es not_active Application Discontinuation
-
2007
- 2007-01-30 IL IL181063A patent/IL181063A0/en unknown
- 2007-02-02 ZA ZA200701016A patent/ZA200701016B/xx unknown
- 2007-03-09 NO NO20071319A patent/NO20071319L/no not_active Application Discontinuation
-
2012
- 2012-03-30 JP JP2012079463A patent/JP5498524B2/ja not_active Expired - Fee Related
-
2014
- 2014-11-10 US US14/537,093 patent/US9371298B2/en not_active Expired - Fee Related