JP2008509146A5 - - Google Patents

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Publication number

JP2008509146A5

JP2008509146A5 JP2007524932A JP2007524932A JP2008509146A5 JP 2008509146 A5 JP2008509146 A5 JP 2008509146A5 JP 2007524932 A JP2007524932 A JP 2007524932A JP 2007524932 A JP2007524932 A JP 2007524932A JP 2008509146 A5 JP2008509146 A5 JP 2008509146A5

Authority

JP

Japan

Prior art keywords

alkyl

halo

group

alkoxy

optionally substituted

Prior art date

2005-08-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000005843 halogen group Chemical group 0.000 claims 37
• 125000000217 alkyl group Chemical group 0.000 claims 30
• 125000003545 alkoxy group Chemical group 0.000 claims 27
• 125000003118 aryl group Chemical group 0.000 claims 21
• 150000001875 compounds Chemical class 0.000 claims 16
• 125000004104 aryloxy group Chemical group 0.000 claims 13
• 125000004093 cyano group Chemical group *C#N 0.000 claims 12
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
• 229910052760 oxygen Inorganic materials 0.000 claims 10
• 229910052717 sulfur Inorganic materials 0.000 claims 10
• 125000004414 alkyl thio group Chemical group 0.000 claims 9
• 125000001424 substituent group Chemical group 0.000 claims 9
• -1 hydroxy, amino Chemical group 0.000 claims 8
• 125000001153 fluoro group Chemical group F* 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 7
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 6
• 125000002619 bicyclic group Chemical group 0.000 claims 6
• 125000004432 carbon atoms Chemical group C* 0.000 claims 6
• 229910052757 nitrogen Inorganic materials 0.000 claims 6
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 6
• 229910052799 carbon Inorganic materials 0.000 claims 5
• 125000001309 chloro group Chemical group Cl* 0.000 claims 5
• 229920000728 polyester Polymers 0.000 claims 5
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000011780 sodium chloride Substances 0.000 claims 4
• 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 3
• 125000005466 alkylenyl group Chemical group 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 125000005647 linker group Chemical group 0.000 claims 3
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 2
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
• 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 2
• 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 2
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
• 206010012601 Diabetes mellitus Diseases 0.000 claims 2
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• 206010003210 Arteriosclerosis Diseases 0.000 claims 1
• 206010058108 Dyslipidaemia Diseases 0.000 claims 1
• 208000009576 Hypercholesterolemia Diseases 0.000 claims 1
• 206010062060 Hyperlipidaemia Diseases 0.000 claims 1
• 208000006575 Hypertriglyceridemia Diseases 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 206010022489 Insulin resistance Diseases 0.000 claims 1
• 206010061227 Lipid metabolism disease Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 201000010390 abdominal obesity-metabolic syndrome 1 Diseases 0.000 claims 1
• 125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 claims 1
• 201000001320 atherosclerosis Diseases 0.000 claims 1
• 230000001419 dependent Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• 0 *C(C(CC1)(CC2)CCC12S(*)(=O)=O)=O Chemical compound *C(C(CC1)(CC2)CCC12S(*)(=O)=O)=O 0.000 description 1