JP2008508352A5 - - Google Patents
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- Publication number
- JP2008508352A5 JP2008508352A5 JP2007524767A JP2007524767A JP2008508352A5 JP 2008508352 A5 JP2008508352 A5 JP 2008508352A5 JP 2007524767 A JP2007524767 A JP 2007524767A JP 2007524767 A JP2007524767 A JP 2007524767A JP 2008508352 A5 JP2008508352 A5 JP 2008508352A5
- Authority
- JP
- Japan
- Prior art keywords
- benzo
- dihydro
- phenyl
- indol
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims description 9
- -1 methoxy, hydroxy Chemical group 0.000 claims 116
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 3
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002249 indol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([*])=C([H])C2=C1[H] 0.000 claims 3
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 3
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims 2
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 claims 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000005956 isoquinolyl group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000005493 quinolyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- QRCGFTXRXYMJOS-UHFFFAOYSA-N 4h-1,4-benzoxazin-3-one Chemical compound C1=CC=C2NC(=O)COC2=C1 QRCGFTXRXYMJOS-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 0 O=C(NCCCN1CCCCC1)N1CCN(Cc2c(CCN=*3)c3ccc2)CC1 Chemical compound O=C(NCCCN1CCCCC1)N1CCN(Cc2c(CCN=*3)c3ccc2)CC1 0.000 description 13
- KPWHQJNIRXSRBQ-UHFFFAOYSA-N CC(CN(CC1)C(NCCCN2CCCCC2)=O)N1c1cccc(C)c1 Chemical compound CC(CN(CC1)C(NCCCN2CCCCC2)=O)N1c1cccc(C)c1 KPWHQJNIRXSRBQ-UHFFFAOYSA-N 0.000 description 1
- BLVXFNBKHSONDD-UHFFFAOYSA-N Cc1cc(N(CC2)CCN2C(NCCCN2CCCCC2)=O)ccc1 Chemical compound Cc1cc(N(CC2)CCN2C(NCCCN2CCCCC2)=O)ccc1 BLVXFNBKHSONDD-UHFFFAOYSA-N 0.000 description 1
- MHFWLJDIZUQWSE-UHFFFAOYSA-N Cc1ccccc1N(CC1)CCN1C(NCCCN1CCCCC1)=O Chemical compound Cc1ccccc1N(CC1)CCN1C(NCCCN1CCCCC1)=O MHFWLJDIZUQWSE-UHFFFAOYSA-N 0.000 description 1
- DMAORECRYRHUBR-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1C1c2ccccc2CCC1 Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1C1c2ccccc2CCC1 DMAORECRYRHUBR-UHFFFAOYSA-N 0.000 description 1
- VHORVPIINKLKEU-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1S(c(cc1)ccc1F)(=O)=O Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1S(c(cc1)ccc1F)(=O)=O VHORVPIINKLKEU-UHFFFAOYSA-N 0.000 description 1
- DITLHGOUPJXJJL-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1c1ccccc1S Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1c1ccccc1S DITLHGOUPJXJJL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401970A SE0401970D0 (sv) | 2004-08-02 | 2004-08-02 | Novel compounds |
| PCT/SE2005/001188 WO2006014135A1 (en) | 2004-08-02 | 2005-07-27 | Novel piperidine derivatives as histamine h3 receptor ligands for treatment of depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008508352A JP2008508352A (ja) | 2008-03-21 |
| JP2008508352A5 true JP2008508352A5 (https=) | 2009-03-12 |
Family
ID=32906882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524767A Abandoned JP2008508352A (ja) | 2004-08-02 | 2005-07-27 | うつ病の治療のためのヒスタミンｈ３受容体リガンドとしての新規なピペリジン誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070249618A1 (https=) |
| EP (1) | EP1784394A1 (https=) |
| JP (1) | JP2008508352A (https=) |
| KR (1) | KR20070039118A (https=) |
| CN (1) | CN1993340A (https=) |
| AU (1) | AU2005267931A1 (https=) |
| BR (1) | BRPI0514032A (https=) |
| CA (1) | CA2576109A1 (https=) |
| IL (1) | IL180547A0 (https=) |
| MX (1) | MX2007001227A (https=) |
| NO (1) | NO20071140L (https=) |
| RU (1) | RU2007106969A (https=) |
| SE (1) | SE0401970D0 (https=) |
| WO (1) | WO2006014135A1 (https=) |
| ZA (1) | ZA200700679B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2309765T3 (es) | 2004-05-28 | 2008-12-16 | 4Sc Ag | Tetrahidropiridotiofenos. |
| US7714134B2 (en) | 2004-06-11 | 2010-05-11 | 4Sc Ag | Compounds and use of tetrahydropyridothiophenes |
| EP1795527B1 (en) * | 2004-09-07 | 2009-04-22 | Banyu Pharmaceutical Co., Ltd. | Carbamoyl-substituted spiro derivative |
| JPWO2006028161A1 (ja) * | 2004-09-09 | 2008-05-08 | 財団法人乙卯研究所 | セロトニン５−ｈｔ３受容体作動薬 |
| GB0611907D0 (en) * | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
| EP1851229A1 (en) | 2005-02-09 | 2007-11-07 | Nycomed GmbH | Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer |
| AU2006212179A1 (en) | 2005-02-11 | 2006-08-17 | 4Sc Ag | Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer |
| US7763728B2 (en) | 2005-05-25 | 2010-07-27 | 4Sc Ag | Tetrahydropyridothiophenes |
| US7714136B2 (en) | 2005-05-25 | 2010-05-11 | 4Sc Ag | Tetrahydropyridothiophenes |
| US7851474B2 (en) | 2005-08-02 | 2010-12-14 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
| EP1991528A2 (en) * | 2006-01-18 | 2008-11-19 | Siena Biotech S.p.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
| US7514433B2 (en) * | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| TW200918062A (en) | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| US20110166124A1 (en) * | 2008-07-23 | 2011-07-07 | Mccormick Kevin D | Tricyclic spirocycle derivatives and methods of use |
| CN106883246B (zh) | 2009-12-04 | 2020-05-29 | 桑诺维恩药品公司 | 多环化合物及其使用方法 |
| DE102011083283A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen |
| CA3032141A1 (en) | 2016-07-29 | 2018-02-01 | Vadim ALEXANDROV | Compounds and compositions and uses thereof |
| UA125519C2 (uk) | 2016-07-29 | 2022-04-13 | Суновіон Фармасьютікалз Інк. | Сполуки і композиції і їх застосування |
| IL268694B2 (en) | 2017-02-16 | 2023-10-01 | Sunovion Pharmaceuticals Inc | Treatment of schizophrenia |
| BR112020001433A2 (pt) | 2017-08-02 | 2020-07-28 | Sunovion Pharmaceuticals Inc. | compostos de isocromano e usos dos mesmos |
| EA202091945A1 (ru) | 2018-02-16 | 2021-01-18 | Суновион Фармасьютикалз Инк. | Соли, кристаллические формы и способы их получения |
| US10689360B1 (en) * | 2019-01-30 | 2020-06-23 | Insilico Medicine Ip Limited | TLR inhibitors |
| MX2021010880A (es) | 2019-03-14 | 2022-01-18 | Sunovion Pharmaceuticals Inc | Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas. |
| CN115734785A (zh) | 2020-04-14 | 2023-03-03 | 桑诺维恩药品公司 | (S)-(4,5-二氢-7H-噻吩并[2,3-c]吡喃-7-基)-N-甲基甲胺用于治疗神经和精神方面的病症 |
| CN114685401A (zh) * | 2020-12-28 | 2022-07-01 | 江苏天士力帝益药业有限公司 | 一种二（4-甲基哌嗪-1-基）甲酮的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1183784B (de) * | 1963-05-16 | 1964-12-17 | Fuji Photo Film Co Ltd | Verfahren zur Empfindlichkeitssteigerung und Beschleunigung der Entwicklung von Halogensilberemulsionen in Photomaterialien |
| FR1589754A (https=) * | 1968-10-17 | 1970-04-06 | ||
| JPS58169143A (ja) * | 1982-03-31 | 1983-10-05 | Fuji Photo Film Co Ltd | 重合画像形成方法 |
| NZ503491A (en) * | 1997-11-10 | 2002-08-28 | Bristol Myers Squibb Co | 2-substituted amino-1,3-benzothiazole derivatives useful as protein tyrosine kinase inhibitors |
| AU8181701A (en) * | 2000-06-21 | 2002-01-02 | Hoffmann La Roche | Benzothiazole derivatives |
-
2004
- 2004-08-02 SE SE0401970A patent/SE0401970D0/xx unknown
-
2005
- 2005-07-27 AU AU2005267931A patent/AU2005267931A1/en not_active Abandoned
- 2005-07-27 JP JP2007524767A patent/JP2008508352A/ja not_active Abandoned
- 2005-07-27 MX MX2007001227A patent/MX2007001227A/es not_active Application Discontinuation
- 2005-07-27 WO PCT/SE2005/001188 patent/WO2006014135A1/en not_active Ceased
- 2005-07-27 RU RU2007106969/04A patent/RU2007106969A/ru unknown
- 2005-07-27 CA CA002576109A patent/CA2576109A1/en not_active Abandoned
- 2005-07-27 CN CNA2005800262338A patent/CN1993340A/zh active Pending
- 2005-07-27 EP EP05766829A patent/EP1784394A1/en not_active Withdrawn
- 2005-07-27 US US11/572,966 patent/US20070249618A1/en not_active Abandoned
- 2005-07-27 KR KR1020077002642A patent/KR20070039118A/ko not_active Withdrawn
- 2005-07-27 BR BRPI0514032-3A patent/BRPI0514032A/pt not_active Application Discontinuation
-
2007
- 2007-01-04 IL IL180547A patent/IL180547A0/en unknown
- 2007-01-24 ZA ZA200700679A patent/ZA200700679B/xx unknown
- 2007-02-28 NO NO20071140A patent/NO20071140L/no not_active Application Discontinuation
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