JP2008506114A - マイクロアレイおよび他のマイクロスケール装置上に高濃度スポットを沈着させるためのスポッティング装置および方法 - Google Patents
マイクロアレイおよび他のマイクロスケール装置上に高濃度スポットを沈着させるためのスポッティング装置および方法 Download PDFInfo
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| KR101179553B1 (ko) | 2008-12-22 | 2012-09-05 | 한국전자통신연구원 | 세포 배양 컴파트먼트 유닛 및 이를 포함하는 어레이 |
| JP2013543971A (ja) * | 2010-10-29 | 2013-12-09 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 多層マイクロ流体プローブ・ヘッド及びその製造方法 |
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| CN110180613B (zh) * | 2019-06-27 | 2020-02-14 | 电子科技大学 | 一种基于表面电荷的移液枪 |
| US20240157317A1 (en) * | 2021-03-24 | 2024-05-16 | Toray Engineering Co., Ltd. | Chemical solution synthesis device |
| CN113546808B (zh) * | 2021-07-19 | 2022-07-19 | 广东工业大学 | 一种面向纳米金属膏体的点胶结构与点胶方法 |
| TW202428605A (zh) | 2022-10-31 | 2024-07-16 | 美商安進公司 | 抗體表徵方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002075280A2 (de) * | 2001-03-16 | 2002-09-26 | Memorec Bi0Tec Gmbh Medizinisch-Molekulare Entwicklung, Köln | Untersuchungsvorrichtung und verfahren zum untersuchen chemischer und/oder biologischer proben |
| JP2004101480A (ja) * | 2002-09-12 | 2004-04-02 | Ckd Corp | 分注装置 |
| JP2004518106A (ja) * | 2000-04-03 | 2004-06-17 | パラボル テクノロジー エス アー | 正確に制御された少量の液体の分配装置 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US639891A (en) * | 1899-05-10 | 1899-12-26 | William H Forsyth | Sand-box for cars. |
| US3974508A (en) * | 1974-12-16 | 1976-08-10 | Gould Inc. | Air purging system for a pulsed droplet ejecting system |
| US4659677A (en) * | 1983-05-26 | 1987-04-21 | Eastman Kodak Company | Method providing liquid mixing outside containers |
| US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5847356A (en) * | 1996-08-30 | 1998-12-08 | Hewlett-Packard Company | Laser welded inkjet printhead assembly utilizing a combination laser and fiber optic push connect system |
| US6699719B2 (en) * | 1996-11-29 | 2004-03-02 | Proteomic Systems, Inc. | Biosensor arrays and methods |
| US6090251A (en) * | 1997-06-06 | 2000-07-18 | Caliper Technologies, Inc. | Microfabricated structures for facilitating fluid introduction into microfluidic devices |
| US5851491A (en) * | 1997-06-13 | 1998-12-22 | Labcon, North America | Pipette tip and filter for accurate sampling and prevention of contamination |
| HUP0003296A3 (en) * | 1997-07-22 | 2001-09-28 | Qiagen Genomics Inc Bothell | Apparatus and methods for arraying solution onto a solid support |
| US6242246B1 (en) * | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
| JP3394181B2 (ja) | 1998-03-30 | 2003-04-07 | 日立ソフトウエアエンジニアリング株式会社 | 試料添加方法及び試料添加装置 |
| US6309891B1 (en) | 1998-09-09 | 2001-10-30 | Incyte Genomics, Inc. | Capillary printing systems |
| KR100379411B1 (ko) * | 1999-06-28 | 2003-04-10 | 엘지전자 주식회사 | 바이오칩 및 그의 생체 물질 패터닝 및 측정 방법 |
| WO2001003848A1 (en) * | 1999-07-13 | 2001-01-18 | The Texas A & M University System | Pneumatic nebulizing interface, method for making and using same and instruments including same |
| US6544480B1 (en) * | 1999-10-26 | 2003-04-08 | Tibotec Bvba | Device and related method for dispensing small volumes of liquid |
| KR100339379B1 (ko) * | 1999-10-29 | 2002-06-03 | 구자홍 | 바이오칩과 그의 생체 물질 측정장치 및 측정방법 |
| KR20020097181A (ko) * | 2000-02-22 | 2002-12-31 | 제노스펙트라 인코포레이티드 | 마이크로어레이 제작 기술 및 장치 |
| US20040014102A1 (en) * | 2000-02-22 | 2004-01-22 | Shiping Chen | High density parallel printing of microarrays |
| US20020028160A1 (en) * | 2000-02-22 | 2002-03-07 | Jianming Xiao | Method and apparatus based on bundled capillaries for high throughput screening |
| JP3502803B2 (ja) * | 2000-03-06 | 2004-03-02 | 日立ソフトウエアエンジニアリング株式会社 | マイクロアレイ、マイクロアレイ作製方法及びマイクロアレイにおけるピン間スポット量誤差補正方法 |
| US20020159918A1 (en) * | 2000-06-25 | 2002-10-31 | Fan-Gang Tseng | Micro-fabricated stamp array for depositing biologic diagnostic testing samples on bio-bindable surface |
| CN1137999C (zh) * | 2000-07-04 | 2004-02-11 | 清华大学 | 集成式微阵列装置 |
| US6656740B1 (en) * | 2000-10-31 | 2003-12-02 | Agilent Technologies, Inc. | Pressure variation in array fabrication |
| US7166258B2 (en) * | 2001-01-31 | 2007-01-23 | Agilent Technologies, Inc. | Automation-optimized microarray package |
| US6994429B1 (en) * | 2001-12-13 | 2006-02-07 | Agilent Technologies, Inc. | Printhead fluid supply system |
| JP3732457B2 (ja) * | 2002-05-20 | 2006-01-05 | 日立ソフトウエアエンジニアリング株式会社 | スポットピン |
-
2005
- 2005-07-06 WO PCT/US2005/023895 patent/WO2006014460A2/en not_active Ceased
- 2005-07-06 CN CNB2005800230252A patent/CN100496749C/zh not_active Expired - Lifetime
- 2005-07-06 EP EP05764557A patent/EP1773498B1/en not_active Expired - Lifetime
- 2005-07-06 CA CA002571859A patent/CA2571859A1/en not_active Abandoned
- 2005-07-06 JP JP2007520456A patent/JP2008506114A/ja active Pending
- 2005-07-06 KR KR1020077002867A patent/KR20070063498A/ko not_active Withdrawn
- 2005-07-06 US US11/632,086 patent/US8210119B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004518106A (ja) * | 2000-04-03 | 2004-06-17 | パラボル テクノロジー エス アー | 正確に制御された少量の液体の分配装置 |
| WO2002075280A2 (de) * | 2001-03-16 | 2002-09-26 | Memorec Bi0Tec Gmbh Medizinisch-Molekulare Entwicklung, Köln | Untersuchungsvorrichtung und verfahren zum untersuchen chemischer und/oder biologischer proben |
| JP2004538446A (ja) * | 2001-03-16 | 2004-12-24 | メモレック バイオテック ゲー・エム・ベー・ハー | 化学的及び/又は生物学的試料を分析する分析装置及び方法 |
| JP2004101480A (ja) * | 2002-09-12 | 2004-04-02 | Ckd Corp | 分注装置 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010082540A (ja) * | 2008-09-30 | 2010-04-15 | Starlite Co Ltd | マイクロ化学デバイス及びその製造方法 |
| KR101179553B1 (ko) | 2008-12-22 | 2012-09-05 | 한국전자통신연구원 | 세포 배양 컴파트먼트 유닛 및 이를 포함하는 어레이 |
| JP2013543971A (ja) * | 2010-10-29 | 2013-12-09 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 多層マイクロ流体プローブ・ヘッド及びその製造方法 |
| US9745949B2 (en) | 2010-10-29 | 2017-08-29 | International Business Machines Corporation | Multilayer microfluidic probe head with immersion channels and fabrication thereof |
| WO2023032883A1 (ja) * | 2021-08-30 | 2023-03-09 | 株式会社ダイセル | マイクロ流体デバイス、及びその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070231458A1 (en) | 2007-10-04 |
| CN100496749C (zh) | 2009-06-10 |
| CA2571859A1 (en) | 2006-02-09 |
| EP1773498A2 (en) | 2007-04-18 |
| KR20070063498A (ko) | 2007-06-19 |
| WO2006014460A3 (en) | 2006-06-29 |
| EP1773498B1 (en) | 2012-06-13 |
| WO2006014460A2 (en) | 2006-02-09 |
| CN1980742A (zh) | 2007-06-13 |
| US8210119B2 (en) | 2012-07-03 |
| EP1773498A4 (en) | 2009-12-02 |
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