JP2008505899A - ヒトグルカゴン様ペプチド−１修飾因子、並びにそれの糖尿病および関連症状の治療における使用 - Google Patents

ヒトグルカゴン様ペプチド−１修飾因子、並びにそれの糖尿病および関連症状の治療における使用 Download PDF

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JP2008505899A
JP2008505899A JP2007520360A JP2007520360A JP2008505899A JP 2008505899 A JP2008505899 A JP 2008505899A JP 2007520360 A JP2007520360 A JP 2007520360A JP 2007520360 A JP2007520360 A JP 2007520360A JP 2008505899 A JP2008505899 A JP 2008505899A
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group
methyl
hydrogen
amino acid
isolated polypeptide
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Japanese (ja)
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JP2008505899A5 (cg-RX-API-DMAC7.html
Inventor
ウィリアム・アール・ユーイング
クラウディオ・マペッリ
リチャード・ビー・サルスカイ
テイサー・エス・ヘイク
ビング・ジー・リー
ダグラス・ジェイムズ・リージンガー
ロゲリオ・エル・マルティネス
イェヘン・チュ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2008505899A publication Critical patent/JP2008505899A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2007520360A 2004-07-02 2005-06-30 ヒトグルカゴン様ペプチド−１修飾因子、並びにそれの糖尿病および関連症状の治療における使用 Pending JP2008505899A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58535804P 2004-07-02 2004-07-02
US68480505P 2005-05-26 2005-05-26
PCT/US2005/023076 WO2006014287A1 (en) 2004-07-02 2005-06-30 Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions

Publications (2)

Publication Number Publication Date
JP2008505899A true JP2008505899A (ja) 2008-02-28
JP2008505899A5 JP2008505899A5 (cg-RX-API-DMAC7.html) 2008-07-17

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JP2007520360A Pending JP2008505899A (ja) 2004-07-02 2005-06-30 ヒトグルカゴン様ペプチド−１修飾因子、並びにそれの糖尿病および関連症状の治療における使用

Country Status (18)

Country Link
US (2) US7417028B2 (cg-RX-API-DMAC7.html)
EP (1) EP1773877B1 (cg-RX-API-DMAC7.html)
JP (1) JP2008505899A (cg-RX-API-DMAC7.html)
KR (1) KR20070042162A (cg-RX-API-DMAC7.html)
AR (1) AR049572A1 (cg-RX-API-DMAC7.html)
AT (1) ATE461218T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005270129A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0511393A (cg-RX-API-DMAC7.html)
CA (1) CA2571794A1 (cg-RX-API-DMAC7.html)
DE (1) DE602005020017D1 (cg-RX-API-DMAC7.html)
ES (1) ES2340181T3 (cg-RX-API-DMAC7.html)
IL (1) IL180434A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA06015193A (cg-RX-API-DMAC7.html)
NO (1) NO20070614L (cg-RX-API-DMAC7.html)
PE (1) PE20060713A1 (cg-RX-API-DMAC7.html)
RU (1) RU2007104105A (cg-RX-API-DMAC7.html)
TW (1) TW200611704A (cg-RX-API-DMAC7.html)
WO (1) WO2006014287A1 (cg-RX-API-DMAC7.html)

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