NO20070614L - Humane glukagon-lignende-peptid-1 modulatorer og anvendelse derav ved behandling av diabetes og beslektede tilstander. - Google Patents
Humane glukagon-lignende-peptid-1 modulatorer og anvendelse derav ved behandling av diabetes og beslektede tilstander.Info
- Publication number
- NO20070614L NO20070614L NO20070614A NO20070614A NO20070614L NO 20070614 L NO20070614 L NO 20070614L NO 20070614 A NO20070614 A NO 20070614A NO 20070614 A NO20070614 A NO 20070614A NO 20070614 L NO20070614 L NO 20070614L
- Authority
- NO
- Norway
- Prior art keywords
- peptide
- glp
- present
- diabetes
- human glucagon
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer nye humant glukagon-lignende peptid-1 - (GLP-1)-reseptor-modulatorer som har biologisk aktivitet lik eller overlegen naturlig GLP-1 -peptid, og således er anvendelige for behandling eller forebygging av sykdommer eller lidelser forbundet med GLP-aktivitet. Videre tilveiebringer foreliggende oppfinnelse nye, kjemisk modifiserte peptider som ikke bare stimulerer insulinsekresjon hos type 11-diabetikere, men som også gir andre fordelaktige insulinotrope responser. Disse syntetiske peptid-GLP-1 -reseptor-modulatorer oppviser øket stabilitet overfor proteolytisk spaltning, noe som gjør dem til ideelle terapeutiske kandidater til oral eller parenteral administrering. Peptidene ifølge foreliggende oppfinnelse viser ønskelige farmakokinetiske egenskaper og ønskelig virkning i effektivitetsmodeller av diabetes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58535804P | 2004-07-02 | 2004-07-02 | |
US68480505P | 2005-05-26 | 2005-05-26 | |
PCT/US2005/023076 WO2006014287A1 (en) | 2004-07-02 | 2005-06-30 | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
Publications (1)
Publication Number | Publication Date |
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NO20070614L true NO20070614L (no) | 2007-03-27 |
Family
ID=35385064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20070614A NO20070614L (no) | 2004-07-02 | 2007-02-01 | Humane glukagon-lignende-peptid-1 modulatorer og anvendelse derav ved behandling av diabetes og beslektede tilstander. |
Country Status (18)
Country | Link |
---|---|
US (2) | US7417028B2 (no) |
EP (1) | EP1773877B1 (no) |
JP (1) | JP2008505899A (no) |
KR (1) | KR20070042162A (no) |
AR (1) | AR049572A1 (no) |
AT (1) | ATE461218T1 (no) |
AU (1) | AU2005270129A1 (no) |
BR (1) | BRPI0511393A (no) |
CA (1) | CA2571794A1 (no) |
DE (1) | DE602005020017D1 (no) |
ES (1) | ES2340181T3 (no) |
IL (1) | IL180434A0 (no) |
MX (1) | MXPA06015193A (no) |
NO (1) | NO20070614L (no) |
PE (1) | PE20060713A1 (no) |
RU (1) | RU2007104105A (no) |
TW (1) | TW200611704A (no) |
WO (1) | WO2006014287A1 (no) |
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US7534763B2 (en) | 2004-07-02 | 2009-05-19 | Bristol-Myers Squibb Company | Sustained release GLP-1 receptor modulators |
JP2008540402A (ja) * | 2005-05-05 | 2008-11-20 | カディラ・ヘルスケア・リミテッド | Glp−1アゴニストとしての新規な化合物 |
WO2006127948A2 (en) * | 2005-05-26 | 2006-11-30 | Bristol-Myers Squibb Company | N-terminally modified glp-1 receptor modulators |
US20070238669A1 (en) * | 2006-01-11 | 2007-10-11 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes related conditions |
US20070197445A1 (en) * | 2006-01-18 | 2007-08-23 | University Of Cincinnati | Compounds for control of appetite |
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AU770609B2 (en) | 1998-12-07 | 2004-02-26 | Ipsen Pharma S.A.S. | GLP-1 analogues |
IL150166A0 (en) | 1999-12-13 | 2002-12-01 | Chugai Pharmaceutical Co Ltd | Compounds with hydroxycarbonyl-halogenoalkyl side chains |
AU4888401A (en) | 2000-04-07 | 2001-10-23 | Samsung Electronics Co., Ltd. | Sulfonamide derivative as a matrix metalloproteinase inhibitor |
US6579889B2 (en) | 2000-06-22 | 2003-06-17 | Merck & Co., Inc. | Substituted isonipecotyl derivatives as inhibitors of cell adhesion |
US7238671B2 (en) | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
PL377687A1 (pl) | 2001-10-18 | 2006-02-06 | Bristol-Myers Squibb Company | Środki naśladujące ludzki peptyd glukagonopodobny typu 1 i ich zastosowanie w leczeniu cukrzycy i stanów związanych z cukrzycą |
-
2005
- 2005-06-29 TW TW094121907A patent/TW200611704A/zh unknown
- 2005-06-30 CA CA002571794A patent/CA2571794A1/en not_active Abandoned
- 2005-06-30 MX MXPA06015193A patent/MXPA06015193A/es unknown
- 2005-06-30 ES ES05763871T patent/ES2340181T3/es active Active
- 2005-06-30 DE DE602005020017T patent/DE602005020017D1/de active Active
- 2005-06-30 JP JP2007520360A patent/JP2008505899A/ja active Pending
- 2005-06-30 RU RU2007104105/04A patent/RU2007104105A/ru not_active Application Discontinuation
- 2005-06-30 EP EP05763871A patent/EP1773877B1/en active Active
- 2005-06-30 AU AU2005270129A patent/AU2005270129A1/en not_active Abandoned
- 2005-06-30 WO PCT/US2005/023076 patent/WO2006014287A1/en active Application Filing
- 2005-06-30 KR KR1020077002645A patent/KR20070042162A/ko not_active Application Discontinuation
- 2005-06-30 US US11/170,968 patent/US7417028B2/en active Active
- 2005-06-30 BR BRPI0511393-8A patent/BRPI0511393A/pt not_active IP Right Cessation
- 2005-06-30 AT AT05763871T patent/ATE461218T1/de not_active IP Right Cessation
- 2005-07-04 AR ARP050102778A patent/AR049572A1/es not_active Application Discontinuation
- 2005-07-04 PE PE2005000775A patent/PE20060713A1/es not_active Application Discontinuation
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2006
- 2006-12-28 IL IL180434A patent/IL180434A0/en unknown
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2007
- 2007-02-01 NO NO20070614A patent/NO20070614L/no not_active Application Discontinuation
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2008
- 2008-03-03 US US12/041,266 patent/US20080242593A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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AR049572A1 (es) | 2006-08-16 |
EP1773877A1 (en) | 2007-04-18 |
US20060287242A1 (en) | 2006-12-21 |
TW200611704A (en) | 2006-04-16 |
BRPI0511393A (pt) | 2007-12-04 |
AU2005270129A1 (en) | 2006-02-09 |
CA2571794A1 (en) | 2006-02-09 |
ATE461218T1 (de) | 2010-04-15 |
DE602005020017D1 (de) | 2010-04-29 |
KR20070042162A (ko) | 2007-04-20 |
PE20060713A1 (es) | 2006-07-09 |
US7417028B2 (en) | 2008-08-26 |
JP2008505899A (ja) | 2008-02-28 |
US20080242593A1 (en) | 2008-10-02 |
RU2007104105A (ru) | 2008-08-10 |
WO2006014287A8 (en) | 2006-05-26 |
MXPA06015193A (es) | 2007-02-28 |
ES2340181T3 (es) | 2010-05-31 |
IL180434A0 (en) | 2007-06-03 |
WO2006014287A1 (en) | 2006-02-09 |
EP1773877B1 (en) | 2010-03-17 |
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