BRPI0511393A - moduladores de peptìdeo 1 semelhantes ao glucagon humano e seu uso no tratamento de diabetes e condições relacionadas - Google Patents
moduladores de peptìdeo 1 semelhantes ao glucagon humano e seu uso no tratamento de diabetes e condições relacionadasInfo
- Publication number
- BRPI0511393A BRPI0511393A BRPI0511393-8A BRPI0511393A BRPI0511393A BR PI0511393 A BRPI0511393 A BR PI0511393A BR PI0511393 A BRPI0511393 A BR PI0511393A BR PI0511393 A BRPI0511393 A BR PI0511393A
- Authority
- BR
- Brazil
- Prior art keywords
- peptide
- diabetes
- treatment
- human glucagon
- modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
MODULADORES DE PEPTìDEO 1 SEMELHANTES AO GLUCAGON HUMANO E SEU USO NO TRATAMENTO DE DIABETES E CONDIçõES RELACIONADAS. A presente invenção refere-se a novos moduladores do receptor de peptídeo-1 (GLP-1) semelhante ao glucagon humano que têm atividade biológica similar ou superior ao peptídeo GLP-1 nativo e, assim, são usados para o tratamento ou prevenção de doenças ou distúrbios associados à atividade de GLP. Ainda, a presente invenção proporciona novos peptídeos quimicamente modificados que não somente estimulam a secreção de insulina em diabetes do tipo II, mas também produzem outras respostas insulino trópicas benéficas. Esses moduladores sintéticos do receptor de peptídeo GLP-1 exibem estabilidade aumentada à clivagem proteolítica, tomando os mesmos candidatos terapêuticos ideais para administração oral ou parenteral. Os peptídeos da presente invenção mostram propriedades farmacocinéticas desejáveis e potência desejável em modelos de eficácia de diabetes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58535804P | 2004-07-02 | 2004-07-02 | |
US68480505P | 2005-05-26 | 2005-05-26 | |
PCT/US2005/023076 WO2006014287A1 (en) | 2004-07-02 | 2005-06-30 | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0511393A true BRPI0511393A (pt) | 2007-12-04 |
Family
ID=35385064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0511393-8A BRPI0511393A (pt) | 2004-07-02 | 2005-06-30 | moduladores de peptìdeo 1 semelhantes ao glucagon humano e seu uso no tratamento de diabetes e condições relacionadas |
Country Status (18)
Country | Link |
---|---|
US (2) | US7417028B2 (pt) |
EP (1) | EP1773877B1 (pt) |
JP (1) | JP2008505899A (pt) |
KR (1) | KR20070042162A (pt) |
AR (1) | AR049572A1 (pt) |
AT (1) | ATE461218T1 (pt) |
AU (1) | AU2005270129A1 (pt) |
BR (1) | BRPI0511393A (pt) |
CA (1) | CA2571794A1 (pt) |
DE (1) | DE602005020017D1 (pt) |
ES (1) | ES2340181T3 (pt) |
IL (1) | IL180434A0 (pt) |
MX (1) | MXPA06015193A (pt) |
NO (1) | NO20070614L (pt) |
PE (1) | PE20060713A1 (pt) |
RU (1) | RU2007104105A (pt) |
TW (1) | TW200611704A (pt) |
WO (1) | WO2006014287A1 (pt) |
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EP1891106A2 (en) * | 2005-05-05 | 2008-02-27 | Cadila Healthcare Ltd. | Novel compounds as glp-i agonists |
TW200716679A (en) * | 2005-05-26 | 2007-05-01 | Bristol Myers Squibb Co | N-terminally modified GLP-1 receptor modulators |
EP1976873A2 (en) * | 2006-01-11 | 2008-10-08 | Brystol-Myers Squibb Company | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
US20070197445A1 (en) | 2006-01-18 | 2007-08-23 | University Of Cincinnati | Compounds for control of appetite |
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US20100022457A1 (en) * | 2006-05-26 | 2010-01-28 | Bristol-Myers Squibb Company | Sustained release glp-1 receptor modulators |
US20080044326A1 (en) * | 2006-07-04 | 2008-02-21 | Esencia Co., Ltd. | Sterilizer for baby products |
DK2084182T3 (da) * | 2006-10-03 | 2013-11-04 | Cadila Healthcare Ltd | Antidiabetiske forbindelser |
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US20140303098A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
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TWI804571B (zh) | 2018-02-02 | 2023-06-11 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑及n-(8-(2-羥苯甲醯基)胺基)辛酸之鹽的固體組成物 |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
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WO2001042186A1 (fr) | 1999-12-13 | 2001-06-14 | Chugai Seiyaku Kabushiki Kaisha | Compose a chaine laterale hydroxycarbonyl-halogenoalkyle |
DE60120881T2 (de) | 2000-04-07 | 2007-01-18 | Samsung Electronics Co., Ltd., Suwon | Sulfonamide als matrix-metalloproteinase inhibitoren |
US6579889B2 (en) | 2000-06-22 | 2003-06-17 | Merck & Co., Inc. | Substituted isonipecotyl derivatives as inhibitors of cell adhesion |
US7238671B2 (en) * | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
EP1572892A4 (en) * | 2001-10-18 | 2007-08-22 | Bristol Myers Squibb Co | HUMAN GLUCAGON-LIKE-PEPTIDE-1 MIMICS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS |
-
2005
- 2005-06-29 TW TW094121907A patent/TW200611704A/zh unknown
- 2005-06-30 ES ES05763871T patent/ES2340181T3/es active Active
- 2005-06-30 RU RU2007104105/04A patent/RU2007104105A/ru not_active Application Discontinuation
- 2005-06-30 KR KR1020077002645A patent/KR20070042162A/ko not_active Application Discontinuation
- 2005-06-30 BR BRPI0511393-8A patent/BRPI0511393A/pt not_active IP Right Cessation
- 2005-06-30 US US11/170,968 patent/US7417028B2/en active Active
- 2005-06-30 DE DE602005020017T patent/DE602005020017D1/de active Active
- 2005-06-30 EP EP05763871A patent/EP1773877B1/en active Active
- 2005-06-30 AU AU2005270129A patent/AU2005270129A1/en not_active Abandoned
- 2005-06-30 WO PCT/US2005/023076 patent/WO2006014287A1/en active Application Filing
- 2005-06-30 CA CA002571794A patent/CA2571794A1/en not_active Abandoned
- 2005-06-30 MX MXPA06015193A patent/MXPA06015193A/es unknown
- 2005-06-30 AT AT05763871T patent/ATE461218T1/de not_active IP Right Cessation
- 2005-06-30 JP JP2007520360A patent/JP2008505899A/ja active Pending
- 2005-07-04 PE PE2005000775A patent/PE20060713A1/es not_active Application Discontinuation
- 2005-07-04 AR ARP050102778A patent/AR049572A1/es not_active Application Discontinuation
-
2006
- 2006-12-28 IL IL180434A patent/IL180434A0/en unknown
-
2007
- 2007-02-01 NO NO20070614A patent/NO20070614L/no not_active Application Discontinuation
-
2008
- 2008-03-03 US US12/041,266 patent/US20080242593A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE602005020017D1 (de) | 2010-04-29 |
AR049572A1 (es) | 2006-08-16 |
JP2008505899A (ja) | 2008-02-28 |
TW200611704A (en) | 2006-04-16 |
ATE461218T1 (de) | 2010-04-15 |
PE20060713A1 (es) | 2006-07-09 |
US20080242593A1 (en) | 2008-10-02 |
CA2571794A1 (en) | 2006-02-09 |
WO2006014287A8 (en) | 2006-05-26 |
IL180434A0 (en) | 2007-06-03 |
US7417028B2 (en) | 2008-08-26 |
AU2005270129A1 (en) | 2006-02-09 |
EP1773877B1 (en) | 2010-03-17 |
KR20070042162A (ko) | 2007-04-20 |
ES2340181T3 (es) | 2010-05-31 |
NO20070614L (no) | 2007-03-27 |
US20060287242A1 (en) | 2006-12-21 |
MXPA06015193A (es) | 2007-02-28 |
WO2006014287A1 (en) | 2006-02-09 |
EP1773877A1 (en) | 2007-04-18 |
RU2007104105A (ru) | 2008-08-10 |
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