JP2008505160A5 - - Google Patents
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- Publication number
- JP2008505160A5 JP2008505160A5 JP2007519776A JP2007519776A JP2008505160A5 JP 2008505160 A5 JP2008505160 A5 JP 2008505160A5 JP 2007519776 A JP2007519776 A JP 2007519776A JP 2007519776 A JP2007519776 A JP 2007519776A JP 2008505160 A5 JP2008505160 A5 JP 2008505160A5
- Authority
- JP
- Japan
- Prior art keywords
- magnesium salt
- omeprazole magnesium
- item
- water
- omeprazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 21
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- 239000006184 cosolvent Substances 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 239000003960 organic solvent Substances 0.000 claims description 7
- 159000000003 magnesium salts Chemical class 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000002441 X-ray diffraction Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 3
- 238000010586 diagram Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 1
- 239000007858 starting material Substances 0.000 description 11
- 229960000381 omeprazole Drugs 0.000 description 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 2
- 238000004807 desolvation Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- MQEUGMWHWPYFDD-UHFFFAOYSA-N magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical class [Mg].N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C MQEUGMWHWPYFDD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200401729A ES2246149B1 (es) | 2004-07-02 | 2004-07-02 | Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion. |
| ESP200401729 | 2004-07-02 | ||
| PCT/EP2005/053062 WO2006003163A1 (en) | 2004-07-02 | 2005-06-29 | Solid forms of the magnesium salt of (s)-omeprazole and processes for their preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014088458A Division JP2014169302A (ja) | 2004-07-02 | 2014-04-22 | （ｓ）−オメプラゾールのマグネシウム塩の固形形態とその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008505160A JP2008505160A (ja) | 2008-02-21 |
| JP2008505160A5 true JP2008505160A5 (cg-RX-API-DMAC7.html) | 2014-06-05 |
| JP5575366B2 JP5575366B2 (ja) | 2014-08-20 |
Family
ID=34972307
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519776A Expired - Fee Related JP5575366B2 (ja) | 2004-07-02 | 2005-06-29 | （ｓ）−オメプラゾールのマグネシウム塩の固形形態とその製造方法 |
| JP2014088458A Pending JP2014169302A (ja) | 2004-07-02 | 2014-04-22 | （ｓ）−オメプラゾールのマグネシウム塩の固形形態とその製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014088458A Pending JP2014169302A (ja) | 2004-07-02 | 2014-04-22 | （ｓ）−オメプラゾールのマグネシウム塩の固形形態とその製造方法 |
Country Status (19)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2246149B1 (es) * | 2004-07-02 | 2007-06-01 | Esteve Quimica, S.A. | Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion. |
| FR2920428B1 (fr) * | 2007-08-29 | 2012-06-15 | Univ Rouen | Procede de dedoublement de sels de l'omeprazole |
| EP2147918A1 (en) * | 2008-07-21 | 2010-01-27 | LEK Pharmaceuticals D.D. | Process for the preparation of S-omeprazole magnesium in a stable form |
| CN103044400A (zh) * | 2012-12-21 | 2013-04-17 | 北京华禧联合科技发展有限公司 | 埃索美拉唑镁盐及其制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9302396D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | A novel compound form |
| DE69522921T2 (de) * | 1994-07-08 | 2002-04-11 | Astrazeneca Ab | Aus mehreren einzeleinheiten zusammengesetzte dosierungsform in tablettenform (i) |
| SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
| SE510666C2 (sv) * | 1996-12-20 | 1999-06-14 | Astra Ab | Nya Kristallmodifikationer |
| SE510650C2 (sv) * | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| EP1206466B1 (en) * | 1999-08-26 | 2005-10-12 | aaiPharma Inc. | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6312712B1 (en) * | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
| US6326384B1 (en) * | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
| CA2409258A1 (en) * | 2000-05-15 | 2001-11-22 | Ranbaxy Laboratories Limited | Novel amorphous form of omeprazole salts |
| DE60123800T2 (de) * | 2000-08-04 | 2007-10-11 | Takeda Pharmaceutical Co. Ltd. | Salze von benzimidazol-derivaten und deren verwendung |
| CA2386716C (en) * | 2002-05-17 | 2012-07-24 | Bernard Charles Sherman | Magnesium salt of s-omeprazole |
| SI20875A (sl) * | 2001-04-25 | 2002-10-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristalna oblika omeprazola |
| AU2003262375A1 (en) | 2002-04-22 | 2003-11-03 | Sun Pharmaceutical Industries Limited | Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts |
| US6894066B2 (en) * | 2002-05-09 | 2005-05-17 | Bernard Charles Sherman | Magnesium salt of S-omeprazole |
| WO2004020436A1 (en) * | 2002-08-30 | 2004-03-11 | Reddy's Laboratories Limited | Amorphous hydrates of esomeprazole magnesium and process for the preparation thereof |
| EP1556043A1 (en) * | 2002-10-22 | 2005-07-27 | Ranbaxy Laboratories, Ltd. | Amorphous form of esomeprazole salts |
| WO2004046134A2 (en) * | 2002-11-18 | 2004-06-03 | Dr. Reddy's Laboratories Limited | Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation |
| AU2003238671A1 (en) * | 2003-04-10 | 2004-11-01 | Hetero Drugs Limitd | Novel crystalline forms of s-omeprazole magnesium |
| ES2246149B1 (es) * | 2004-07-02 | 2007-06-01 | Esteve Quimica, S.A. | Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion. |
-
2004
- 2004-07-02 ES ES200401729A patent/ES2246149B1/es not_active Expired - Fee Related
-
2005
- 2005-06-29 CA CA2570559A patent/CA2570559C/en not_active Expired - Fee Related
- 2005-06-29 EP EP05760736A patent/EP1765807B1/en not_active Expired - Lifetime
- 2005-06-29 AT AT05760736T patent/ATE425975T1/de active
- 2005-06-29 DE DE602005013382T patent/DE602005013382D1/de not_active Expired - Lifetime
- 2005-06-29 HR HR20090211T patent/HRP20090211T1/xx unknown
- 2005-06-29 ZA ZA200700865A patent/ZA200700865B/xx unknown
- 2005-06-29 CN CN2005800215619A patent/CN1976923B/zh not_active Expired - Fee Related
- 2005-06-29 ES ES05760736T patent/ES2323319T3/es not_active Expired - Lifetime
- 2005-06-29 KR KR1020077000063A patent/KR101290035B1/ko not_active Expired - Fee Related
- 2005-06-29 JP JP2007519776A patent/JP5575366B2/ja not_active Expired - Fee Related
- 2005-06-29 DK DK05760736T patent/DK1765807T3/da active
- 2005-06-29 AU AU2005259205A patent/AU2005259205B2/en not_active Ceased
- 2005-06-29 US US11/571,564 patent/US7902370B2/en not_active Expired - Fee Related
- 2005-06-29 PT PT05760736T patent/PT1765807E/pt unknown
- 2005-06-29 MX MXPA06014736A patent/MXPA06014736A/es active IP Right Grant
- 2005-06-29 WO PCT/EP2005/053062 patent/WO2006003163A1/en not_active Ceased
- 2005-06-29 NZ NZ552458A patent/NZ552458A/en not_active IP Right Cessation
-
2007
- 2007-02-02 NO NO20070635A patent/NO20070635L/no not_active Application Discontinuation
-
2009
- 2009-04-29 CY CY20091100473T patent/CY1109048T1/el unknown
-
2014
- 2014-04-22 JP JP2014088458A patent/JP2014169302A/ja active Pending
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