JP2008501656A5 - - Google Patents
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- Publication number
- JP2008501656A5 JP2008501656A5 JP2007513821A JP2007513821A JP2008501656A5 JP 2008501656 A5 JP2008501656 A5 JP 2008501656A5 JP 2007513821 A JP2007513821 A JP 2007513821A JP 2007513821 A JP2007513821 A JP 2007513821A JP 2008501656 A5 JP2008501656 A5 JP 2008501656A5
- Authority
- JP
- Japan
- Prior art keywords
- reuptake inhibitor
- monoamine neurotransmitter
- neurotransmitter reuptake
- inhibitor according
- amyloidosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003112 inhibitor Substances 0.000 claims 12
- 230000001561 neurotransmitter reuptake Effects 0.000 claims 11
- 206010002022 amyloidosis Diseases 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000007505 plaque formation Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLRPYZSEQKXZAA-OCAPTIKFSA-N tropane Chemical group C1CC[C@H]2CC[C@@H]1N2C XLRPYZSEQKXZAA-OCAPTIKFSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000031124 Dementia Alzheimer type Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000007507 senile plaque formation Effects 0.000 claims 1
- 208000022288 senile plaque formation Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04013242 | 2004-06-04 | ||
| PCT/EP2005/005748 WO2005117874A1 (en) | 2004-06-04 | 2005-05-28 | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008501656A JP2008501656A (ja) | 2008-01-24 |
| JP2008501656A5 true JP2008501656A5 (enExample) | 2008-06-19 |
Family
ID=34925256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007513821A Abandoned JP2008501656A (ja) | 2004-06-04 | 2005-05-28 | β−アミロイド（Ａβ４０及びＡβ４２）生成阻害のためのモノアミン神経伝達物質再取り込み阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20050277664A1 (enExample) |
| EP (1) | EP1755602A1 (enExample) |
| JP (1) | JP2008501656A (enExample) |
| WO (1) | WO2005117874A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE519486T1 (de) * | 2003-10-16 | 2011-08-15 | Neurosearch As | Pharmazeutische zusammensetzung mit einem monoamin-neurotransmitter-wiederaufnahmehemmer und einem acetylcholinesterase-hemmer |
| CA2554617A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| WO2005070427A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| WO2007028769A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for neuroprotection |
| GB2447191B (en) | 2005-12-22 | 2011-08-03 | Es Cell Int Pte Ltd | Direct differentiation of cardiomyocytes from human embryonic stem cells |
| JP7132218B2 (ja) * | 2016-11-08 | 2022-09-06 | エフ．ホフマン－ラ ロシュ アーゲー | フェノキシトリアゾール |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2957693A (en) * | 1956-12-03 | 1960-10-25 | Arthur C Ross | Electrical robot dueler |
| US4934937A (en) * | 1988-12-14 | 1990-06-19 | Tommy Judd | Combat training system and apparatus |
| US5320358A (en) * | 1993-04-27 | 1994-06-14 | Rpb, Inc. | Shooting game having programmable targets and course for use therewith |
| US5599187A (en) * | 1994-12-21 | 1997-02-04 | Mesiano; Dominick N. | Firearm use training device and method |
| US5676548A (en) * | 1995-11-21 | 1997-10-14 | Mcalpin; Jim L. | Apparatus for target practice |
| ZA971525B (en) * | 1996-02-22 | 1997-10-21 | Neurosearch As | Tropane derivatives, their preparation and use. |
| US20040106643A1 (en) * | 2001-05-23 | 2004-06-03 | Gouliaev Alex Haarh | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US7250425B2 (en) * | 2003-02-12 | 2007-07-31 | Neurosearch A/S | 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| ATE519486T1 (de) * | 2003-10-16 | 2011-08-15 | Neurosearch As | Pharmazeutische zusammensetzung mit einem monoamin-neurotransmitter-wiederaufnahmehemmer und einem acetylcholinesterase-hemmer |
| CA2554617A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| WO2005070428A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist |
-
2005
- 2005-05-28 WO PCT/EP2005/005748 patent/WO2005117874A1/en not_active Ceased
- 2005-05-28 EP EP05754244A patent/EP1755602A1/en not_active Withdrawn
- 2005-05-28 JP JP2007513821A patent/JP2008501656A/ja not_active Abandoned
- 2005-06-03 US US11/144,481 patent/US20050277664A1/en not_active Abandoned