JP2008500391A5 - - Google Patents
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- JP2008500391A5 JP2008500391A5 JP2007527494A JP2007527494A JP2008500391A5 JP 2008500391 A5 JP2008500391 A5 JP 2008500391A5 JP 2007527494 A JP2007527494 A JP 2007527494A JP 2007527494 A JP2007527494 A JP 2007527494A JP 2008500391 A5 JP2008500391 A5 JP 2008500391A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- moiety
- branched
- unbranched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *[C@]([C@](*)(C(*)(*)[C@]([C@](*)(C(*)(CCCC1)C1(*)C1=O)I)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound *[C@]([C@](*)(C(*)(*)[C@]([C@](*)(C(*)(CCCC1)C1(*)C1=O)I)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O 0.000 description 62
- CVQUWLDCFXOXEN-UHFFFAOYSA-N O=C1C=COC=C1 Chemical compound O=C1C=COC=C1 CVQUWLDCFXOXEN-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 5
- GCNTZFIIOFTKIY-UHFFFAOYSA-N Oc1ccncc1 Chemical compound Oc1ccncc1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 description 4
- FVDHISZJWKGJBG-UHFFFAOYSA-N C1=CN=[I]C=N1 Chemical compound C1=CN=[I]C=N1 FVDHISZJWKGJBG-UHFFFAOYSA-N 0.000 description 3
- GSQFIZQPEKLFBK-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2cccc(O)c22)C3)C(O)=C1C2=O)=O)=C3O)=O Chemical compound NC(C(C(C(C(CC1Cc2cccc(O)c22)C3)C(O)=C1C2=O)=O)=C3O)=O GSQFIZQPEKLFBK-UHFFFAOYSA-N 0.000 description 2
- ZXFCRFYULUUSDW-OWXODZSWSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2cccc(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2cccc(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O ZXFCRFYULUUSDW-OWXODZSWSA-N 0.000 description 2
- CADMLLAWKHABIJ-UXSWERMXSA-N N[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound N[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O CADMLLAWKHABIJ-UXSWERMXSA-N 0.000 description 2
- UBQKCCHYAOITMY-UHFFFAOYSA-N O=C1NC=CC=C1 Chemical compound O=C1NC=CC=C1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 2
- QGEQTBNMGHWHBJ-UHFFFAOYSA-N O=C1NCC=CC=C1 Chemical compound O=C1NCC=CC=C1 QGEQTBNMGHWHBJ-UHFFFAOYSA-N 0.000 description 2
- QTJMEGVCSPTQDY-HZDAAVBUSA-N C/C=C/S/C=C\N Chemical compound C/C=C/S/C=C\N QTJMEGVCSPTQDY-HZDAAVBUSA-N 0.000 description 1
- ZWVVGYSAWRURPJ-DNVGVPOPSA-N C=C/C=C\C=C(/N)\O Chemical compound C=C/C=C\C=C(/N)\O ZWVVGYSAWRURPJ-DNVGVPOPSA-N 0.000 description 1
- HLPIHRDZBHXTFJ-UHFFFAOYSA-N CCc1ccc[o]1 Chemical compound CCc1ccc[o]1 HLPIHRDZBHXTFJ-UHFFFAOYSA-N 0.000 description 1
- LNPCVMAMMOWWNA-JCWFFFCVSA-N CN(C)[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound CN(C)[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O LNPCVMAMMOWWNA-JCWFFFCVSA-N 0.000 description 1
- AGICWGYTRZOXTK-RISOHXOYSA-N CN(C)[C@@H]([C@H](CC=CC1=O)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound CN(C)[C@@H]([C@H](CC=CC1=O)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O AGICWGYTRZOXTK-RISOHXOYSA-N 0.000 description 1
- VAJQQYNAZZDPSF-ILBVQXBRSA-N CN(C)[C@@H]([C@H](C[C@@H](C1=C2O)Nc3cccc(O)c3C1=O)[C@]21O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@@H](C1=C2O)Nc3cccc(O)c3C1=O)[C@]21O)C(O)=C(C(N)=O)C1=O VAJQQYNAZZDPSF-ILBVQXBRSA-N 0.000 description 1
- PNEIPZRZIYUCAJ-PHQPAESFSA-N CN(C)[C@@H]([C@H](C[C@H](Cc(cc(cc1O)N(C)C)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H](Cc(cc(cc1O)N(C)C)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O PNEIPZRZIYUCAJ-PHQPAESFSA-N 0.000 description 1
- YLDDJDHRUCEIPV-WZDYVRJHSA-N CN(C)[C@@H]([C@H](C[C@H](Cc1cc(cccc2)c2c(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(Nc(cc2)cc3c2cc(C[C@@H]([C@@H]([C@@H]([C@@H](C(O)=C(C(N)=O)C2=O)N(C)C)[C@@]22O)O)C(C4=O)=C2O)c4c3O)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H](Cc1cc(cccc2)c2c(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(Nc(cc2)cc3c2cc(C[C@@H]([C@@H]([C@@H]([C@@H](C(O)=C(C(N)=O)C2=O)N(C)C)[C@@]22O)O)C(C4=O)=C2O)c4c3O)=O)C1=O YLDDJDHRUCEIPV-WZDYVRJHSA-N 0.000 description 1
- UGDVSQPADGAASW-YLJJCILVSA-N CN(C)[C@@H]([C@H](C[C@H]([C@@H](C=C)c1cccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@@H](C=C)c1cccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O UGDVSQPADGAASW-YLJJCILVSA-N 0.000 description 1
- HMNIESCBNPRAGK-KREUMBAPSA-N CN(C)[C@@H]([C@H](C[C@H]([C@@H](Cc1ccccc1)c(cccc1O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@@H](Cc1ccccc1)c(cccc1O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O HMNIESCBNPRAGK-KREUMBAPSA-N 0.000 description 1
- VPSYZTXEIWRROQ-IZULZFRASA-N CN(C)[C@@H]([C@H](C[C@H]([C@H](c1cccc(O)c1C1=O)N)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@H](c1cccc(O)c1C1=O)N)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O VPSYZTXEIWRROQ-IZULZFRASA-N 0.000 description 1
- HXEHTAQRKPBRKA-PYCKEEFSSA-N CN(C)[C@@H]([C@H]([C@H]([C@@H](C1=C2O)Nc3cccc(O)c3C1=O)O)[C@]21O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@@H](C1=C2O)Nc3cccc(O)c3C1=O)O)[C@]21O)C(O)=C(C(N)=O)C1=O HXEHTAQRKPBRKA-PYCKEEFSSA-N 0.000 description 1
- HFANKLFGBAEFCU-LNRRCFIDSA-N CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(c(N(C)C)ccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(c(N(C)C)ccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O HFANKLFGBAEFCU-LNRRCFIDSA-N 0.000 description 1
- WTEHJBKCQZLJQY-KHKNGSCWSA-N CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(cccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(cccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O WTEHJBKCQZLJQY-KHKNGSCWSA-N 0.000 description 1
- AMAIXBQOAQTXQV-WNBBPZJKSA-N C[C@@](C1)([C@@]1(C[C@@H]([C@@H](C(O)=C(C(N)=O)C1=O)N(C)C)[C@@]11O)C2=C1O)c1cccc(O)c1C2=O Chemical compound C[C@@](C1)([C@@]1(C[C@@H]([C@@H](C(O)=C(C(N)=O)C1=O)N(C)C)[C@@]11O)C2=C1O)c1cccc(O)c1C2=O AMAIXBQOAQTXQV-WNBBPZJKSA-N 0.000 description 1
- KWMSNSRQDXXQIO-REDYYMJGSA-N N/C(/O)=C\C=C/C=[IH] Chemical compound N/C(/O)=C\C=C/C=[IH] KWMSNSRQDXXQIO-REDYYMJGSA-N 0.000 description 1
- BVUCSUXMIMMGLO-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2c3[nH]cc2)C2)C(O)=C1C3=O)=O)=C2O)=O Chemical compound NC(C(C(C(C(CC1Cc2c3[nH]cc2)C2)C(O)=C1C3=O)=O)=C2O)=O BVUCSUXMIMMGLO-UHFFFAOYSA-N 0.000 description 1
- BYSOXTSLPHTBAL-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2c3[nH]cn2)C2)C(O)=C1C3=O)=O)=C2O)=O Chemical compound NC(C(C(C(C(CC1Cc2c3[nH]cn2)C2)C(O)=C1C3=O)=O)=C2O)=O BYSOXTSLPHTBAL-UHFFFAOYSA-N 0.000 description 1
- QMXZMGVLLYUITI-GANBNBROSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2c3c(O)c4ncccc4c2)C2)(C(O)=C1C3=O)O)=O)=C2O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2c3c(O)c4ncccc4c2)C2)(C(O)=C1C3=O)O)=O)=C2O)=O QMXZMGVLLYUITI-GANBNBROSA-N 0.000 description 1
- FSFVYRPQKBDXJN-LYSPQLLHSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2cc3cccc(O)c3c(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2cc3cccc(O)c3c(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O FSFVYRPQKBDXJN-LYSPQLLHSA-N 0.000 description 1
- ZPSJGADGUYYRKE-UHFFFAOYSA-N O=C1OC=CC=C1 Chemical compound O=C1OC=CC=C1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 description 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N c1nc(cccc2)c2[s]1 Chemical compound c1nc(cccc2)c2[s]1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57362304P | 2004-05-21 | 2004-05-21 | |
| US60/573,623 | 2004-05-21 | ||
| US66094705P | 2005-03-11 | 2005-03-11 | |
| US60/660,947 | 2005-03-11 | ||
| PCT/US2005/017831 WO2005112945A2 (en) | 2004-05-21 | 2005-05-20 | Synthesis of tetracyclines and analogues thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011119770A Division JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008500391A JP2008500391A (ja) | 2008-01-10 |
| JP2008500391A5 true JP2008500391A5 (enExample) | 2008-07-10 |
| JP5242161B2 JP5242161B2 (ja) | 2013-07-24 |
Family
ID=35428840
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527494A Expired - Lifetime JP5242161B2 (ja) | 2004-05-21 | 2005-05-20 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2011119770A Expired - Lifetime JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2013164980A Withdrawn JP2013227346A (ja) | 2004-05-21 | 2013-08-08 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2015168496A Expired - Lifetime JP6185966B2 (ja) | 2004-05-21 | 2015-08-28 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2016243003A Pending JP2017052797A (ja) | 2004-05-21 | 2016-12-15 | テトラサイクリンおよびそれらの類似物の合成 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011119770A Expired - Lifetime JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2013164980A Withdrawn JP2013227346A (ja) | 2004-05-21 | 2013-08-08 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2015168496A Expired - Lifetime JP6185966B2 (ja) | 2004-05-21 | 2015-08-28 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2016243003A Pending JP2017052797A (ja) | 2004-05-21 | 2016-12-15 | テトラサイクリンおよびそれらの類似物の合成 |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US7807842B2 (enExample) |
| EP (2) | EP1753713B1 (enExample) |
| JP (5) | JP5242161B2 (enExample) |
| KR (2) | KR101171408B1 (enExample) |
| CN (3) | CN101027279B (enExample) |
| AU (1) | AU2005244988C1 (enExample) |
| BR (2) | BRPI0510113B1 (enExample) |
| CA (3) | CA2892332C (enExample) |
| CY (1) | CY1118519T1 (enExample) |
| DK (1) | DK1753713T3 (enExample) |
| ES (1) | ES2607453T3 (enExample) |
| HU (1) | HUE030212T2 (enExample) |
| IL (5) | IL179467A (enExample) |
| LT (1) | LT1753713T (enExample) |
| PL (1) | PL1753713T3 (enExample) |
| PT (1) | PT1753713T (enExample) |
| SG (1) | SG10201810312UA (enExample) |
| SI (1) | SI1753713T1 (enExample) |
| WO (1) | WO2005112945A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| EP1381372A2 (en) | 2001-03-14 | 2004-01-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| WO2003055441A2 (en) * | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
| EA201000491A1 (ru) * | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
| EA012136B1 (ru) * | 2002-07-12 | 2009-08-28 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
| EP1648859B1 (en) | 2003-07-09 | 2013-02-27 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| CN101027279B (zh) | 2004-05-21 | 2013-03-27 | 哈佛大学校长及研究员协会 | 四环素及其类似物的合成 |
| CA2585418A1 (en) * | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP2284152A3 (en) | 2004-10-25 | 2011-10-05 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1848685A1 (en) | 2005-02-04 | 2007-10-31 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| AU2006272698B2 (en) * | 2005-07-21 | 2012-11-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| AU2007235279B2 (en) * | 2006-04-07 | 2012-12-06 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| US8440646B1 (en) * | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| US7763735B2 (en) * | 2006-10-11 | 2010-07-27 | President And Fellows Of Harvard College | Synthesis of enone intermediate |
| ES2548261T3 (es) * | 2006-12-21 | 2015-10-15 | Paratek Pharmaceuticals, Inc. | Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias |
| US20080305186A1 (en) * | 2007-06-11 | 2008-12-11 | Board Of Regents, The University Of Texas System | Method and Composition for the Treatment of Cardiac Hypertrophy |
| DE102008028334B4 (de) * | 2008-06-13 | 2014-02-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Probenkammer-Adapter für die Kryokonservierung biologischer Proben |
| CA2730377C (en) | 2008-07-11 | 2017-09-19 | Neumedics | Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits |
| ES2655911T3 (es) | 2008-08-08 | 2018-02-22 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina sustituidos con C7-fluoro |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| WO2010129055A1 (en) * | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | 8-aza tetracycline compounds |
| ES2627772T3 (es) | 2009-05-08 | 2017-07-31 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina |
| WO2010132670A2 (en) * | 2009-05-13 | 2010-11-18 | Tetraphase Pharmaceuticals, Inc. | Pentacycline compounds |
| JP5944825B2 (ja) | 2009-08-28 | 2016-07-05 | テトラフェース ファーマシューティカルズ，インコーポレイテッド | テトラサイクリン化合物 |
| JP5820462B2 (ja) * | 2010-03-31 | 2015-11-24 | テトラフェース ファーマシューティカルズ，インコーポレイテッド | 多環式テトラサイクリン化合物 |
| WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
| CN102675145B (zh) * | 2012-04-27 | 2013-10-16 | 山东恩康药业有限公司 | 一种愈创木酚磺酸多西环素的制备方法 |
| CN103387511B (zh) * | 2012-05-08 | 2016-12-28 | 成都睿智化学研究有限公司 | 一种山环素的制备方法 |
| BR112015004523B1 (pt) * | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| CN103044281A (zh) * | 2013-01-02 | 2013-04-17 | 湖南赛隆药业有限公司 | 高纯度替加环素的制法 |
| TW201615195A (zh) * | 2014-10-24 | 2016-05-01 | 朗齊生物醫學股份有限公司 | 阿那格雷藥物應用於癌症治療 |
| HUE055500T2 (hu) * | 2015-03-09 | 2021-11-29 | Sinai Health Sys | Eszközök és módszerek a sejtdivíciós loci használatára a sejtek szaporodásának szabályozására |
| KR20170134514A (ko) | 2015-03-23 | 2017-12-06 | 바이오팜엑스 인코포레이티드 | 피부과 사용을 위한 약학 테트라사이클린 조성물 |
| CN107188875B (zh) * | 2016-03-15 | 2020-11-10 | 联化科技股份有限公司 | 一种取代苯酞类化合物的制备方法及其中间体 |
| ES2978198T3 (es) | 2016-10-19 | 2024-09-06 | Tetraphase Pharmaceuticals Inc | Formas cristalinas de eravaciclina |
| WO2019241466A1 (en) | 2018-06-13 | 2019-12-19 | Texas Tech University System | Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes |
| GB201914847D0 (en) * | 2019-10-14 | 2019-11-27 | Helperby Therapeutics Ltd | Combination |
| CN112979666A (zh) * | 2019-12-18 | 2021-06-18 | 中国科学院生态环境研究中心 | 土霉素衍生物、制备方法及其检测方法 |
| CN115340446B (zh) * | 2021-05-12 | 2024-04-19 | 复旦大学 | 一种手性苯并环丁烯醇、其合成方法及用途 |
| CN113388556B (zh) * | 2021-08-02 | 2022-12-02 | 金河生物科技股份有限公司 | 利用金色链霉菌生产金霉素的方法 |
| CN113929593B (zh) * | 2021-09-02 | 2024-05-31 | 河北圣雪大成唐山制药有限责任公司 | 一种土霉素-2,5-二羟基苯甲酸共晶及其制备方法 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2482055A (en) | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
| GB935384A (en) * | 1959-03-30 | 1963-08-28 | Pfizer & Co C | Tetracycline derivatives and preparation thereof |
| US3019260A (en) * | 1959-05-13 | 1962-01-30 | American Cyanamid Co | Process for the catalytic reduction of 6-hydroxy hydronaphthacenes |
| US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| US3219671A (en) * | 1961-04-14 | 1965-11-23 | American Cyanamid Co | Substituted 6-deoxytetracyclines and 6-demethyl-6-deoxytetracyclines |
| FR1365279A (fr) | 1961-08-18 | 1964-07-03 | Pfizer & Co C | Dérivés d'octahydroanthracènes, et procédé pour leur préparation |
| US3697552A (en) * | 1961-08-18 | 1972-10-10 | Pfizer | Anthracyclidine-acetic acid derivatives |
| GB973022A (en) | 1961-08-18 | 1964-10-21 | Pfizer & Co C | New acetyl malonamates |
| US3772363A (en) * | 1961-08-18 | 1973-11-13 | Pfizer | 3,4,10-trioxo octahydroanthracene-2-aminoacetic acids and derivatives thereof |
| US3829453A (en) * | 1961-08-18 | 1974-08-13 | Pfizer | Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof |
| US3862225A (en) * | 1961-08-18 | 1975-01-21 | Pfizer | D-ring substituted tetracyclines |
| US3509184A (en) * | 1961-08-18 | 1970-04-28 | Pfizer & Co C | Anthracyclidine-acetic acid derivatives |
| US3109007A (en) * | 1962-10-02 | 1963-10-29 | Pfizer & Co C | Derivatives of tetracycline and its analogs |
| USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| GB1100884A (en) | 1965-03-15 | 1968-01-24 | Pfizer & Co C | Oxytetracycline esters and preparation thereof |
| GB1077598A (en) * | 1965-05-12 | 1967-08-02 | Pfizer & Co C | Preparation of n-demethyl tetracyclines |
| US3849493A (en) | 1966-08-01 | 1974-11-19 | Pfizer | D-ring substituted 6-deoxytetracyclines |
| US3502660A (en) * | 1967-01-12 | 1970-03-24 | Pfizer & Co C | 2-((5'-(3' and/or 4'-substituted)isoxazoyl) methylidene)-3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes |
| US4066694A (en) * | 1971-02-09 | 1978-01-03 | Pfizer Inc. | 4-hydroxy-4-dedimethylamino-tetracyclines |
| US4052467A (en) * | 1967-11-08 | 1977-10-04 | Phillips Petroleum Company | Catalytic reduction of aldehydes to alcohols |
| US3914299A (en) | 1969-06-12 | 1975-10-21 | Research Corp | Tetracyclines |
| US3947517A (en) * | 1969-06-12 | 1976-03-30 | Research Corporation | Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines |
| US3699117A (en) * | 1969-07-29 | 1972-10-17 | Pfizer | 2-((5'-(3'-and/or 4'-substituted) isoxazolyl) aminoethyl) - 3,4,10 - trioxo-1,2,3,4,4,9,9,10-octahydroanthracenes and related compounds |
| BE788479A (fr) * | 1971-09-06 | 1973-01-02 | Medimpex Gyogyszerkulkereskede | Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques |
| US4060605A (en) * | 1973-09-28 | 1977-11-29 | Ankerfarm, S.P.A. | Water-soluble derivative of 6-deoxy-tetracyclines |
| US3962330A (en) * | 1973-09-28 | 1976-06-08 | Ankerfarm, S.P.A. | Process for the preparation of 6-demethyl-6-deoxy-6-methylene-tetracyclines |
| DE2355118A1 (de) * | 1973-11-03 | 1975-05-28 | Hoechst Ag | 2-carboxamido-substituierte tetracycline und verfahren zu ihrer herstellung |
| DE2527568A1 (de) * | 1974-06-25 | 1976-01-15 | Farmaceutici Italia | Verfahren zur herstellung von alkyltetracyclinen und neue tetracyclinderivate |
| US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| DK386784A (da) * | 1983-08-17 | 1985-02-18 | Hovione Int Ltd | Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner |
| ES2168254T3 (es) | 1991-10-04 | 2002-06-16 | American Cyanamid Co | Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas. |
| US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US5420272A (en) | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| SG47520A1 (en) | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5362754A (en) * | 1992-11-12 | 1994-11-08 | Univ. Of Tx Md Anderson Cancer Center | M-EDTA pharmaceutical preparations and uses thereof |
| US5688516A (en) * | 1992-11-12 | 1997-11-18 | Board Of Regents, The University Of Texas System | Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices |
| US5538954A (en) * | 1994-06-24 | 1996-07-23 | A/S Dumex (Dumex Ltd.) | Salts of tetracyclines |
| US5834450A (en) * | 1994-02-17 | 1998-11-10 | Pfizer Inc. | 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| US5574026A (en) | 1994-12-13 | 1996-11-12 | American Cyanamid Company | Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth |
| US6165999A (en) * | 1995-05-03 | 2000-12-26 | Pfizer Inc | Tetracycline derivatives |
| WO1996036229A1 (en) | 1995-05-17 | 1996-11-21 | E.I. Du Pont De Nemours And Company | Fungicidal cyclic amides |
| US6165484A (en) * | 1997-08-26 | 2000-12-26 | Wake Forest University | EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections |
| PT102160B (pt) * | 1998-05-26 | 2001-04-30 | Hovione Sociedade Quimica S A | Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| US6581606B2 (en) | 1999-07-06 | 2003-06-24 | The Rx Files Corporation | Method, apparatus and system for use in treating patient with a drug having an antineoplastic effect to optimize therapy and prevent an adverse drug response |
| US6849615B2 (en) * | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| PT1240133E (pt) * | 1999-09-14 | 2006-07-31 | Tufts College | Processos para preparar tetraciclinas substituidas com quimicas baseadas em metais de transicao |
| US6638532B2 (en) * | 2000-02-24 | 2003-10-28 | Advancis Pharmaceutical Corp. | Tetracycline—doxycycline antibiotic composition |
| US6730320B2 (en) * | 2000-02-24 | 2004-05-04 | Advancis Pharmaceutical Corp. | Tetracycline antibiotic product, use and formulation thereof |
| DE60129116T2 (de) * | 2000-03-31 | 2008-03-13 | Trustees Of Tufts College, Medford | 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen |
| EP1286954B1 (en) * | 2000-05-15 | 2004-04-14 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
| AU2000254942A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20020128237A1 (en) * | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-N-substituted phenyl tetracycline compounds |
| WO2001098260A1 (en) | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-n-substituted phenyl tetracycline compounds |
| AU2001268475A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| MXPA03000055A (es) * | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de monociclina sustituidos en posicion 9.. |
| DE60144375D1 (de) * | 2000-07-07 | 2011-05-19 | Trustees Of Tufts College Medford | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
| WO2002012170A1 (en) | 2000-08-04 | 2002-02-14 | Trustees Of Tufts College | 8-substituted tetracycline compounds |
| KR100997596B1 (ko) * | 2000-07-07 | 2010-11-30 | 파라테크 파마슈티컬스, 인크. | 7-치환 테트라사이클린 화합물 |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| EP2298732A1 (en) * | 2001-03-13 | 2011-03-23 | Paratek Pharmaceuticals, Inc. | 7,9-Substituted tetracycline compounds |
| EP1241160A1 (en) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| US6841546B2 (en) * | 2001-03-14 | 2005-01-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
| EP1381372A2 (en) * | 2001-03-14 | 2004-01-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| US20040092490A1 (en) * | 2001-04-24 | 2004-05-13 | Michael Draper | Substituted tetracycline compounds for the treatment of malaria |
| EP2332546A1 (en) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of stroke |
| RU2300380C2 (ru) * | 2001-10-05 | 2007-06-10 | Тетрадженекс Фармасьютикалс, Инк. | Производные тетрациклина и способы их применения |
| EP2311797A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| ES2555307T3 (es) | 2002-03-08 | 2015-12-30 | Eisai R&D Management Co., Ltd. | Compuestos macrocíclicos útiles como agentes farmacéuticos |
| JP2006503898A (ja) * | 2002-10-24 | 2006-02-02 | パラテック ファーマシューティカルズ， インク． | マラリア治療のための置換テトラサイクリン化合物 |
| WO2004064728A2 (en) * | 2003-01-16 | 2004-08-05 | Paratek Pharmaceuticals, Inc. | Use of specific tetracycline compounds in therapy |
| WO2005030149A2 (en) * | 2003-09-26 | 2005-04-07 | The Johns Hopkins University | Suppression of hiv replication for prevention and treatment of hiv |
| UA83266C2 (en) * | 2003-12-08 | 2008-06-25 | Уайет | Oxazole derivatives of tetracyclines |
| DE102004024674A1 (de) | 2004-05-18 | 2005-12-15 | Wolfgang Lorenz | Mittel und Verfahren zur Diagnose, Prophylaxe und Therapie von Bindegewebserkrankungen |
| CN101027279B (zh) | 2004-05-21 | 2013-03-27 | 哈佛大学校长及研究员协会 | 四环素及其类似物的合成 |
| RU2006138907A (ru) * | 2004-06-08 | 2008-07-20 | Метабазис Терапеутикс | Синтез сложных циклических эфиров с применением кислоты льюиса |
| US7327803B2 (en) * | 2004-10-22 | 2008-02-05 | Parkervision, Inc. | Systems and methods for vector power amplification |
| JP4857634B2 (ja) * | 2005-07-22 | 2012-01-18 | 三菱瓦斯化学株式会社 | ポリアミド樹脂 |
| WO2007067807A1 (en) | 2005-12-07 | 2007-06-14 | Alacrity Biosciences, Inc. | Tetracyclines for treating ocular diseases and disorders |
| CA2646244A1 (en) | 2006-03-27 | 2007-10-04 | Government Of The United States Of Americas, As Represented By The Secre | Tetracycline compounds and methods of treatment |
| WO2007118237A2 (en) | 2006-04-07 | 2007-10-18 | President And Fellows Of Harvard College | Nano-scale gas separation device utilizing thin film structures for hydrogen production |
| AU2007235279B2 (en) | 2006-04-07 | 2012-12-06 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| US7763735B2 (en) * | 2006-10-11 | 2010-07-27 | President And Fellows Of Harvard College | Synthesis of enone intermediate |
| CN101684101B (zh) | 2008-09-16 | 2011-11-09 | 山东轩竹医药科技有限公司 | 哌嗪酮取代的四环素衍生物 |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
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