JP2008115113A - 乳化剤形の皮膚外用剤 - Google Patents
乳化剤形の皮膚外用剤 Download PDFInfo
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- JP2008115113A JP2008115113A JP2006299875A JP2006299875A JP2008115113A JP 2008115113 A JP2008115113 A JP 2008115113A JP 2006299875 A JP2006299875 A JP 2006299875A JP 2006299875 A JP2006299875 A JP 2006299875A JP 2008115113 A JP2008115113 A JP 2008115113A
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- JP
- Japan
- Prior art keywords
- alkyl
- emulsifier
- mass
- extract
- carboxyvinyl polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000000839 emulsion Substances 0.000 title abstract description 15
- 239000002552 dosage form Substances 0.000 title abstract 3
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 32
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 20
- XSEOYPMPHHCUBN-FGYWBSQSSA-N hydroxylated lecithin Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCC[C@@H](O)[C@H](O)CCCCCCCC XSEOYPMPHHCUBN-FGYWBSQSSA-N 0.000 claims abstract description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 18
- 239000002736 nonionic surfactant Substances 0.000 claims description 5
- 239000002537 cosmetic Substances 0.000 abstract description 13
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- 230000001804 emulsifying effect Effects 0.000 abstract 1
- -1 alkyl methacrylate Chemical compound 0.000 description 28
- 239000000284 extract Substances 0.000 description 25
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 12
- 239000004094 surface-active agent Substances 0.000 description 12
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical class C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 7
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- 230000000694 effects Effects 0.000 description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 7
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
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- 241000237536 Mytilus edulis Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000004945 emulsification Methods 0.000 description 4
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- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
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- 239000000843 powder Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
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- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 3
- 229920001214 Polysorbate 60 Polymers 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 229960003720 enoxolone Drugs 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
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- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- OOHKTNVQRTUZRS-GFCCVEGCSA-N C1=CC(OC)=CC=C1C[C@H]1C(=O)C2=C(O)C(C)=C(O)C=C2OC1 Chemical compound C1=CC(OC)=CC=C1C[C@H]1C(=O)C2=C(O)C(C)=C(O)C=C2OC1 OOHKTNVQRTUZRS-GFCCVEGCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- 244000068988 Glycine max Species 0.000 description 2
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- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
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- 241000546188 Hypericum Species 0.000 description 2
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- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 2
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- 125000002252 acyl group Chemical group 0.000 description 2
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| JP2009013100A (ja) * | 2007-07-04 | 2009-01-22 | Pola Chem Ind Inc | 水中油乳化剤形の皮膚外用剤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0623256A (ja) * | 1992-06-29 | 1994-02-01 | Nikko Kemikaruzu Kk | レシチンを利用した乳化剤及びｏ／ｗ型エマルション |
| JP2001328917A (ja) * | 2000-05-22 | 2001-11-27 | Nonogawa Shoji Kk | 乳化化粧料 |
| JP2002068922A (ja) * | 2000-08-23 | 2002-03-08 | Nonogawa Shoji Kk | 液状乳化化粧料 |
| JP2003238380A (ja) * | 2002-02-12 | 2003-08-27 | Nikko Chemical Co Ltd | 化粧料 |
| JP2005008591A (ja) * | 2003-06-20 | 2005-01-13 | Pola Chem Ind Inc | 乳化・可溶化皮膚外用剤 |
| JP2006036715A (ja) * | 2004-07-29 | 2006-02-09 | Pola Chem Ind Inc | 局所用の皮膚外用剤 |
| JP2006036716A (ja) * | 2004-07-29 | 2006-02-09 | Pola Chem Ind Inc | シワ改善、予防用の皮膚外用剤 |
| JP2006328024A (ja) * | 2005-05-30 | 2006-12-07 | Seiren Co Ltd | 皮膚用外用剤 |
-
2006
- 2006-11-06 JP JP2006299875A patent/JP2008115113A/ja active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0623256A (ja) * | 1992-06-29 | 1994-02-01 | Nikko Kemikaruzu Kk | レシチンを利用した乳化剤及びｏ／ｗ型エマルション |
| JP2001328917A (ja) * | 2000-05-22 | 2001-11-27 | Nonogawa Shoji Kk | 乳化化粧料 |
| JP2002068922A (ja) * | 2000-08-23 | 2002-03-08 | Nonogawa Shoji Kk | 液状乳化化粧料 |
| JP2003238380A (ja) * | 2002-02-12 | 2003-08-27 | Nikko Chemical Co Ltd | 化粧料 |
| JP2005008591A (ja) * | 2003-06-20 | 2005-01-13 | Pola Chem Ind Inc | 乳化・可溶化皮膚外用剤 |
| JP2006036715A (ja) * | 2004-07-29 | 2006-02-09 | Pola Chem Ind Inc | 局所用の皮膚外用剤 |
| JP2006036716A (ja) * | 2004-07-29 | 2006-02-09 | Pola Chem Ind Inc | シワ改善、予防用の皮膚外用剤 |
| JP2006328024A (ja) * | 2005-05-30 | 2006-12-07 | Seiren Co Ltd | 皮膚用外用剤 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009013100A (ja) * | 2007-07-04 | 2009-01-22 | Pola Chem Ind Inc | 水中油乳化剤形の皮膚外用剤 |
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