JP2008044952A5 - - Google Patents
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- JP2008044952A5 JP2008044952A5 JP2007241012A JP2007241012A JP2008044952A5 JP 2008044952 A5 JP2008044952 A5 JP 2008044952A5 JP 2007241012 A JP2007241012 A JP 2007241012A JP 2007241012 A JP2007241012 A JP 2007241012A JP 2008044952 A5 JP2008044952 A5 JP 2008044952A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- mono
- substituted
- halogen atom
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000005236 alkanoylamino group Chemical group 0.000 claims 2
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 claims 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- -1 nitrogen containing 5-membered heterocyclic compound Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Claims (2)
- 式（Ｉ）
［式中、ＸはＳ又はＯを表す。
Ｒ1はニトロ基、アミノ基、ヒドロキシル基、ホルミル基、カルバモイル基、シアノ基、カルボキシル基、低級アルコキシカルボニル基、ハロゲン原子、低級アルキル基、ヒドロキシ低級アルキル基、低級アルコキシ基、モノ若しくはジ低級アルキルアミノ基、モノ若しくはジ低級アルカノイルアミノ基、低級アルキルチオ基、低級アルキルスルホニル基、低級アルキルスルフィニル基、スルファモイル基及びモノ若しくはジ低級アルキルスルファモイル基から選ばれる少なくとも１つの基で置換されていてもよい複素環式基を表す。
Ｒ2は、カルボキシル基、又は低級アルコキシカルボニル基で置換されている低級アルキル基を表す。
Ｒ3はニトロ基、アミノ基、ヒドロキシル基、カルバモイル基、シアノ基、カルボキシル基、トリフルオロメチル基、低級アルコキシカルボニル基、ハロゲン原子、低級アルキル基、ヒドロキシ低級アルキル基、低級アルコキシ基、低級アルコキシ−低級アルコキシ基、モノ若しくはジ低級アルキルアミノ基、モノ若しくはジ低級アルカノイルアミノ基、低級アルキルチオ基、低級アルキルスルホニル基、低級アルキルスルフィニル基、スルファモイル基、モノ若しくはジ低級アルキルスルファモイル基、低級アルキルスルホニルアミノ基、及びフェニル低級アルコキシ基から選ばれる少なくとも１つの基で置換されていてもよいアリール基を表す。
］
で示される含窒素５員複素環化合物又はその薬理的に許容し得る塩。 - Ｒ1が、ハロゲン原子、及び、低級アルコキシ基から選ばれる少なくとも１つの基で置換されているチオフェニル基であり、
Ｒ2が、カルボキシメチルであり、
Ｒ3が、ハロゲン原子、及び、低級アルコキシ基から選ばれる少なくとも１つの基で置換されているフェニル基である請求項１記載の含窒素５員複素環化合物又はその薬理的に許容し得る塩。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007241012A JP2008044952A (ja) | 2001-04-16 | 2007-09-18 | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001116436 | 2001-04-16 | ||
| JP2001249671 | 2001-08-20 | ||
| JP2007241012A JP2008044952A (ja) | 2001-04-16 | 2007-09-18 | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580915A Division JP4073786B2 (ja) | 2001-04-16 | 2002-04-15 | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008044952A JP2008044952A (ja) | 2008-02-28 |
| JP2008044952A5 true JP2008044952A5 (ja) | 2008-06-26 |
Family
ID=26613619
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580915A Expired - Fee Related JP4073786B2 (ja) | 2001-04-16 | 2002-04-15 | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
| JP2007241012A Pending JP2008044952A (ja) | 2001-04-16 | 2007-09-18 | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580915A Expired - Fee Related JP4073786B2 (ja) | 2001-04-16 | 2002-04-15 | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7759373B2 (ja) |
| EP (1) | EP1432690A2 (ja) |
| JP (2) | JP4073786B2 (ja) |
| KR (1) | KR100863659B1 (ja) |
| CN (2) | CN101519386A (ja) |
| AR (1) | AR035828A1 (ja) |
| AU (1) | AU2002246397B2 (ja) |
| BR (1) | BR0208956A (ja) |
| CA (1) | CA2444596A1 (ja) |
| CZ (1) | CZ20032829A3 (ja) |
| HU (1) | HUP0303829A3 (ja) |
| IL (1) | IL158168A0 (ja) |
| MX (1) | MXPA03009440A (ja) |
| NZ (1) | NZ529043A (ja) |
| PL (1) | PL367325A1 (ja) |
| TW (2) | TW201006831A (ja) |
| WO (1) | WO2002083111A2 (ja) |
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| NL151519B (nl) | 1966-07-15 | 1976-11-15 | Oce Van Der Grinten Nv | Lichtgevoelig diazotypmateriaal, alsmede de daarin te gebruiken diazoverbindingen. |
| US3546342A (en) | 1966-11-18 | 1970-12-08 | Wyeth John & Brother Ltd | Method of relieving inflammation by administration of 2,4 - diarylthiazole- 5 - alkanoic acids and derivatives thereof |
| GB1145884A (en) | 1966-11-18 | 1969-03-19 | Wyeth John & Brother Ltd | Thiazole derivatives |
| FI53314C (fi) | 1967-06-14 | 1978-04-10 | Wyeth John & Brother Ltd | Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-(fenyleller p-klorfenyl) oxazol-4-yl (aettiksyra -acetatsalt eller -acetamid) |
| GB1245087A (en) * | 1967-10-26 | 1971-09-02 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| US3528107A (en) * | 1968-07-15 | 1970-09-15 | Harold Rosenbaum | Baseball glove |
| US3575991A (en) | 1969-03-11 | 1971-04-20 | American Home Prod | 1-(4-aryl - 5 - carboxymethyl-2-thiazolyl)-1,6-dihydro -6 - oxonicotinic acids and esters thereof |
| FR2096994A1 (en) | 1970-07-24 | 1972-03-03 | Roussel Uclaf | 2-para-cyclopropyl phenyl-4-(halo)phenyl-5-thiazolyl - alkanoic acids -antiinflammatory analgesic, antipyretic agents |
| FR2146575A5 (ja) | 1971-07-20 | 1973-03-02 | Labo Braglia Spa | |
| US4127863A (en) * | 1975-10-01 | 1978-11-28 | Tokyo Shibaura Electric Co., Ltd. | Gate turn-off type thyristor with separate semiconductor resistive wafer providing emitter ballast |
| GB1539450A (en) | 1976-06-08 | 1979-01-31 | Wyeth John & Brother Ltd | Thiazole derivatives |
| GB1574583A (en) | 1978-02-09 | 1980-09-10 | Wyeth John & Brother Ltd | Process for preparing thiazoles |
| ZA811691B (en) | 1980-04-03 | 1982-10-27 | Wyeth John & Brother Ltd | Thiazoles |
| GR74148B (ja) | 1980-04-03 | 1984-06-06 | Wyeth John & Brother Ltd | |
| JPS57188587A (en) * | 1981-05-15 | 1982-11-19 | Tanabe Seiyaku Co Ltd | Thienyloxazolylacetic acid derivative and its preparation |
| DE3128492A1 (de) | 1981-07-18 | 1983-02-03 | A. Nattermann & Cie GmbH, 5000 Köln | 4-chlorthienyl-5-thiazolalkancarbonsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3128453A1 (de) | 1981-07-18 | 1983-02-03 | A. Nattermann & Cie GmbH, 5000 Köln | 4-chlorthienyl-2-thienyl-4-thiazolalkancarbonsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| JPS58148882A (ja) * | 1982-02-26 | 1983-09-05 | Tanabe Seiyaku Co Ltd | フリルオキサゾリル酢酸誘導体及びその製法 |
| JPS58183676A (ja) | 1982-04-19 | 1983-10-26 | Takeda Chem Ind Ltd | オキサゾ−ル誘導体 |
| US4486436A (en) * | 1982-07-22 | 1984-12-04 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| JPS5936614A (ja) * | 1982-08-25 | 1984-02-28 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
| JPS59152382A (ja) * | 1983-02-18 | 1984-08-31 | Tanabe Seiyaku Co Ltd | フリルオキサゾリル酢酸誘導体 |
| JPS59172488A (ja) * | 1983-03-18 | 1984-09-29 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
| JPS60188371A (ja) | 1984-03-07 | 1985-09-25 | Tanabe Seiyaku Co Ltd | イミダゾール誘導体 |
| JPS60202820A (ja) * | 1984-03-27 | 1985-10-14 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
| DE3425118A1 (de) * | 1984-07-07 | 1986-01-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue redox-indikatoren |
| JPS61167676A (ja) * | 1985-01-21 | 1986-07-29 | Tanabe Seiyaku Co Ltd | アゾ−ル類化合物及びその製法 |
| JPS61167685A (ja) | 1985-01-21 | 1986-07-29 | Tanabe Seiyaku Co Ltd | テトラゾ−ル誘導体およびその製法 |
| GB8531608D0 (en) | 1985-12-23 | 1986-02-05 | Beecham Group Plc | Treatment |
| JPH03258770A (ja) * | 1990-03-08 | 1991-11-19 | Tanabe Seiyaku Co Ltd | ベンズアゾール誘導体、その製法及びその合成中間体 |
| JPH04117371A (ja) * | 1990-09-05 | 1992-04-17 | Otsuka Pharmaceut Factory Inc | チアゾール誘導体 |
| EP0489660B1 (fr) | 1990-12-06 | 1994-11-02 | Roussel-Uclaf | Utilisation de thiazolylalkoxy acrylates pour la fabrication de compositions insecticides et/ou acaricides |
| DE69224507T2 (de) | 1991-12-26 | 1998-08-20 | Mitsubishi Chem Corp | Beta-Oxo-Beta-Benzenepropanthioamidderivate |
| US5340826A (en) | 1993-02-04 | 1994-08-23 | Pfizer Inc. | Pharmaceutical agents for treatment of urinary incontinence |
| JPH07173141A (ja) | 1993-08-10 | 1995-07-11 | Nissan Chem Ind Ltd | 新規ピリミジン誘導体及び除草、植調剤 |
| JPH07291936A (ja) | 1994-03-01 | 1995-11-07 | Kyorin Pharmaceut Co Ltd | 新規イミダゾール誘導体及びその製造法 |
| EP0842923B1 (en) | 1995-06-07 | 2006-03-01 | Nippon Shinyaku Company, Limited | Pyrrole derivatives and medicinal composition |
| HUP9900424A2 (hu) * | 1996-01-22 | 1999-05-28 | Fujisawa Pharmaceutical Co., Ltd. | Tiazolil-benzfurán-származékok és a vegyületeket tartalmazó gyógyászati készítmények |
| US5677321A (en) * | 1996-02-29 | 1997-10-14 | Synaptic Pharmaceutical Corporation | 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands |
| PT891340E (pt) | 1996-04-03 | 2003-03-31 | Takeda Chemical Industries Ltd | Derivados de oxazol sua preparacao e utilizacao |
| TW467902B (en) | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
| US6121260A (en) | 1997-07-03 | 2000-09-19 | Neurogen Corporation | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives |
| GB9726989D0 (en) | 1997-12-22 | 1998-02-18 | Ciba Geigy Ag | Organic compounds |
| WO1999038510A1 (en) | 1998-01-29 | 1999-08-05 | Bristol-Myers Squibb Company | Derivatives of 1,3,4-oxadiazolone |
| US6248897B1 (en) | 1998-03-30 | 2001-06-19 | Japan Tobacco Inc. | Process for producing isoxazolidinedione compound |
-
2002
- 2002-04-15 AU AU2002246397A patent/AU2002246397B2/en not_active Ceased
- 2002-04-15 HU HU0303829A patent/HUP0303829A3/hu unknown
- 2002-04-15 CN CNA200910004656XA patent/CN101519386A/zh active Pending
- 2002-04-15 NZ NZ529043A patent/NZ529043A/en unknown
- 2002-04-15 WO PCT/JP2002/003723 patent/WO2002083111A2/en active IP Right Grant
- 2002-04-15 CN CNB028083709A patent/CN100540538C/zh not_active Expired - Fee Related
- 2002-04-15 CA CA002444596A patent/CA2444596A1/en not_active Abandoned
- 2002-04-15 CZ CZ20032829A patent/CZ20032829A3/cs unknown
- 2002-04-15 JP JP2002580915A patent/JP4073786B2/ja not_active Expired - Fee Related
- 2002-04-15 IL IL15816802A patent/IL158168A0/xx unknown
- 2002-04-15 EP EP02714577A patent/EP1432690A2/en not_active Withdrawn
- 2002-04-15 KR KR1020037013493A patent/KR100863659B1/ko not_active IP Right Cessation
- 2002-04-15 PL PL02367325A patent/PL367325A1/xx unknown
- 2002-04-15 BR BR0208956-4A patent/BR0208956A/pt not_active IP Right Cessation
- 2002-04-15 US US10/474,850 patent/US7759373B2/en not_active Expired - Fee Related
- 2002-04-16 AR ARP020101381A patent/AR035828A1/es unknown
- 2002-04-16 TW TW098138199A patent/TW201006831A/zh unknown
- 2002-04-16 TW TW091107687A patent/TWI322686B/zh not_active IP Right Cessation
-
2003
- 2003-10-15 MX MXPA03009440A patent/MXPA03009440A/es active IP Right Grant
-
2007
- 2007-09-18 JP JP2007241012A patent/JP2008044952A/ja active Pending
-
2010
- 2010-06-07 US US12/795,323 patent/US20100256165A1/en not_active Abandoned
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