JP2007538004A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007538004A5 JP2007538004A5 JP2007504171A JP2007504171A JP2007538004A5 JP 2007538004 A5 JP2007538004 A5 JP 2007538004A5 JP 2007504171 A JP2007504171 A JP 2007504171A JP 2007504171 A JP2007504171 A JP 2007504171A JP 2007538004 A5 JP2007538004 A5 JP 2007538004A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkyloxy
- hydrogen
- amino
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QOFQBGVDXIFFKM-UHFFFAOYSA-N 6-[(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethoxyphenyl)-1-methylquinolin-2-one Chemical compound CCOC1=CC=CC(C=2C3=CC(=CC=C3N(C)C(=O)C=2)C(O)(C=2N(C=NC=2)C)C=2C=CC(Cl)=CC=2)=C1 QOFQBGVDXIFFKM-UHFFFAOYSA-N 0.000 claims description 2
- PLHJCIYEEKOWNM-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one Chemical compound CN1C=NC=C1C(N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-UHFFFAOYSA-N 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 112
- 239000001257 hydrogen Substances 0.000 claims 46
- 229910052739 hydrogen Inorganic materials 0.000 claims 46
- 125000003545 alkoxy group Chemical group 0.000 claims 41
- 150000002431 hydrogen Chemical class 0.000 claims 32
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 22
- 125000005843 halogen group Chemical group 0.000 claims 19
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 18
- -1 4,4-dimethyloxazolyl Chemical group 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 8
- 150000003839 salts Chemical group 0.000 claims 8
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 7
- 229940124226 Farnesyltransferase inhibitor Drugs 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 claims 7
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 6
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 125000002883 imidazolyl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 125000004951 trihalomethoxy group Chemical group 0.000 claims 4
- 125000004953 trihalomethyl group Chemical group 0.000 claims 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 2
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims 2
- 208000001089 Multiple system atrophy Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 208000032859 Synucleinopathies Diseases 0.000 claims 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 2
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 229910052717 sulfur Chemical group 0.000 claims 2
- 239000011593 sulfur Chemical group 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- WOYOASASOHZEDR-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-[(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-1-methylquinolin-2-one Chemical compound CN1C=NC=C1C(O)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 WOYOASASOHZEDR-UHFFFAOYSA-N 0.000 claims 1
- ZMLMGCPNMBRTKN-UHFFFAOYSA-N 6-[(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-ethoxyphenyl)-1-methylquinolin-2-one;hydrate;hydrochloride Chemical compound O.Cl.CCOC1=CC=CC(C=2C3=CC(=CC=C3N(C)C(=O)C=2)C(C=2N(C=NC=2)C)C=2C=CC(Cl)=CC=2)=C1 ZMLMGCPNMBRTKN-UHFFFAOYSA-N 0.000 claims 1
- ALKQAQOKGRWMSJ-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-ethoxyphenyl)-1-methylquinolin-2-one Chemical compound CCOC1=CC=CC(C=2C3=CC(=CC=C3N(C)C(=O)C=2)C(N)(C=2N(C=NC=2)C)C=2C=CC(Cl)=CC=2)=C1 ALKQAQOKGRWMSJ-UHFFFAOYSA-N 0.000 claims 1
- 229940099362 Catechol O methyltransferase inhibitor Drugs 0.000 claims 1
- 229940081615 DOPA decarboxylase inhibitor Drugs 0.000 claims 1
- 102000010909 Monoamine Oxidase Human genes 0.000 claims 1
- 108010062431 Monoamine oxidase Proteins 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229940039856 aricept Drugs 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000003543 catechol methyltransferase inhibitor Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 239000000534 dopa decarboxylase inhibitor Substances 0.000 claims 1
- 229960003638 dopamine Drugs 0.000 claims 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004640 memantine Drugs 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 0 C*C=CC([C@@](C1*=C)C(C=C(*(C)C=C2)[C@@](*)(C(NC)=CN=*C)c3ccccc3)=C2N(*)C1=*)=CC=C Chemical compound C*C=CC([C@@](C1*=C)C(C=C(*(C)C=C2)[C@@](*)(C(NC)=CN=*C)c3ccccc3)=C2N(*)C1=*)=CC=C 0.000 description 2
- BGVQSAWORUAXAY-UHFFFAOYSA-N C[n]1c(C(c(cc2)ccc2Cl)(c(cc2C(C3)c4cccc(Cl)c4)ccc2N(C)C3=O)O)cnc1 Chemical compound C[n]1c(C(c(cc2)ccc2Cl)(c(cc2C(C3)c4cccc(Cl)c4)ccc2N(C)C3=O)O)cnc1 BGVQSAWORUAXAY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55509204P | 2004-03-18 | 2004-03-18 | |
| PCT/US2005/009235 WO2005089504A2 (en) | 2004-03-18 | 2005-03-18 | Methods for the treatment of synucleinopathies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007538004A JP2007538004A (ja) | 2007-12-27 |
| JP2007538004A5 true JP2007538004A5 (enExample) | 2008-05-15 |
Family
ID=34994396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504171A Pending JP2007538004A (ja) | 2004-03-18 | 2005-03-18 | シヌクレイノパチーを治療する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060106060A1 (enExample) |
| EP (1) | EP1809265A4 (enExample) |
| JP (1) | JP2007538004A (enExample) |
| CA (1) | CA2559221A1 (enExample) |
| WO (1) | WO2005089504A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005089502A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
| EP1732549A4 (en) * | 2004-03-18 | 2009-11-11 | Brigham & Womens Hospital | METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES |
| WO2005089518A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Uch-l1 expression and cancer therapy |
| WO2005089515A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| EP1656931A1 (en) * | 2004-11-15 | 2006-05-17 | Exonhit Therapeutics SA | Compounds which inhibits protein prenylation ( e.g. geranylgeranyltransferase or farnesyltransferase inhibitors) for treating Parkinson's disease |
| GB0611907D0 (en) | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
| US20060194821A1 (en) * | 2005-02-18 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Compounds inhibiting the aggregation of superoxide dismutase-1 |
| KR20080018874A (ko) * | 2005-04-27 | 2008-02-28 | 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. | 인간 질병과 관련된 돌연변이 단백질의 분해 촉진을 위한물질 및 방법 |
| DK1907374T3 (da) * | 2005-07-26 | 2012-10-15 | Glaxo Group Ltd | Til behandling af gastrointestinale sygdomme anvendelige benzylpiperazin-derivater |
| CA2634598A1 (en) * | 2005-12-23 | 2007-07-05 | Link Medicine Corporation | Treatment of synucleinopathies |
| EP2155197A4 (en) * | 2007-03-09 | 2011-10-12 | Link Medicine Corp | TREATMENT OF LYSOSOMAL STORAGE DISEASES |
| WO2008137692A1 (en) * | 2007-05-03 | 2008-11-13 | Link Medicine Corporation | Treatment of synucleinopathies |
| WO2009018088A2 (en) * | 2007-08-01 | 2009-02-05 | Link Medicine Corporation | Imaging of alpha-synuclein |
| WO2009151683A2 (en) * | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| WO2010057006A1 (en) | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
| US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| US20100160372A1 (en) * | 2008-11-13 | 2010-06-24 | Link Medicine Corporation | Treatment of proteinopathies using a farnesyl transferase inhibitor |
| US9701669B2 (en) | 2013-08-22 | 2017-07-11 | Merck Sharp & Dohme Corp. | Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists |
| US9808473B2 (en) | 2013-08-22 | 2017-11-07 | Merck Sharp & Dohme Corp. | Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists |
| US12226410B2 (en) | 2019-10-18 | 2025-02-18 | Northwestern University | Methods for enhancing cellular clearance of pathological molecules via activation of the cellular protein ykt6 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4576957A (en) * | 1984-07-05 | 1986-03-18 | American Cyanamid Company | N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas |
| US5017584A (en) * | 1984-12-20 | 1991-05-21 | Sterling Drug Inc. | Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, -1,2,3,4-tetrahydroquinolines and -1H-indoles, and methods of use thereas |
| US4902505A (en) * | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| IT1222563B (it) * | 1986-09-30 | 1990-09-05 | Brasil Compressores Sa | Compressore ermetico ad albero a gomiti orizzontale |
| US5004697A (en) * | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
| US4933324A (en) * | 1988-02-26 | 1990-06-12 | Shashoua Victor E | Fatty acid-neuroactive drug conjugate as a prodrug |
| US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
| US5112596A (en) * | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| US5185248A (en) * | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
| US5633376A (en) * | 1990-12-28 | 1997-05-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; and 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype ligands |
| US5614560A (en) * | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US5322950A (en) * | 1991-12-05 | 1994-06-21 | Warner-Lambert Company | Imidazole with angiotensin II antagonist properties |
| GB2267966A (en) * | 1992-06-17 | 1993-12-22 | Merck & Co Inc | A fluorescence assay for farnesyl protein transferase activity |
| US5726197A (en) * | 1992-11-02 | 1998-03-10 | Syntex (U.S.A.) Inc. | Isoindolinyl derivatives |
| US5523317A (en) * | 1993-07-05 | 1996-06-04 | Nippon Chemiphar Co., Ltd. | Method of reducing blood pressure |
| US6365588B1 (en) * | 1993-10-15 | 2002-04-02 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| US5576437A (en) * | 1993-12-17 | 1996-11-19 | The Procter & Gamble Company | 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists |
| PT736020E (pt) * | 1993-12-17 | 2000-10-31 | Procter & Gamble | Compostos 6-(2-imidazolinilamino)quinolina uteis como alfa-2 adrenoceptor agonistas |
| US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
| US5856326A (en) * | 1995-03-29 | 1999-01-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| GB9515975D0 (en) * | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
| IL123568A (en) * | 1995-12-08 | 2001-08-08 | Janssen Pharmaceutica Nv | History (Imidazole - 5Il) Methyl-2-quinolinone inhibitors of Prenzyl transferase, their preparation, pharmaceutical preparations containing them and their preparation and drugs containing them |
| US5874442A (en) * | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US5859012A (en) * | 1996-04-03 | 1999-01-12 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| TW436484B (en) * | 1996-04-24 | 2001-05-28 | Dev Center Biotechnology | 1,2,3,4-tetrahydroisoquinoline derivatives having a nitrogen-containing heterocyclic methyl substituent, the preparation process and pharmaceutical composition thereof |
| FR2757855B1 (fr) * | 1996-12-30 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US6013662A (en) * | 1996-12-30 | 2000-01-11 | Rhone-Poulenc Rorer S.A. | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments |
| TW591030B (en) * | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| KR100520401B1 (ko) * | 1997-04-25 | 2005-10-12 | 얀센 파마슈티카 엔.브이. | 파네실 트랜스퍼라제 억제작용을 갖는 퀴나졸리논 |
| US6060038A (en) * | 1997-05-15 | 2000-05-09 | Merck & Co., Inc. | Radiolabeled farnesyl-protein transferase inhibitors |
| CN1231215C (zh) * | 1997-06-02 | 2005-12-14 | 詹森药业有限公司 | (咪唑－5－基)甲基－2－喹啉酮衍生物用作平滑肌细胞增殖抑制剂 |
| US6358968B1 (en) * | 1997-06-17 | 2002-03-19 | Schering Corporation | N-substituted urea inhibitors of farnesyl-protein transferase |
| TW527355B (en) * | 1997-07-02 | 2003-04-11 | Bristol Myers Squibb Co | Inhibitors of farnesyl protein transferase |
| US6387903B1 (en) * | 1997-08-27 | 2002-05-14 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| WO1999026657A1 (en) * | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| AU1767599A (en) * | 1997-12-23 | 1999-07-19 | Aventis Pharma S.A. | Novel farnesyl transferase inhibitors, preparation, pharmaceutical compositions containing them and use for preparing medicines |
| AU2578499A (en) * | 1998-02-03 | 1999-08-16 | Continental Pet Technologies, Inc. | Enhanced oxygen-scavenging polymers, and packaging made therefrom |
| US6562823B1 (en) * | 1998-07-02 | 2003-05-13 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| ATE238811T1 (de) * | 1998-07-06 | 2003-05-15 | Janssen Pharmaceutica Nv | Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften |
| HRP20000904A2 (en) * | 1998-07-06 | 2001-12-31 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors for treating arthropathies |
| US6338092B1 (en) * | 1998-09-24 | 2002-01-08 | International Business Machines Corporation | Method, system and computer program for replicating data in a distributed computed environment |
| US20020064142A1 (en) * | 1998-10-13 | 2002-05-30 | Franklin P. Antonio | Base station architecture |
| JP4090200B2 (ja) * | 1999-02-11 | 2008-05-28 | ファイザー・プロダクツ・インク | 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体 |
| US6328988B1 (en) * | 1999-04-23 | 2001-12-11 | Rutgers, The State University Of New Jersey | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules |
| JP5491681B2 (ja) * | 2000-02-04 | 2014-05-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 乳ガンの治療のためのファルネシルタンパク質トランスフェラーゼ阻害剤 |
| US20020052380A1 (en) * | 2000-02-18 | 2002-05-02 | Dinsmore Christopher J. | Inhibitors of prenyl-protein transferase |
| US20020010184A1 (en) * | 2000-02-18 | 2002-01-24 | Dinsmore Christopher J. | Inhibitors of prenyl-protein transferase |
| EP1267848B1 (en) * | 2000-02-24 | 2007-10-17 | Janssen Pharmaceutica N.V. | Dosing regimen comprising a farnesyl protein transferase inhibitor for the treatment of cancer |
| WO2001064226A2 (en) * | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with platinum compounds |
| US20030100553A1 (en) * | 2000-02-29 | 2003-05-29 | Palmer Peter Albert | Farnesyl protein transferase inhibitor combinations with camptothecin compounds |
| EP1267929A2 (en) * | 2000-02-29 | 2003-01-02 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with an her2 antibody |
| EP1261348A2 (en) * | 2000-02-29 | 2002-12-04 | Janssen Pharmaceutica N.V. | Combinations of a farnesyl protein transferase inhibitor with nitrogen mustard or nitrosourea alkylating agents |
| CA2397694A1 (en) * | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica Inc. | Farnesyl protein transferase inhibitor combinations |
| DK1311272T3 (da) * | 2000-03-03 | 2007-02-26 | Eisai R&D Man Co Ltd | Hidtil ukendte fremgangsmåder hvor der anvendes cholinesteraseinhibitorer |
| TWI310684B (en) * | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
| US20010051642A1 (en) * | 2000-04-17 | 2001-12-13 | Kyunghye Ahn | Method for treating Alzheimer's disease |
| US6844357B2 (en) * | 2000-05-01 | 2005-01-18 | Pfizer Inc. | Substituted quinolin-2-one derivatives useful as antiproliferative agents |
| DE60135122D1 (de) * | 2000-06-23 | 2008-09-11 | Invista Tech Sarl | Spinnvorrichtung enthaltend Spinndüse mit Dampfverteilungsring |
| CA2417149C (en) * | 2000-07-27 | 2009-09-08 | City Technology Limited | Gas sensors |
| US7196094B2 (en) * | 2000-09-25 | 2007-03-27 | Janssen Pharmaceutica, N.V. | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives |
| DE60118225T2 (de) * | 2000-09-25 | 2007-05-03 | Janssen Pharmaceutica N.V. | Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren |
| EP1322636A1 (en) * | 2000-09-25 | 2003-07-02 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 6- (substituted phenyl)methyl]-quinoline and quinazoline derivatives |
| GB0023915D0 (en) * | 2000-09-29 | 2000-11-15 | Inst Of Ophthalmology | Treatment of neuroinflammatory disease |
| ES2261523T3 (es) * | 2000-11-28 | 2006-11-16 | Janssen Pharmaceutica N.V. | Inhibidores de farnesil proteina transferasa para el tratamiento de enfermedad intestinal inflamatoria. |
| CA2632091C (en) * | 2000-12-19 | 2011-03-22 | Pfizer Products Inc. | Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1h-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production |
| US6645966B2 (en) * | 2001-01-22 | 2003-11-11 | Schering Corporation | Treatment of malaria with farnesyl protein transferase inhibitors |
| HU230282B1 (hu) * | 2001-03-12 | 2015-12-28 | Janssen Pharmaceutica N.V | Eljárás imidazol-származékok előállítására |
| CZ305799B6 (cs) * | 2001-03-14 | 2016-03-23 | Bristol-Myers Squibb Company | Kombinace analogů epothilonu a chemoterapeutických činidel pro léčení proliferačních nemocí |
| US20020151563A1 (en) * | 2001-03-29 | 2002-10-17 | Pfizer Inc. | Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the inhibition of abnormal cell growth |
| AU2002257114A1 (en) * | 2001-04-06 | 2002-10-21 | Schering Corporation | Treatment of malaria with farsenyl protein transferase inhibitors |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US6740757B2 (en) * | 2001-08-29 | 2004-05-25 | Pfizer Inc | Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer |
| EP1453513A1 (en) * | 2001-12-03 | 2004-09-08 | Schering Corporation | Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer |
| CA2469204A1 (en) * | 2001-12-07 | 2003-06-19 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
| CA2484634C (en) * | 2002-01-18 | 2012-05-22 | Lonza Ag | Virucidal disinfectant |
| US6837693B2 (en) * | 2002-01-31 | 2005-01-04 | Ashear, Ltd. | Fluid-pumping system employing piston-driven pump and employing at least one pulsation dampener |
| US6974818B2 (en) * | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| US20030060480A1 (en) * | 2002-08-28 | 2003-03-27 | Horak Ivan David | Farnesyl protein transferase inhibitor combinations with vinca alkaloids |
| US20030050323A1 (en) * | 2002-08-28 | 2003-03-13 | Rybak Mary Ellen Margaret | Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives |
| US7082558B2 (en) * | 2002-11-25 | 2006-07-25 | Texas Instruments Incorporated | Increasing possible test patterns which can be used with sequential scanning techniques to perform speed analysis |
| UA81790C2 (uk) * | 2002-12-19 | 2008-02-11 | Фармация Италия С.П.А. | Заміщені піролопіразольні похідні як інгібітори кінази |
| WO2004103352A1 (en) * | 2003-05-23 | 2004-12-02 | Ramot At Tel Aviv University, Ltd. | Ras antagonists for treating neurodegenerative disorders |
| WO2005021056A1 (en) * | 2003-08-21 | 2005-03-10 | Cns, Inc. | Effervescent delivery system |
| AU2004268145B2 (en) * | 2003-08-29 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Poly-PEGylated protease inhibitors |
| EP1626339B1 (en) * | 2004-08-13 | 2016-02-24 | Sap Se | Data processing system and method for assigning objects to processing units |
| WO2006006730A1 (ja) * | 2004-07-15 | 2006-01-19 | Nikon Corporation | 平面モータ装置、ステージ装置、露光装置及びデバイスの製造方法 |
| AU2005272815A1 (en) * | 2004-08-13 | 2006-02-23 | Genentech, Inc. | Thiazole based inhibitors of ATP-utilizing enzymes |
| DK2362218T3 (en) * | 2004-11-05 | 2014-11-17 | Janssen Pharmaceutica Nv | Methods for monitoring the effectiveness of farnesyl transferase |
| US20080002621A1 (en) * | 2006-06-29 | 2008-01-03 | Boris Ginzburg | Reliable multicast techniques for wireless links |
| US20090036275A1 (en) * | 2007-07-31 | 2009-02-05 | Chi-Chang Hsiao | Power-Supplying and Shock-Absorbing Device for an Exerciser |
-
2005
- 2005-03-18 JP JP2007504171A patent/JP2007538004A/ja active Pending
- 2005-03-18 EP EP05732712A patent/EP1809265A4/en not_active Withdrawn
- 2005-03-18 CA CA002559221A patent/CA2559221A1/en not_active Abandoned
- 2005-03-18 WO PCT/US2005/009235 patent/WO2005089504A2/en not_active Ceased
- 2005-03-18 US US11/084,715 patent/US20060106060A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007538004A5 (enExample) | ||
| WO2006055854A3 (en) | Methods for reducing the side effects associated with mirtazapine treatment | |
| JP2020534355A5 (enExample) | ||
| JP2009523760A5 (enExample) | ||
| JP2010509366A5 (enExample) | ||
| WO2001062234A2 (en) | Dosing regimen | |
| WO2012147107A3 (en) | Novel & improved processes for preparing indoline derivatives and its pharmaceutical composition | |
| JP2010539186A5 (enExample) | ||
| PH12013501341A1 (en) | Morphinan compounds | |
| EP1974722A3 (en) | Modified dosage forms of tacrolimus | |
| JP2013521286A5 (enExample) | ||
| JP2010511626A5 (enExample) | ||
| US20040157773A1 (en) | Farnesyl protein transferase inhibitors for treating cachexia | |
| JP2003525252A (ja) | Ｈｅｒ２抗体とのファルネシルタンパク質トランスフェラーゼ阻害剤組み合わせ剤 | |
| JP2010523674A5 (enExample) | ||
| WO2010011821A3 (en) | Dual-acting antihypertensive agents | |
| EP2286825A3 (en) | Melanocortin receptor ligands | |
| WO2007103970A3 (en) | Compositions and methods for treating respiratory disorders | |
| JP2011521938A5 (enExample) | ||
| CA2563302A1 (en) | Combinations of glycopyrrolate and beta2 adrenoceptor agonists | |
| JP2009541209A5 (enExample) | ||
| WO2007127196A3 (en) | DIALKYLPHENYL COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | |
| WO2008115385A3 (en) | Piperazine-substituted pyridazinone derivatives useful as glucan synthase inhibitors | |
| JP2015503596A5 (enExample) | ||
| JP2009513713A5 (enExample) |