JP2007535668A5 - - Google Patents

Info

Publication number

JP2007535668A5

JP2007535668A5 JP2007509977A JP2007509977A JP2007535668A5 JP 2007535668 A5 JP2007535668 A5 JP 2007535668A5 JP 2007509977 A JP2007509977 A JP 2007509977A JP 2007509977 A JP2007509977 A JP 2007509977A JP 2007535668 A5 JP2007535668 A5 JP 2007535668A5

Authority

JP

Japan

Prior art keywords

agent

analyte

antibody

cell

support

Prior art date

2005-04-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 21
• 239000003795 chemical substances by application Substances 0.000 claims 17
• 239000012491 analyte Substances 0.000 claims 14
• 210000004027 cell Anatomy 0.000 claims 10
• 238000003556 assay Methods 0.000 claims 7
• 230000028327 secretion Effects 0.000 claims 7
• 230000002708 enhancing effect Effects 0.000 claims 5
• 230000002401 inhibitory effect Effects 0.000 claims 5
• 241000700605 Viruses Species 0.000 claims 4
• 238000001514 detection method Methods 0.000 claims 4
• 108090000695 Cytokines Proteins 0.000 claims 3
• 102000004127 Cytokines Human genes 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 230000003248 secreting effect Effects 0.000 claims 3
• 230000004936 stimulating effect Effects 0.000 claims 3
• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 2
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 2
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 2
• 229940126530 T cell activator Drugs 0.000 claims 2
• 239000012190 activator Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 101150013553 CD40 gene Proteins 0.000 claims 1
• 102000016359 Fibronectins Human genes 0.000 claims 1
• 108010067306 Fibronectins Proteins 0.000 claims 1
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
• -1 ICOS Proteins 0.000 claims 1
• 108010065805 Interleukin-12 Proteins 0.000 claims 1
• 108090000172 Interleukin-15 Proteins 0.000 claims 1
• 108010002350 Interleukin-2 Proteins 0.000 claims 1
• 108090000978 Interleukin-4 Proteins 0.000 claims 1
• 102000004856 Lectins Human genes 0.000 claims 1
• 108090001090 Lectins Proteins 0.000 claims 1
• 239000000020 Nitrocellulose Substances 0.000 claims 1
• 239000002033 PVDF binder Substances 0.000 claims 1
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 239000003443 antiviral agent Substances 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 230000003308 immunostimulating effect Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 239000002523 lectin Substances 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 229920001220 nitrocellulos Polymers 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
• 230000004044 response Effects 0.000 claims 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1