JP2007535520A - 抗腫瘍作用を有するインドール及びアザインドール誘導体 - Google Patents

抗腫瘍作用を有するインドール及びアザインドール誘導体 Download PDF

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Publication number
JP2007535520A
JP2007535520A JP2007510035A JP2007510035A JP2007535520A JP 2007535520 A JP2007535520 A JP 2007535520A JP 2007510035 A JP2007510035 A JP 2007510035A JP 2007510035 A JP2007510035 A JP 2007510035A JP 2007535520 A JP2007535520 A JP 2007535520A
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JP
Japan
Prior art keywords
dimethoxy
indole
methoxyphenyl
group
carboxylic acid
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Pending
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JP2007510035A
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English (en)
Japanese (ja)
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JP2007535520A5 (https=
Inventor
ファリナ・カルロ
ガガリアルディ・ステファニア
ミシアノ・パオラ
セレスティニ・パオロ
ズニノ・フランコ
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NiKem Research SRL
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NiKem Research SRL
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Publication of JP2007535520A publication Critical patent/JP2007535520A/ja
Publication of JP2007535520A5 publication Critical patent/JP2007535520A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
JP2007510035A 2004-04-30 2005-04-27 抗腫瘍作用を有するインドール及びアザインドール誘導体 Pending JP2007535520A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000874A ITMI20040874A1 (it) 2004-04-30 2004-04-30 Derivati indolici ed azaindolici con azione antitumorale
PCT/EP2005/051908 WO2005105213A2 (en) 2004-04-30 2005-04-27 Indole and azaindole derivatives with antitumor action

Publications (2)

Publication Number Publication Date
JP2007535520A true JP2007535520A (ja) 2007-12-06
JP2007535520A5 JP2007535520A5 (https=) 2008-06-19

Family

ID=34968098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007510035A Pending JP2007535520A (ja) 2004-04-30 2005-04-27 抗腫瘍作用を有するインドール及びアザインドール誘導体

Country Status (7)

Country Link
US (1) US20070248672A1 (https=)
EP (1) EP1750687A2 (https=)
JP (1) JP2007535520A (https=)
AU (1) AU2005237788A1 (https=)
CA (1) CA2564249A1 (https=)
IT (1) ITMI20040874A1 (https=)
WO (1) WO2005105213A2 (https=)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
KR20150058441A (ko) * 2012-09-21 2015-05-28 비보룩스 아베 고형 종양의 치료 수단 및 방법
JP2016516828A (ja) * 2013-04-23 2016-06-09 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ ピラジノ［１，２−ａ］インドール化合物、その調製および医薬としての使用
JP2018521986A (ja) * 2015-06-17 2018-08-09 ファイザー・インク 三環式化合物およびホスホジエステラーゼ阻害剤としてのそれらの使用

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Publication number Priority date Publication date Assignee Title
TWI372624B (en) 2004-03-30 2012-09-21 Vertex Pharma Azaindoles useful as inhibitors of jak and other protein kinases
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
EP1779849A1 (en) * 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of septic shock
WO2008033464A2 (en) 2006-09-15 2008-03-20 Schering Corporation Azetidinone derivatives for the treatment of disorders of the lipid metabolism
AU2007338754A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
EP2134176A4 (en) * 2007-03-30 2012-08-29 Brigham & Womens Hospital COMPOUNDS AND METHODS FOR ENHANCING MHC CLASS II THERAPIES
MX2009011210A (es) * 2007-04-16 2009-10-30 Abbott Lab Inhibidores de mcl1 de indol 7-no sustituido.
WO2010144611A2 (en) * 2009-06-10 2010-12-16 3-V Biosciences, Inc. Antivirals that target transporters, carriers, and ion channels
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
CN102791688B (zh) * 2009-10-07 2014-11-12 卡罗生物股份公司 雌激素受体配体
US8691830B2 (en) 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
KR102051881B1 (ko) 2010-10-25 2019-12-04 쥐원 쎄라퓨틱스, 인크. Cdk 억제제
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
SI2825541T1 (sl) 2012-03-16 2016-10-28 Vitae Pharmaceuticals, Inc. Modulatorji jetrnega receptorja X
ES2607113T3 (es) 2012-03-16 2017-03-29 Vitae Pharmaceuticals, Inc. Moduladores de los receptores X del hígado
AU2013239816B2 (en) 2012-03-29 2017-08-24 G1 Therapeutics, Inc. Lactam kinase inhibitors
HK1222766A1 (zh) 2013-03-15 2017-07-14 G1治疗公司 高效的抗赘生剂和抗增生剂
DK2968290T3 (da) 2013-03-15 2019-11-25 G1 Therapeutics Inc Transient beskyttelse af normale celler under kemoterapi
RS59144B1 (sr) 2013-11-13 2019-09-30 Vertex Pharma Inhibitori replikacije virusa influence
HRP20181272T1 (hr) 2013-11-13 2018-10-05 Vertex Pharmaceuticals Incorporated Postupci priprave inhibitora replikacije virusa influence
WO2015161285A1 (en) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic lactams for use in the protection of hematopoietic stem and progenitor cells against ionizing radiation
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
WO2016040858A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
US11866409B2 (en) 2015-11-02 2024-01-09 Carmel-Haifa University Economic Corporation Ltd. Apoptosis related protein in the tgf-beta signaling pathway (ARTS) mimetic compounds, compositions, methods and uses thereof in induction of differentiation and/or apoptosis of premalignant and malignant cells, thereby restoring their normal-like phenotype
GB201521059D0 (en) 2015-11-30 2016-01-13 Isis Innovation Inhibitors of metallo-beta-lactamases
EP3565558B1 (en) 2017-01-06 2023-12-06 G1 Therapeutics, Inc. Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer
FI3645001T3 (fi) 2017-06-29 2024-09-25 G1 Therapeutics Inc Git38:n morfisia muotoja ja niiden valmistusmenetelmiä
RS67557B1 (sr) 2018-08-24 2026-01-30 Pharmacosmos Holding As Unapređena sinteza 1,4-diazaspiro[5.5]undekan-3-ona
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
US12404261B2 (en) * 2020-12-22 2025-09-02 Novartis Ag Compounds and compositions for treating conditions associated with cGAS

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1286701A (en) * 1969-02-12 1972-08-23 Sumitomo Chemical Co Pyridophenone derivatives and conversion to benzodiazepine derivatives
JPS4969698A (https=) * 1972-09-25 1974-07-05
JPS5566578A (en) * 1978-10-02 1980-05-20 Schering Corp Novel 22substitutedd33heterocyclic indoles* their manufacture and medical composition containing them
JPH04211651A (ja) * 1990-03-26 1992-08-03 Takeda Chem Ind Ltd 骨吸収抑制剤およびインドール誘導体
EP0643059A1 (en) * 1993-09-15 1995-03-15 Pfizer Limited 3-(3-Pyridinyl)-1H-indoles as thromboxane A2 synthetase inhibitors
JP2001122855A (ja) * 1999-10-27 2001-05-08 Japan Tobacco Inc インドール化合物及びその医薬用途
WO2002094830A2 (en) * 2001-05-23 2002-11-28 Merck Frosst Canada & Co. DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
WO2003039539A2 (de) * 2001-11-09 2003-05-15 Merck Patent Gmbh Verwendung von endothelin-rezeptor-antagonisten zur behandlung von tumorerkrankungen
US20030105140A1 (en) * 2000-12-07 2003-06-05 Cytovia, Inc. Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US105140A (en) * 1870-07-05 Improvement in cigar-wrapping machines
CA1012147A (en) * 1972-09-25 1977-06-14 Hoffmann-La Roche Limited Indolo quinoline derivatives
CA2038925A1 (en) * 1990-03-26 1991-09-27 Takashi Sohda Indole derivatives, their production and use
US6323228B1 (en) * 2000-09-15 2001-11-27 Abbott Laboratories 3-substituted indole angiogenesis inhibitors
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1286701A (en) * 1969-02-12 1972-08-23 Sumitomo Chemical Co Pyridophenone derivatives and conversion to benzodiazepine derivatives
JPS4969698A (https=) * 1972-09-25 1974-07-05
JPS5566578A (en) * 1978-10-02 1980-05-20 Schering Corp Novel 22substitutedd33heterocyclic indoles* their manufacture and medical composition containing them
JPH04211651A (ja) * 1990-03-26 1992-08-03 Takeda Chem Ind Ltd 骨吸収抑制剤およびインドール誘導体
EP0643059A1 (en) * 1993-09-15 1995-03-15 Pfizer Limited 3-(3-Pyridinyl)-1H-indoles as thromboxane A2 synthetase inhibitors
JP2001122855A (ja) * 1999-10-27 2001-05-08 Japan Tobacco Inc インドール化合物及びその医薬用途
US20030105140A1 (en) * 2000-12-07 2003-06-05 Cytovia, Inc. Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2002094830A2 (en) * 2001-05-23 2002-11-28 Merck Frosst Canada & Co. DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
WO2003039539A2 (de) * 2001-11-09 2003-05-15 Merck Patent Gmbh Verwendung von endothelin-rezeptor-antagonisten zur behandlung von tumorerkrankungen

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150058441A (ko) * 2012-09-21 2015-05-28 비보룩스 아베 고형 종양의 치료 수단 및 방법
KR102190768B1 (ko) 2012-09-21 2020-12-14 비보룩스 아베 고형 종양의 치료 수단 및 방법
JP2016516828A (ja) * 2013-04-23 2016-06-09 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ ピラジノ［１，２−ａ］インドール化合物、その調製および医薬としての使用
JP2018521986A (ja) * 2015-06-17 2018-08-09 ファイザー・インク 三環式化合物およびホスホジエステラーゼ阻害剤としてのそれらの使用

Also Published As

Publication number Publication date
EP1750687A2 (en) 2007-02-14
US20070248672A1 (en) 2007-10-25
WO2005105213A2 (en) 2005-11-10
CA2564249A1 (en) 2005-11-10
AU2005237788A1 (en) 2005-11-10
ITMI20040874A1 (it) 2004-07-30
WO2005105213A3 (en) 2006-06-22

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