JP2007532577A - 塩基性浸透促進剤と共に用いるための経皮デリバリー・システム - Google Patents
塩基性浸透促進剤と共に用いるための経皮デリバリー・システム Download PDFInfo
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- JP2007532577A JP2007532577A JP2007507560A JP2007507560A JP2007532577A JP 2007532577 A JP2007532577 A JP 2007532577A JP 2007507560 A JP2007507560 A JP 2007507560A JP 2007507560 A JP2007507560 A JP 2007507560A JP 2007532577 A JP2007532577 A JP 2007532577A
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- drugs
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- hydroxide
- insoluble hydrophilic
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- 229960004492 suprofen Drugs 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
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- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
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- 125000005270 trialkylamine group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- VSRBKQFNFZQRBM-UHFFFAOYSA-N tuaminoheptane Chemical compound CCCCCC(C)N VSRBKQFNFZQRBM-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56049904P | 2004-04-07 | 2004-04-07 | |
| PCT/US2005/012163 WO2005099676A2 (en) | 2004-04-07 | 2005-04-07 | Transdermal delivery system for use with basic permeation enhancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532577A true JP2007532577A (ja) | 2007-11-15 |
| JP2007532577A5 JP2007532577A5 (https=) | 2008-05-22 |
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| JP2007507560A Pending JP2007532577A (ja) | 2004-04-07 | 2005-04-07 | 塩基性浸透促進剤と共に用いるための経皮デリバリー・システム |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080138390A1 (https=) |
| EP (1) | EP1744714A4 (https=) |
| JP (1) | JP2007532577A (https=) |
| CA (1) | CA2564341A1 (https=) |
| IL (1) | IL178499A0 (https=) |
| WO (1) | WO2005099676A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011516166A (ja) * | 2008-03-31 | 2011-05-26 | アルテア セラピューティクス コーポレイション | 浸透物送達システム及びその使用方法 |
| JP2020532558A (ja) * | 2017-09-04 | 2020-11-12 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 乳化剤を含む経皮送達システム |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| CA2769633C (en) | 2009-07-31 | 2017-06-06 | Thar Pharma, Llc | Crystallization method and bioavailability |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US8633178B2 (en) | 2011-11-23 | 2014-01-21 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20160199316A1 (en) | 2013-06-14 | 2016-07-14 | Tesa Labtec Gmbh | Three-layer transdermal therapy system (tts) |
| DE102014000200A1 (de) | 2014-01-03 | 2015-07-09 | Michael Horstmann | Transdermales Therapeutisches System |
| JP6173491B2 (ja) * | 2014-01-31 | 2017-08-02 | 久光製薬株式会社 | エメダスチン含有テープ剤 |
| US9468606B2 (en) * | 2014-03-31 | 2016-10-18 | Johnson & Johnson Consumer Inc. | Compostions and methods for enhancing the topical application of an acidic benefit agent |
| EP3145489A1 (en) | 2014-05-22 | 2017-03-29 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0413617A (ja) * | 1990-04-27 | 1992-01-17 | Sekisui Chem Co Ltd | 貼付剤 |
| JPH0912448A (ja) * | 1995-04-28 | 1997-01-14 | Read Chem Kk | 薬物放出制御型経皮吸収製剤 |
| JPH10306023A (ja) * | 1997-05-06 | 1998-11-17 | Sekisui Chem Co Ltd | 経皮吸収製剤及びその製造方法 |
| US6303700B1 (en) * | 1997-04-30 | 2001-10-16 | Coloplast A/S | Adhesive agent and use of such adhesive agent |
| JP2002536403A (ja) * | 1999-02-10 | 2002-10-29 | イエナフアルム ゲーエムベーハー ウント ツェーオー. カーゲー | 経皮系のための作用物質含有ラミネート |
| JP2004500360A (ja) * | 1999-12-16 | 2004-01-08 | ダーマトレンズ, インコーポレイテッド | 皮膚浸透促進剤としての水酸化物放出剤 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| SG59962A1 (en) * | 1989-11-03 | 1999-02-22 | Riker Laboratories Inc | Bioadhersive composition and patch |
| US6558695B2 (en) * | 1999-12-16 | 2003-05-06 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers |
| US20020192242A1 (en) * | 1999-12-16 | 2002-12-19 | Tsung-Min Hsu | Transdermal and topical administration of bone density regulators using basic enhancers |
| US6565879B1 (en) * | 1999-12-16 | 2003-05-20 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers |
| US6586000B2 (en) * | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
-
2005
- 2005-04-07 US US11/547,987 patent/US20080138390A1/en not_active Abandoned
- 2005-04-07 EP EP05732883A patent/EP1744714A4/en not_active Withdrawn
- 2005-04-07 WO PCT/US2005/012163 patent/WO2005099676A2/en not_active Ceased
- 2005-04-07 JP JP2007507560A patent/JP2007532577A/ja active Pending
- 2005-04-07 CA CA002564341A patent/CA2564341A1/en not_active Abandoned
-
2006
- 2006-10-05 IL IL178499A patent/IL178499A0/en unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0413617A (ja) * | 1990-04-27 | 1992-01-17 | Sekisui Chem Co Ltd | 貼付剤 |
| JPH0912448A (ja) * | 1995-04-28 | 1997-01-14 | Read Chem Kk | 薬物放出制御型経皮吸収製剤 |
| US6303700B1 (en) * | 1997-04-30 | 2001-10-16 | Coloplast A/S | Adhesive agent and use of such adhesive agent |
| JPH10306023A (ja) * | 1997-05-06 | 1998-11-17 | Sekisui Chem Co Ltd | 経皮吸収製剤及びその製造方法 |
| JP2002536403A (ja) * | 1999-02-10 | 2002-10-29 | イエナフアルム ゲーエムベーハー ウント ツェーオー. カーゲー | 経皮系のための作用物質含有ラミネート |
| JP2004500360A (ja) * | 1999-12-16 | 2004-01-08 | ダーマトレンズ, インコーポレイテッド | 皮膚浸透促進剤としての水酸化物放出剤 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011516166A (ja) * | 2008-03-31 | 2011-05-26 | アルテア セラピューティクス コーポレイション | 浸透物送達システム及びその使用方法 |
| JP2020532558A (ja) * | 2017-09-04 | 2020-11-12 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 乳化剤を含む経皮送達システム |
| JP7212676B2 (ja) | 2017-09-04 | 2023-01-25 | エルテーエス ローマン テラピー-ジステーメ アーゲー | 乳化剤を含む経皮送達システム |
| US12383509B2 (en) | 2017-09-04 | 2025-08-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an emulsifier |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005099676A2 (en) | 2005-10-27 |
| WO2005099676A3 (en) | 2006-04-27 |
| IL178499A0 (en) | 2007-02-11 |
| US20080138390A1 (en) | 2008-06-12 |
| EP1744714A4 (en) | 2009-08-26 |
| CA2564341A1 (en) | 2005-10-27 |
| EP1744714A2 (en) | 2007-01-24 |
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