JP2007530546A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007530546A5 JP2007530546A5 JP2007505043A JP2007505043A JP2007530546A5 JP 2007530546 A5 JP2007530546 A5 JP 2007530546A5 JP 2007505043 A JP2007505043 A JP 2007505043A JP 2007505043 A JP2007505043 A JP 2007505043A JP 2007530546 A5 JP2007530546 A5 JP 2007530546A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- composition
- mmp
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 39
- 239000000203 mixture Substances 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 6
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 6
- 230000005764 inhibitory process Effects 0.000 claims 6
- 206010027476 Metastases Diseases 0.000 claims 4
- 230000009401 metastasis Effects 0.000 claims 4
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 3
- 101710151806 72 kDa type IV collagenase Proteins 0.000 claims 3
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 3
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000003200 Adenoma Diseases 0.000 claims 1
- 206010001233 Adenoma benign Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 229940124639 Selective inhibitor Drugs 0.000 claims 1
- 206010064390 Tumour invasion Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000009400 cancer invasion Effects 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55538004P | 2004-03-22 | 2004-03-22 | |
| PCT/US2005/009263 WO2005092844A1 (en) | 2004-03-22 | 2005-03-21 | Nonpeptide inhibitors of matrix metalloproteinases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011011407A Division JP2011079866A (ja) | 2004-03-22 | 2011-01-21 | マトリックスメタロプロテイナーゼの非ペプチドインヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007530546A JP2007530546A (ja) | 2007-11-01 |
| JP2007530546A5 true JP2007530546A5 (https=) | 2008-05-01 |
Family
ID=34963517
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505043A Pending JP2007530546A (ja) | 2004-03-22 | 2005-03-21 | マトリックスメタロプロテイナーゼの非ペプチドインヒビター |
| JP2011011407A Pending JP2011079866A (ja) | 2004-03-22 | 2011-01-21 | マトリックスメタロプロテイナーゼの非ペプチドインヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011011407A Pending JP2011079866A (ja) | 2004-03-22 | 2011-01-21 | マトリックスメタロプロテイナーゼの非ペプチドインヒビター |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8129406B2 (https=) |
| EP (1) | EP1735274B1 (https=) |
| JP (2) | JP2007530546A (https=) |
| KR (1) | KR20070046025A (https=) |
| CN (1) | CN101001834B (https=) |
| AT (1) | ATE449760T1 (https=) |
| AU (1) | AU2005227311B2 (https=) |
| CA (1) | CA2560739A1 (https=) |
| DE (1) | DE602005017879D1 (https=) |
| DK (1) | DK1735274T3 (https=) |
| ES (1) | ES2338243T3 (https=) |
| MX (1) | MXPA06010974A (https=) |
| NZ (1) | NZ550621A (https=) |
| PL (1) | PL1735274T3 (https=) |
| PT (1) | PT1735274E (https=) |
| SI (1) | SI1735274T1 (https=) |
| WO (1) | WO2005092844A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2231596A4 (en) * | 2007-12-14 | 2012-06-06 | Univ Georgetown | INHIBITORS OF HISTONATE ACETYLASE |
| GB0817207D0 (en) * | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| WO2010047803A2 (en) * | 2008-10-22 | 2010-04-29 | Oncotx, L.L.C. | A method for the treatment of proliferative disorders of the eye |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753653A (en) | 1995-12-08 | 1998-05-19 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| DE69624081T2 (de) | 1995-12-20 | 2003-06-12 | Agouron Pharmaceuticals, Inc. | Matrix-metalloprotease Inhibitoren |
| NZ332711A (en) * | 1996-05-17 | 2000-06-23 | Warner Lambert Co | Biphenylsulfonylamino carboxylic acid derivatives as matrix metalloproteinase inhibitors |
| EP0818442A3 (en) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor |
| JP2001502326A (ja) | 1996-10-16 | 2001-02-20 | アメリカン・サイアナミド・カンパニー | マトリクス金属プロテナイーゼおよびＴＡＣＥに対する阻害薬としてのβ―スルホンアミドヒドロキサム酸 |
| US5977408A (en) | 1996-10-16 | 1999-11-02 | American Cyanamid Company | Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| US6380258B2 (en) * | 1997-03-04 | 2002-04-30 | G. D. Searle, L.L.C. | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds |
| GB9708133D0 (en) | 1997-04-22 | 1997-06-11 | British Biotech Pharm | Novel use of matrix metalloproteinase inhibitors |
| US6326516B1 (en) * | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
| AR035478A1 (es) * | 1999-01-27 | 2004-06-02 | Wyeth Corp | Acido amida-hidroxamico, acido acetilenico, beta-sulfonamido y fosfinico como inhibidores de la tace, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene |
| AUPP982399A0 (en) * | 1999-04-19 | 1999-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Mmp inhibitor |
| US6642255B2 (en) * | 2001-01-11 | 2003-11-04 | Bristol-Myers Squibb Pharma Company | 1,2,-Disubstituted cyclic inhibitors of matrix metalloproteases and TNF-alpha |
-
2005
- 2005-03-21 MX MXPA06010974A patent/MXPA06010974A/es active IP Right Grant
- 2005-03-21 EP EP05729212A patent/EP1735274B1/en not_active Expired - Lifetime
- 2005-03-21 AT AT05729212T patent/ATE449760T1/de active
- 2005-03-21 WO PCT/US2005/009263 patent/WO2005092844A1/en not_active Ceased
- 2005-03-21 SI SI200530912T patent/SI1735274T1/sl unknown
- 2005-03-21 DK DK05729212.0T patent/DK1735274T3/da active
- 2005-03-21 CN CN200580016346XA patent/CN101001834B/zh not_active Expired - Fee Related
- 2005-03-21 CA CA002560739A patent/CA2560739A1/en not_active Abandoned
- 2005-03-21 ES ES05729212T patent/ES2338243T3/es not_active Expired - Lifetime
- 2005-03-21 KR KR1020067021920A patent/KR20070046025A/ko not_active Ceased
- 2005-03-21 NZ NZ550621A patent/NZ550621A/en unknown
- 2005-03-21 JP JP2007505043A patent/JP2007530546A/ja active Pending
- 2005-03-21 DE DE602005017879T patent/DE602005017879D1/de not_active Expired - Lifetime
- 2005-03-21 US US10/593,748 patent/US8129406B2/en not_active Expired - Fee Related
- 2005-03-21 PT PT05729212T patent/PT1735274E/pt unknown
- 2005-03-21 AU AU2005227311A patent/AU2005227311B2/en not_active Expired - Fee Related
- 2005-03-21 PL PL05729212T patent/PL1735274T3/pl unknown
-
2011
- 2011-01-21 JP JP2011011407A patent/JP2011079866A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102746336B (zh) | 氨基磷酸酯烷化剂前体药物 | |
| ATE322264T1 (de) | Medizinische zusammensetzungen als begleittherapie gegen krebs | |
| JP2007511504A5 (https=) | ||
| JP2006515858A5 (https=) | ||
| JP2006511534A5 (https=) | ||
| CA2494049A1 (en) | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof | |
| JP2008535902A5 (https=) | ||
| JP2010511721A5 (https=) | ||
| FI952920A0 (fi) | 7-halogeeni- ja 7beta,8beta-metano-taksolit, niiden antineoplastinen käyttö ja niitä sisältävät farmaseuttiset koostumukset | |
| RU2000129508A (ru) | Сульфонамид-содержащие соединения индола | |
| ES2196527T3 (es) | Derivados de 11,15-o-dialquilprostaglandina e, su procedimiento de produccion y medicamentos que incluyen estos como principio activo. | |
| JP2008505117A5 (https=) | ||
| WO2004084812A3 (en) | Tamandarin analogs and fragments thereof and methods of making and using | |
| JPWO2020163823A5 (https=) | ||
| JPWO2020173935A5 (https=) | ||
| RU2006103858A (ru) | Способ лечения пролиферативных заболеваний | |
| ATE381554T1 (de) | Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen | |
| SG145570A1 (en) | 4-æ7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents | |
| JP2007530546A5 (https=) | ||
| RU2007141398A (ru) | НОВЫЕ ПРОИЗВОДНЫЕ ИЗОИНДОЛОВ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ИХ, ИХ ПОЛУЧЕНИЕ И ФАРМАЦЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ, В ЧАСТНОСТИ, В КАЧЕСТВЕ ИНГИБИТОРОВ АКТИВНОСТИ БЕЛКА-ШАПЕРОНА Hsp90 | |
| JP2008133274A5 (https=) | ||
| JP2005501121A5 (https=) | ||
| CN102625805A (zh) | 治疗癌症的化合物和组分 | |
| CA2511242A1 (en) | Inhibitors of human tumor-expressed ccxckr2 | |
| AU2019216757A1 (en) | Mebendazole prodrugs with enhanced solubility and oral bioavailability |