JP2007530492A5 - - Google Patents
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- JP2007530492A5 JP2007530492A5 JP2007504366A JP2007504366A JP2007530492A5 JP 2007530492 A5 JP2007530492 A5 JP 2007530492A5 JP 2007504366 A JP2007504366 A JP 2007504366A JP 2007504366 A JP2007504366 A JP 2007504366A JP 2007530492 A5 JP2007530492 A5 JP 2007530492A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical dosage
- dosage form
- form according
- coat
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002552 dosage form Substances 0.000 claims 39
- 239000013543 active substance Substances 0.000 claims 11
- 229920000642 polymer Polymers 0.000 claims 11
- 239000003826 tablet Substances 0.000 claims 9
- 239000011159 matrix material Substances 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 7
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 239000003094 microcapsule Substances 0.000 claims 6
- 239000000454 talc Substances 0.000 claims 6
- 229910052623 talc Inorganic materials 0.000 claims 6
- 239000001069 triethyl citrate Substances 0.000 claims 6
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 6
- 235000013769 triethyl citrate Nutrition 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 5
- 239000002775 capsule Substances 0.000 claims 4
- 208000037976 chronic inflammation Diseases 0.000 claims 4
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 4
- 230000002496 gastric effect Effects 0.000 claims 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 4
- 150000004676 glycans Chemical class 0.000 claims 4
- 229920001282 polysaccharide Polymers 0.000 claims 4
- 239000005017 polysaccharide Substances 0.000 claims 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 4
- FDNPKSCZFOAEDF-SMDDNHRTSA-N (2r)-2-[[(2s)-2-[[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]acetyl]amino]propanoyl]amino]pentanedioic acid Chemical compound C1=CC=C2C(=O)N(CCOCC(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O)C(=O)C2=C1 FDNPKSCZFOAEDF-SMDDNHRTSA-N 0.000 claims 3
- 229920003134 Eudragit® polymer Polymers 0.000 claims 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 3
- 108010087378 N-(2-(2-phthalimidoethoxy)acetyl)-L-alanyl-D-glutamic acid Proteins 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 3
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
- GVIRAXRGZUXHCI-UHFFFAOYSA-N 2-acetyloxycarbonylbenzoic acid Chemical compound CC(=O)OC(=O)C1=CC=CC=C1C(O)=O GVIRAXRGZUXHCI-UHFFFAOYSA-N 0.000 claims 2
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 229920003152 Eudragit® RS polymer Polymers 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 claims 2
- 210000004534 cecum Anatomy 0.000 claims 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 2
- 206010009887 colitis Diseases 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 2
- FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 claims 2
- 239000001087 glyceryl triacetate Substances 0.000 claims 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims 2
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 2
- 210000003405 ileum Anatomy 0.000 claims 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 2
- 239000004014 plasticizer Substances 0.000 claims 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims 2
- 239000011118 polyvinyl acetate Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229960002622 triacetin Drugs 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims 1
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims 1
- 229910002012 Aerosil® Inorganic materials 0.000 claims 1
- 239000005995 Aluminium silicate Substances 0.000 claims 1
- 229920000856 Amylose Polymers 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- 229920003151 Eudragit® RL polymer Polymers 0.000 claims 1
- 229920000926 Galactomannan Polymers 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000012211 aluminium silicate Nutrition 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 239000007931 coated granule Substances 0.000 claims 1
- 229960002380 dibutyl phthalate Drugs 0.000 claims 1
- 229940031954 dibutyl sebacate Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 125000005395 methacrylic acid group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims 1
- -1 polyoxyethylene Polymers 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 150000003839 salts Chemical group 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 239000007962 solid dispersion Substances 0.000 claims 1
- 239000001593 sorbitan monooleate Substances 0.000 claims 1
- 235000011069 sorbitan monooleate Nutrition 0.000 claims 1
- 229940035049 sorbitan monooleate Drugs 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200400094 | 2004-03-26 | ||
| PCT/EP2005/003175 WO2005092295A1 (en) | 2004-03-26 | 2005-03-24 | Gastroresistant pharmaceutical dosage form comprising n-(2-(2-phthalimidoethoxy)-acetyl)-l-alanyl-d-glutamic acid (lk-423) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007530492A JP2007530492A (ja) | 2007-11-01 |
| JP2007530492A5 true JP2007530492A5 (https=) | 2008-04-10 |
Family
ID=34964906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504366A Pending JP2007530492A (ja) | 2004-03-26 | 2005-03-24 | Ｎ−（２−（２−フタルイミドエトキシ）−アセチル）−ｌ−アラニル−ｄ−グルタミン酸（ｌｋ−４２３）を含む胃耐性の医薬品投薬形態物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100183714A1 (https=) |
| EP (1) | EP1734933B1 (https=) |
| JP (1) | JP2007530492A (https=) |
| CN (1) | CN1956707B (https=) |
| AR (1) | AR048342A1 (https=) |
| AT (1) | ATE468846T1 (https=) |
| AU (1) | AU2005226927B2 (https=) |
| BR (1) | BRPI0509271A (https=) |
| CA (1) | CA2559685A1 (https=) |
| DE (1) | DE602005021475D1 (https=) |
| MY (1) | MY145329A (https=) |
| PE (1) | PE20051163A1 (https=) |
| RU (1) | RU2375047C2 (https=) |
| TW (1) | TW200600121A (https=) |
| WO (1) | WO2005092295A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8273376B2 (en) | 2006-11-17 | 2012-09-25 | Da Volterra | Colonic delivery of metallo-dependent enzymes |
| WO2008059062A1 (en) * | 2006-11-17 | 2008-05-22 | Da Volterra | Colonic delivery using zn/pectin beads with a eudragit coating. |
| US20100239682A1 (en) * | 2007-09-17 | 2010-09-23 | Antoine Andremont | Colonic delivery of antimicrobial agents |
| RU2593939C2 (ru) | 2008-11-13 | 2016-08-10 | Ногра Фарма Лимитед | Антисмысловые композиции и способы их получения и применения |
| CA2987863A1 (en) * | 2015-06-01 | 2016-12-08 | Xeno Biosciences Inc. | Methods and compositions to modulate the gut microbiota and to manage weight |
| CN109562158A (zh) * | 2016-06-23 | 2019-04-02 | 纽特莱特公司 | 在动物中促进生长和提高饲料转化率的方法 |
| EP3538659A4 (en) * | 2016-11-09 | 2020-07-15 | Engene, Inc. | INTESTINAL EXPRESSION OF THE SCHEDULED DEATH LIGAND 1 |
| JP2020502126A (ja) | 2016-12-14 | 2020-01-23 | プロジェニティ， インコーポレイテッド | 消化管疾病のｊａｋ阻害薬による治療 |
| CN110430801B (zh) * | 2016-12-14 | 2024-04-30 | 比奥拉治疗股份有限公司 | 使用tnf抑制剂治疗胃肠道疾病 |
| US20200253506A1 (en) * | 2016-12-14 | 2020-08-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| CN108968074B (zh) * | 2018-06-06 | 2021-09-28 | 福建省农业科学院农业工程技术研究所 | 一种结肠靶向递送的银耳糖醛酸多糖-芙蓉李花青素复合物及其制备方法 |
| KR102104507B1 (ko) * | 2019-08-23 | 2020-04-24 | 브릿지바이오테라퓨틱스(주) | 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법 |
| ES3014076T3 (en) | 2020-03-26 | 2025-04-16 | Nutrivert Inc | Lipophilic enantiomers of desacetylglucosamine muramyl dipeptide with anti-inflammatory and growth promoting activity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69131688T2 (de) * | 1990-05-04 | 2000-05-25 | Perio Products Ltd., Hahotzvim | System zur arzneistoffabgabe im colon |
| JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| SI9011830B (sl) * | 1990-09-27 | 1999-12-31 | Univerza V Ljubljani, Fakulteta Za Farmacijo | Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo |
| DE19732903A1 (de) * | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| US6627223B2 (en) * | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
-
2005
- 2005-03-24 CN CN2005800168849A patent/CN1956707B/zh not_active Expired - Fee Related
- 2005-03-24 US US10/599,289 patent/US20100183714A1/en not_active Abandoned
- 2005-03-24 EP EP05733297A patent/EP1734933B1/en not_active Expired - Lifetime
- 2005-03-24 AU AU2005226927A patent/AU2005226927B2/en not_active Ceased
- 2005-03-24 JP JP2007504366A patent/JP2007530492A/ja active Pending
- 2005-03-24 MY MYPI20051274A patent/MY145329A/en unknown
- 2005-03-24 DE DE602005021475T patent/DE602005021475D1/de not_active Expired - Fee Related
- 2005-03-24 RU RU2006137660/15A patent/RU2375047C2/ru not_active IP Right Cessation
- 2005-03-24 BR BRPI0509271-0A patent/BRPI0509271A/pt not_active IP Right Cessation
- 2005-03-24 CA CA002559685A patent/CA2559685A1/en not_active Abandoned
- 2005-03-24 WO PCT/EP2005/003175 patent/WO2005092295A1/en not_active Ceased
- 2005-03-24 AT AT05733297T patent/ATE468846T1/de active
- 2005-03-28 TW TW094109593A patent/TW200600121A/zh unknown
- 2005-03-28 AR ARP050101197A patent/AR048342A1/es unknown
- 2005-03-28 PE PE2005000349A patent/PE20051163A1/es not_active Application Discontinuation
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