CN1956707B - 包含n-(2-(2-苯二酰亚氨基乙氧基)-乙酰基)-l-丙氨酰基-d-谷氨酸(lk-423)的耐胃酸的药物剂型 - Google Patents

包含n-(2-(2-苯二酰亚氨基乙氧基)-乙酰基)-l-丙氨酰基-d-谷氨酸(lk-423)的耐胃酸的药物剂型 Download PDF

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Publication number
CN1956707B
CN1956707B CN2005800168849A CN200580016884A CN1956707B CN 1956707 B CN1956707 B CN 1956707B CN 2005800168849 A CN2005800168849 A CN 2005800168849A CN 200580016884 A CN200580016884 A CN 200580016884A CN 1956707 B CN1956707 B CN 1956707B
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China
Prior art keywords
coating
dosage form
pharmaceutical dosage
eudragit
tablet
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Expired - Fee Related
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CN2005800168849A
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English (en)
Chinese (zh)
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CN1956707A (zh
Inventor
M·博加塔耶
A·姆尔哈
A·拉夫里克
M·切尔内
D·蒂鲍特
A·斯塔利克
U·乌尔莱波
T·马泰奥维奇
G·科夫
J·柯克
R·德勒
米田文士
村冈贱子
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Lek Pharmaceuticals dd
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Lek Pharmaceuticals dd
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Publication of CN1956707A publication Critical patent/CN1956707A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2005800168849A 2004-03-26 2005-03-24 包含n-(2-(2-苯二酰亚氨基乙氧基)-乙酰基)-l-丙氨酰基-d-谷氨酸(lk-423)的耐胃酸的药物剂型 Expired - Fee Related CN1956707B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SIP200400094 2004-03-26
SI200400094 2004-03-26
PCT/EP2005/003175 WO2005092295A1 (en) 2004-03-26 2005-03-24 Gastroresistant pharmaceutical dosage form comprising n-(2-(2-phthalimidoethoxy)-acetyl)-l-alanyl-d-glutamic acid (lk-423)

Publications (2)

Publication Number Publication Date
CN1956707A CN1956707A (zh) 2007-05-02
CN1956707B true CN1956707B (zh) 2010-12-29

Family

ID=34964906

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800168849A Expired - Fee Related CN1956707B (zh) 2004-03-26 2005-03-24 包含n-(2-(2-苯二酰亚氨基乙氧基)-乙酰基)-l-丙氨酰基-d-谷氨酸(lk-423)的耐胃酸的药物剂型

Country Status (15)

Country Link
US (1) US20100183714A1 (https=)
EP (1) EP1734933B1 (https=)
JP (1) JP2007530492A (https=)
CN (1) CN1956707B (https=)
AR (1) AR048342A1 (https=)
AT (1) ATE468846T1 (https=)
AU (1) AU2005226927B2 (https=)
BR (1) BRPI0509271A (https=)
CA (1) CA2559685A1 (https=)
DE (1) DE602005021475D1 (https=)
MY (1) MY145329A (https=)
PE (1) PE20051163A1 (https=)
RU (1) RU2375047C2 (https=)
TW (1) TW200600121A (https=)
WO (1) WO2005092295A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8273376B2 (en) 2006-11-17 2012-09-25 Da Volterra Colonic delivery of metallo-dependent enzymes
CN101795675A (zh) * 2006-11-17 2010-08-04 达沃尔泰拉公司 使用具有Eudragit包衣的Zn/果胶珠粒进行的结肠递送
WO2009037264A2 (en) * 2007-09-17 2009-03-26 Da Volterra Colonic delivery of antimicrobial agents
ES2627745T3 (es) * 2008-11-13 2017-07-31 Nogra Pharma Limited Composiciones antisentido, y procedimientos de fabricación y uso de las mismas
EP3915552A1 (en) * 2015-06-01 2021-12-01 Xeno Biosciences Inc. Compositions for use in modulating the gut microbiota and managing weight
BR112018077032A2 (pt) * 2016-06-23 2019-04-02 Nutrivert Llc método para aprimorar o crescimento ou a conversão alimentar em um animal, uso de pgn, mdp ou um análogo de mdp na preparação de um medicamento e pgn, mdp ou um análogo de mdp
WO2018085935A1 (en) * 2016-11-09 2018-05-17 Engene, Inc. Intestinal expression of programmed death ligand 1
BR112019012071A2 (pt) * 2016-12-14 2019-11-12 Progenity Inc tratamento de uma doença do trato gastrointestinal com um inibidor de integrina
EP3554485B9 (en) * 2016-12-14 2023-09-27 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a jak inhibitor and devices
EP3554342B1 (en) * 2016-12-14 2024-07-24 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a tnf inhibitor
CN108968074B (zh) * 2018-06-06 2021-09-28 福建省农业科学院农业工程技术研究所 一种结肠靶向递送的银耳糖醛酸多糖-芙蓉李花青素复合物及其制备方法
KR102104507B1 (ko) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법
ES3014076T3 (en) 2020-03-26 2025-04-16 Nutrivert Inc Lipophilic enantiomers of desacetylglucosamine muramyl dipeptide with anti-inflammatory and growth promoting activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1058904A (zh) * 1990-07-10 1992-02-26 信越化学工业株式会社 在大肠内具有释放能力的包衣固体药物型
CN1338925A (zh) * 1998-07-17 2002-03-06 布里斯托尔-迈尔斯斯奎布公司 肠溶衣药用片剂及其生产方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2113221C1 (ru) * 1990-05-04 1998-06-20 Ииссум Рисерч Дивелопмент Компани оф дзе Хебрю Юниверсити оф Иеруcалим Фармацевтическая форма для введения лекарственного средства в ободочную кишку, способ введения лекарственного препарата и способ получения матриц для такой формы
YU183090A (sh) * 1990-09-27 1992-12-21 Lek Novi n-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, kojih vsebujejo
DE19732903A1 (de) * 1997-07-30 1999-02-04 Falk Pharma Gmbh Pellet-Formulierung zur Behandlung des Intestinaltraktes
US6627223B2 (en) * 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1058904A (zh) * 1990-07-10 1992-02-26 信越化学工业株式会社 在大肠内具有释放能力的包衣固体药物型
CN1338925A (zh) * 1998-07-17 2002-03-06 布里斯托尔-迈尔斯斯奎布公司 肠溶衣药用片剂及其生产方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MORIGUCHI M ET AL..Therapeutic effects of LK423,aphthalimido-desmuramyl-dipeptide compound,ondextransulfate sodium-induced colitis in rodentsthroughrestoring theirinterleukin-10 producing capacity.Arzneimittelforschung49 2.1999,49(2),184-192. *
OCHI C ET AL..Interleukin-10 inducing activity of LK423,aphthalimido-desmuramyldipeptide compound.Arzneimittelforschung49 1.1999,49(1),72-79. *

Also Published As

Publication number Publication date
ATE468846T1 (de) 2010-06-15
PE20051163A1 (es) 2006-02-21
EP1734933A1 (en) 2006-12-27
US20100183714A1 (en) 2010-07-22
RU2006137660A (ru) 2008-05-10
CA2559685A1 (en) 2005-10-06
EP1734933B1 (en) 2010-05-26
AU2005226927A1 (en) 2005-10-06
CN1956707A (zh) 2007-05-02
JP2007530492A (ja) 2007-11-01
BRPI0509271A (pt) 2007-09-04
AR048342A1 (es) 2006-04-19
MY145329A (en) 2012-01-31
RU2375047C2 (ru) 2009-12-10
DE602005021475D1 (de) 2010-07-08
AU2005226927B2 (en) 2010-09-23
WO2005092295A1 (en) 2005-10-06
TW200600121A (en) 2006-01-01

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Granted publication date: 20101229

Termination date: 20120324