JP2007529485A5 - - Google Patents

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Publication number

JP2007529485A5

JP2007529485A5 JP2007503402A JP2007503402A JP2007529485A5 JP 2007529485 A5 JP2007529485 A5 JP 2007529485A5 JP 2007503402 A JP2007503402 A JP 2007503402A JP 2007503402 A JP2007503402 A JP 2007503402A JP 2007529485 A5 JP2007529485 A5 JP 2007529485A5

Authority

JP

Japan

Prior art keywords

alkyl

compound

formula

nitrogen

independently

Prior art date

2005-03-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 45
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 44
• 150000003839 salts Chemical class 0.000 claims 39
• 150000001875 compounds Chemical class 0.000 claims 36
• 229910052757 nitrogen Inorganic materials 0.000 claims 24
• 125000003709 fluoroalkyl group Chemical group 0.000 claims 22
• 229910052799 carbon Inorganic materials 0.000 claims 20
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 19
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 18
• 125000001424 substituent group Chemical group 0.000 claims 18
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 14
• 125000004428 fluoroalkoxy group Chemical group 0.000 claims 12
• 125000003545 alkoxy group Chemical group 0.000 claims 11
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 10
• 125000000623 heterocyclic group Chemical group 0.000 claims 10
• 229910052739 hydrogen Inorganic materials 0.000 claims 10
• -1 hydroxyimino Chemical group 0.000 claims 9
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
• 125000001153 fluoro group Chemical group F* 0.000 claims 8
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 7
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 7
• NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 7
• 229910052760 oxygen Inorganic materials 0.000 claims 7
• 125000000753 cycloalkyl group Chemical group 0.000 claims 6
• 125000005843 halogen group Chemical group 0.000 claims 6
• 229960003753 nitric oxide Drugs 0.000 claims 6
• 235000019391 nitrogen oxide Nutrition 0.000 claims 6
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
• 229910052717 sulfur Inorganic materials 0.000 claims 5
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
• 125000005037 alkyl phenyl group Chemical group 0.000 claims 3
• 150000001721 carbon Chemical group 0.000 claims 3
• 125000001309 chloro group Chemical group Cl* 0.000 claims 3
• 239000001257 hydrogen Substances 0.000 claims 3
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
• 125000004076 pyridyl group Chemical group 0.000 claims 3
• 241000124008 Mammalia Species 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
• 125000002619 bicyclic group Chemical group 0.000 claims 2
• NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 claims 2
• 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 230000002757 inflammatory effect Effects 0.000 claims 2
• 239000001301 oxygen Substances 0.000 claims 2
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
• JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 1
• 101100240527 Caenorhabditis elegans nhr-22 gene Proteins 0.000 claims 1
• KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
• 229930194542 Keto Natural products 0.000 claims 1
• 206010039085 Rhinitis allergic Diseases 0.000 claims 1
• 229910005965 SO 2 Inorganic materials 0.000 claims 1
• 125000004848 alkoxyethyl group Chemical group 0.000 claims 1
• 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
• 125000005036 alkoxyphenyl group Chemical group 0.000 claims 1
• 201000010105 allergic rhinitis Diseases 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
• 229910052801 chlorine Inorganic materials 0.000 claims 1
• 239000000460 chlorine Substances 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 claims 1
• 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims 1
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• 239000011737 fluorine Substances 0.000 claims 1
• 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
• 125000000468 ketone group Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 238000003419 tautomerization reaction Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1