JP2007528424A5 - - Google Patents
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- Publication number
- JP2007528424A5 JP2007528424A5 JP2007503103A JP2007503103A JP2007528424A5 JP 2007528424 A5 JP2007528424 A5 JP 2007528424A5 JP 2007503103 A JP2007503103 A JP 2007503103A JP 2007503103 A JP2007503103 A JP 2007503103A JP 2007528424 A5 JP2007528424 A5 JP 2007528424A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- independently
- hydroxy
- substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 31
- -1 hydroxypropyl Chemical group 0.000 claims 12
- 125000004122 cyclic group Chemical group 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 9
- 239000000539 dimer Substances 0.000 claims 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 7
- 239000000178 monomer Substances 0.000 claims 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 5
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 5
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 5
- 229960004537 ioversol Drugs 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
- 239000012216 imaging agent Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- DLPPIGPJCKKVBA-UHFFFAOYSA-N Iosimenol Chemical group OCC(O)CNC(=O)C1=C(I)C(C(=O)N)=C(I)C(N(CC(O)CO)C(=O)CC(=O)N(CC(O)CO)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(N)=O)C=2I)I)=C1I DLPPIGPJCKKVBA-UHFFFAOYSA-N 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- 239000011575 calcium Substances 0.000 claims 3
- 239000002872 contrast media Substances 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 229960001025 iohexol Drugs 0.000 claims 3
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims 3
- 229960004647 iopamidol Drugs 0.000 claims 3
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 239000003146 anticoagulant agent Substances 0.000 claims 2
- 229940127219 anticoagulant drug Drugs 0.000 claims 2
- 239000012062 aqueous buffer Substances 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 238000002059 diagnostic imaging Methods 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 235000021317 phosphate Nutrition 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 102000007625 Hirudins Human genes 0.000 claims 1
- 108010007267 Hirudins Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims 1
- 229940006607 hirudin Drugs 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 229960004108 iobitridol Drugs 0.000 claims 1
- YLPBXIKWXNRACS-UHFFFAOYSA-N iobitridol Chemical compound OCC(O)CN(C)C(=O)C1=C(I)C(NC(=O)C(CO)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I YLPBXIKWXNRACS-UHFFFAOYSA-N 0.000 claims 1
- 229960000780 iomeprol Drugs 0.000 claims 1
- NJKDOADNQSYQEV-UHFFFAOYSA-N iomeprol Chemical group OCC(=O)N(C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NJKDOADNQSYQEV-UHFFFAOYSA-N 0.000 claims 1
- 229960000824 iopentol Drugs 0.000 claims 1
- IUNJANQVIJDFTQ-UHFFFAOYSA-N iopentol Chemical compound COCC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I IUNJANQVIJDFTQ-UHFFFAOYSA-N 0.000 claims 1
- 229960002603 iopromide Drugs 0.000 claims 1
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 claims 1
- 229950004246 iosimenol Drugs 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000008227 sterile water for injection Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 1
- GKODZWOPPOTFGA-UHFFFAOYSA-N tris(hydroxyethyl)aminomethane Chemical compound OCCC(N)(CCO)CCO GKODZWOPPOTFGA-UHFFFAOYSA-N 0.000 claims 1
- 238000012285 ultrasound imaging Methods 0.000 claims 1
- 238000012800 visualization Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55224004P | 2004-03-11 | 2004-03-11 | |
| PCT/US2005/008389 WO2005087272A2 (en) | 2004-03-11 | 2005-03-11 | X-ray contrast formulation comprising a mixture of iodinated monomer and dimer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007528424A JP2007528424A (ja) | 2007-10-11 |
| JP2007528424A5 true JP2007528424A5 (https=) | 2008-04-24 |
Family
ID=34964357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503103A Withdrawn JP2007528424A (ja) | 2004-03-11 | 2005-03-11 | ヨウ化単量体および二量体の混合物を含むｘ線造影剤製剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8679460B2 (https=) |
| EP (2) | EP1725268B1 (https=) |
| JP (1) | JP2007528424A (https=) |
| KR (1) | KR20070015517A (https=) |
| CN (1) | CN1938050A (https=) |
| AT (1) | ATE529135T1 (https=) |
| AU (1) | AU2005221716A1 (https=) |
| CA (1) | CA2559628A1 (https=) |
| ES (1) | ES2374633T3 (https=) |
| IL (1) | IL177888A0 (https=) |
| NO (1) | NO20064629L (https=) |
| WO (1) | WO2005087272A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2240432B1 (en) * | 2008-01-14 | 2012-07-04 | Mallinckrodt LLC | Process for the preparation of iosimenol |
| US11219696B2 (en) | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
| CN102271715A (zh) | 2009-01-09 | 2011-12-07 | 通用电气医疗集团股份有限公司 | 对比剂组合物 |
| JP5947784B2 (ja) * | 2010-03-23 | 2016-07-06 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 安定化ｘ線診断用組成物の製法 |
| US20130039888A1 (en) | 2011-06-08 | 2013-02-14 | Nationwide Children's Hospital Inc. | Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders |
| JP2013091701A (ja) | 2011-10-25 | 2013-05-16 | Dow Corning Toray Co Ltd | 硬化性組成物 |
| US9725716B2 (en) * | 2011-12-06 | 2017-08-08 | Ohio State Innovation Foundation and Research Institute at Nationwide Children's Hospital | Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease |
| CN104114190A (zh) * | 2012-01-11 | 2014-10-22 | 通用电气医疗集团股份有限公司 | 具有低碘浓度的x-射线成像造影介质和x-射线成像方法 |
| WO2013180777A1 (en) * | 2012-05-30 | 2013-12-05 | Verrow Pharmaceuticals, Inc. | Stabilized formulations containing iodinated contrast agents and cyclodextrins |
| AU2013296425B2 (en) | 2012-08-01 | 2018-06-07 | Nationwide Children's Hospital | Intrathecal delivery of recombinant adeno-associated virus 9 |
| KR102151088B1 (ko) * | 2018-07-10 | 2020-09-02 | 한국원자력연구원 | 소체와 연결된 실 모양의 구조물 가시화 조성물 및 이의 가시화 방법 |
| CN112386712B (zh) * | 2020-11-09 | 2022-08-30 | 张洪 | 分子探针及其制备方法和用途 |
| CN119656340A (zh) * | 2024-12-13 | 2025-03-21 | 福安药业集团宁波天衡制药有限公司 | 一种碘佛醇注射液及其制备方法 |
| CN120899953B (zh) * | 2025-10-13 | 2025-12-12 | 浙江迪安鉴识科技有限公司 | 一种尸体用血管造影剂及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2511871A1 (fr) | 1981-08-28 | 1983-03-04 | Guerbet Sa | Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus |
| US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
| EP0619744A4 (en) | 1991-12-03 | 1995-02-08 | Mallinckrodt Medical Inc | NON-ionic X-RAY CONTRASTS, COMPOSITIONS AND METHODS. |
| IT1256248B (it) | 1992-12-24 | 1995-11-29 | Bracco Spa | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
| DE19627309C2 (de) | 1996-06-27 | 1999-07-29 | Schering Ag | Wäßrige injizierbare Formulierungen verwendbar als Kontrastmittel |
| ITMI20011706A1 (it) | 2001-08-03 | 2003-02-03 | Bracco Imaging Spa | Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic |
| US8518373B2 (en) * | 2001-08-03 | 2013-08-27 | Bracco Imaging Spa | Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics |
| US7250153B2 (en) * | 2002-12-12 | 2007-07-31 | Biophysica Research, Inc. | Contrast media formulations having improved biological tolerance |
-
2005
- 2005-03-11 AT AT05731581T patent/ATE529135T1/de not_active IP Right Cessation
- 2005-03-11 ES ES05731581T patent/ES2374633T3/es not_active Expired - Lifetime
- 2005-03-11 EP EP05731581A patent/EP1725268B1/en not_active Expired - Lifetime
- 2005-03-11 US US10/588,674 patent/US8679460B2/en not_active Expired - Fee Related
- 2005-03-11 JP JP2007503103A patent/JP2007528424A/ja not_active Withdrawn
- 2005-03-11 KR KR1020067018308A patent/KR20070015517A/ko not_active Withdrawn
- 2005-03-11 WO PCT/US2005/008389 patent/WO2005087272A2/en not_active Ceased
- 2005-03-11 CA CA002559628A patent/CA2559628A1/en not_active Abandoned
- 2005-03-11 EP EP10174231A patent/EP2253332B1/en not_active Expired - Lifetime
- 2005-03-11 CN CNA2005800078749A patent/CN1938050A/zh active Pending
- 2005-03-11 AU AU2005221716A patent/AU2005221716A1/en not_active Abandoned
-
2006
- 2006-09-04 IL IL177888A patent/IL177888A0/en unknown
- 2006-10-10 NO NO20064629A patent/NO20064629L/no not_active Application Discontinuation
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