JP2007528409A5 - - Google Patents
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- Publication number
- JP2007528409A5 JP2007528409A5 JP2007503004A JP2007503004A JP2007528409A5 JP 2007528409 A5 JP2007528409 A5 JP 2007528409A5 JP 2007503004 A JP2007503004 A JP 2007503004A JP 2007503004 A JP2007503004 A JP 2007503004A JP 2007528409 A5 JP2007528409 A5 JP 2007528409A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- aat
- use according
- functionally active
- halide salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 66
- -1 halide salt Chemical class 0.000 claims 22
- 239000000843 powder Substances 0.000 claims 12
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- 150000003841 chloride salts Chemical group 0.000 claims 8
- 230000005714 functional activity Effects 0.000 claims 8
- 210000004072 lung Anatomy 0.000 claims 6
- 102100022712 Alpha-1-antitrypsin Human genes 0.000 claims 4
- 241000208125 Nicotiana Species 0.000 claims 4
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 4
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 4
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 235000014633 carbohydrates Nutrition 0.000 claims 4
- 235000019504 cigarettes Nutrition 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 108010006035 Metalloproteases Proteins 0.000 claims 2
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims 2
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 2
- 102100026261 Metalloproteinase inhibitor 3 Human genes 0.000 claims 2
- 102100024289 Metalloproteinase inhibitor 4 Human genes 0.000 claims 2
- 108050006579 Metalloproteinase inhibitor 4 Proteins 0.000 claims 2
- 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 claims 2
- 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 claims 2
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 claims 2
- 229940124630 bronchodilator Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 230000001590 oxidative effect Effects 0.000 claims 2
- 239000000779 smoke Substances 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55185604P | 2004-03-09 | 2004-03-09 | |
| PCT/US2005/007959 WO2005086915A2 (en) | 2004-03-09 | 2005-03-09 | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007528409A JP2007528409A (ja) | 2007-10-11 |
| JP2007528409A5 true JP2007528409A5 (https=) | 2009-08-06 |
Family
ID=34976236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503004A Pending JP2007528409A (ja) | 2004-03-09 | 2005-03-09 | プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7914771B2 (https=) |
| EP (1) | EP1737499A4 (https=) |
| JP (1) | JP2007528409A (https=) |
| AU (1) | AU2005221151A1 (https=) |
| CA (1) | CA2559062A1 (https=) |
| WO (1) | WO2005086915A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060257324A1 (en) | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
| EP1737499A4 (en) * | 2004-03-09 | 2009-07-22 | Arriva Pharmaceuticals Inc | TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE BY INHALATION OF LOW DOSES OF A PROTEASE HEMMER |
| EP1981572B1 (en) | 2006-02-09 | 2012-11-21 | Kamada Ltd. | Pulmonary delivery of alpha-i proteinase inhibitor |
| WO2008053199A1 (en) * | 2006-10-30 | 2008-05-08 | Astrazeneca Ab | Combination therapy for the treatment of respiratory diseases |
| GB0716026D0 (en) * | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| AU2012275295B2 (en) * | 2011-06-28 | 2016-11-10 | Inhibrx, Lp | WAP domain fusion polypeptides and methods of use thereof |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| KR102231139B1 (ko) * | 2011-06-28 | 2021-03-24 | 인히브릭스, 인크. | 세르핀 융합 폴리펩타이드 및 이의 이용 방법 |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| KR20140108516A (ko) | 2011-12-30 | 2014-09-11 | 그리폴스, 에스.에이. | 폐 악화의 발현 또는 진행을 지연시키기 위한 알파1-프로테이나제 억제제 |
| WO2014089262A1 (en) * | 2012-12-07 | 2014-06-12 | Virginia Commonwealth University | Diagnosis and therapy of chronic inflammation-induced disorders |
| KR20160054475A (ko) * | 2013-08-05 | 2016-05-16 | 제라드 뵈르만 | 흡연의 해로운 영향을 감소시키는 신규의 수단 |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| WO2018116300A1 (en) * | 2016-12-22 | 2018-06-28 | Kamada Ltd. | Dry powder formulations of alpha-1 antitrypsin |
| EP3915574A1 (en) * | 2020-05-27 | 2021-12-01 | Grifols Worldwide Operations Limited | Method for the treatment of cytokine release syndrome |
| US12440488B2 (en) | 2020-12-01 | 2025-10-14 | Reverspah Llc | Methods and compositions for treating chronic obstructive pulmonary disease, asthma, pneumonia, bronchitis, cystic fibrosis, pulmonary edema, interstitial lung disease, sarcoidosis, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and pulmonary arterial hypertension |
| US11324694B1 (en) * | 2021-10-28 | 2022-05-10 | Cmpd Licensing, Llc | Nebulization formulations for delivery to lower respiratory tract |
| WO2023091081A2 (en) * | 2021-11-16 | 2023-05-25 | Agency For Science, Technology And Research | Inhalable recombinant protein powder formulation for treating genetic and autoimmune disorders |
| EP4480493A1 (en) | 2023-06-22 | 2024-12-25 | AATEC Medical GmbH | A recombinant human alpha-1 antitrypsin glycoprotein for treating non-viral inflammatory diseases of the lung |
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| US20060205671A1 (en) | 2003-07-02 | 2006-09-14 | Jakob Vinten-Johansen | Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury |
| ATE530165T1 (de) * | 2003-11-14 | 2011-11-15 | Baxter Int | Alpha1-antitrypsin-zusammensetzungen und behandlungsverfahren unter verwendung dieser zusammensetzungen |
| EP1737499A4 (en) * | 2004-03-09 | 2009-07-22 | Arriva Pharmaceuticals Inc | TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE BY INHALATION OF LOW DOSES OF A PROTEASE HEMMER |
-
2005
- 2005-03-09 EP EP05725249A patent/EP1737499A4/en not_active Withdrawn
- 2005-03-09 JP JP2007503004A patent/JP2007528409A/ja active Pending
- 2005-03-09 CA CA002559062A patent/CA2559062A1/en not_active Abandoned
- 2005-03-09 WO PCT/US2005/007959 patent/WO2005086915A2/en not_active Ceased
- 2005-03-09 US US11/077,276 patent/US7914771B2/en not_active Expired - Fee Related
- 2005-03-09 AU AU2005221151A patent/AU2005221151A1/en not_active Abandoned
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