JP2007526460A5 - - Google Patents
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- JP2007526460A5 JP2007526460A5 JP2007501122A JP2007501122A JP2007526460A5 JP 2007526460 A5 JP2007526460 A5 JP 2007526460A5 JP 2007501122 A JP2007501122 A JP 2007501122A JP 2007501122 A JP2007501122 A JP 2007501122A JP 2007526460 A5 JP2007526460 A5 JP 2007526460A5
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- Prior art keywords
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- proteins
- measurement
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000010410 layer Substances 0.000 claims description 64
- 238000005259 measurement Methods 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 49
- 239000007787 solid Substances 0.000 claims description 42
- 230000001737 promoting effect Effects 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 9
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- -1 alkyl phosphates Chemical class 0.000 claims description 4
- 125000005600 alkyl phosphonate group Chemical group 0.000 claims description 4
- 229920001400 block copolymer Polymers 0.000 claims description 4
- 150000002118 epoxides Chemical class 0.000 claims description 4
- 235000021317 phosphate Nutrition 0.000 claims description 4
- 229920006112 polar polymer Polymers 0.000 claims description 4
- 150000003573 thiols Chemical class 0.000 claims description 4
- 239000013545 self-assembled monolayer Substances 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 2
- 238000000813 microcontact printing Methods 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 42
- 102000004169 proteins and genes Human genes 0.000 claims 42
- 108090000623 proteins and genes Proteins 0.000 claims 42
- 210000004027 cell Anatomy 0.000 claims 37
- 239000013592 cell lysate Substances 0.000 claims 31
- 230000027455 binding Effects 0.000 claims 29
- 238000009739 binding Methods 0.000 claims 29
- 238000001514 detection method Methods 0.000 claims 25
- 239000000523 sample Substances 0.000 claims 19
- 238000003491 array Methods 0.000 claims 17
- 230000003287 optical effect Effects 0.000 claims 17
- 239000006166 lysate Substances 0.000 claims 11
- 238000000151 deposition Methods 0.000 claims 8
- 239000002184 metal Substances 0.000 claims 7
- 229910052751 metal Inorganic materials 0.000 claims 7
- 230000009870 specific binding Effects 0.000 claims 7
- 230000008859 change Effects 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 5
- 239000012788 optical film Substances 0.000 claims 5
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims 4
- 239000010839 body fluid Substances 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 4
- 230000008021 deposition Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 229910000077 silane Inorganic materials 0.000 claims 4
- 238000004020 luminiscence type Methods 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 108010089610 Nuclear Proteins Proteins 0.000 claims 2
- 102000007999 Nuclear Proteins Human genes 0.000 claims 2
- 108010026552 Proteome Proteins 0.000 claims 2
- 239000012790 adhesive layer Substances 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 239000000470 constituent Substances 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 102000034287 fluorescent proteins Human genes 0.000 claims 2
- 108091006047 fluorescent proteins Proteins 0.000 claims 2
- 230000036541 health Effects 0.000 claims 2
- 229910044991 metal oxide Inorganic materials 0.000 claims 2
- 150000004706 metal oxides Chemical class 0.000 claims 2
- 229910052914 metal silicate Inorganic materials 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108091005573 modified proteins Proteins 0.000 claims 2
- 102000035118 modified proteins Human genes 0.000 claims 2
- 230000009871 nonspecific binding Effects 0.000 claims 2
- 239000004033 plastic Substances 0.000 claims 2
- 102000035123 post-translationally modified proteins Human genes 0.000 claims 2
- 108091005626 post-translationally modified proteins Proteins 0.000 claims 2
- 238000011160 research Methods 0.000 claims 2
- 150000004760 silicates Chemical class 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- 239000012780 transparent material Substances 0.000 claims 2
- 239000013594 undilute cell lysate Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000012491 analyte Substances 0.000 claims 1
- 238000003795 desorption Methods 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000005284 excitation Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000005194 fractionation Methods 0.000 claims 1
- 238000005286 illumination Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 238000011170 pharmaceutical development Methods 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 238000012910 preclinical development Methods 0.000 claims 1
- 238000012545 processing Methods 0.000 claims 1
- 238000002331 protein detection Methods 0.000 claims 1
- 238000004451 qualitative analysis Methods 0.000 claims 1
- 238000004445 quantitative analysis Methods 0.000 claims 1
- 239000000700 radioactive tracer Substances 0.000 claims 1
- 238000013517 stratification Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000009452 underexpressoin Effects 0.000 claims 1
- 150000004756 silanes Chemical class 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000000206 photolithography Methods 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2004/002127 WO2005095965A1 (en) | 2004-03-03 | 2004-03-03 | Analytical platform and method for generating protein expression profiles of cell populations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007526460A JP2007526460A (ja) | 2007-09-13 |
| JP2007526460A5 true JP2007526460A5 (https=) | 2011-02-24 |
Family
ID=34957113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501122A Pending JP2007526460A (ja) | 2004-03-03 | 2004-03-03 | 細胞集団のタンパク質発現プロファイルの作成のための分析用プラットフォームおよび方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080020409A1 (https=) |
| EP (1) | EP1730530A1 (https=) |
| JP (1) | JP2007526460A (https=) |
| CN (1) | CN1954213A (https=) |
| AU (1) | AU2004318038A1 (https=) |
| CA (1) | CA2559803A1 (https=) |
| WO (1) | WO2005095965A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ575827A (en) * | 2006-09-21 | 2012-02-24 | Prometheus Lab Inc | Antibody-based arrays for detecting multiple signal transducers in rare circulating cells |
| BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
| EP2179291B1 (en) | 2007-07-13 | 2014-10-22 | Nestec S.A. | Drug selection for lung cancer therapy using antibody-based arrays |
| AU2009219437B2 (en) | 2008-02-25 | 2014-10-16 | Nestec S.A. | Drug selection for breast cancer therapy using antibody-based arrays |
| US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
| WO2010101626A1 (en) | 2009-03-02 | 2010-09-10 | Seventh Sense Biosystems, Inc. | Techniques and devices associated with blood sampling |
| JP5795311B2 (ja) | 2009-07-15 | 2015-10-14 | ネステク ソシエテ アノニム | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
| US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
| US20120039809A1 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
| WO2012046412A1 (ja) * | 2010-10-07 | 2012-04-12 | パナソニック株式会社 | プラズモンセンサ |
| WO2012064802A1 (en) | 2010-11-09 | 2012-05-18 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
| US9719995B2 (en) | 2011-02-03 | 2017-08-01 | Pierian Holdings, Inc. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
| US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| JP6121400B2 (ja) | 2011-04-29 | 2017-04-26 | セブンス センス バイオシステムズ，インコーポレーテッド | 流体の送達および／または受け取り |
| EP3236259A1 (en) | 2011-04-29 | 2017-10-25 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
| EP2751562B1 (en) | 2011-09-02 | 2015-09-16 | Nestec S.A. | Profiling of signal pathway proteins to determine therapeutic efficacy |
| EP2573565A1 (en) | 2011-09-23 | 2013-03-27 | Gerhard Matthias Kresbach | Immune detection method for common epitopes of two or more analytes in samples of complex compositions, device, and kit for enabling said immune detection method |
| WO2014110327A1 (en) * | 2013-01-10 | 2014-07-17 | Emory University | Systems, methods and computer readable storage media for analyzing a sample |
| KR101527797B1 (ko) | 2014-06-03 | 2015-06-15 | 한국과학기술원 | 신호전달경로의 활성화 상태 분석방법 및 이를 이용한 개인 맞춤형 치료제의 선정방법 |
| JP2016148655A (ja) * | 2015-02-05 | 2016-08-18 | 日東電工株式会社 | 計測装置 |
| US20190233832A1 (en) * | 2016-07-19 | 2019-08-01 | National Agriculture And Food Research Organization | Method for introducing substance into plant cell using plasma |
| US10520514B2 (en) * | 2017-02-01 | 2019-12-31 | Korea Institute Of Science And Technology | Method for monitoring post-translational modification of protein |
| US11391735B2 (en) * | 2017-09-06 | 2022-07-19 | AimPlex Biosciences, Inc. | Methods for improving the dynamic range of biological assays |
| KR102342302B1 (ko) * | 2018-09-28 | 2021-12-24 | 주식회사 스몰머신즈 | 정량 분석용 단백질 칩 |
| CN110609078B (zh) * | 2019-09-20 | 2022-03-11 | 南京谱利健生物技术有限公司 | 一种检测蛋白磷酸化和乙酰氨基葡萄糖化关联作用的方法 |
| CN114112305B (zh) * | 2021-12-06 | 2024-02-06 | 西南石油大学 | 一种内外流夹击的柔性立管流固耦合效应测试装置及方法 |
| CN113970644B (zh) * | 2021-12-24 | 2022-05-27 | 天德瑞(北京)生物科技有限公司 | 基于hrp标记蛋白的工作浓度检测方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA96005828A (es) * | 1994-05-27 | 2005-07-15 | Novartis Ag Tambien Denominada | Proceso para detectar luminescencia excitada evanescentemente. |
| KR19990014709A (ko) * | 1995-05-12 | 1999-02-25 | 한스루돌프하우스 | 센서 플랫폼 및 감쇠 여기된 발광을 이용한 복수 분석물의병렬 검출 방법 |
| DE19628928A1 (de) * | 1996-07-18 | 1998-01-22 | Basf Ag | Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| WO1998009156A1 (en) * | 1996-08-29 | 1998-03-05 | Novartis Ag | Optical chemical / biochemical sensor |
| US6087102A (en) * | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
| EP1053347B1 (en) * | 1998-01-09 | 2007-02-28 | Phylogica Limited | Peptide detection method |
| US6197599B1 (en) * | 1998-07-30 | 2001-03-06 | Guorong Chin | Method to detect proteins |
| DE69919179T2 (de) * | 1998-09-09 | 2005-07-28 | Inflazyme Pharmaceuticals, Ltd., Richmond | Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen |
| US20030027214A1 (en) * | 1999-02-17 | 2003-02-06 | Kamb Carl Alexander | Methods for substrate-ligand interaction screening |
| US6972198B2 (en) * | 1999-02-26 | 2005-12-06 | Cyclacel, Ltd. | Methods and compositions using protein binding partners |
| GB0007088D0 (en) * | 2000-03-23 | 2000-05-17 | Torsana A S | Detection of immunological memory determining the position of loci of pathologyand therapeutic t-cell conjugates |
| EP1285290A1 (en) * | 2000-04-28 | 2003-02-26 | Edgelight Biosciences, Inc. | Micro-array evanescent wave fluorescence detection device |
| WO2001092870A2 (de) * | 2000-06-02 | 2001-12-06 | Zeptosens Ag | Kit und verfahren zur multianalytbestimmung |
| AU2001289859A1 (en) * | 2000-09-05 | 2002-03-22 | Zeptosens Ag | Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof |
| JP5021143B2 (ja) * | 2000-09-14 | 2012-09-05 | 株式会社リバース・プロテオミクス研究所 | 医療および他の用途に用いる化合物の発見および創製のための方法 |
| US7070740B1 (en) * | 2000-09-28 | 2006-07-04 | Beckman Coulter, Inc. | Method and apparatus for processing biomolecule arrays |
| US7332286B2 (en) * | 2001-02-02 | 2008-02-19 | University Of Pennsylvania | Peptide or protein microassay method and apparatus |
| AU2003231152A1 (en) * | 2002-04-26 | 2003-11-10 | Bristol-Myers Squibb Company | Novel essential fungal polynucleotides, polypeptides, and methods of use |
| US20060172344A1 (en) * | 2002-07-18 | 2006-08-03 | Yaeta Endo | Single chain antibody and use thereof |
| WO2004023143A2 (de) * | 2002-09-03 | 2004-03-18 | Zeptosens Ag | Analytische plattform und nachweisverfahren |
| WO2004023170A2 (en) * | 2002-09-07 | 2004-03-18 | Lightwave Bioapplications | Bioanalysis systems including optical integrated circuit |
-
2004
- 2004-03-03 EP EP04716582A patent/EP1730530A1/en not_active Withdrawn
- 2004-03-03 CA CA002559803A patent/CA2559803A1/en not_active Abandoned
- 2004-03-03 AU AU2004318038A patent/AU2004318038A1/en not_active Abandoned
- 2004-03-03 WO PCT/EP2004/002127 patent/WO2005095965A1/en not_active Ceased
- 2004-03-03 US US10/598,418 patent/US20080020409A1/en not_active Abandoned
- 2004-03-03 CN CNA2004800422474A patent/CN1954213A/zh active Pending
- 2004-03-03 JP JP2007501122A patent/JP2007526460A/ja active Pending
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