CN1954213A - 用于产生细胞群体的蛋白表达谱的分析平台和方法 - Google Patents

用于产生细胞群体的蛋白表达谱的分析平台和方法 Download PDF

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Publication number
CN1954213A
CN1954213A CNA2004800422474A CN200480042247A CN1954213A CN 1954213 A CN1954213 A CN 1954213A CN A2004800422474 A CNA2004800422474 A CN A2004800422474A CN 200480042247 A CN200480042247 A CN 200480042247A CN 1954213 A CN1954213 A CN 1954213A
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solid support
different
lysate
proteins
layer
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CNA2004800422474A
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English (en)
Chinese (zh)
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M·帕夫拉克
E·施克
P·奥罗什兰
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Bayer AG
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Bayer AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CNA2004800422474A 2004-03-03 2004-03-03 用于产生细胞群体的蛋白表达谱的分析平台和方法 Pending CN1954213A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2004/002127 WO2005095965A1 (en) 2004-03-03 2004-03-03 Analytical platform and method for generating protein expression profiles of cell populations

Publications (1)

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CN1954213A true CN1954213A (zh) 2007-04-25

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CNA2004800422474A Pending CN1954213A (zh) 2004-03-03 2004-03-03 用于产生细胞群体的蛋白表达谱的分析平台和方法

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US (1) US20080020409A1 (https=)
EP (1) EP1730530A1 (https=)
JP (1) JP2007526460A (https=)
CN (1) CN1954213A (https=)
AU (1) AU2004318038A1 (https=)
CA (1) CA2559803A1 (https=)
WO (1) WO2005095965A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107209114A (zh) * 2015-02-05 2017-09-26 日东电工株式会社 测量装置
CN109459562A (zh) * 2017-09-06 2019-03-12 阿姆普勒斯生物科学公司 用于提高生物测定动态范围的方法
CN109477084A (zh) * 2016-07-19 2019-03-15 国立研究开发法人农业·食品产业技术综合研究机构 使用等离子体在植物细胞内导入物质的方法
CN110609078A (zh) * 2019-09-20 2019-12-24 南京谱利健生物技术有限公司 一种检测蛋白磷酸化和乙酰氨基葡萄糖化关联作用的方法
CN113970644A (zh) * 2021-12-24 2022-01-25 天德瑞(北京)生物科技有限公司 基于hrp标记蛋白的工作浓度检测方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
DK2064549T3 (da) * 2006-09-21 2013-02-04 Nestec Sa Antistof-baserede arrays til detektion af flere signaltransducere i sjældne cirkulerende celler
ES2526211T3 (es) 2007-07-13 2015-01-08 Nestec S.A. Selección de fármacos para la terapia del cáncer de pulmón utilizando matrices basadas en anticuerpos
NZ617520A (en) 2008-02-25 2015-05-29 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
CN102405018B (zh) 2009-03-02 2014-11-19 第七感生物系统有限公司 与血液取样相关联的技术和装置
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
AU2010273319B2 (en) 2009-07-15 2015-01-22 Nestec S.A. Drug selection for gastric cancer therapy using antibody-based arrays
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
JP5938585B2 (ja) * 2010-10-07 2016-06-22 パナソニックＩｐマネジメント株式会社 プラズモンセンサ
EP2992827B1 (en) 2010-11-09 2017-04-19 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
CN103874460B (zh) 2011-04-29 2016-06-22 第七感生物系统有限公司 一种用于从受验者的皮肤接收血液或其它物质的装置
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
KR20140034200A (ko) 2011-04-29 2014-03-19 세븐쓰 센스 바이오시스템즈, 인크. 혈액 스폿들 또는 다른 신체 유체들을 수집 및/또는 조작하기 위한 시스템들 및 방법들
JP6186575B2 (ja) 2011-09-02 2017-08-30 ダイアテック ホールディングス， インコーポレイテッドＤｉａＴｅｃｈ Ｈｏｌｄｉｎｇｓ， Ｉｎｃ． 治療有効性を判定するためのシグナル経路タンパク質のプロファイリング
EP2573565A1 (en) 2011-09-23 2013-03-27 Gerhard Matthias Kresbach Immune detection method for common epitopes of two or more analytes in samples of complex compositions, device, and kit for enabling said immune detection method
EP3892997A1 (en) * 2013-01-10 2021-10-13 Emory University Systems, methods and computer readable storage media for analyzing a sample
KR101527797B1 (ko) * 2014-06-03 2015-06-15 한국과학기술원 신호전달경로의 활성화 상태 분석방법 및 이를 이용한 개인 맞춤형 치료제의 선정방법
US10520514B2 (en) * 2017-02-01 2019-12-31 Korea Institute Of Science And Technology Method for monitoring post-translational modification of protein
KR102342302B1 (ko) * 2018-09-28 2021-12-24 주식회사 스몰머신즈 정량 분석용 단백질 칩
CN114112305B (zh) * 2021-12-06 2024-02-06 西南石油大学 一种内外流夹击的柔性立管流固耦合效应测试装置及方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1149335A (zh) * 1994-05-27 1997-05-07 希巴-盖吉股份公司 探测短暂受激发光的方法
TW302435B (https=) * 1995-05-12 1997-04-11 Ciba Geigy Ag
DE19628928A1 (de) * 1996-07-18 1998-01-22 Basf Ag Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
AU4207897A (en) * 1996-08-29 1998-03-19 Novartis Ag Optical chemical / biochemical sensor
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
CA2317816C (en) * 1998-01-09 2009-02-17 Tvw Telethon Institute For Child Health Research Peptide detection method
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
WO2000014083A1 (en) * 1998-09-09 2000-03-16 Inflazyme Pharmaceuticals Ltd. SUBSTITUTED η-PHENYL-Δ-LACTONES AND ANALOGS THEREOF AND USES RELATED THERETO
US20030027214A1 (en) * 1999-02-17 2003-02-06 Kamb Carl Alexander Methods for substrate-ligand interaction screening
US6972198B2 (en) * 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
GB0007088D0 (en) * 2000-03-23 2000-05-17 Torsana A S Detection of immunological memory determining the position of loci of pathologyand therapeutic t-cell conjugates
US7175811B2 (en) * 2000-04-28 2007-02-13 Edgelight Biosciences Micro-array evanescent wave fluorescence detection device
WO2001092870A2 (de) * 2000-06-02 2001-12-06 Zeptosens Ag Kit und verfahren zur multianalytbestimmung
WO2002020873A2 (de) * 2000-09-05 2002-03-14 Zeptosens Ag Verfahren zur abscheidung von mono- und mehrfachschichten von organophosphor- und -phosphonsäuren und deren salzen sowie deren verwendung
EP2071481A3 (en) * 2000-09-14 2009-09-02 Reverse Proteomics Research Institute Co., Ltd Method system, apparatus and device for discovering and preparing chemical compounds for medical and other uses
US7070740B1 (en) * 2000-09-28 2006-07-04 Beckman Coulter, Inc. Method and apparatus for processing biomolecule arrays
US7332286B2 (en) * 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
WO2003091418A2 (en) * 2002-04-26 2003-11-06 Bristol-Myers Squibb Company Novel essential fungal polynucleotides, polypeptides, and methods of use
US20060172344A1 (en) * 2002-07-18 2006-08-03 Yaeta Endo Single chain antibody and use thereof
ATE520027T1 (de) * 2002-09-03 2011-08-15 Bayer Technology Services Gmbh Analytische plattform und nachweisverfahren mit gegebenenfalls nach fraktionierung in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
US6956651B2 (en) * 2002-09-07 2005-10-18 Hilary S. Lackritz Bioanalysis systems including optical integrated circuit

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107209114A (zh) * 2015-02-05 2017-09-26 日东电工株式会社 测量装置
CN109477084A (zh) * 2016-07-19 2019-03-15 国立研究开发法人农业·食品产业技术综合研究机构 使用等离子体在植物细胞内导入物质的方法
CN109459562A (zh) * 2017-09-06 2019-03-12 阿姆普勒斯生物科学公司 用于提高生物测定动态范围的方法
CN110609078A (zh) * 2019-09-20 2019-12-24 南京谱利健生物技术有限公司 一种检测蛋白磷酸化和乙酰氨基葡萄糖化关联作用的方法
CN113970644A (zh) * 2021-12-24 2022-01-25 天德瑞(北京)生物科技有限公司 基于hrp标记蛋白的工作浓度检测方法
CN113970644B (zh) * 2021-12-24 2022-05-27 天德瑞(北京)生物科技有限公司 基于hrp标记蛋白的工作浓度检测方法

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CA2559803A1 (en) 2005-10-13
WO2005095965A1 (en) 2005-10-13
US20080020409A1 (en) 2008-01-24
EP1730530A1 (en) 2006-12-13
JP2007526460A (ja) 2007-09-13
AU2004318038A1 (en) 2005-10-13

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Open date: 20070425