JP2007526318A

JP2007526318A - Ｃｈｌａｍｙｄｉａｐｎｅｕｍｏｎｉａｅに対する免疫原性組成物

Ｃｈｌａｍｙｄｉａｐｎｅｕｍｏｎｉａｅに対する免疫原性組成物 Download PDF

Info

Publication number: JP2007526318A
Authority: JP; Japan
Prior art keywords: seq; amino acid; protein; amino acids; antigen
Prior art date: 2004-03-02
Legal status : Withdrawn

Application number

JP2007501899A

Other languages

English (en)

Japanese (ja)

Other versions

JP2007526318A5 (OSRAM

Inventor

グイドグランディ，

ラッティグィリオ，

Original Assignee

カイロンコーポレイション

Priority date

2004-03-02

Filing date

2005-03-02

Publication date

2007-09-13

2005-03-02 Application filed by カイロンコーポレイション filed Critical カイロンコーポレイション

2007-09-13 Publication of JP2007526318A publication Critical patent/JP2007526318A/ja

2008-04-03 Publication of JP2007526318A5 publication Critical patent/JP2007526318A5/ja

Status Withdrawn legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims description 237
241001647372 Chlamydia pneumoniae Species 0.000 title claims description 204
230000002163 immunogen Effects 0.000 title claims description 53
108091007433 antigens Proteins 0.000 claims abstract description 529
102000036639 antigens Human genes 0.000 claims abstract description 529
239000000427 antigen Substances 0.000 claims abstract description 526
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 151
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 108
229920001184 polypeptide Polymers 0.000 claims abstract description 93
238000000034 method Methods 0.000 claims abstract description 76
230000028993 immune response Effects 0.000 claims abstract description 54
238000003556 assay Methods 0.000 claims abstract description 29
238000011282 treatment Methods 0.000 claims abstract description 20
238000002360 preparation method Methods 0.000 claims abstract description 15
239000003814 drug Substances 0.000 claims abstract description 14
230000002265 prevention Effects 0.000 claims abstract description 12
206010061041 Chlamydial infection Diseases 0.000 claims abstract description 11
208000035086 Chlamydophila Infections Diseases 0.000 claims abstract description 11
238000003745 diagnosis Methods 0.000 claims abstract 3
102000004169 proteins and genes Human genes 0.000 claims description 440
108090000623 proteins and genes Proteins 0.000 claims description 436
150000001413 amino acids Chemical class 0.000 claims description 320
239000012634 fragment Substances 0.000 claims description 290
125000003275 alpha amino acid group Chemical group 0.000 claims description 145
210000004027 cell Anatomy 0.000 claims description 89
230000007246 mechanism Effects 0.000 claims description 17
230000028327 secretion Effects 0.000 claims description 15
238000004519 manufacturing process Methods 0.000 claims description 14
230000009885 systemic effect Effects 0.000 claims description 14
108010073429 Type V Secretion Systems Proteins 0.000 claims description 13
230000003308 immunostimulating effect Effects 0.000 claims description 13
210000000805 cytoplasm Anatomy 0.000 claims description 8
239000011230 binding agent Substances 0.000 claims description 6
239000012472 biological sample Substances 0.000 claims description 6
229960001438 immunostimulant agent Drugs 0.000 claims description 4
239000003022 immunostimulating agent Substances 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 3
235000018102 proteins Nutrition 0.000 description 430
235000001014 amino acid Nutrition 0.000 description 317
239000002671 adjuvant Substances 0.000 description 110
108010076504 Protein Sorting Signals Proteins 0.000 description 86
241000606161 Chlamydia Species 0.000 description 78
210000001744 T-lymphocyte Anatomy 0.000 description 74
208000015181 infectious disease Diseases 0.000 description 73
230000004044 response Effects 0.000 description 73
230000001086 cytosolic effect Effects 0.000 description 64
229960005486 vaccine Drugs 0.000 description 48
210000002966 serum Anatomy 0.000 description 38
239000002245 particle Substances 0.000 description 33
239000013598 vector Substances 0.000 description 33
238000000338 in vitro Methods 0.000 description 32
150000007523 nucleic acids Chemical class 0.000 description 32
102000039446 nucleic acids Human genes 0.000 description 30
108020004707 nucleic acids Proteins 0.000 description 30
230000003472 neutralizing effect Effects 0.000 description 28
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 27
108010069584 Type III Secretion Systems Proteins 0.000 description 25
238000009472 formulation Methods 0.000 description 25
241000699666 Mus <mouse, genus> Species 0.000 description 24
201000010099 disease Diseases 0.000 description 24
239000012528 membrane Substances 0.000 description 24
239000003053 toxin Substances 0.000 description 24
231100000765 toxin Toxicity 0.000 description 24
108700012359 toxins Proteins 0.000 description 24
241000588724 Escherichia coli Species 0.000 description 23
241000282414 Homo sapiens Species 0.000 description 23
108091034117 Oligonucleotide Proteins 0.000 description 23
102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 23
108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 23
210000004379 membrane Anatomy 0.000 description 23
210000003000 inclusion body Anatomy 0.000 description 21
-1 aluminum salt Chemical class 0.000 description 20
230000001580 bacterial effect Effects 0.000 description 20
230000036039 immunity Effects 0.000 description 20
108020004414 DNA Proteins 0.000 description 18
238000001727 in vivo Methods 0.000 description 18
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 18
101100030139 Chlamydia pneumoniae pmp10 gene Proteins 0.000 description 17
241001465754 Metazoa Species 0.000 description 17
238000001943 fluorescence-activated cell sorting Methods 0.000 description 17
239000002773 nucleotide Substances 0.000 description 17
241000699800 Cricetinae Species 0.000 description 16
108010074328 Interferon-gamma Proteins 0.000 description 16
238000004458 analytical method Methods 0.000 description 16
210000002443 helper t lymphocyte Anatomy 0.000 description 16
238000006386 neutralization reaction Methods 0.000 description 16
125000003729 nucleotide group Chemical group 0.000 description 16
210000003719 b-lymphocyte Anatomy 0.000 description 15
239000000839 emulsion Substances 0.000 description 15
239000000499 gel Substances 0.000 description 15
230000005847 immunogenicity Effects 0.000 description 15
230000002458 infectious effect Effects 0.000 description 15
229930182490 saponin Natural products 0.000 description 15
150000007949 saponins Chemical class 0.000 description 15
235000017709 saponins Nutrition 0.000 description 15
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 14
102000004127 Cytokines Human genes 0.000 description 14
108090000695 Cytokines Proteins 0.000 description 14
230000005867 T cell response Effects 0.000 description 14
239000011575 calcium Substances 0.000 description 14
229910052791 calcium Inorganic materials 0.000 description 14
238000010790 dilution Methods 0.000 description 14
239000012895 dilution Substances 0.000 description 14
230000000694 effects Effects 0.000 description 14
230000014509 gene expression Effects 0.000 description 14
230000003053 immunization Effects 0.000 description 14
239000000243 solution Substances 0.000 description 14
108010049048 Cholera Toxin Proteins 0.000 description 13
102000009016 Cholera Toxin Human genes 0.000 description 13
102100037850 Interferon gamma Human genes 0.000 description 13
239000012636 effector Substances 0.000 description 13
230000006870 function Effects 0.000 description 13
238000002649 immunization Methods 0.000 description 13
230000008569 process Effects 0.000 description 13
241000894007 species Species 0.000 description 13
101710116435 Outer membrane protein Proteins 0.000 description 12
210000004369 blood Anatomy 0.000 description 12
239000008280 blood Substances 0.000 description 12
239000000872 buffer Substances 0.000 description 12
229910052500 inorganic mineral Inorganic materials 0.000 description 12
230000003834 intracellular effect Effects 0.000 description 12
230000001404 mediated effect Effects 0.000 description 12
239000011707 mineral Substances 0.000 description 12
230000004224 protection Effects 0.000 description 12
150000003839 salts Chemical class 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
208000007190 Chlamydia Infections Diseases 0.000 description 11
241000699670 Mus sp. Species 0.000 description 11
239000000147 enterotoxin Substances 0.000 description 11
231100000655 enterotoxin Toxicity 0.000 description 11
230000001976 improved effect Effects 0.000 description 11
230000001939 inductive effect Effects 0.000 description 11
231100000252 nontoxic Toxicity 0.000 description 11
230000003000 nontoxic effect Effects 0.000 description 11
230000000069 prophylactic effect Effects 0.000 description 11
210000000952 spleen Anatomy 0.000 description 11
230000024932 T cell mediated immunity Effects 0.000 description 10
230000029662 T-helper 1 type immune response Effects 0.000 description 10
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 10
238000003119 immunoblot Methods 0.000 description 10
230000001965 increasing effect Effects 0.000 description 10
101710146739 Enterotoxin Proteins 0.000 description 9
101001041393 Homo sapiens Serine protease HTRA1 Proteins 0.000 description 9
241000699660 Mus musculus Species 0.000 description 9
108091028043 Nucleic acid sequence Proteins 0.000 description 9
102100021119 Serine protease HTRA1 Human genes 0.000 description 9
229910052737 gold Inorganic materials 0.000 description 9
239000010931 gold Substances 0.000 description 9
JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 description 9
229960005225 mifamurtide Drugs 0.000 description 9
229940035032 monophosphoryl lipid a Drugs 0.000 description 9
JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 9
239000013612 plasmid Substances 0.000 description 9
239000000047 product Substances 0.000 description 9
239000001397 quillaja saponaria molina bark Substances 0.000 description 9
229940032094 squalane Drugs 0.000 description 9
239000000126 substance Substances 0.000 description 9
238000012360 testing method Methods 0.000 description 9
230000001225 therapeutic effect Effects 0.000 description 9
238000011830 transgenic mouse model Methods 0.000 description 9
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 8
238000002347 injection Methods 0.000 description 8
239000007924 injection Substances 0.000 description 8
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 8
229920000053 polysorbate 80 Polymers 0.000 description 8
230000001681 protective effect Effects 0.000 description 8
238000000746 purification Methods 0.000 description 8
230000009467 reduction Effects 0.000 description 8
239000000725 suspension Substances 0.000 description 8
QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 7
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 7
231100000699 Bacterial toxin Toxicity 0.000 description 7
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 7
239000000688 bacterial toxin Substances 0.000 description 7
150000001720 carbohydrates Chemical class 0.000 description 7
230000036755 cellular response Effects 0.000 description 7
239000002158 endotoxin Substances 0.000 description 7
210000004698 lymphocyte Anatomy 0.000 description 7
239000000463 material Substances 0.000 description 7
244000052769 pathogen Species 0.000 description 7
230000001717 pathogenic effect Effects 0.000 description 7
108091003079 Bovine Serum Albumin Proteins 0.000 description 6
102000014914 Carrier Proteins Human genes 0.000 description 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
102000025850 HLA-A2 Antigen Human genes 0.000 description 6
108010074032 HLA-A2 Antigen Proteins 0.000 description 6
108091054437 MHC class I family Proteins 0.000 description 6
108700026244 Open Reading Frames Proteins 0.000 description 6
201000005702 Pertussis Diseases 0.000 description 6
206010035664 Pneumonia Diseases 0.000 description 6
108020004511 Recombinant DNA Proteins 0.000 description 6
241000700605 Viruses Species 0.000 description 6
229910052782 aluminium Inorganic materials 0.000 description 6
230000000890 antigenic effect Effects 0.000 description 6
238000005119 centrifugation Methods 0.000 description 6
238000010367 cloning Methods 0.000 description 6
230000002708 enhancing effect Effects 0.000 description 6
239000013604 expression vector Substances 0.000 description 6
108020001507 fusion proteins Proteins 0.000 description 6
238000011553 hamster model Methods 0.000 description 6
229920006008 lipopolysaccharide Polymers 0.000 description 6
239000007764 o/w emulsion Substances 0.000 description 6
239000003921 oil Substances 0.000 description 6
102000040430 polynucleotide Human genes 0.000 description 6
108091033319 polynucleotide Proteins 0.000 description 6
239000002157 polynucleotide Substances 0.000 description 6
230000035755 proliferation Effects 0.000 description 6
239000000523 sample Substances 0.000 description 6
238000012216 screening Methods 0.000 description 6
208000024891 symptom Diseases 0.000 description 6
210000001519 tissue Anatomy 0.000 description 6
239000003981 vehicle Substances 0.000 description 6
108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
238000011510 Elispot assay Methods 0.000 description 5
101000874355 Escherichia coli (strain K12) Outer membrane protein assembly factor BamA Proteins 0.000 description 5
108090000174 Interleukin-10 Proteins 0.000 description 5
108090000978 Interleukin-4 Proteins 0.000 description 5
241000124008 Mammalia Species 0.000 description 5
108010052285 Membrane Proteins Proteins 0.000 description 5
101710098399 Outer membrane protein YopN Proteins 0.000 description 5
108010081690 Pertussis Toxin Proteins 0.000 description 5
208000019802 Sexually transmitted disease Diseases 0.000 description 5
PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 5
230000004913 activation Effects 0.000 description 5
239000004480 active ingredient Substances 0.000 description 5
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 5
230000005875 antibody response Effects 0.000 description 5
210000000612 antigen-presenting cell Anatomy 0.000 description 5
230000027455 binding Effects 0.000 description 5
229940098773 bovine serum albumin Drugs 0.000 description 5
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
239000003153 chemical reaction reagent Substances 0.000 description 5
239000003937 drug carrier Substances 0.000 description 5
238000005516 engineering process Methods 0.000 description 5
238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 5
210000003527 eukaryotic cell Anatomy 0.000 description 5
238000000684 flow cytometry Methods 0.000 description 5
102000037865 fusion proteins Human genes 0.000 description 5
230000002068 genetic effect Effects 0.000 description 5
229940042743 immune sera Drugs 0.000 description 5
210000000987 immune system Anatomy 0.000 description 5
230000001024 immunotherapeutic effect Effects 0.000 description 5
201000001371 inclusion conjunctivitis Diseases 0.000 description 5
230000005764 inhibitory process Effects 0.000 description 5
229920002521 macromolecule Polymers 0.000 description 5
238000012544 monitoring process Methods 0.000 description 5
108010055837 phosphocarrier protein HPr Proteins 0.000 description 5
230000007398 protein translocation Effects 0.000 description 5
230000001105 regulatory effect Effects 0.000 description 5
210000004988 splenocyte Anatomy 0.000 description 5
230000004936 stimulating effect Effects 0.000 description 5
230000032258 transport Effects 0.000 description 5
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 5
229910052721 tungsten Inorganic materials 0.000 description 5
239000010937 tungsten Substances 0.000 description 5
238000000539 two dimensional gel electrophoresis Methods 0.000 description 5
238000002255 vaccination Methods 0.000 description 5
GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 4
101710118202 43 kDa protein Proteins 0.000 description 4
241000271566 Aves Species 0.000 description 4
241000894006 Bacteria Species 0.000 description 4
241000700198 Cavia Species 0.000 description 4
101710102044 Envelope protein F13 homolog Proteins 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 4
101000575173 Homo sapiens 60S ribosomal protein L12 Proteins 0.000 description 4
101000659995 Homo sapiens Ribosomal L1 domain-containing protein 1 Proteins 0.000 description 4
102000014150 Interferons Human genes 0.000 description 4
108010050904 Interferons Proteins 0.000 description 4
101710105759 Major outer membrane porin Proteins 0.000 description 4
101710164702 Major outer membrane protein Proteins 0.000 description 4
102000018697 Membrane Proteins Human genes 0.000 description 4
229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
102100036164 Putative phospholipase B-like 2 Human genes 0.000 description 4
101710200837 Putative phospholipase B-like 2 Proteins 0.000 description 4
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 4
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 4
206010043376 Tetanus Diseases 0.000 description 4
210000000447 Th1 cell Anatomy 0.000 description 4
239000013566 allergen Substances 0.000 description 4
229940037003 alum Drugs 0.000 description 4
238000010171 animal model Methods 0.000 description 4
238000013459 approach Methods 0.000 description 4
230000008901 benefit Effects 0.000 description 4
239000000227 bioadhesive Substances 0.000 description 4
238000004422 calculation algorithm Methods 0.000 description 4
238000004113 cell culture Methods 0.000 description 4
230000003915 cell function Effects 0.000 description 4
YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 4
230000007423 decrease Effects 0.000 description 4
229940079593 drug Drugs 0.000 description 4
238000011156 evaluation Methods 0.000 description 4
239000002095 exotoxin Substances 0.000 description 4
231100000776 exotoxin Toxicity 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
230000004927 fusion Effects 0.000 description 4
230000028996 humoral immune response Effects 0.000 description 4
230000004727 humoral immunity Effects 0.000 description 4
230000002519 immonomodulatory effect Effects 0.000 description 4
210000004201 immune sera Anatomy 0.000 description 4
230000006872 improvement Effects 0.000 description 4
230000006698 induction Effects 0.000 description 4
239000012678 infectious agent Substances 0.000 description 4
238000010255 intramuscular injection Methods 0.000 description 4
239000007927 intramuscular injection Substances 0.000 description 4
238000010253 intravenous injection Methods 0.000 description 4
230000021633 leukocyte mediated immunity Effects 0.000 description 4
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 4
238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 4
108020004999 messenger RNA Proteins 0.000 description 4
238000007911 parenteral administration Methods 0.000 description 4
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
239000011148 porous material Substances 0.000 description 4
238000012545 processing Methods 0.000 description 4
238000011321 prophylaxis Methods 0.000 description 4
210000005000 reproductive tract Anatomy 0.000 description 4
238000011160 research Methods 0.000 description 4
238000012552 review Methods 0.000 description 4
239000002356 single layer Substances 0.000 description 4
239000007921 spray Substances 0.000 description 4
238000010254 subcutaneous injection Methods 0.000 description 4
239000007929 subcutaneous injection Substances 0.000 description 4
206010044325 trachoma Diseases 0.000 description 4
230000029069 type 2 immune response Effects 0.000 description 4
239000013603 viral vector Substances 0.000 description 4
239000000277 virosome Substances 0.000 description 4
238000001262 western blot Methods 0.000 description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
239000004475 Arginine Substances 0.000 description 3
201000001320 Atherosclerosis Diseases 0.000 description 3
208000035143 Bacterial infection Diseases 0.000 description 3
125000001433 C-terminal amino-acid group Chemical group 0.000 description 3
108010078791 Carrier Proteins Proteins 0.000 description 3
108010039939 Cell Wall Skeleton Proteins 0.000 description 3
241000606153 Chlamydia trachomatis Species 0.000 description 3
206010008631 Cholera Diseases 0.000 description 3
108091026890 Coding region Proteins 0.000 description 3
102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 3
108010053187 Diphtheria Toxin Proteins 0.000 description 3
102000016607 Diphtheria Toxin Human genes 0.000 description 3
238000002965 ELISA Methods 0.000 description 3
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 3
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 3
102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 3
241000282412 Homo Species 0.000 description 3
241000701806 Human papillomavirus Species 0.000 description 3
102000008070 Interferon-gamma Human genes 0.000 description 3
108090001005 Interleukin-6 Proteins 0.000 description 3
102000004889 Interleukin-6 Human genes 0.000 description 3
102000043129 MHC class I family Human genes 0.000 description 3
102000043131 MHC class II family Human genes 0.000 description 3
108091054438 MHC class II family Proteins 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
108010006519 Molecular Chaperones Proteins 0.000 description 3
108700020354 N-acetylmuramyl-threonyl-isoglutamine Proteins 0.000 description 3
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 3
101100190845 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pmp-1 gene Proteins 0.000 description 3
239000000020 Nitrocellulose Substances 0.000 description 3
101710188053 Protein D Proteins 0.000 description 3
101710132893 Resolvase Proteins 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
229930182558 Sterol Natural products 0.000 description 3
210000004241 Th2 cell Anatomy 0.000 description 3
108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
230000000240 adjuvant effect Effects 0.000 description 3
239000008135 aqueous vehicle Substances 0.000 description 3
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
208000022362 bacterial infectious disease Diseases 0.000 description 3
108091008324 binding proteins Proteins 0.000 description 3
230000008512 biological response Effects 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
210000004899 c-terminal region Anatomy 0.000 description 3
235000014633 carbohydrates Nutrition 0.000 description 3
239000013553 cell monolayer Substances 0.000 description 3
210000004520 cell wall skeleton Anatomy 0.000 description 3
229940038705 chlamydia trachomatis Drugs 0.000 description 3
235000012000 cholesterol Nutrition 0.000 description 3
230000001684 chronic effect Effects 0.000 description 3
239000011248 coating agent Substances 0.000 description 3
238000000576 coating method Methods 0.000 description 3
VEXWNPGPVMYVDU-UHFFFAOYSA-N collidinium p-toluenesulfonate Chemical compound CC1=CC(C)=[NH+]C(C)=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 VEXWNPGPVMYVDU-UHFFFAOYSA-N 0.000 description 3
230000000295 complement effect Effects 0.000 description 3
239000002299 complementary DNA Substances 0.000 description 3
230000037029 cross reaction Effects 0.000 description 3
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
235000018417 cysteine Nutrition 0.000 description 3
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
238000001514 detection method Methods 0.000 description 3
230000018109 developmental process Effects 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
206010013023 diphtheria Diseases 0.000 description 3
208000035475 disorder Diseases 0.000 description 3
230000008030 elimination Effects 0.000 description 3
238000003379 elimination reaction Methods 0.000 description 3
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
238000009396 hybridization Methods 0.000 description 3
230000001900 immune effect Effects 0.000 description 3
208000026278 immune system disease Diseases 0.000 description 3
239000002955 immunomodulating agent Substances 0.000 description 3
229940121354 immunomodulator Drugs 0.000 description 3
239000000411 inducer Substances 0.000 description 3
230000028709 inflammatory response Effects 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
230000014828 interferon-gamma production Effects 0.000 description 3
229940047124 interferons Drugs 0.000 description 3
239000007928 intraperitoneal injection Substances 0.000 description 3
150000002632 lipids Chemical class 0.000 description 3
239000002502 liposome Substances 0.000 description 3
230000005923 long-lasting effect Effects 0.000 description 3
238000004949 mass spectrometry Methods 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
230000000813 microbial effect Effects 0.000 description 3
239000003607 modifier Substances 0.000 description 3
238000010172 mouse model Methods 0.000 description 3
125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 description 3
229920001220 nitrocellulos Polymers 0.000 description 3
102000022744 oligopeptide binding proteins Human genes 0.000 description 3
108091013547 oligopeptide binding proteins Proteins 0.000 description 3
210000001322 periplasm Anatomy 0.000 description 3
239000008194 pharmaceutical composition Substances 0.000 description 3
229920000056 polyoxyethylene ether Polymers 0.000 description 3
239000000843 powder Substances 0.000 description 3
230000002685 pulmonary effect Effects 0.000 description 3
230000010076 replication Effects 0.000 description 3
238000010845 search algorithm Methods 0.000 description 3
235000003702 sterols Nutrition 0.000 description 3
238000006467 substitution reaction Methods 0.000 description 3
239000000829 suppository Substances 0.000 description 3
239000004094 surface-active agent Substances 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
230000002194 synthesizing effect Effects 0.000 description 3
239000003826 tablet Substances 0.000 description 3
238000011200 topical administration Methods 0.000 description 3
238000012546 transfer Methods 0.000 description 3
241000712461 unidentified influenza virus Species 0.000 description 3
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 2
WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 description 2
OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 description 2
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
102000009062 ADP Ribose Transferases Human genes 0.000 description 2
108010049290 ADP Ribose Transferases Proteins 0.000 description 2
102000007469 Actins Human genes 0.000 description 2
108010085238 Actins Proteins 0.000 description 2
102000006306 Antigen Receptors Human genes 0.000 description 2
108010083359 Antigen Receptors Proteins 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
241001415830 Bubo Species 0.000 description 2
241000283707 Capra Species 0.000 description 2
101710132601 Capsid protein Proteins 0.000 description 2
208000024172 Cardiovascular disease Diseases 0.000 description 2
241000700199 Cavia porcellus Species 0.000 description 2
101100298037 Chlamydia pneumoniae pmp19 gene Proteins 0.000 description 2
208000035473 Communicable disease Diseases 0.000 description 2
MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 2
NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 2
206010015226 Erythema nodosum Diseases 0.000 description 2
241000672609 Escherichia coli BL21 Species 0.000 description 2
238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
108010024636 Glutathione Proteins 0.000 description 2
108091006054 His-tagged proteins Proteins 0.000 description 2
108010072039 Histidine kinase Proteins 0.000 description 2
241000700588 Human alphaherpesvirus 1 Species 0.000 description 2
241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
241000725303 Human immunodeficiency virus Species 0.000 description 2
108010002616 Interleukin-5 Proteins 0.000 description 2
102000015696 Interleukins Human genes 0.000 description 2
108010063738 Interleukins Proteins 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
102000004895 Lipoproteins Human genes 0.000 description 2
108090001030 Lipoproteins Proteins 0.000 description 2
206010065224 Lymphadenitis bacterial Diseases 0.000 description 2
108091061960 Naked DNA Proteins 0.000 description 2
206010028980 Neoplasm Diseases 0.000 description 2
108010079246 OMPA outer membrane proteins Proteins 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
108091093037 Peptide nucleic acid Proteins 0.000 description 2
201000007100 Pharyngitis Diseases 0.000 description 2
241000288906 Primates Species 0.000 description 2
101710192597 Protein map Proteins 0.000 description 2
108010026552 Proteome Proteins 0.000 description 2
241000219287 Saponaria Species 0.000 description 2
241000700584 Simplexvirus Species 0.000 description 2
101710118448 Small cysteine-rich outer membrane protein OmcA Proteins 0.000 description 2
238000000692 Student's t-test Methods 0.000 description 2
108010008038 Synthetic Vaccines Proteins 0.000 description 2
102100033130 T-box transcription factor T Human genes 0.000 description 2
101710086566 T-box transcription factor T Proteins 0.000 description 2
241000589884 Treponema pallidum Species 0.000 description 2
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
108090000631 Trypsin Proteins 0.000 description 2
102000004142 Trypsin Human genes 0.000 description 2
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
206010046914 Vaginal infection Diseases 0.000 description 2
241000251539 Vertebrata <Metazoa> Species 0.000 description 2
108010067390 Viral Proteins Proteins 0.000 description 2
238000012382 advanced drug delivery Methods 0.000 description 2
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
125000000539 amino acid group Chemical group 0.000 description 2
230000000919 anti-host Effects 0.000 description 2
230000000692 anti-sense effect Effects 0.000 description 2
208000006673 asthma Diseases 0.000 description 2
239000012639 bacterial effector Substances 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
230000008827 biological function Effects 0.000 description 2
206010006451 bronchitis Diseases 0.000 description 2
239000000969 carrier Substances 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
230000007969 cellular immunity Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
230000009260 cross reactivity Effects 0.000 description 2
210000000172 cytosol Anatomy 0.000 description 2
210000004443 dendritic cell Anatomy 0.000 description 2
238000013461 design Methods 0.000 description 2
238000011161 development Methods 0.000 description 2
229960003983 diphtheria toxoid Drugs 0.000 description 2
239000002270 dispersing agent Substances 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000012377 drug delivery Methods 0.000 description 2
210000002919 epithelial cell Anatomy 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
210000001723 extracellular space Anatomy 0.000 description 2
239000000284 extract Substances 0.000 description 2
210000004392 genitalia Anatomy 0.000 description 2
150000004676 glycans Chemical class 0.000 description 2
229930182470 glycoside Natural products 0.000 description 2
229940029575 guanosine Drugs 0.000 description 2
238000011554 guinea pig model Methods 0.000 description 2
230000008348 humoral response Effects 0.000 description 2
230000036737 immune function Effects 0.000 description 2
238000003018 immunoassay Methods 0.000 description 2
238000010166 immunofluorescence Methods 0.000 description 2
238000010820 immunofluorescence microscopy Methods 0.000 description 2
230000016784 immunoglobulin production Effects 0.000 description 2
238000011534 incubation Methods 0.000 description 2
239000007972 injectable composition Substances 0.000 description 2
230000003993 interaction Effects 0.000 description 2
229960003130 interferon gamma Drugs 0.000 description 2
238000001361 intraarterial administration Methods 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000001155 isoelectric focusing Methods 0.000 description 2
230000002147 killing effect Effects 0.000 description 2
239000007788 liquid Substances 0.000 description 2
210000002540 macrophage Anatomy 0.000 description 2
230000031864 metaphase Effects 0.000 description 2
229930182817 methionine Natural products 0.000 description 2
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 2
238000002493 microarray Methods 0.000 description 2
239000011859 microparticle Substances 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
238000010369 molecular cloning Methods 0.000 description 2
230000003232 mucoadhesive effect Effects 0.000 description 2
210000004400 mucous membrane Anatomy 0.000 description 2
229940066429 octoxynol Drugs 0.000 description 2
229920002113 octoxynol Polymers 0.000 description 2
UNEIHNMKASENIG-UHFFFAOYSA-N para-chlorophenylpiperazine Chemical compound C1=CC(Cl)=CC=C1N1CCNCC1 UNEIHNMKASENIG-UHFFFAOYSA-N 0.000 description 2
235000021317 phosphate Nutrition 0.000 description 2
150000003904 phospholipids Chemical class 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
108010094020 polyglycine Proteins 0.000 description 2
229920000232 polyglycine polymer Polymers 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
229920001282 polysaccharide Polymers 0.000 description 2
239000005017 polysaccharide Substances 0.000 description 2
239000013641 positive control Substances 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
230000037452 priming Effects 0.000 description 2
239000000186 progesterone Substances 0.000 description 2
229960003387 progesterone Drugs 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
208000002574 reactive arthritis Diseases 0.000 description 2
229940124551 recombinant vaccine Drugs 0.000 description 2
230000002829 reductive effect Effects 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
238000004007 reversed phase HPLC Methods 0.000 description 2
238000013207 serial dilution Methods 0.000 description 2
201000009890 sinusitis Diseases 0.000 description 2
210000003491 skin Anatomy 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 description 2
238000010186 staining Methods 0.000 description 2
239000008223 sterile water Substances 0.000 description 2
150000003432 sterols Chemical class 0.000 description 2
239000000375 suspending agent Substances 0.000 description 2
238000013268 sustained release Methods 0.000 description 2
239000012730 sustained-release form Substances 0.000 description 2
230000008685 targeting Effects 0.000 description 2
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 2
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
238000004448 titration Methods 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
230000009466 transformation Effects 0.000 description 2
230000014616 translation Effects 0.000 description 2
230000005945 translocation Effects 0.000 description 2
XETCRXVKJHBPMK-MJSODCSWSA-N trehalose 6,6'-dimycolate Chemical compound C([C@@H]1[C@H]([C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)C(CCCCCCCCCCC3C(C3)CCCCCCCCCCCCCCCCCC)C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)O2)O)O1)O)OC(=O)C(C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC XETCRXVKJHBPMK-MJSODCSWSA-N 0.000 description 2
239000012588 trypsin Substances 0.000 description 2
241001430294 unidentified retrovirus Species 0.000 description 2
229940125575 vaccine candidate Drugs 0.000 description 2
210000001215 vagina Anatomy 0.000 description 2
230000003612 virological effect Effects 0.000 description 2
230000001018 virulence Effects 0.000 description 2
238000005406 washing Methods 0.000 description 2
239000000080 wetting agent Substances 0.000 description 2
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
JPOKAKNGULMYHZ-UILVTTEASA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-3-(4-hydroxyp Chemical compound C([C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCN=C(N)N)C1=CC=C(O)C=C1 JPOKAKNGULMYHZ-UILVTTEASA-N 0.000 description 1
YHQZWWDVLJPRIF-JLHRHDQISA-N (4R)-4-[[(2S,3R)-2-[acetyl-[(3R,4R,5S,6R)-3-amino-4-[(1R)-1-carboxyethoxy]-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid Chemical compound C(C)(=O)N([C@@H]([C@H](O)C)C(=O)N[C@H](CCC(=O)O)C(N)=O)C1[C@H](N)[C@@H](O[C@@H](C(=O)O)C)[C@H](O)[C@H](O1)CO YHQZWWDVLJPRIF-JLHRHDQISA-N 0.000 description 1
102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
PFCLMNDDPTZJHQ-XLPZGREQSA-N 2-amino-7-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidin-4-one Chemical compound C1=CC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PFCLMNDDPTZJHQ-XLPZGREQSA-N 0.000 description 1
UMCMPZBLKLEWAF-BCTGSCMUSA-N 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 UMCMPZBLKLEWAF-BCTGSCMUSA-N 0.000 description 1
102100025643 60S ribosomal protein L12 Human genes 0.000 description 1
101100295756 Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG 19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81) omp38 gene Proteins 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
208000024827 Alzheimer disease Diseases 0.000 description 1
102100033899 Ankyrin repeat and SOCS box protein 14 Human genes 0.000 description 1
102100034278 Annexin A6 Human genes 0.000 description 1
108090000656 Annexin A6 Proteins 0.000 description 1
206010059313 Anogenital warts Diseases 0.000 description 1
241000272517 Anseriformes Species 0.000 description 1
206010003267 Arthritis reactive Diseases 0.000 description 1
241000972773 Aulopiformes Species 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
101100281245 Bacillus subtilis (strain 168) fliY gene Proteins 0.000 description 1
108010077805 Bacterial Proteins Proteins 0.000 description 1
238000009010 Bradford assay Methods 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
108090000565 Capsid Proteins Proteins 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
240000001817 Cereus hexagonus Species 0.000 description 1
102100023321 Ceruloplasmin Human genes 0.000 description 1
LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
102000019034 Chemokines Human genes 0.000 description 1
108010012236 Chemokines Proteins 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
241000606069 Chlamydiaceae Species 0.000 description 1
241001185363 Chlamydiae Species 0.000 description 1
241000498849 Chlamydiales Species 0.000 description 1
241000201569 Chlamydophila pneumoniae CWL029 Species 0.000 description 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
241000744472 Cinna Species 0.000 description 1
101710094648 Coat protein Proteins 0.000 description 1
108020004705 Codon Proteins 0.000 description 1
208000000907 Condylomata Acuminata Diseases 0.000 description 1
206010010741 Conjunctivitis Diseases 0.000 description 1
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 description 1
238000000018 DNA microarray Methods 0.000 description 1
101710101803 DNA-binding protein J Proteins 0.000 description 1
241000702421 Dependoparvovirus Species 0.000 description 1
108010016626 Dipeptides Proteins 0.000 description 1
108010012253 E coli heat-labile enterotoxin Proteins 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
239000006145 Eagle's minimal essential medium Substances 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
241000792859 Enema Species 0.000 description 1
241000305071 Enterobacterales Species 0.000 description 1
101710181478 Envelope glycoprotein GP350 Proteins 0.000 description 1
101710204837 Envelope small membrane protein Proteins 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241000588722 Escherichia Species 0.000 description 1
101000585903 Escherichia coli (strain K12) Outer membrane porin G Proteins 0.000 description 1
101100003258 Escherichia coli (strain K12) atoS gene Proteins 0.000 description 1
241000710198 Foot-and-mouth disease virus Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
108700039691 Genetic Promoter Regions Proteins 0.000 description 1
108010070675 Glutathione transferase Proteins 0.000 description 1
102000005720 Glutathione transferase Human genes 0.000 description 1
BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 description 1
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
102000002068 Glycopeptides Human genes 0.000 description 1
108010015899 Glycopeptides Proteins 0.000 description 1
102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
206010018612 Gonorrhoea Diseases 0.000 description 1
240000003824 Gypsophila paniculata Species 0.000 description 1
208000031886 HIV Infections Diseases 0.000 description 1
102000018932 HSP70 Heat-Shock Proteins Human genes 0.000 description 1
108010027992 HSP70 Heat-Shock Proteins Proteins 0.000 description 1
241000606768 Haemophilus influenzae Species 0.000 description 1
102000002812 Heat-Shock Proteins Human genes 0.000 description 1
108010004889 Heat-Shock Proteins Proteins 0.000 description 1
241000700721 Hepatitis B virus Species 0.000 description 1
241000724675 Hepatitis E virus Species 0.000 description 1
208000001688 Herpes Genitalis Diseases 0.000 description 1
208000009889 Herpes Simplex Diseases 0.000 description 1
241001272567 Hominoidea Species 0.000 description 1
101000925508 Homo sapiens Ankyrin repeat and SOCS box protein 14 Proteins 0.000 description 1
241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
206010020880 Hypertrophy Diseases 0.000 description 1
102100026720 Interferon beta Human genes 0.000 description 1
108010047761 Interferon-alpha Proteins 0.000 description 1
102000006992 Interferon-alpha Human genes 0.000 description 1
108090000467 Interferon-beta Proteins 0.000 description 1
108010002352 Interleukin-1 Proteins 0.000 description 1
108010002586 Interleukin-7 Proteins 0.000 description 1
108091092195 Intron Proteins 0.000 description 1
YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
101710149059 Large cysteine-rich periplasmic protein OmcB Proteins 0.000 description 1
201000008197 Laryngitis Diseases 0.000 description 1
229920002884 Laureth 4 Polymers 0.000 description 1
241000713666 Lentivirus Species 0.000 description 1
102000004083 Lymphotoxin-alpha Human genes 0.000 description 1
108090000542 Lymphotoxin-alpha Proteins 0.000 description 1
101710145006 Lysis protein Proteins 0.000 description 1
241000282560 Macaca mulatta Species 0.000 description 1
102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
101710125418 Major capsid protein Proteins 0.000 description 1
241000712079 Measles morbillivirus Species 0.000 description 1
241000699673 Mesocricetus auratus Species 0.000 description 1
241001300083 Milax Species 0.000 description 1
102000005431 Molecular Chaperones Human genes 0.000 description 1
241001092142 Molina Species 0.000 description 1
WPNJAUFVNXKLIM-UHFFFAOYSA-N Moxonidine Chemical compound COC1=NC(C)=NC(Cl)=C1NC1=NCCN1 WPNJAUFVNXKLIM-UHFFFAOYSA-N 0.000 description 1
241001529936 Murinae Species 0.000 description 1
101100462201 Mus musculus Opn4 gene Proteins 0.000 description 1
241000588653 Neisseria Species 0.000 description 1
241000588649 Neisseria lactamica Species 0.000 description 1
241000714209 Norwalk virus Species 0.000 description 1
101710163270 Nuclease Proteins 0.000 description 1
101710141454 Nucleoprotein Proteins 0.000 description 1
208000011623 Obstructive Lung disease Diseases 0.000 description 1
108010038807 Oligopeptides Proteins 0.000 description 1
102000015636 Oligopeptides Human genes 0.000 description 1
108700020796 Oncogene Proteins 0.000 description 1
206010033078 Otitis media Diseases 0.000 description 1
101710203389 Outer membrane porin F Proteins 0.000 description 1
101710160102 Outer membrane protein B Proteins 0.000 description 1
101150002010 PMP3 gene Proteins 0.000 description 1
241000282579 Pan Species 0.000 description 1
241001494479 Pecora Species 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
108010013639 Peptidoglycan Proteins 0.000 description 1
108010092494 Periplasmic binding proteins Proteins 0.000 description 1
208000037581 Persistent Infection Diseases 0.000 description 1
241001250141 Phacotus sphaericus Species 0.000 description 1
241000286209 Phasianidae Species 0.000 description 1
229920002732 Polyanhydride Polymers 0.000 description 1
229920000954 Polyglycolide Polymers 0.000 description 1
229920001710 Polyorthoester Polymers 0.000 description 1
108010076039 Polyproteins Proteins 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
101710083689 Probable capsid protein Proteins 0.000 description 1
206010036774 Proctitis Diseases 0.000 description 1
239000004365 Protease Substances 0.000 description 1
241000125945 Protoparvovirus Species 0.000 description 1
241000589516 Pseudomonas Species 0.000 description 1
101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 1
241000700159 Rattus Species 0.000 description 1
208000035415 Reinfection Diseases 0.000 description 1
208000033464 Reiter syndrome Diseases 0.000 description 1
206010057190 Respiratory tract infections Diseases 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
241000702670 Rotavirus Species 0.000 description 1
241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
108091081021 Sense strand Proteins 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
108010022999 Serine Proteases Proteins 0.000 description 1
102000012479 Serine Proteases Human genes 0.000 description 1
101710084578 Short neurotoxin 1 Proteins 0.000 description 1
241000710960 Sindbis virus Species 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
239000004147 Sorbitan trioleate Substances 0.000 description 1
238000002105 Southern blotting Methods 0.000 description 1
108010088897 Staphylococcus aureus epidermal cell differentiation inhibitor Proteins 0.000 description 1
208000006011 Stroke Diseases 0.000 description 1
101710172711 Structural protein Proteins 0.000 description 1
241000282887 Suidae Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
230000006052 T cell proliferation Effects 0.000 description 1
108091008874 T cell receptors Proteins 0.000 description 1
102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
102000008235 Toll-Like Receptor 9 Human genes 0.000 description 1
108010060818 Toll-Like Receptor 9 Proteins 0.000 description 1
101710182223 Toxin B Proteins 0.000 description 1
101710182532 Toxin a Proteins 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
208000006374 Uterine Cervicitis Diseases 0.000 description 1
201000008100 Vaginitis Diseases 0.000 description 1
241000607626 Vibrio cholerae Species 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 1
241000606834 [Haemophilus] ducreyi Species 0.000 description 1
208000002223 abdominal aortic aneurysm Diseases 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
150000005215 alkyl ethers Chemical class 0.000 description 1
229960004784 allergens Drugs 0.000 description 1
230000000961 alloantigen Effects 0.000 description 1
NWMHDZMRVUOQGL-CZEIJOLGSA-N almurtide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)CO[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O NWMHDZMRVUOQGL-CZEIJOLGSA-N 0.000 description 1
229940061720 alpha hydroxy acid Drugs 0.000 description 1
150000001280 alpha hydroxy acids Chemical class 0.000 description 1
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
JTXJZBMXQMTSQN-UHFFFAOYSA-N amino hydrogen carbonate Chemical compound NOC(O)=O JTXJZBMXQMTSQN-UHFFFAOYSA-N 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
230000003321 amplification Effects 0.000 description 1
208000025009 anogenital human papillomavirus infection Diseases 0.000 description 1
201000004201 anogenital venereal wart Diseases 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000003466 anti-cipated effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
230000030741 antigen processing and presentation Effects 0.000 description 1
208000007474 aortic aneurysm Diseases 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
101150042295 arfA gene Proteins 0.000 description 1
101150002692 artJ gene Proteins 0.000 description 1
210000004507 artificial chromosome Anatomy 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
229920002988 biodegradable polymer Polymers 0.000 description 1
239000004621 biodegradable polymer Substances 0.000 description 1
239000012620 biological material Substances 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
244000309464 bull Species 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910002091 carbon monoxide Inorganic materials 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
210000002421 cell wall Anatomy 0.000 description 1
230000005754 cellular signaling Effects 0.000 description 1
206010008323 cervicitis Diseases 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
230000000112 colonic effect Effects 0.000 description 1
238000010961 commercial manufacture process Methods 0.000 description 1
238000004891 communication Methods 0.000 description 1
230000006854 communication Effects 0.000 description 1
238000004590 computer program Methods 0.000 description 1
230000021615 conjugation Effects 0.000 description 1
239000000599 controlled substance Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
210000004351 coronary vessel Anatomy 0.000 description 1
230000000139 costimulatory effect Effects 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000012258 culturing Methods 0.000 description 1
238000009109 curative therapy Methods 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 1
230000006378 damage Effects 0.000 description 1
238000007405 data analysis Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
229940063223 depo-provera Drugs 0.000 description 1
210000004207 dermis Anatomy 0.000 description 1
238000001784 detoxification Methods 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000003828 downregulation Effects 0.000 description 1
239000000428 dust Substances 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000007920 enema Substances 0.000 description 1
229940095399 enema Drugs 0.000 description 1
230000000688 enterotoxigenic effect Effects 0.000 description 1
244000000015 environmental pathogen Species 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
210000000918 epididymis Anatomy 0.000 description 1
201000010063 epididymitis Diseases 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
230000008029 eradication Effects 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
239000010419 fine particle Substances 0.000 description 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
230000005021 gait Effects 0.000 description 1
229940044627 gamma-interferon Drugs 0.000 description 1
102000034356 gene-regulatory proteins Human genes 0.000 description 1
108091006104 gene-regulatory proteins Proteins 0.000 description 1
238000007429 general method Methods 0.000 description 1
201000004946 genital herpes Diseases 0.000 description 1
239000011521 glass Substances 0.000 description 1
108010016102 glutamine transport proteins Proteins 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
230000002414 glycolytic effect Effects 0.000 description 1
208000001786 gonorrhea Diseases 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
229940046528 grass pollen Drugs 0.000 description 1
235000021384 green leafy vegetables Nutrition 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
230000036541 health Effects 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
244000052637 human pathogen Species 0.000 description 1
229920002674 hyaluronan Polymers 0.000 description 1
229960003160 hyaluronic acid Drugs 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
230000000521 hyperimmunizing effect Effects 0.000 description 1
HOPZBJPSUKPLDT-UHFFFAOYSA-N imidazo[4,5-h]quinolin-2-one Chemical class C1=CN=C2C3=NC(=O)N=C3C=CC2=C1 HOPZBJPSUKPLDT-UHFFFAOYSA-N 0.000 description 1
229960002751 imiquimod Drugs 0.000 description 1
DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 1
230000008076 immune mechanism Effects 0.000 description 1
230000008073 immune recognition Effects 0.000 description 1
229940124644 immune regulator Drugs 0.000 description 1
230000028802 immunoglobulin-mediated neutralization Effects 0.000 description 1
239000000367 immunologic factor Substances 0.000 description 1
230000002480 immunoprotective effect Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
238000012405 in silico analysis Methods 0.000 description 1
238000012750 in vivo screening Methods 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
206010022000 influenza Diseases 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
229940079322 interferon Drugs 0.000 description 1
229940047122 interleukins Drugs 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
230000001788 irregular Effects 0.000 description 1
230000002262 irrigation Effects 0.000 description 1
238000003973 irrigation Methods 0.000 description 1
BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
206010023332 keratitis Diseases 0.000 description 1
229960003299 ketamine Drugs 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
239000004816 latex Substances 0.000 description 1
229920000126 latex Polymers 0.000 description 1
229940062711 laureth-9 Drugs 0.000 description 1
239000010410 layer Substances 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
239000003446 ligand Substances 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
210000002751 lymph Anatomy 0.000 description 1
230000002101 lytic effect Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
238000001819 mass spectrum Methods 0.000 description 1
230000035800 maturation Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
239000002609 medium Substances 0.000 description 1
PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
210000001806 memory b lymphocyte Anatomy 0.000 description 1
210000003071 memory t lymphocyte Anatomy 0.000 description 1
238000010208 microarray analysis Methods 0.000 description 1
244000000010 microbial pathogen Species 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
238000000329 molecular dynamics simulation Methods 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
239000000178 monomer Substances 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
201000006417 multiple sclerosis Diseases 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
239000013642 negative control Substances 0.000 description 1
210000001577 neostriatum Anatomy 0.000 description 1
208000015122 neurodegenerative disease Diseases 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
239000000346 nonvolatile oil Substances 0.000 description 1
238000003199 nucleic acid amplification method Methods 0.000 description 1
239000002674 ointment Substances 0.000 description 1
238000002515 oligonucleotide synthesis Methods 0.000 description 1
101150087557 omcB gene Proteins 0.000 description 1
101150115693 ompA gene Proteins 0.000 description 1
101150047779 ompB gene Proteins 0.000 description 1
101150060808 ompH gene Proteins 0.000 description 1
238000010397 one-hybrid screening Methods 0.000 description 1
239000006179 pH buffering agent Substances 0.000 description 1
239000006072 paste Substances 0.000 description 1
230000007110 pathogen host interaction Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
230000035515 penetration Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
102000013415 peroxidase activity proteins Human genes 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
TWHXWYVOWJCXSI-UHFFFAOYSA-N phosphoric acid;hydrate Chemical class O.OP(O)(O)=O TWHXWYVOWJCXSI-UHFFFAOYSA-N 0.000 description 1
239000013600 plasmid vector Substances 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
229920002627 poly(phosphazenes) Polymers 0.000 description 1
229920001610 polycaprolactone Polymers 0.000 description 1
239000004632 polycaprolactone Substances 0.000 description 1
239000004633 polyglycolic acid Substances 0.000 description 1
239000004626 polylactic acid Substances 0.000 description 1
229940051841 polyoxyethylene ether Drugs 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
101150031507 porB gene Proteins 0.000 description 1
230000001323 posttranslational effect Effects 0.000 description 1
244000144977 poultry Species 0.000 description 1
235000013594 poultry meat Nutrition 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
238000011809 primate model Methods 0.000 description 1
210000001236 prokaryotic cell Anatomy 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
201000007094 prostatitis Diseases 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
238000001243 protein synthesis Methods 0.000 description 1
230000002797 proteolythic effect Effects 0.000 description 1
239000002510 pyrogen Substances 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
239000009342 ragweed pollen Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
238000003259 recombinant expression Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000007634 remodeling Methods 0.000 description 1
230000003362 replicative effect Effects 0.000 description 1
BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 description 1
229950010550 resiquimod Drugs 0.000 description 1
210000003660 reticulum Anatomy 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
201000000306 sarcoidosis Diseases 0.000 description 1
238000007790 scraping Methods 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
230000035939 shock Effects 0.000 description 1
238000004513 sizing Methods 0.000 description 1
101150038679 skp gene Proteins 0.000 description 1
239000000344 soap Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
235000019337 sorbitan trioleate Nutrition 0.000 description 1
229960000391 sorbitan trioleate Drugs 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
229940063673 spermidine Drugs 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000012289 standard assay Methods 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
229940031626 subunit vaccine Drugs 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
208000006379 syphilis Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
101150056277 tcyJ gene Proteins 0.000 description 1
229960000814 tetanus toxoid Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
230000002103 transcriptional effect Effects 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
230000007723 transport mechanism Effects 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
108010087967 type I signal peptidase Proteins 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
230000003827 upregulation Effects 0.000 description 1
208000000143 urethritis Diseases 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1
229940118696 vibrio cholerae Drugs 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
239000000304 virulence factor Substances 0.000 description 1
230000007923 virulence factor Effects 0.000 description 1
210000003905 vulva Anatomy 0.000 description 1
238000005303 weighing Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
229910000859 α-Fe Inorganic materials 0.000 description 1