JP2007525661A5 - - Google Patents
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- JP2007525661A5 JP2007525661A5 JP2006543991A JP2006543991A JP2007525661A5 JP 2007525661 A5 JP2007525661 A5 JP 2007525661A5 JP 2006543991 A JP2006543991 A JP 2006543991A JP 2006543991 A JP2006543991 A JP 2006543991A JP 2007525661 A5 JP2007525661 A5 JP 2007525661A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- epitope
- polypeptide
- label
- construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091023037 Aptamer Proteins 0.000 claims description 111
- 238000000034 method Methods 0.000 claims description 92
- 229920001184 polypeptide Polymers 0.000 claims description 59
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 59
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 59
- 230000011664 signaling Effects 0.000 claims description 50
- 238000001514 detection method Methods 0.000 claims description 18
- 230000007613 environmental effect Effects 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims 41
- 239000012491 analyte Substances 0.000 claims 15
- 230000000295 complement effect Effects 0.000 claims 9
- 238000000338 in vitro Methods 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 239000003153 chemical reaction reagent Substances 0.000 claims 8
- 239000000758 substrate Substances 0.000 claims 8
- 108090000190 Thrombin Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 6
- 229960004072 thrombin Drugs 0.000 claims 6
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 5
- 125000006850 spacer group Chemical group 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 206010003445 Ascites Diseases 0.000 claims 3
- 108010049003 Fibrinogen Proteins 0.000 claims 3
- 102000008946 Fibrinogen Human genes 0.000 claims 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 3
- 238000013459 approach Methods 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940012952 fibrinogen Drugs 0.000 claims 3
- 238000001917 fluorescence detection Methods 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 230000009878 intermolecular interaction Effects 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 3
- 102000005636 Cyclic AMP Response Element-Binding Protein Human genes 0.000 claims 2
- 108010045171 Cyclic AMP Response Element-Binding Protein Proteins 0.000 claims 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000000475 fluorescence cross-correlation spectroscopy Methods 0.000 claims 2
- 238000002875 fluorescence polarization Methods 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 150000002605 large molecules Chemical class 0.000 claims 2
- 229920002521 macromolecule Polymers 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 238000002165 resonance energy transfer Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- WCKQPPQRFNHPRJ-UHFFFAOYSA-N 4-[[4-(dimethylamino)phenyl]diazenyl]benzoic acid Chemical compound C1=CC(N(C)C)=CC=C1N=NC1=CC=C(C(O)=O)C=C1 WCKQPPQRFNHPRJ-UHFFFAOYSA-N 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 claims 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000005415 bioluminescence Methods 0.000 claims 1
- 230000029918 bioluminescence Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000004020 luminiscence type Methods 0.000 claims 1
- 230000000873 masking effect Effects 0.000 claims 1
- 239000008196 pharmacological composition Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 230000000171 quenching effect Effects 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 238000002331 protein detection Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52907603P | 2003-12-12 | 2003-12-12 | |
| PCT/US2004/041315 WO2005059509A2 (en) | 2003-12-12 | 2004-12-10 | Biosensors for detecting macromolecules and other analytes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011284014A Division JP2012115269A (ja) | 2003-12-12 | 2011-12-26 | 大分子その他の分析物の検出用生物センサー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007525661A JP2007525661A (ja) | 2007-09-06 |
| JP2007525661A5 true JP2007525661A5 (https=) | 2008-01-31 |
Family
ID=34699935
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006543991A Pending JP2007525661A (ja) | 2003-12-12 | 2004-12-10 | 大分子その他の分析物の検出用生物センサー |
| JP2011284014A Pending JP2012115269A (ja) | 2003-12-12 | 2011-12-26 | 大分子その他の分析物の検出用生物センサー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011284014A Pending JP2012115269A (ja) | 2003-12-12 | 2011-12-26 | 大分子その他の分析物の検出用生物センサー |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7939313B2 (https=) |
| EP (1) | EP1692486B1 (https=) |
| JP (2) | JP2007525661A (https=) |
| CN (1) | CN101208437B (https=) |
| CA (1) | CA2545006C (https=) |
| WO (1) | WO2005059509A2 (https=) |
Families Citing this family (86)
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| JP2007525661A (ja) | 2003-12-12 | 2007-09-06 | セントルイス ユニバーシティー | 大分子その他の分析物の検出用生物センサー |
| WO2006128138A2 (en) * | 2005-05-26 | 2006-11-30 | Ensemble Discovery Corportion | Biodetection by nucleic acid-templated chemistry |
| US7795009B2 (en) | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| US8956857B2 (en) | 2005-06-06 | 2015-02-17 | Mediomics, Llc | Three-component biosensors for detecting macromolecules and other analytes |
| EP1907410B1 (en) | 2005-06-10 | 2012-07-04 | Saint Louis University | Methods for the selection of aptamers |
| US7811809B2 (en) | 2005-06-15 | 2010-10-12 | Saint Louis University | Molecular biosensors for use in competition assays |
| MEP0208A (xx) * | 2005-08-26 | 2010-02-10 | Archemix Corp | Aptameri koji vezuje trombin sa visokim afininitetom |
| EP2046998B1 (en) * | 2006-08-09 | 2013-10-02 | Saint Louis University | Molecular biosensors for detecting macromolecules and other analytes |
| EP2629094A1 (en) * | 2007-01-24 | 2013-08-21 | Carnegie Mellon University | Optical biosensors |
| DE102007041476B4 (de) | 2007-08-31 | 2017-03-30 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamere, die an ein an der Hämostase beteiligtes Zielmolekül binden |
| DE102007063902B3 (de) * | 2007-08-31 | 2017-11-23 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamere, die an ein an der Hämostase beteiligtes Zielmolekül binden |
| CN101868728A (zh) * | 2007-11-21 | 2010-10-20 | 鹿特丹伊拉斯姆斯大学医疗中心 | 改进的fret探针及其应用 |
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-
2004
- 2004-12-10 JP JP2006543991A patent/JP2007525661A/ja active Pending
- 2004-12-10 CN CN2004800368747A patent/CN101208437B/zh not_active Expired - Fee Related
- 2004-12-10 WO PCT/US2004/041315 patent/WO2005059509A2/en not_active Ceased
- 2004-12-10 EP EP04813618.8A patent/EP1692486B1/en not_active Expired - Lifetime
- 2004-12-10 CA CA2545006A patent/CA2545006C/en not_active Expired - Fee Related
- 2004-12-11 US US10/539,107 patent/US7939313B2/en not_active Expired - Fee Related
-
2010
- 2010-12-06 US US12/961,135 patent/US8592202B2/en not_active Expired - Fee Related
-
2011
- 2011-12-26 JP JP2011284014A patent/JP2012115269A/ja active Pending
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