JP2007524571A5 - - Google Patents
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- Publication number
- JP2007524571A5 JP2007524571A5 JP2006500994A JP2006500994A JP2007524571A5 JP 2007524571 A5 JP2007524571 A5 JP 2007524571A5 JP 2006500994 A JP2006500994 A JP 2006500994A JP 2006500994 A JP2006500994 A JP 2006500994A JP 2007524571 A5 JP2007524571 A5 JP 2007524571A5
- Authority
- JP
- Japan
- Prior art keywords
- kit
- assay
- tyr
- glu
- phosphorylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003556 assay Methods 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43815203P | 2003-01-06 | 2003-01-06 | |
| US52497203P | 2003-11-25 | 2003-11-25 | |
| US52635803P | 2003-12-02 | 2003-12-02 | |
| PCT/US2004/001188 WO2004063330A2 (en) | 2003-01-06 | 2004-01-06 | (2-carboxamido) (3-amino) thiophene compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007524571A JP2007524571A (ja) | 2007-08-30 |
| JP2007524571A5 true JP2007524571A5 (https=) | 2010-05-27 |
| JP4685755B2 JP4685755B2 (ja) | 2011-05-18 |
Family
ID=32719185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500994A Expired - Fee Related JP4685755B2 (ja) | 2003-01-06 | 2004-01-06 | （２−カルボキサミド）（３−アミノ）チオフェン化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6949563B2 (https=) |
| EP (1) | EP1590328B1 (https=) |
| JP (1) | JP4685755B2 (https=) |
| KR (1) | KR101017140B1 (https=) |
| AR (1) | AR042706A1 (https=) |
| AT (1) | ATE546435T1 (https=) |
| BR (1) | BRPI0406646A (https=) |
| CA (1) | CA2512608C (https=) |
| ES (1) | ES2379874T3 (https=) |
| LV (1) | LV13360B (https=) |
| MX (1) | MXPA05007296A (https=) |
| PE (1) | PE20040938A1 (https=) |
| TW (1) | TWI299664B (https=) |
| WO (1) | WO2004063330A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20041220A2 (hr) * | 2002-05-28 | 2006-04-30 | 3-Dimensional Pharmaceuticals | Novi tiofen amidini, njihovi pripravci i postupci liječenja komplementom posredovanih bolesti i stanja |
| TWI299664B (en) * | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
| US7696225B2 (en) * | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
| AU2005230676B2 (en) * | 2004-04-01 | 2010-10-07 | Rexahn Corporation | Nucleoside derivatives and therapeutic use thereof |
| WO2006023707A2 (en) * | 2004-08-20 | 2006-03-02 | Bayer Pharmaceuticals Corporation | 2-aminothiophenecarboxamides useful as cancer chemotherapeutic agents |
| WO2006034075A1 (en) * | 2004-09-17 | 2006-03-30 | Osi Pharmaceuticals, Inc. | (hydrazido) (amino) thiophene compounds |
| WO2006034016A1 (en) * | 2004-09-17 | 2006-03-30 | Osi Pharmaceuticals, Inc. | (arylamidoanilino) nitroethylene compounds |
| AU2005287057A1 (en) * | 2004-09-17 | 2006-03-30 | Osi Pharmaceuticals, Inc. | (spirocyclylamido) aminothiophene compounds as c-Kit proto- oncogene inhibitors |
| CA2600039A1 (en) * | 2005-03-04 | 2006-09-14 | Bayer Pharmaceuticals Corporation | 1,3-thiazole-5-carboxamides useful as cancer chemotherapeutic agents |
| WO2007028145A2 (en) * | 2005-09-02 | 2007-03-08 | Dara Biosciences, Inc. | Agents and methods for reducing protein tyrosine phosphatase 1b activity in the central nervous system |
| TW200730529A (en) * | 2005-12-07 | 2007-08-16 | Osi Pharm Inc | Process to prepare substituted imidazopyrazine compounds |
| KR100863094B1 (ko) * | 2007-08-21 | 2008-10-13 | 현대자동차주식회사 | 셀프 클리닝 효과를 이용한 에어백 저항 과대방지 시스템 |
| WO2009073139A2 (en) * | 2007-11-28 | 2009-06-11 | Osi Pharmaceuticals, Inc. | Combined treatment with an egfr kinase inhibitor and an inhibitor of c-kit |
| WO2010088000A2 (en) * | 2009-02-02 | 2010-08-05 | Angion Biomedica Corp. | Antifibrotic compounds and uses thereof |
| WO2010099139A2 (en) | 2009-02-25 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Combination anti-cancer therapy |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| EP2401614A1 (en) | 2009-02-27 | 2012-01-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| EP2702173A1 (en) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| US9845507B2 (en) | 2014-09-30 | 2017-12-19 | Sysmex Corporation | Methods for detecting oncogenic mutations |
| CN115872995B (zh) * | 2022-12-27 | 2024-10-01 | 上海凌凯科技股份有限公司 | 一种吡唑并吡啶化合物及一种羧酸衍生物的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US5242921A (en) * | 1988-04-27 | 1993-09-07 | Yale University | Compositions and methods for treating cutaneous hyperproliferative disorders |
| US5430049A (en) * | 1993-12-08 | 1995-07-04 | Gaut; Zane N. | Treating hyperproliferative disorders |
| GB9511694D0 (en) | 1995-06-09 | 1995-08-02 | Fujisawa Pharmaceutical Co | Benzamide derivatives |
| US5968965A (en) | 1996-01-30 | 1999-10-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AUPO395396A0 (en) * | 1996-12-02 | 1997-01-02 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
| US6187799B1 (en) * | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
| US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| EP1040108B1 (en) | 1997-12-19 | 2004-02-25 | Schering Aktiengesellschaft | Ortho-anthranilamide derivatives as anti-coagulants |
| EP1072263A4 (en) | 1998-03-26 | 2004-03-31 | Japan Tobacco Inc | AMID DERIVATIVES AND NOCICEPTINANT AGONISTS |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| JP2003509412A (ja) | 1999-09-17 | 2003-03-11 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子阻害剤 |
| GT200000158A (es) | 1999-09-28 | 2002-03-16 | Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis. | |
| AU2001250783A1 (en) | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| WO2002000651A2 (en) | 2000-06-27 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Factor xa inhibitors |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US20020147198A1 (en) | 2001-01-12 | 2002-10-10 | Guoqing Chen | Substituted arylamine derivatives and methods of use |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| TWI299664B (en) | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
-
2003
- 2003-12-19 TW TW092136301A patent/TWI299664B/zh not_active IP Right Cessation
-
2004
- 2004-01-05 AR ARP040100012A patent/AR042706A1/es unknown
- 2004-01-06 PE PE2004000046A patent/PE20040938A1/es not_active Application Discontinuation
- 2004-01-06 BR BR0406646-4A patent/BRPI0406646A/pt not_active IP Right Cessation
- 2004-01-06 EP EP04700407A patent/EP1590328B1/en not_active Expired - Lifetime
- 2004-01-06 AT AT04700407T patent/ATE546435T1/de active
- 2004-01-06 KR KR1020057012689A patent/KR101017140B1/ko not_active Expired - Fee Related
- 2004-01-06 US US10/752,342 patent/US6949563B2/en not_active Expired - Lifetime
- 2004-01-06 CA CA2512608A patent/CA2512608C/en not_active Expired - Fee Related
- 2004-01-06 JP JP2006500994A patent/JP4685755B2/ja not_active Expired - Fee Related
- 2004-01-06 WO PCT/US2004/001188 patent/WO2004063330A2/en not_active Ceased
- 2004-01-06 ES ES04700407T patent/ES2379874T3/es not_active Expired - Lifetime
- 2004-01-06 MX MXPA05007296A patent/MXPA05007296A/es active IP Right Grant
-
2005
- 2005-04-27 US US11/116,007 patent/US7101893B2/en not_active Expired - Fee Related
- 2005-07-05 LV LVP-05-85A patent/LV13360B/en unknown
-
2006
- 2006-06-28 US US11/476,952 patent/US7524859B2/en not_active Expired - Fee Related
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