JP2007524571A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007524571A5 JP2007524571A5 JP2006500994A JP2006500994A JP2007524571A5 JP 2007524571 A5 JP2007524571 A5 JP 2007524571A5 JP 2006500994 A JP2006500994 A JP 2006500994A JP 2006500994 A JP2006500994 A JP 2006500994A JP 2007524571 A5 JP2007524571 A5 JP 2007524571A5
- Authority
- JP
- Japan
- Prior art keywords
- kit
- assay
- tyr
- glu
- phosphorylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003556 assay Methods 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43815203P | 2003-01-06 | 2003-01-06 | |
| US52497203P | 2003-11-25 | 2003-11-25 | |
| US52635803P | 2003-12-02 | 2003-12-02 | |
| PCT/US2004/001188 WO2004063330A2 (en) | 2003-01-06 | 2004-01-06 | (2-carboxamido) (3-amino) thiophene compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007524571A JP2007524571A (ja) | 2007-08-30 |
| JP2007524571A5 true JP2007524571A5 (https=) | 2010-05-27 |
| JP4685755B2 JP4685755B2 (ja) | 2011-05-18 |
Family
ID=32719185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500994A Expired - Fee Related JP4685755B2 (ja) | 2003-01-06 | 2004-01-06 | （２−カルボキサミド）（３−アミノ）チオフェン化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6949563B2 (https=) |
| EP (1) | EP1590328B1 (https=) |
| JP (1) | JP4685755B2 (https=) |
| KR (1) | KR101017140B1 (https=) |
| AR (1) | AR042706A1 (https=) |
| AT (1) | ATE546435T1 (https=) |
| BR (1) | BRPI0406646A (https=) |
| CA (1) | CA2512608C (https=) |
| ES (1) | ES2379874T3 (https=) |
| LV (1) | LV13360B (https=) |
| MX (1) | MXPA05007296A (https=) |
| PE (1) | PE20040938A1 (https=) |
| TW (1) | TWI299664B (https=) |
| WO (1) | WO2004063330A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138530B2 (en) * | 2002-05-28 | 2006-11-21 | 3-Dimensional Pharmaceuticals, Inc. | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
| TWI299664B (en) * | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
| US7696225B2 (en) | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
| MXPA06011141A (es) * | 2004-04-01 | 2007-08-14 | Rexahn Corp | Derivados de nucleosidos y usos terapeuticos de los mismos. |
| WO2006023707A2 (en) * | 2004-08-20 | 2006-03-02 | Bayer Pharmaceuticals Corporation | 2-aminothiophenecarboxamides useful as cancer chemotherapeutic agents |
| US7388012B2 (en) * | 2004-09-17 | 2008-06-17 | Osi Pharmaceuticals, Inc. | (Hydrazido)(amino)thiophene compounds |
| WO2006034015A1 (en) * | 2004-09-17 | 2006-03-30 | Osi Pharmaceuticals, Inc. | (spirocyclylamido) aminothiophene compounds as c-kit proto- oncogene inhibitors |
| US7618965B2 (en) * | 2004-09-17 | 2009-11-17 | Osi Pharmaceuticals, Inc. | (Arylamidoanilino)nitroethylene compounds |
| WO2006096338A1 (en) * | 2005-03-04 | 2006-09-14 | Bayer Healthcare Ag | 1,3-thiazole-5-carboxamides useful as cancer chemotherapeutic agents |
| WO2007028145A2 (en) * | 2005-09-02 | 2007-03-08 | Dara Biosciences, Inc. | Agents and methods for reducing protein tyrosine phosphatase 1b activity in the central nervous system |
| TW200730529A (en) * | 2005-12-07 | 2007-08-16 | Osi Pharm Inc | Process to prepare substituted imidazopyrazine compounds |
| KR100863094B1 (ko) * | 2007-08-21 | 2008-10-13 | 현대자동차주식회사 | 셀프 클리닝 효과를 이용한 에어백 저항 과대방지 시스템 |
| JP2011504926A (ja) * | 2007-11-28 | 2011-02-17 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | Ｅｇｆｒキナーゼ阻害剤とｃ−ｋｉｔ阻害剤による併用治療 |
| WO2010088000A2 (en) * | 2009-02-02 | 2010-08-05 | Angion Biomedica Corp. | Antifibrotic compounds and uses thereof |
| WO2010099139A2 (en) | 2009-02-25 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Combination anti-cancer therapy |
| WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2010099364A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2012149014A1 (en) | 2011-04-25 | 2012-11-01 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| US9845507B2 (en) | 2014-09-30 | 2017-12-19 | Sysmex Corporation | Methods for detecting oncogenic mutations |
| CN115872995B (zh) * | 2022-12-27 | 2024-10-01 | 上海凌凯科技股份有限公司 | 一种吡唑并吡啶化合物及一种羧酸衍生物的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US5242921A (en) * | 1988-04-27 | 1993-09-07 | Yale University | Compositions and methods for treating cutaneous hyperproliferative disorders |
| US5430049A (en) * | 1993-12-08 | 1995-07-04 | Gaut; Zane N. | Treating hyperproliferative disorders |
| GB9511694D0 (en) | 1995-06-09 | 1995-08-02 | Fujisawa Pharmaceutical Co | Benzamide derivatives |
| US5968965A (en) * | 1996-01-30 | 1999-10-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AUPO395396A0 (en) * | 1996-12-02 | 1997-01-02 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
| US6187799B1 (en) * | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
| US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| ATE260103T1 (de) | 1997-12-19 | 2004-03-15 | Schering Ag | Ortho-anthranilamide derivate als antikoagulantien |
| NZ507760A (en) * | 1998-03-26 | 2002-10-25 | Japan Tobacco Inc | Amide derivatives and nociceptin antagonists |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| CZ2002959A3 (cs) | 1999-09-17 | 2002-07-17 | Millennium Pharmaceuticals, Inc. | Inhibitory faktoru Xa |
| DOP2000000070A (es) | 1999-09-28 | 2002-02-28 | Bayer Healthcare Llc | Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
| US20020147198A1 (en) | 2001-01-12 | 2002-10-10 | Guoqing Chen | Substituted arylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| TWI299664B (en) | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
-
2003
- 2003-12-19 TW TW092136301A patent/TWI299664B/zh not_active IP Right Cessation
-
2004
- 2004-01-05 AR ARP040100012A patent/AR042706A1/es unknown
- 2004-01-06 BR BR0406646-4A patent/BRPI0406646A/pt not_active IP Right Cessation
- 2004-01-06 US US10/752,342 patent/US6949563B2/en not_active Expired - Lifetime
- 2004-01-06 ES ES04700407T patent/ES2379874T3/es not_active Expired - Lifetime
- 2004-01-06 CA CA2512608A patent/CA2512608C/en not_active Expired - Fee Related
- 2004-01-06 KR KR1020057012689A patent/KR101017140B1/ko not_active Expired - Fee Related
- 2004-01-06 AT AT04700407T patent/ATE546435T1/de active
- 2004-01-06 JP JP2006500994A patent/JP4685755B2/ja not_active Expired - Fee Related
- 2004-01-06 WO PCT/US2004/001188 patent/WO2004063330A2/en not_active Ceased
- 2004-01-06 MX MXPA05007296A patent/MXPA05007296A/es active IP Right Grant
- 2004-01-06 EP EP04700407A patent/EP1590328B1/en not_active Expired - Lifetime
- 2004-01-06 PE PE2004000046A patent/PE20040938A1/es not_active Application Discontinuation
-
2005
- 2005-04-27 US US11/116,007 patent/US7101893B2/en not_active Expired - Fee Related
- 2005-07-05 LV LVP-05-85A patent/LV13360B/en unknown
-
2006
- 2006-06-28 US US11/476,952 patent/US7524859B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007524571A5 (https=) | ||
| IL287708A (en) | Janus kinase inhibitor salts | |
| NO20076502L (no) | Pyrrolopyridiner nyttige som inhibitorer av proteinkinase | |
| BRPI0418112A (pt) | inibidores de p-38 quinase bicìclico heterocìclicos | |
| JP2007515400A5 (https=) | ||
| WO2002060900A3 (en) | Antagonists of mcp-1 function and methods of use thereof | |
| NO20054404L (no) | 5,7-Diaminopyrazolo [4,3-D] Pyrimidiner Anvendelige ved behandling av of Hypertensjon | |
| WO2005049581A8 (en) | Pyridazin-3 (2h) -one derivatives and their use as pde4 inhibitors | |
| NO20064015L (no) | Kondenserte derivater av pyrazol | |
| UA84318C2 (ru) | Гетерополициклические соединения и их применение как метаботропических антагонистов рецепторов глутамата, фармацевтическая композиция на их основе | |
| WO2005000298A3 (en) | 5-membered heterocycle-based p-38 inhibitors | |
| WO2005019190A3 (en) | (4 -amino -1,2, 5-oxadiazol-4-yl) -hetξroaromatic compounds useful as protein kinase inhibitors | |
| NO20051503L (no) | Pyrazolopyridiner og fremgangsmater for fremstilling og anvendelse av de samme. | |
| NO20052497D0 (no) | Fremgangsmater for selektiv inhibering av Janus tyrosinkinase 3 (JAK3). | |
| WO2003042214A3 (en) | A2b adenosine receptor antagonists | |
| IS6913A (is) | 3-(4-amídópýrról-2-ýlmetlíden)-2-indólínon afleiður sem prótein kínasa hindrar | |
| JP2007513058A5 (https=) | ||
| ECSP056206A (es) | Inhibidores de quinasa p38 basados en heterociclos de 5 miembros | |
| CA2439291A1 (en) | Imidazo (1,2-a)-pyridine derivatives as mglur5 antagonists | |
| NO20061415L (no) | Kinazolinderivater | |
| NO20034311D0 (no) | CCR5-antagonister for behandling av AIDS | |
| WO2007067875A3 (en) | Pyridinyl sulfonamide modulators of chemokine receptors | |
| HUP0401633A3 (en) | Use of irbesartan for the preparation of pharmaceutical compositions that are used to prevent or treat pulmonary hypertension | |
| NO20042613L (no) | Ny anvendelse for behandling av gastroosofagial refluks | |
| HUP0500078A2 (hu) | PDE inhibitort és leukotrién antagonistát tartalmazó kombinált gyógyszerkészítmény |