JP2007523139A5 - - Google Patents

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Publication number
JP2007523139A5
JP2007523139A5 JP2006553649A JP2006553649A JP2007523139A5 JP 2007523139 A5 JP2007523139 A5 JP 2007523139A5 JP 2006553649 A JP2006553649 A JP 2006553649A JP 2006553649 A JP2006553649 A JP 2006553649A JP 2007523139 A5 JP2007523139 A5 JP 2007523139A5
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JP
Japan
Prior art keywords
base
formula
group
substituted
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006553649A
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English (en)
Japanese (ja)
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JP2007523139A (ja
JP4208925B2 (ja
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Publication date
Priority claimed from GB0403779A external-priority patent/GB0403779D0/en
Priority claimed from GB0420780A external-priority patent/GB0420780D0/en
Application filed filed Critical
Priority claimed from PCT/GB2005/000534 external-priority patent/WO2005080343A2/en
Publication of JP2007523139A publication Critical patent/JP2007523139A/ja
Publication of JP2007523139A5 publication Critical patent/JP2007523139A5/ja
Application granted granted Critical
Publication of JP4208925B2 publication Critical patent/JP4208925B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2006553649A 2004-02-20 2005-02-16 治療薬 Expired - Fee Related JP4208925B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0403779A GB0403779D0 (en) 2004-02-20 2004-02-20 Therapeutic agents
GB0420780A GB0420780D0 (en) 2004-09-18 2004-09-18 Therapeutic agents
PCT/GB2005/000534 WO2005080343A2 (en) 2004-02-20 2005-02-16 3-substituted 1,5-diphenylpyrazole derivatives useful as cb1 modulators

Publications (3)

Publication Number Publication Date
JP2007523139A JP2007523139A (ja) 2007-08-16
JP2007523139A5 true JP2007523139A5 (US20040106767A1-20040603-C00005.png) 2008-04-03
JP4208925B2 JP4208925B2 (ja) 2009-01-14

Family

ID=34889139

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006553649A Expired - Fee Related JP4208925B2 (ja) 2004-02-20 2005-02-16 治療薬

Country Status (18)

Country Link
US (1) US20090149463A1 (US20040106767A1-20040603-C00005.png)
EP (1) EP1718617B1 (US20040106767A1-20040603-C00005.png)
JP (1) JP4208925B2 (US20040106767A1-20040603-C00005.png)
KR (1) KR20060131906A (US20040106767A1-20040603-C00005.png)
AR (1) AR047683A1 (US20040106767A1-20040603-C00005.png)
AT (1) ATE440085T1 (US20040106767A1-20040603-C00005.png)
AU (1) AU2005214130B2 (US20040106767A1-20040603-C00005.png)
BR (1) BRPI0507786A (US20040106767A1-20040603-C00005.png)
CA (1) CA2555331C (US20040106767A1-20040603-C00005.png)
DE (1) DE602005016082D1 (US20040106767A1-20040603-C00005.png)
ES (1) ES2329915T3 (US20040106767A1-20040603-C00005.png)
HK (1) HK1095329A1 (US20040106767A1-20040603-C00005.png)
IL (1) IL177218A0 (US20040106767A1-20040603-C00005.png)
NO (1) NO20063787L (US20040106767A1-20040603-C00005.png)
RU (1) RU2375349C2 (US20040106767A1-20040603-C00005.png)
TW (1) TW200531689A (US20040106767A1-20040603-C00005.png)
UY (1) UY28752A1 (US20040106767A1-20040603-C00005.png)
WO (1) WO2005080343A2 (US20040106767A1-20040603-C00005.png)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
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JP2008525404A (ja) * 2004-12-23 2008-07-17 アストラゼネカ アクチボラグ 治療剤
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
GB0514738D0 (en) * 2005-07-19 2005-08-24 Astrazeneca Ab Therapeutic agents
GB0516661D0 (en) * 2005-08-13 2005-09-21 Astrazeneca Ab Therapeutic agents
AR056560A1 (es) 2005-10-06 2007-10-10 Astrazeneca Ab Pirrolopiridinonas como moduladores cb1
JP5069894B2 (ja) * 2005-10-21 2012-11-07 田辺三菱製薬株式会社 ピラゾール化合物
WO2007046550A1 (en) 2005-10-21 2007-04-26 Mitsubishi Tanabe Pharma Corporation Pyrazole compounds having cannabinoid receptor (cb1) antagonizing activity
CN101472897A (zh) * 2006-06-20 2009-07-01 阿斯利康(瑞典)有限公司 治疗剂
US20100234439A1 (en) * 2006-06-20 2010-09-16 Leifeng Cheng Therapeutic agents
EP2061767B1 (de) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
EP2121617B1 (en) * 2006-12-18 2014-01-22 7TM Pharma A/S Cb1 receptor modulators
RU2492858C2 (ru) 2007-04-11 2013-09-20 Омерос Корпорейшн Композиции и способы профилактики и лечения зависимостей
US20160331729A9 (en) 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
TW201014822A (en) 2008-07-09 2010-04-16 Sanofi Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
GB0815134D0 (en) * 2008-08-19 2008-09-24 Univ Aberdeen Therapeutic compounds and their use
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
DE102008062878A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102009036604A1 (de) 2009-07-30 2011-02-03 Aicuris Gmbh & Co. Kg Substituierte Bis-Arylpyrazolamide mit terminaler primärer Amidfunktionalisierung und ihre Verwendung
DK2470552T3 (en) 2009-08-26 2014-02-17 Sanofi Sa NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
WO2012120050A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120057A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
CN102358735B (zh) * 2011-08-23 2013-09-04 范如霖 低毒性的多头分导药,带羟基或取代羟基的含氮芳环cb1受体抑制剂及其制药用途
DE102011055815A1 (de) 2011-11-29 2013-05-29 Aicuris Gmbh & Co. Kg Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung
DE102012016908A1 (de) 2012-08-17 2014-02-20 Aicuris Gmbh & Co. Kg Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
BR112021009123A2 (pt) * 2018-12-04 2021-08-10 Basf Se processo para a preparação de 5-bromo-1,3-dicloro-2-fluoro-benzeno e processo para a preparação de composto de fórmula v
CN113816892A (zh) * 2021-08-27 2021-12-21 安徽鼎旺医药有限公司 一种醋酸巴多昔芬的合成方法

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FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
FR2732967B1 (fr) * 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
FR2789079B3 (fr) * 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
CA2399791A1 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
CA2457922A1 (en) * 2001-08-31 2003-03-13 University Of Connecticut Novel pyrazole analogs acting on cannabinoid receptors
US6825209B2 (en) * 2002-04-15 2004-11-30 Research Triangle Institute Compounds having unique CB1 receptor binding selectivity and methods for their production and use
CA2505945A1 (en) * 2002-12-02 2004-06-17 Fujisawa Pharmaceutical Co., Ltd. Pyrazole derivatives useful as cox-i inhibitors

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