JP2007521013A5 - - Google Patents

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Publication number
JP2007521013A5
JP2007521013A5 JP2006521315A JP2006521315A JP2007521013A5 JP 2007521013 A5 JP2007521013 A5 JP 2007521013A5 JP 2006521315 A JP2006521315 A JP 2006521315A JP 2006521315 A JP2006521315 A JP 2006521315A JP 2007521013 A5 JP2007521013 A5 JP 2007521013A5
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JP
Japan
Prior art keywords
term
ambient temperature
temperature
mmhg
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2006521315A
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English (en)
Other versions
JP2007521013A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/024318 external-priority patent/WO2005010015A1/en
Publication of JP2007521013A publication Critical patent/JP2007521013A/ja
Publication of JP2007521013A5 publication Critical patent/JP2007521013A5/ja
Ceased legal-status Critical Current

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Description

発明の特定の記載
本明細書においては使用される場合、用語、周囲温度とは、約0℃〜約40℃、好ましくは約10℃〜約35℃の温度に関する。
本明細書において使用される場合、用語、低められた圧力とは、約760mmHg以下の圧力を言及する。
本明細書において使用される場合、用語、抗−溶媒とは、マクロライドを精々僅かに溶解する物質、通常、周囲温度での液体を意味する。
JP2006521315A 2003-07-24 2004-07-26 マクロライドの精製方法 Ceased JP2007521013A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49007003P 2003-07-24 2003-07-24
US53936304P 2004-01-26 2004-01-26
PCT/US2004/024318 WO2005010015A1 (en) 2003-07-24 2004-07-26 Method of purifying macrolides

Publications (2)

Publication Number Publication Date
JP2007521013A JP2007521013A (ja) 2007-08-02
JP2007521013A5 true JP2007521013A5 (ja) 2009-07-16

Family

ID=34107827

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006521315A Ceased JP2007521013A (ja) 2003-07-24 2004-07-26 マクロライドの精製方法

Country Status (13)

Country Link
US (2) US7220357B2 (ja)
EP (1) EP1558622B1 (ja)
JP (1) JP2007521013A (ja)
KR (1) KR20060052874A (ja)
AT (1) ATE378345T1 (ja)
CA (1) CA2533548C (ja)
DE (1) DE602004010059T2 (ja)
DK (1) DK1558622T3 (ja)
ES (1) ES2297481T3 (ja)
PL (1) PL1558622T3 (ja)
PT (1) PT1558622E (ja)
TW (1) TW200523266A (ja)
WO (1) WO2005010015A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473366B2 (en) * 2003-12-05 2009-01-06 Biocon Limited Process for the purification of macrolides
EP1817315A1 (en) 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Processes for producing crystalline macrolides
US20060149057A1 (en) * 2004-12-22 2006-07-06 Vilmos Keri Method of purifying macrolides
CA2630786A1 (en) * 2005-12-07 2007-06-14 Wyeth Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
KR100859670B1 (ko) * 2006-09-13 2008-09-23 동국제약 주식회사 타크로리무스를 고수율 및 고순도로 정제하는 방법
US20090082386A1 (en) * 2006-11-06 2009-03-26 Erzsebet Meszarosne Sos Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
KR100891313B1 (ko) * 2007-08-17 2009-03-31 (주) 제노텍 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법
WO2010121203A1 (en) * 2009-04-16 2010-10-21 Ocean Spray Cranberries, Inc. Phenolics extraction and use
CN106478664B (zh) * 2016-08-29 2017-12-05 广东蓝宝制药有限公司 一种发酵液中提取纯化他克莫司的方法
WO2018202733A1 (en) 2017-05-01 2018-11-08 Meda Pharma Gmbh & Co. Kg Process to convert crude ascomycin into purified pimecrolimus
CN108409751A (zh) * 2018-02-24 2018-08-17 海正药业(杭州)有限公司 一种子囊霉素的纯化方法
CN111693635A (zh) * 2020-07-23 2020-09-22 北京和合医学诊断技术股份有限公司 检测血液中雷帕霉素含量的方法
CN113325108B (zh) * 2021-06-04 2022-12-09 山东霆科药业有限公司 一种他克莫司软膏的样品前处理方法
CN115716839A (zh) * 2022-11-15 2023-02-28 无锡福祈制药有限公司 一种依维莫司杂质的合成方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2121517C3 (de) 1971-04-30 1974-06-27 Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Ssr, Leningrad (Sowjetunion) Verfahren zur Gewinnung von Amphoterizin B
US3993749A (en) 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US4160861A (en) 1977-10-03 1979-07-10 Merck & Co., Inc. Method for the separation of antibiotic macrolides
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JP2639737B2 (ja) 1990-01-23 1997-08-13 寳酒造株式会社 新規r106類化合物
US5116756A (en) 1991-01-28 1992-05-26 Merck & Co., Inc. Process for producing FK-506
JPH06501026A (ja) 1991-04-11 1994-01-27 ファイザー・インコーポレーテッド ストレプトミセス・ブレジェンシス由来の新規の免疫抑制剤
US5091389A (en) 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
ATE205496T1 (de) 1992-03-02 2001-09-15 Pfizer Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel
UA41884C2 (uk) 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5622866A (en) 1994-06-23 1997-04-22 Merck & Co., Inc. Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
GB9618952D0 (en) 1996-09-11 1996-10-23 Sandoz Ltd Process
GB9826882D0 (en) 1998-12-07 1999-01-27 Novartis Ag Organic compounds
TW553946B (en) * 1999-09-08 2003-09-21 Fujisawa Pharmaceutical Co Method for separating lactone-containing high-molecular weight compounds
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
FR2803307A1 (fr) * 1999-12-30 2001-07-06 Centre Nat Rech Scient Lignees de lymphocytes t cd4 specifiques de type th1 et procede pour leur induction ex vivo
JP3740062B2 (ja) 2000-02-24 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ 培養液の精製方法
AUPQ801700A0 (en) * 2000-06-07 2000-06-29 Peplin Research Pty Ltd Enzyme and viral activation
AUPQ923100A0 (en) * 2000-08-07 2000-08-31 Peplin Research Pty Ltd Treatment of prostate cancer
EP1474404A4 (en) 2002-02-13 2006-01-11 Biogal Gyogyszergyar PROCESS FOR EXTRACTION OF A BIOLOGICAL MATERIAL

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