JP2007519609A - 細胞増殖を制御するためのｃｈｋ１インヒビターの使用 - Google Patents

細胞増殖を制御するためのｃｈｋ１インヒビターの使用 Download PDF

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JP2007519609A
JP2007519609A JP2006527120A JP2006527120A JP2007519609A JP 2007519609 A JP2007519609 A JP 2007519609A JP 2006527120 A JP2006527120 A JP 2006527120A JP 2006527120 A JP2006527120 A JP 2006527120A JP 2007519609 A JP2007519609 A JP 2007519609A
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JP2007519609A5 (cg-RX-API-DMAC7.html
Inventor
ダルシー クラーク，
キャサリン エス． キーガン，
スコット ピーターソン，
マーガレット ワイドナー，
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Icos Corp
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Icos Corp
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    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2006527120A 2003-09-17 2004-09-17 細胞増殖を制御するためのｃｈｋ１インヒビターの使用 Pending JP2007519609A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50392503P 2003-09-17 2003-09-17
PCT/US2004/030806 WO2005027907A1 (en) 2003-09-17 2004-09-17 Use of chk1 inhibitors to control cell proliferation

Publications (2)

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JP2007519609A true JP2007519609A (ja) 2007-07-19
JP2007519609A5 JP2007519609A5 (cg-RX-API-DMAC7.html) 2007-11-01

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US (1) US20070185013A1 (cg-RX-API-DMAC7.html)
EP (1) EP1667684A1 (cg-RX-API-DMAC7.html)
JP (1) JP2007519609A (cg-RX-API-DMAC7.html)
KR (1) KR20070064414A (cg-RX-API-DMAC7.html)
CN (1) CN1882342A (cg-RX-API-DMAC7.html)
AU (1) AU2004274013A1 (cg-RX-API-DMAC7.html)
CA (1) CA2539320A1 (cg-RX-API-DMAC7.html)
IL (1) IL174334A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA06003110A (cg-RX-API-DMAC7.html)
NO (1) NO20061475L (cg-RX-API-DMAC7.html)
RU (1) RU2006112548A (cg-RX-API-DMAC7.html)
WO (1) WO2005027907A1 (cg-RX-API-DMAC7.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510719A (ja) * 2004-08-19 2008-04-10 イコス・コーポレイション Ｃｈｋ１の阻害に有用な化合物
JP2012523435A (ja) * 2009-04-11 2012-10-04 アレイ バイオファーマ、インコーポレイテッド Ｄｎａ損傷因子増強のためのチェックポイントキナーゼ１阻害剤
JP2013542997A (ja) * 2010-11-16 2013-11-28 アレイ バイオファーマ、インコーポレイテッド チェックポイントキナーゼ１阻害剤とｗｅｅ１キナーゼ阻害剤の組み合わせ
JP2015078190A (ja) * 2009-03-20 2015-04-23 ザ、ジェネラル、ホスピタル、コーポレイションＴｈｅ Ｇｅｎｅｒａｌｈｏｓｐｉｔａｌ Ｃｏｒｐｏｒａｔｉｏｎ 熱傷及び二次性合併症の予防及び治療方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196078B2 (en) 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7572914B2 (en) 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
USRE46379E1 (en) 2004-04-08 2017-04-25 Cornell Research Foundation, Inc. Functional immunohistochemical cell cycle analysis as a prognostic indicator for cancer
WO2006023931A2 (en) 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2008530575A (ja) * 2005-02-18 2008-08-07 アストラゼネカ アクチボラグ Ｃｈｋ１阻害薬に対する応答性を判定する方法
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2009523149A (ja) * 2006-01-12 2009-06-18 ノバルティス アクチエンゲゼルシャフト ｍＴＯＲ阻害剤および抗葉酸化合物の組み合わせ
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
NZ575394A (en) * 2006-10-20 2012-01-12 Icos Corp Compositions of chk1 inhibitors and cyclodextrin
EP2086644A2 (en) * 2006-11-17 2009-08-12 Schering Corporation Combination of an inhibitor of dna polymerase-alpha and an inhibitor of a checkpoint kinase for proliferative disorders
CA2674075C (en) * 2006-12-29 2012-10-30 Charles P. Theuer Antifolate agent combinations in the treatment of cancer
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US8481557B2 (en) 2009-04-11 2013-07-09 Array Biopharma Inc. Method of treatment using checkpoint kinase 1 inhibitors
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