JP2007518822A - 抗癌剤としてのテトラヒドロカルボリン化合物 - Google Patents

抗癌剤としてのテトラヒドロカルボリン化合物 Download PDF

Info

Publication number
JP2007518822A
JP2007518822A JP2006551391A JP2006551391A JP2007518822A JP 2007518822 A JP2007518822 A JP 2007518822A JP 2006551391 A JP2006551391 A JP 2006551391A JP 2006551391 A JP2006551391 A JP 2006551391A JP 2007518822 A JP2007518822 A JP 2007518822A
Authority
JP
Japan
Prior art keywords
substituted
group
unsubstituted
hydrogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006551391A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007518822A5 (OSRAM
Inventor
ウェイボー ワン，
ジー−ジエ ニー，
パウル バルサンティ，
サビナ ペッチ，
イー シャー，
ナタン ブラムマイアー，
ミーガン トロイトル，
エリサ ジャーザン，
ケリー ウェイマン，
デイビッド ディブル，
ジエ−カイ チェン，
Original Assignee
カイロン コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by カイロン コーポレイション filed Critical カイロン コーポレイション
Publication of JP2007518822A publication Critical patent/JP2007518822A/ja
Publication of JP2007518822A5 publication Critical patent/JP2007518822A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006551391A 2004-01-23 2005-01-24 抗癌剤としてのテトラヒドロカルボリン化合物 Pending JP2007518822A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53898004P 2004-01-23 2004-01-23
PCT/US2005/002270 WO2005070930A2 (en) 2004-01-23 2005-01-24 Tetrahydrocarboline compounds as anticancer agents

Publications (2)

Publication Number Publication Date
JP2007518822A true JP2007518822A (ja) 2007-07-12
JP2007518822A5 JP2007518822A5 (OSRAM) 2008-01-31

Family

ID=34807249

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006551391A Pending JP2007518822A (ja) 2004-01-23 2005-01-24 抗癌剤としてのテトラヒドロカルボリン化合物

Country Status (9)

Country Link
US (1) US7855295B2 (OSRAM)
EP (1) EP1706404A2 (OSRAM)
JP (1) JP2007518822A (OSRAM)
CN (1) CN1910183A (OSRAM)
AU (1) AU2005206570A1 (OSRAM)
BR (1) BRPI0506977A (OSRAM)
CA (1) CA2554150A1 (OSRAM)
MX (1) MXPA06008211A (OSRAM)
WO (1) WO2005070930A2 (OSRAM)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008536876A (ja) * 2005-04-18 2008-09-11 ピーティーシー セラピューティクス，インコーポレーテッド 癌の治療に有用なカルボリン誘導体
WO2012005227A1 (ja) * 2010-07-06 2012-01-12 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
JP2013513649A (ja) * 2009-12-14 2013-04-22 サノフイ 新規（複素環／縮合ピペリジン）−（ピペラジニル）−１−アルカノンまたは（複素環／縮合ピロリジン）−（ピペラジニル）−１−アルカノン誘導体およびｐ７５阻害剤としてのこれらの使用
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
JP2016522835A (ja) * 2013-05-28 2016-08-04 アストラゼネカ アクチボラグ 化合物
WO2017073743A1 (ja) * 2015-10-30 2017-05-04 協和発酵キリン株式会社 三環性化合物
US11458126B2 (en) 2017-08-01 2022-10-04 Ptc Therapeutics, Inc. DHODH inhibitor for use in treating hematologic cancers
US11613538B2 (en) 2009-05-27 2023-03-28 Ptc Therapeutics, Inc. Method of inhibiting or reducing a viral infection

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2427166T3 (es) 2003-06-23 2013-10-29 Ono Pharmaceutical Co., Ltd. Compuesto heterocíclico tricíclico novedoso
SG184755A1 (en) 2004-03-15 2012-10-30 Ptc Therapeutics Inc Carboline derivatives useful in the inhibition of angiogenesis
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7964726B2 (en) 2004-12-22 2011-06-21 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
WO2008103470A2 (en) 2007-02-21 2008-08-28 Trustees Of Columbia University In The City Of New York Oncogenic-ras-signal dependent lethal compounds
US11202775B2 (en) 2007-09-25 2021-12-21 Minerva Biotechnologies Corporation Methods for treatment of cancer
WO2009042815A1 (en) * 2007-09-25 2009-04-02 Minerva Biotechnologies Corp. Methods for treatment of cancer
EP2050747A1 (en) * 2007-10-12 2009-04-22 BioAlliance Pharma Dimers of harmol or of its derivatives and uses thereof
KR101614723B1 (ko) 2008-01-11 2016-04-22 알바니 몰레큘라 리써치, 인크. Ｍｃｈ 길항물질로서 (1-아지논)-치환된 피리도인돌
CN101591348B (zh) * 2008-05-30 2011-07-27 首都医科大学 四氢咔啉酰氨基酸苄酯及其制备方法和应用
CN101597289B (zh) * 2008-06-02 2011-09-21 首都医科大学 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用
WO2010138652A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating kaposi sarcoma
MX2011012517A (es) 2009-05-27 2012-01-27 Ptc Therapeutics Inc Procesos para la preparacion de tetrahidro beta - carbolina sustituidas.
US8703726B2 (en) 2009-05-27 2014-04-22 Ptc Therapeutics, Inc. Methods for treating prostate conditions
US8629158B2 (en) * 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
JP2012532144A (ja) 2009-07-01 2012-12-13 アルバニー モレキュラー リサーチ， インコーポレイテッド アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US8697700B2 (en) 2010-12-21 2014-04-15 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
DK2802328T3 (en) * 2012-01-09 2018-06-14 X Chem Inc TRYPTOLIN DERIVATIVES WITH KINASE INHIBITIVE ACTIVITY AND APPLICATIONS THEREOF
CN103087062B (zh) * 2013-01-19 2015-06-03 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
CN108513537A (zh) * 2015-09-23 2018-09-07 米纳瓦生物技术公司 筛选分化干细胞的试剂的方法
US10519148B2 (en) * 2015-11-12 2019-12-31 Zhejiang Hisun Pharmaceutical Co., Ltd. Acrylic acid derivative, preparation method and use in medicine thereof
CN106967063B (zh) * 2017-03-21 2019-01-11 浙江大学 1-三氟甲基-1,2,3,4-四氢-β-咔啉衍生物及其制备方法
WO2020072675A1 (en) 2018-10-02 2020-04-09 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c)
CN110791389B (zh) * 2019-09-30 2021-06-01 义乌欧风汽车用品有限公司 一种除胶剂及其制备方法和应用
CR20240264A (es) * 2021-12-31 2024-09-03 Ptc Therapeutics Inc Compuestos de carbolina y uso de los mismos
EP4615838A1 (en) * 2022-11-07 2025-09-17 Merck Patent GmbH Substituted bi-and tricyclic hset inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02111772A (ja) * 1988-08-29 1990-04-24 Duphar Internatl Res Bv β―カルボリン類、ベンゾフラン類似体及びベンゾチオフェン類似体並びにこれらの調剤上許容される酸付加塩、β―カルボリン類、ベンゾフラン類似体及びベンゾチオフェン類似体を製造する方法、静細胞特性を有する組成物、腫瘍の治療方法
JPH05246987A (ja) * 1991-12-05 1993-09-24 Whitby Res Inc 抗増殖剤として有用な化合物
US5606060A (en) * 1992-04-14 1997-02-25 The United States Of America As Represented By The Department Of Health & Human Services Topoisomerase II inhibitors and therapeutic uses therefor
JP2000508302A (ja) * 1996-04-04 2000-07-04 エフ．ホフマン―ラ ロッシュ エイジー 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用
US20030040527A1 (en) * 2001-04-03 2003-02-27 Yeh Sheau Farn 1-substituted 1,2,3,4-tetrahydro-beta-carboline and 3,4-dihydro-beta-carboline and analogs as antitumor agents
WO2003033496A1 (en) * 2001-10-19 2003-04-24 Transtech Pharma, Inc. Beta-carbolin derivatives as ptp-inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE136032T1 (de) 1987-07-20 1996-04-15 Duphar Int Res 8,9-anellierte 1,2,3,4-tetrahydro-beta-carbolin- derivate
JPH03287586A (ja) 1990-04-02 1991-12-18 Taisho Pharmaceut Co Ltd テトラヒドロ―β―カルボリン誘導体
JP3287586B2 (ja) 1991-07-09 2002-06-04 キヤノン株式会社 カラー画像処理方法、及びカラー画像処理装置
FR2796644B1 (fr) 1999-07-23 2001-09-07 Adir Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02111772A (ja) * 1988-08-29 1990-04-24 Duphar Internatl Res Bv β―カルボリン類、ベンゾフラン類似体及びベンゾチオフェン類似体並びにこれらの調剤上許容される酸付加塩、β―カルボリン類、ベンゾフラン類似体及びベンゾチオフェン類似体を製造する方法、静細胞特性を有する組成物、腫瘍の治療方法
JPH05246987A (ja) * 1991-12-05 1993-09-24 Whitby Res Inc 抗増殖剤として有用な化合物
US5606060A (en) * 1992-04-14 1997-02-25 The United States Of America As Represented By The Department Of Health & Human Services Topoisomerase II inhibitors and therapeutic uses therefor
JP2000508302A (ja) * 1996-04-04 2000-07-04 エフ．ホフマン―ラ ロッシュ エイジー 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用
US20030040527A1 (en) * 2001-04-03 2003-02-27 Yeh Sheau Farn 1-substituted 1,2,3,4-tetrahydro-beta-carboline and 3,4-dihydro-beta-carboline and analogs as antitumor agents
WO2003033496A1 (en) * 2001-10-19 2003-04-24 Transtech Pharma, Inc. Beta-carbolin derivatives as ptp-inhibitors

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008536876A (ja) * 2005-04-18 2008-09-11 ピーティーシー セラピューティクス，インコーポレーテッド 癌の治療に有用なカルボリン誘導体
US11613538B2 (en) 2009-05-27 2023-03-28 Ptc Therapeutics, Inc. Method of inhibiting or reducing a viral infection
JP2013513649A (ja) * 2009-12-14 2013-04-22 サノフイ 新規（複素環／縮合ピペリジン）−（ピペラジニル）−１−アルカノンまたは（複素環／縮合ピロリジン）−（ピペラジニル）−１−アルカノン誘導体およびｐ７５阻害剤としてのこれらの使用
JP2015214544A (ja) * 2010-07-06 2015-12-03 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
JP5821848B2 (ja) * 2010-07-06 2015-11-24 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
CN102971318B (zh) * 2010-07-06 2015-11-25 小野药品工业株式会社 四氢咔啉衍生物
CN102971318A (zh) * 2010-07-06 2013-03-13 小野药品工业株式会社 四氢咔啉衍生物
US9636330B2 (en) 2010-07-06 2017-05-02 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
US9974777B2 (en) 2010-07-06 2018-05-22 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
WO2012005227A1 (ja) * 2010-07-06 2012-01-12 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
US9862721B2 (en) 2011-03-18 2018-01-09 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
JP2016522835A (ja) * 2013-05-28 2016-08-04 アストラゼネカ アクチボラグ 化合物
WO2017073743A1 (ja) * 2015-10-30 2017-05-04 協和発酵キリン株式会社 三環性化合物
US11458126B2 (en) 2017-08-01 2022-10-04 Ptc Therapeutics, Inc. DHODH inhibitor for use in treating hematologic cancers

Also Published As

Publication number Publication date
WO2005070930A2 (en) 2005-08-04
US20050215580A1 (en) 2005-09-29
MXPA06008211A (es) 2006-08-31
WO2005070930A3 (en) 2006-01-19
AU2005206570A1 (en) 2005-08-04
US7855295B2 (en) 2010-12-21
CA2554150A1 (en) 2005-08-04
EP1706404A2 (en) 2006-10-04
BRPI0506977A (pt) 2007-07-03
CN1910183A (zh) 2007-02-07

Similar Documents

Publication Publication Date Title
JP2007518822A (ja) 抗癌剤としてのテトラヒドロカルボリン化合物
JP4778439B2 (ja) 抗癌剤としてのキナゾリノン化合物
EP1636225B1 (en) Pyridino 1,2-a pyrimidin-4-one compounds as anticancer agents
JP2007500237A5 (OSRAM)
US7345046B2 (en) Heteroaryl-fused pyrimidinyl compounds as anticancer agents
JP2007512368A5 (OSRAM)
JP4895220B2 (ja) キネシン有糸分裂インヒビター

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071130

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071130

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110121

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110729

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110729