JP2007518452A - 熱傷、創傷、および関連皮膚疾患の光力学治療のためのシステムおよび方法 - Google Patents
熱傷、創傷、および関連皮膚疾患の光力学治療のためのシステムおよび方法 Download PDFInfo
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Abstract
Description
本発明は、細胞増殖および遺伝子発現の光力学的調節のための方法および装置に関する。特に、本発明は、日焼け、熱傷、化学熱傷、放射線熱傷、例えば外傷、外科的手術、レーザー、化学的表皮剥離、美容整形、化学兵器または戦争傷害、凍傷、低酸素症、血管不全、打撲傷、慢性潰瘍等の様々な創傷、アレルギー反応または接触皮膚炎、および様々な炎症性疾患の影響の軽減、回復、および/または減少に関する。
加齢による老化、「光老化(photo-aging)」すなわち自然光および人工光源への曝露による皮膚の老化、疾患、および外傷の全ては、ヒトおよび哺乳動物の皮膚において外観の変化、ならびに皮膚の構造および機能に変化をもたらす。全ての生細胞、組織、および器官もまた、加齢による老化、打撲傷、光老化、疾患、および外傷に関連する変化を受けている。ヒトの皮膚は非常に目につきやすい器官なので、これらの状態に関連する変化は容易に明らかかつ目に見える。これらの変化は基礎となる構造的および機能的な変化を反映している。
本明細書において具体化され広く記載されるように、本発明は光老化または損傷した皮膚の外観を改善する方法および装置にに向けられている。方法と装置には、光調節等の光力学的手段による皮膚および他の細胞増殖および遺伝子発現の制御が含まれる。
本明細書において具体化され広く記載されるように、本発明は細胞増殖および遺伝子発現の調節、特に皮膚の光老化の抑制、ならびに壊死細胞の再生のための方法および装置を目的とする。また、本発明は壊死の各段階における細胞を若返らせるシステムおよび方法を目的とする。
紫外線光による傷害は、活性酸素種およびキナーゼカスケードと呼ばれる一連の細胞シグナル伝達事象を誘発する。線維芽細胞活性における上方制御および下方制御の通常の最終経路の1つは、MMP-1(コラゲナーゼ1および間質性コラゲナーゼ合成)、MMP-9(ゼラチナーゼB)、およびMMP-3(ストロメリシン1)を含む様々なMMPの産生を上方制御および増加させるAP-1を介する。これらのMMP酵素の産生は結果として、皮膚の真皮において、コラーゲン、エラスチン、およびECMの破壊をもたらす。同時にコラーゲンIおよび他の構造タンパク質の実際の産生は減少または下方制御されうり、そのためこの過程がさらに促進される。
皮膚において増加したROS産生は細胞のシグナル伝達またはシグナル伝達経路を刺激し、遺伝子活性に変化を生じさせる。構造タンパク質の損傷(例えば、UV光によって引き起こされるコラーゲンの損傷、破壊、および断片化)は、タンパク質、構造、および次いで細胞シグナル伝達を変えて遺伝子活性を変えることもある機能を変化させる。増加したROS産生の、他の可能性のある結果は、DNAに変異が生じることであり、これは次いで遺伝子構造を変化させ、したがって細胞の正常な構造および機能を変えることもある。疾病および環境による損傷への応答に限り、ヒトの体質の相違の大部分は、個人間の遺伝子の構成における比較的小さな差異によって左右されることがある。一塩基多型(SNP)は、ヒトおよび他の動物の生物学反応における差異を同定し、潜在的に予見する方法として現在非常に活発に研究されている。例えば、SNPの特徴は、患者が特定の疾病または腫瘍を発症する可能性が高いかまたは低いかという予見を可能としうり、したがって公知の予防的手段をとる事ができる。別の可能性のある適用は、処方薬を与える前に、個体をSNPを使ってスクリーニングして深刻な副作用を起こす可能性のある個体を見極めることであり、したがってその薬の使用を避けることができる。別の潜在的なSNPの新規な使用法は、例えば、皮膚の加齢による老化に関連するSNPのハプロタイプまたはパターンを同定することである。ある人々や家族は、皮膚癌の危険性が低いか、または単純に同じ年代や同じような環境の仲間よりも若く見える。SNPのプロファイルを開発することが可能であり、これは老化皮膚の表現型の変化に関連する共通因子を特徴付ける(個体の、環境作用因子からの増加した酸化ストレスよる老化加速の危険性をより高くするSNPの遺伝子型パターンを定義)。これはより大きな老化防止的恩典をもたらす治療計画を可能にする。
ミトコンドリアおよびATPの産生機構(例えばチトクローム発現)は電磁照射によって調節可能である。活性化で媒介される酸化還元または受容体型タンパク質チロシンホスファターゼ(RTPT)によって、LED光は細胞表面の受容体を活性化する。SAP(ストレス活性化経路) 対 分裂促進因子活性化経路を比較対照すると、c-Junが増加した場合SAPはMMPを増加させ、プロコラーゲン1および2を減少させる。最初はECM産生によって行わなくてはならばいが、MAP経路がERK誘導サイクリンを活性化して細胞増殖を促進し、そのため、PSATはタンパク質産生を増加または減少させる傾向があるが、MAPSが細胞増殖を増加または減少させる。Ras/MAP/AP-1経路は創傷への応答において重要な役割を担う。FGFR1はプロモーター領域およびIL-1アンタゴニストプロモーター中の部位を含む。また抗酸化化合物はUV曝露後に増加MMPを抑制できないが、抗紅斑日焼け止め効果があり、これらの1つはリコピンある。LED光調節も日焼け活性を減少させるのに使用でき、MMPレベルは約24時間後に最大になる。太陽光シミュレーターの使用によりボランティアの腕の二ヶ所に1つのMED最小紅斑量を発生させ、その1つを毎日2回GW装置で治療し、比色計で赤みの減少を測定する。生検により、UV後GWによりこれらを治療する際に何が起こるのかが示される。チトクロームP-450 のレチノイド分解を抑制するとレチノイドの濃度が増加する。
ECMのタンパク質分解は、継続的な創傷治癒の間の修復および再生における基本的な特徴である。創傷修復は、麻酔性または損傷した組織、細胞および/または組織の移動、血管新生、新しく合成されたECMの再生、および細胞増殖因子の調節からなる。創傷治癒の間、MMP 1およびMMP 3ならびにMMP 2および9も増加する。MMP-1、3は特に慢性の創傷で増加するが、急性創傷でも増加する。TIMPもまた変化する。MMP 1、3、9は、UVBによって増加し;増加したエラスチンおよびフィブリリンバーシカンによって増加し;結果的に、非機能的なエラスチン線維を形成し、皮膚の弾性を減少させ、老化したまたは光老化した皮膚となる。コラーゲンIが減少し、UVAはMMP 1、2、3の増加した発現を示す。
本発明の様々な態様についてさらに説明するグラフ、データ表、および実施例、ならびに本発明の方法で調節される遺伝子産物の一覧を本明細書に添付する。付記に本発明を説明する2つの実験の結果を示す。
本研究に参加した、光老化したIII型皮膚を有する健康な50歳の女性ボランティアを週2回、計8回治療した。皮膚生検は治療前と最終治療(590/810 nm LEDパネル(ZZ)+IRフィルター、250m秒オン/100m秒オフ/100パルス)の4ヶ月後に採取した。
UVA1照射シミュレートのためにSchott WG-360フィルターを使用した。残余可視光および赤外線照射の除去するために、中心波長を365 nmとしたI-Lineフィルターを追加し、いかなる残余UVB放射およびUVC放射も除去するためにHoya UV34フィルターを使用した。
全放射度の測定のために、光レジスト放射計(International Light Inc. Newburyport MA)を使用した。
590/810 nm LED(DD) 24時間 老化関連遺伝子マイクロアレイ
インターロイキン 24時間 ヒト線維芽細胞におけるマイクロアレイ結果 590/810 nm LED(DD)
JJ= 623 nm LEDアレイ、250m秒オン/100m秒オフ/100パルス、3.6mW/cm2
ケラチノサイトマーカーのマイクロアレイ結果(ヒト線維芽細胞試料)LED曝露24時間後
590/810 nm (DD)+IRフィルターパネル 24時間
インターロイキン 24時間 ヒト線維芽細胞におけるマイクロアレイ結果 590/810 nm LED(DD)
590/810 nm LED(DD) 24時間
増殖:
(刺激性の役割)
ヒト線維芽細胞のミトコンドリア遺伝子
590/810 nm LED(DD) 24時間
MAPK関連遺伝子
590/810 nm LED(DD) 24時間
590/810 nm LED(DD) ヒト線維芽細胞マイクロアレイ 24時間 上方制御
Claims (10)
- 以下を含む装置:
少なくとも1つの光源が黄色光に相当する波長で放射線を放射し、かつ少なくとも1つの光源が赤外線光に相当する放射線を放射する、複数の狭帯域多色電磁照射光源。 - 黄色光:赤外線光の強度比が約4:1である、請求項1記載の装置。
- 少なくとも1つの光源が約590 nmの主放射波長の放射線を放射し、および少なくとも1つの光源が約850 nmの主放射波長の放射線を放射する、請求項1記載の装置。
- 少なくとも1つの光源が約590 nmの主放射波長の放射線を約4mW/cm2のエネルギー出力で放射し、かつ少なくとも1つの光源が約850 nmの主放射波長の放射線を約1mW/cm2のエネルギー出力で放射する、請求項3記載の装置。
- 黄色光強度に対する赤外線光強度の比率を変更するために、少なくとも1つの光学的、機械的、または電気的フィルターを含む、請求項1記載の装置。
- 以下の段階を含む方法:
少なくとも1つの光源が黄色光に相当する波長で放射線を放射し、かつ少なくとも1つの光源が赤外線光に相当する放射線を放射する、複数の狭帯域多色電磁照射光源で哺乳動物組織を光調節する。 - 黄色光:赤外線光の強度比が約4:1である、請求項6記載の方法。
- 少なくとも1つの光源が約590 nmの主放射波長の放射線を放射し、かつ少なくとも1つの光源が約850 nmの主放射波長の放射線を放射する、請求項6記載の方法。
- 少なくとも1つの光源が約590 nmの主放射波長の放射線を約4mW/cm2のエネルギー出力で放射し、かつ少なくとも1つの光源が約850 nmの主放射波長の放射線を約1mW/cm2のエネルギー出力で放射する、請求項8記載の方法。
- 少なくとも1つの光学的、機械的、または電気的なフィルターによって黄色光強度に対する赤外線光強度の比率を変更することを含む、請求項6記載の方法。
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- 2004-08-02 CN CNA2004800215760A patent/CN101247768A/zh active Pending
- 2004-08-02 US US10/903,483 patent/US20050149150A1/en not_active Abandoned
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- 2004-08-02 KR KR1020067002207A patent/KR101160343B1/ko active IP Right Grant
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JP2017080425A (ja) * | 2011-02-14 | 2017-05-18 | メルク パテント ゲーエムベーハー | 細胞および細胞組織の処置のためのデバイスおよび方法 |
JP2016082932A (ja) * | 2014-10-28 | 2016-05-19 | 花王株式会社 | 皮膚性状判定のための遺伝子検出方法 |
KR20170125325A (ko) * | 2015-02-03 | 2017-11-14 | 로레알 | 연속 광을 이용한 피부 치료 장치 및 방법 |
KR20170125324A (ko) * | 2015-02-03 | 2017-11-14 | 로레알 | 펄스 광을 이용한 피부 치료 장치 및 방법 |
JP2018503476A (ja) * | 2015-02-03 | 2018-02-08 | ロレアル | 連続光を用いたスキンケアのための装置と方法 |
JP2018507029A (ja) * | 2015-02-03 | 2018-03-15 | ロレアル | パルス光を用いたスキンケアのための装置と方法 |
KR102044490B1 (ko) * | 2015-02-03 | 2019-11-13 | 로레알 | 펄스 광을 이용한 피부 치료 장치 및 방법 |
KR102132417B1 (ko) * | 2015-02-03 | 2020-07-09 | 로레알 | 연속 광을 이용한 피부 치료 장치 |
JP7040942B2 (ja) | 2015-02-03 | 2022-03-23 | ロレアル | 連続光を用いたスキンケアのための装置と方法 |
Also Published As
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WO2005011606A3 (en) | 2006-12-28 |
EP1648385A4 (en) | 2009-02-04 |
IL173123A0 (en) | 2006-06-11 |
WO2005011606A2 (en) | 2005-02-10 |
CN101247768A (zh) | 2008-08-20 |
CA2533129A1 (en) | 2005-02-10 |
US20100137950A1 (en) | 2010-06-03 |
KR20060060670A (ko) | 2006-06-05 |
US9144690B2 (en) | 2015-09-29 |
JP4739202B2 (ja) | 2011-08-03 |
EP1648385B1 (en) | 2016-05-04 |
EP1648385A2 (en) | 2006-04-26 |
US20150328479A1 (en) | 2015-11-19 |
ES2572976T3 (es) | 2016-06-03 |
KR101160343B1 (ko) | 2012-06-26 |
US20050149150A1 (en) | 2005-07-07 |
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